Amyloid Protein Precursor In Development Aging And Alzheimer S Disease

Author : C.L. Masters,K. Beyreuther,Marc Trillet
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 51,8 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783662011355

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Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease by C.L. Masters,K. Beyreuther,Marc Trillet Pdf

This book summarizes the last ten years' research on Alzheimer's disease. Genetic mutations in the gene which codes for amyloid precursor protein (APP) have now been shown to cause Alzheimer's disease in some families. Other genetic loci are now being discovered which relate to Alzheimer's disease in some families. Understanding the normal structure and function of the APP gene product will eventually provide avenues for developing specific therapeutic strategies targeted at the amyloid deposition in the Alzheimer's disease brain. Drugs which can inhibit or dissolve the amyloid, affect the synthesis and proteolysis of APP, or which regulate the activity of the APP gene all hold the promise of eventually yielding an effective treatment for Alzheimer's disease.

Author : Colin L. Masters
Publisher : Springer Verlag
Page : 257 pages
File Size : 51,9 Mb
Release : 1994-01-01
Category : Medical
ISBN : 0387577882

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Amyloid Protein Precursor in Development, Aging, and Alzheimer's Disease by Colin L. Masters Pdf

Author : Konrad Beyreuther,Gotthard Schettler
Publisher : Springer Science & Business Media
Page : 206 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642842245

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Molecular Mechanisms of Aging by Konrad Beyreuther,Gotthard Schettler Pdf

Author : Robert Marr,Eliezer Masliah
Publisher : Frontiers Media SA
Page : 112 pages
File Size : 51,6 Mb
Release : 2015-03-24
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 9782889194438

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Amyloid-beta clearance in Alzheimer’s disease by Robert Marr,Eliezer Masliah Pdf

Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.

Author : Anonim
Publisher : Unknown
Page : 266 pages
File Size : 50,7 Mb
Release : 1995
Category : Alzheimer's disease
ISBN : UCBK:C095493472

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Progress Report on Alzheimer's Disease by Anonim Pdf

Author : Sangram S. Sisodia,Rudolph E. Tanzi
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 40,9 Mb
Release : 2007-02-16
Category : Medical
ISBN : 9780387351353

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Alzheimer's Disease by Sangram S. Sisodia,Rudolph E. Tanzi Pdf

This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.

Author : Roger M. Nitsch
Publisher : Unknown
Page : 368 pages
File Size : 40,8 Mb
Release : 1993
Category : Medical
ISBN : UVA:X002402561

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Alzheimer's Disease by Roger M. Nitsch Pdf

This is a combination of basic research findings and clinical studies regarding principles of neural transmission in ageing and dementia, the amyloid precursor proteins, and transplantation of neural tissues. Information on the sixth meeting is available as Annals volume 640.

Author : Nigel M. Hooper
Publisher : Springer Science & Business Media
Page : 411 pages
File Size : 50,6 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592591954

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Alzheimer's Disease by Nigel M. Hooper Pdf

Alzheimer's disease is the most common cause of senile dementia. Since the discovery in 1984 of the amyloid ?-peptide (A?) as the core protein of the senile plaques present in the brains of Alzheimer's disease sufferers, an immense amount of research has gone into mapping out the molecular basis of this debilitating disease. The aim of Alzheimer's Disease: Methods and Protocols is to bring together the main biochemical, cell biological, and molecular biological techniques and approaches that are being used to investigate the molecular basis of Alzheimer's disease. This volume begins with chapters of an introductory/ review nature. Chapter 1 provides a historical introduction to Alzheimer's d- ease with particular emphasis on the central role played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.

Author : Mathias Jucker,Konrad Beyreuther,Christian Haass,Roger M. Nitsch
Publisher : Springer Science & Business Media
Page : 541 pages
File Size : 51,7 Mb
Release : 2006-11-22
Category : Medical
ISBN : 9783540376521

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Alzheimer: 100 Years and Beyond by Mathias Jucker,Konrad Beyreuther,Christian Haass,Roger M. Nitsch Pdf

Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.

Author : Christian Haass
Publisher : CRC Press
Page : 350 pages
File Size : 55,9 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203303610

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Molecular Biology of Alzheimer's Disease by Christian Haass Pdf

Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.

Author : David Dawbarn,Shelley J. Allen
Publisher : Molecular and Cellular Neurobi
Page : 495 pages
File Size : 53,7 Mb
Release : 2007
Category : Health & Fitness
ISBN : 0198566611

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Neurobiology of Alzheimer's Disease by David Dawbarn,Shelley J. Allen Pdf

Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Author : Einar M. Sigurdsson
Publisher : Springer Science & Business Media
Page : 390 pages
File Size : 48,8 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592598748

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Amyloid Proteins by Einar M. Sigurdsson Pdf

A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Author : Wilma Wasco,Rudolph Tanzi
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 49,7 Mb
Release : 1996-11-01
Category : Medical
ISBN : 9781592594719

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Molecular Mechanisms of Dementia by Wilma Wasco,Rudolph Tanzi Pdf

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Author : G. Perry,J. Avila,J. Kinoshita
Publisher : IOS Press
Page : 468 pages
File Size : 44,7 Mb
Release : 2006-06-26
Category : Medical
ISBN : 9781607501756

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Alzheimer's Disease: A Century of Scientific and Clinical Research by G. Perry,J. Avila,J. Kinoshita Pdf

This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer’s original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.

Author : Steven G. Younkin,Rudolph E. Tanzi
Publisher : Springer Science & Business Media
Page : 111 pages
File Size : 41,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642721038

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Presenilins and Alzheimer’s Disease by Steven G. Younkin,Rudolph E. Tanzi Pdf

The role of the familial Alzheimer's Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.