Chemical Approaches To The Synthesis Of Peptides And Proteins

Author : Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt
Publisher : CRC Press
Page : 306 pages
File Size : 40,8 Mb
Release : 2020-08-18
Category : Cooking
ISBN : 9781000151688

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Chemical Approaches to the Synthesis of Peptides and Proteins by Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt Pdf

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

Author : John Jones
Publisher : Oxford University Press, USA
Page : 248 pages
File Size : 48,7 Mb
Release : 1991
Category : Language Arts & Disciplines
ISBN : UOM:39015031709291

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The Chemical Synthesis of Peptides by John Jones Pdf

This book focuses on the chemical principles behind the more important methods of peptide synthesis, and it provides a critical, concise, and up-to-date survey of the field.

Author : Ashraf Brik,Philip Dawson,Lei Liu
Publisher : John Wiley & Sons
Page : 626 pages
File Size : 41,8 Mb
Release : 2021-06-08
Category : Science
ISBN : 9783527346608

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Total Chemical Synthesis of Proteins by Ashraf Brik,Philip Dawson,Lei Liu Pdf

How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: Contains valuable insights from the pioneers in the field of chemical protein synthesis Presents proven synthetic approaches for a range of protein families Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.

Author : G. C. Barrett,D. T. Elmore
Publisher : Cambridge University Press
Page : 246 pages
File Size : 44,5 Mb
Release : 1998-10-29
Category : Science
ISBN : 0521468272

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Amino Acids and Peptides by G. C. Barrett,D. T. Elmore Pdf

This text is suitable for advanced undergraduate and beginning graduate students in chemistry and biochemistry studying amino acids and peptides. The authors concentrate on amino acids and peptides without detailed discussions of proteins, although the book gives all the essential background chemistry, including sequence determination, synthesis and spectroscopic methods, to enable the reader to appreciate protein behaviour at the molecular level. The approach is intended to encourage the reader to cross classical boundaries, as in the later chapters on the biological roles of amino acids and the design of peptide-based drugs. For example, there is a section on the enzyme-catalysed synthesis of peptides, with suitable examples, an area often neglected in texts describing peptide synthesis. This modern text will be of value in the amino acid, peptide and protein field, to advanced undergraduates, graduate students and research workers.

Author : W. Chan,Peter White
Publisher : Oxford University Press
Page : 371 pages
File Size : 50,8 Mb
Release : 1999-12-16
Category : Science
ISBN : 9780191565892

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Fmoc Solid Phase Peptide Synthesis by W. Chan,Peter White Pdf

In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now for the most part, been solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers the essential procedures for the production of linear peptides and more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly. Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as t-bag, SPOT and PIN synthesis, have naturally been included. Finally, a survey of available automated instrumentation has also been provided.

Author : Bernd Gutte
Publisher : Elsevier
Page : 527 pages
File Size : 53,5 Mb
Release : 1995-10-24
Category : Science
ISBN : 9780080538594

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Peptides by Bernd Gutte Pdf

In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines

Author : Xuechen Li
Publisher : Springer Nature
Page : 258 pages
File Size : 47,9 Mb
Release : 2022-06-27
Category : Science
ISBN : 9781071624890

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Chemical Protein Synthesis by Xuechen Li Pdf

This volume provides updated protocols for chemical protein synthesis. Chapters guide readers through development methods, strategies, and applications of protein chemical synthesis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Chemical Protein Synthesis aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.

