Amyloid Beta Clearance In Alzheimer S Disease

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Amyloid-beta clearance in Alzheimer’s disease

Robert Marr,Eliezer Masliah
Amyloid beta clearance in Alzheimer s disease Book PDF

Author : Robert Marr,Eliezer Masliah
Publisher : Frontiers Media SA
Page : 112 pages
File Size : 46,7 Mb
Release : 2015-03-24
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 9782889194438

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Amyloid-beta clearance in Alzheimer’s disease by Robert Marr,Eliezer Masliah Pdf

Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.

Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta

J. Robin Harris,Falk Fahrenholz
Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta Book PDF

Author : J. Robin Harris,Falk Fahrenholz
Publisher : Springer Science & Business Media
Page : 409 pages
File Size : 49,6 Mb
Release : 2006-11-22
Category : Science
ISBN : 9780387232263

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Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta by J. Robin Harris,Falk Fahrenholz Pdf

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

Apolipoprotein E and Alzheimer’s Disease

A.D. Roses,K.H. Weisgraber,Y. Christen
Apolipoprotein E and Alzheimer s Disease Book PDF

Author : A.D. Roses,K.H. Weisgraber,Y. Christen
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642801099

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Apolipoprotein E and Alzheimer’s Disease by A.D. Roses,K.H. Weisgraber,Y. Christen Pdf

There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

J. Robin Harris
Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease Book PDF

Author : J. Robin Harris
Publisher : Springer
Page : 650 pages
File Size : 51,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9400754159

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Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease by J. Robin Harris Pdf

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

Pathogenesis of Encephalitis

Daisuke Hayasaka
Pathogenesis of Encephalitis Book PDF

Author : Daisuke Hayasaka
Publisher : BoD – Books on Demand
Page : 358 pages
File Size : 40,5 Mb
Release : 2011-12-09
Category : Medical
ISBN : 9789533077413

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Pathogenesis of Encephalitis by Daisuke Hayasaka Pdf

Many infectious agents, such as viruses, bacteria, and parasites, can cause inflammation of the central nervous system (CNS). Encephalitis is an inflammation of the brain parenchyma, which may result in a more advanced and serious disease meningoencephalitis. To establish accurate diagnosis and develop effective vaccines and drugs to overcome this disease, it is important to understand and elucidate the mechanism of its pathogenesis. This book, which is divided into four sections, provides comprehensive commentaries on encephalitis. The first section (6 chapters) covers diagnosis and clinical symptoms of encephalitis with some neurological disorders. The second section (5 chapters) reviews some virus infections with the outlines of inflammatory and chemokine responses. The third section (7 chapters) deals with the non-viral causative agents of encephalitis. The last section (4 chapters) discusses the experimental model of encephalitis. The different chapters of this book provide valuable and important information not only to the researchers, but also to the physician and health care workers.

Abeta Peptide and Alzheimer's Disease

Colin J. Barrow,David H. Small
Abeta Peptide and Alzheimer s Disease Book PDF

Author : Colin J. Barrow,David H. Small
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 47,5 Mb
Release : 2006-12-22
Category : Medical
ISBN : 9781846284403

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Abeta Peptide and Alzheimer's Disease by Colin J. Barrow,David H. Small Pdf

Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer’s Disease (AD). This book summarizes current knowledge of the Abeta peptide and its role in AD. Written by specialists in this fast moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta.

Pathobiology of Alzheimer's Disease

Anonim
Pathobiology of Alzheimer s Disease Book PDF

Author : Anonim
Publisher : Elsevier
Page : 256 pages
File Size : 51,5 Mb
Release : 1995-10-17
Category : Medical
ISBN : 0080538495

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Pathobiology of Alzheimer's Disease by Anonim Pdf

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field. With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease. Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research. * * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective * A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease. * Up-to-date research data * Clear illustrations complement the text

Update on Dementia

Davide Moretti
Update on Dementia Book PDF

Author : Davide Moretti
Publisher : Unknown
Page : 128 pages
File Size : 48,5 Mb
Release : 2016
Category : Alzheimer's disease
ISBN : 9535126555

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Update on Dementia by Davide Moretti Pdf

"The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities."--Provided by publisher

Magnesium in the Central Nervous System

Robert Vink,Mihai Nechifor
Magnesium in the Central Nervous System Book PDF

Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 42,8 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051

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Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Alzheimer's Disease

George Perry,Jesús Avila,Xiongwei Zhu,Mark A. Smith,Aaron Sorensen
Alzheimer s Disease Book PDF

Author : George Perry,Jesús Avila,Xiongwei Zhu,Mark A. Smith,Aaron Sorensen
Publisher : IOS Press
Page : 486 pages
File Size : 53,5 Mb
Release : 2013
Category : Medical
ISBN : 9781614991533

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Alzheimer's Disease by George Perry,Jesús Avila,Xiongwei Zhu,Mark A. Smith,Aaron Sorensen Pdf

This volume is a companion to the highly successful book published in association with the Journal of Alzheimer's Disease (JAD) on the centennial of Alzheimer's discovery: "Alzheimer's Disease: A Century of Scientific and Clinical Research". Instead of looking back, this collection, "Alzheimer's Disease: Advances for a New Century", will look forward. Using scientometric analysis the most promising developments since the Alzheimer Centennial in 2006 have been substantiated. While prior trends and advances in genetics, amyloid-β, tau, neuropathology, and oxidative stress continue as active areas, emergent areas impacting the transition from normal cognition to Alzheimer's disease such as diagnostic imaging, biomarkers, metabolism, and lifestyle (areas conceived only a few years ago) now dominate the debate.Invited contributors have summarized their landmark publications identified by our analysis and have put them into perspective, explaining the impetus behind the work, the contribution of the results to the field, and who played a role in the work.

The Biology of Alzheimer Disease

Dennis J. Selkoe,David Michael Holtzman,Eckhard Mandelkow
The Biology of Alzheimer Disease Book PDF

Author : Dennis J. Selkoe,David Michael Holtzman,Eckhard Mandelkow
Publisher : Cold Spring Harbor Perspective
Page : 0 pages
File Size : 55,6 Mb
Release : 2012
Category : Medical
ISBN : 1936113449

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The Biology of Alzheimer Disease by Dennis J. Selkoe,David Michael Holtzman,Eckhard Mandelkow Pdf

Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progressesincluding the accumulation of amyloid plaques and neurofibrillary tanglesis critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid -protein precursor (APP), tau, presenilin, -secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.

Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease

C.L. Masters,K. Beyreuther,Marc Trillet
Amyloid Protein Precursor in Development Aging and Alzheimer s Disease Book PDF

Author : C.L. Masters,K. Beyreuther,Marc Trillet
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 52,9 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783662011355

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Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease by C.L. Masters,K. Beyreuther,Marc Trillet Pdf

This book summarizes the last ten years' research on Alzheimer's disease. Genetic mutations in the gene which codes for amyloid precursor protein (APP) have now been shown to cause Alzheimer's disease in some families. Other genetic loci are now being discovered which relate to Alzheimer's disease in some families. Understanding the normal structure and function of the APP gene product will eventually provide avenues for developing specific therapeutic strategies targeted at the amyloid deposition in the Alzheimer's disease brain. Drugs which can inhibit or dissolve the amyloid, affect the synthesis and proteolysis of APP, or which regulate the activity of the APP gene all hold the promise of eventually yielding an effective treatment for Alzheimer's disease.

The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders

David F. Cechetto,Nina Weishaupt
The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders Book PDF

Author : David F. Cechetto,Nina Weishaupt
Publisher : Academic Press
Page : 340 pages
File Size : 48,7 Mb
Release : 2017-02-24
Category : Medical
ISBN : 9780128019566

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The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders by David F. Cechetto,Nina Weishaupt Pdf

The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer’s Disease, Parkinson’s, addiction, and cardiovascular dysregulation. Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value. Offers a comprehensive overview on the best available in vivo and in vitro models to study cortical involvement Presents models and specific techniques that help to guide investigators in their choices on how to address research questions experimentally Provides expert commentary and a perspective on future trends at the end of each chapter Addresses translational advances and promising therapeutic options Includes references to key articles for additional detailed study

Alzheimer's Disease Pathogenesis

Suzanne De La Monte
Alzheimer s Disease Pathogenesis Book PDF

Author : Suzanne De La Monte
Publisher : BoD – Books on Demand
Page : 706 pages
File Size : 47,9 Mb
Release : 2011-09-12
Category : Medical
ISBN : 9789533076904

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Alzheimer's Disease Pathogenesis by Suzanne De La Monte Pdf

Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.

A-Beta Metabolism and Alzheimer's Disease

Takaomi Comings Saido
A Beta Metabolism and Alzheimer s Disease Book PDF

Author : Takaomi Comings Saido
Publisher : CRC Press
Page : 179 pages
File Size : 43,5 Mb
Release : 2003-02-18
Category : Science
ISBN : 9781498713641

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A-Beta Metabolism and Alzheimer's Disease by Takaomi Comings Saido Pdf

This book provides information regarding three major aspects of Aβ metabolism: generation from its precursor, degradation within the brain, and transport out of the brain. It is useful for graduate students, post-doctoral fellows, and scientists both in this and other disciplines.