Author : Bruce Merrifield
Publisher : Unknown
Page : 328 pages
File Size : 53,7 Mb
Release : 1993
Category : Biography & Autobiography
ISBN : STANFORD:36105003439804

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Life During a Golden Age of Peptide Chemistry by Bruce Merrifield Pdf

Thirteenth in a series of autobiographies of 22 eminent organic chemists, the present volume chronicles the life and contributions to the field of Bruce Merrifield, winner of the 1984 Nobel Prize for chemistry. Subtitled The Concept and Development of Solid-Phase Peptide Synthesis. Highly illustrated with diagrams, tables, graphs and (bandw) photographs. Annotation copyright by Book News, Inc., Portland, OR

Author : Hans Neurath
Publisher : Elsevier
Page : 603 pages
File Size : 55,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323162104

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The Proteins Pt 3 by Hans Neurath Pdf

The Proteins, Third Edition, Volume II is a three-chapter text that highlights the application of methods of organic chemistry to the study of protein structure. Chapter 1 reviews the chemical modification of proteins by group- and site-specific reagents. This chapter also discusses the methods for the chemical modification of proteins and their application to the study of the structure, conformation, and biologic activity of certain proteins. Chapter 2 describes the synthesis of peptides by solution methods and the procedures employed for the synthesis of biologically active peptide hormones. This chapter also deals with the many difficulties inherent in the application of the existing synthetic methods and emphasizes the stringent standards that must be maintained for the successful chemical synthesis of naturally occurring polypeptides. Chapter 3 presents the solid-phase methods for the synthesis of peptides on solid supports. Organic chemists and researchers, teachers and undergraduate students will find this book invaluable.

Author : Shawn Doonan
Publisher : Royal Society of Chemistry
Page : 196 pages
File Size : 40,9 Mb
Release : 2002
Category : Education
ISBN : 0854046925

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Peptides and Proteins by Shawn Doonan Pdf

Encompassing all aspects of the structures of peptides and proteins, this book adopts a uniquely problem-oriented approach to the topic. Starting with a look at the structures and properties of the twenty amino acids that occur in proteins, and moving on to the synthesis of polypeptides and the isolation of proteins, Peptides and Proteins then addresses the methods of analysis of protein characteristics, including the modern methods of sequence analysis by mass spectrometry. Further chapters examine the three-dimensional nature of protein structure, and introduce the student to the use of computer applications (molecular graphics, databases, bioinformatics) in protein chemistry. Original research data is used in many of the problems, and throughout sufficient background biology is included, thus putting the subject into context for chemists. Aimed at first and second-year chemistry students, this title will also be of interest to students of biochemistry. Ideal for the needs of undergraduate chemistry students, Tutorial Chemistry Texts is a major new series consisting of short, single topic or modular texts concentrating on the fundamental areas of chemistry taught in undergraduate science courses. Each book provides a concise account of the basic principles underlying a given subject, embodying an independent-learning philosophy and including worked examples.

Author : Ulo Langel,Benjamin F. Cravatt,Astrid Graslund,N.G.H. von Heijne,Matjaz Zorko,Tiit Land,Sherry Niessen
Publisher : CRC Press
Page : 440 pages
File Size : 42,7 Mb
Release : 2009-11-18
Category : Medical
ISBN : 9781439882047

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Introduction to Peptides and Proteins by Ulo Langel,Benjamin F. Cravatt,Astrid Graslund,N.G.H. von Heijne,Matjaz Zorko,Tiit Land,Sherry Niessen Pdf

Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform

Author : Theodor Wieland,Miklos Bodanszky
Publisher : Springer
Page : 328 pages
File Size : 42,9 Mb
Release : 1991
Category : Science
ISBN : STANFORD:36105033145389

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The World of Peptides by Theodor Wieland,Miklos Bodanszky Pdf

Author : Anonim
Publisher : John Wiley & Sons
Page : 541 pages
File Size : 49,5 Mb
Release : 2011-06-03
Category : Science
ISBN : 9783527641574

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Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis by Anonim Pdf

This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Author : Antonio Guarna,Andrea Trabocchi
Publisher : John Wiley & Sons
Page : 334 pages
File Size : 47,5 Mb
Release : 2014-03-14
Category : Science
ISBN : 9781118683149

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Peptidomimetics in Organic and Medicinal Chemistry by Antonio Guarna,Andrea Trabocchi Pdf

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Author : N. Leo Benoiton
Publisher : CRC Press
Page : 304 pages
File Size : 44,9 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420027693

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Chemistry of Peptide Synthesis by N. Leo Benoiton Pdf

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th