Amyloid Proteins

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Amyloid Proteins

Einar M. Sigurdsson
Amyloid Proteins Book PDF

Author : Einar M. Sigurdsson
Publisher : Springer Science & Business Media
Page : 390 pages
File Size : 41,5 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592598748

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Amyloid Proteins by Einar M. Sigurdsson Pdf

A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

The Nature and Origin of Amyloid Fibrils

Gregory R. Bock,Jamie A. Goode
The Nature and Origin of Amyloid Fibrils Book PDF

Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 266 pages
File Size : 49,8 Mb
Release : 2008-04-30
Category : Medical
ISBN : 9780470514931

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The Nature and Origin of Amyloid Fibrils by Gregory R. Bock,Jamie A. Goode Pdf

Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.

Amyloid and Amyloidosis

Gilles Grateau,Robert A. Kyle,Martha Skinner
Amyloid and Amyloidosis Book PDF

Author : Gilles Grateau,Robert A. Kyle,Martha Skinner
Publisher : CRC Press
Page : 862 pages
File Size : 50,7 Mb
Release : 2004-11-29
Category : Medical
ISBN : 9781000612004

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Amyloid and Amyloidosis by Gilles Grateau,Robert A. Kyle,Martha Skinner Pdf

This authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, incl

Amyloidosis

J. Marrink,M.H. van Rijswijk
Amyloidosis Book PDF

Author : J. Marrink,M.H. van Rijswijk
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 51,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400943094

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Amyloidosis by J. Marrink,M.H. van Rijswijk Pdf

This book is a gift from the international community of amyloid friends, presented to Professor Dr. Enno Mandema on the occasion of his retirement from the University of Groningen, the Netherlands. It is the "precipitation" of up to date knowledge of amyloidosis, as presented at the International Course on Amyloidosis in Groningen, on the 10th and 11th of October 1986. Twenty years ago, Professor Mandema invited a group of scientists, who were studying the various aspects of amyloidosis from different points of view, to discuss their mutual interest in the subject. This "First International Symposium" was held for five days in September 1967. It was a wonderful experience for the participants, as most of them had until then only read each others work in the literature. The proceedings of that symposium, which contained the "lively" dis cussions, became a text-book for the following years. Research continued, and while the book was still in preparation, the revolutionary method of "water-soluble amyloid" was published. In the following years, different amyloid proteins were discovered and the mo lecular basis of the different amyloid syndromes was elucidated. The increase in knowledge parallelled the availability of modern, ingenious and also rapid methods in the biomedical sciences.

Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease

C.L. Masters,K. Beyreuther,Marc Trillet
Amyloid Protein Precursor in Development Aging and Alzheimer s Disease Book PDF

Author : C.L. Masters,K. Beyreuther,Marc Trillet
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 49,8 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783662011355

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Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease by C.L. Masters,K. Beyreuther,Marc Trillet Pdf

This book summarizes the last ten years' research on Alzheimer's disease. Genetic mutations in the gene which codes for amyloid precursor protein (APP) have now been shown to cause Alzheimer's disease in some families. Other genetic loci are now being discovered which relate to Alzheimer's disease in some families. Understanding the normal structure and function of the APP gene product will eventually provide avenues for developing specific therapeutic strategies targeted at the amyloid deposition in the Alzheimer's disease brain. Drugs which can inhibit or dissolve the amyloid, affect the synthesis and proteolysis of APP, or which regulate the activity of the APP gene all hold the promise of eventually yielding an effective treatment for Alzheimer's disease.

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

J. Robin Harris
Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease Book PDF

Author : J. Robin Harris
Publisher : Springer Science & Business Media
Page : 654 pages
File Size : 51,9 Mb
Release : 2012-12-09
Category : Medical
ISBN : 9789400754164

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Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease by J. Robin Harris Pdf

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

Amyloid Precursor Protein

Weiming Xia,Huaxi Xu
Amyloid Precursor Protein Book PDF

Author : Weiming Xia,Huaxi Xu
Publisher : CRC Press
Page : 240 pages
File Size : 41,7 Mb
Release : 2004-12-16
Category : Science
ISBN : 9780203492185

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Amyloid Precursor Protein by Weiming Xia,Huaxi Xu Pdf

In the search for an effective treatment for Alzheimer's disease, APP is a unique model protein that illustrates the wide array of basic and sophisticated characterization techniques available. Exploring a variety of biological techniques to clarify the structure and function of this transmembrane protein, this text presents each method with detail

Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta

J. Robin Harris,Falk Fahrenholz
Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta Book PDF

Author : J. Robin Harris,Falk Fahrenholz
Publisher : Springer Science & Business Media
Page : 409 pages
File Size : 48,9 Mb
Release : 2006-11-22
Category : Science
ISBN : 9780387232263

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Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta by J. Robin Harris,Falk Fahrenholz Pdf

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

Amyloid Proteins

Einar M. Sigurdsson,Miguel Calero,María Gasset
Amyloid Proteins Book PDF

Author : Einar M. Sigurdsson,Miguel Calero,María Gasset
Publisher : Humana Press
Page : 0 pages
File Size : 49,5 Mb
Release : 2012-02-24
Category : Science
ISBN : 161779550X

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Amyloid Proteins by Einar M. Sigurdsson,Miguel Calero,María Gasset Pdf

Amyloid diseases are characterized by the deposition of insoluble fibrous amyloid proteins. The word “amyloid” indicates a starch-like compound, and though a misnomer, continues to be the accepted term for this group of protein conformational disorders. The second edition of Amyloid Proteins expands upon the previous edition with current, detailed protocols for the preparation of amyloid and its precursors, specific analytical methods for studying these proteins, cell culture models and assays for production of amyloid proteins, and protocols for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Amyloid Proteins, Second Edition seeks to aid scientists in the amyloid field to establish new techniques in their laboratories. Authoritative and practical, Amyloid Proteins, Second Edition seeks to aid scientists in the amyloid field to establish new techniques in their laboratories.

Amyloid and Amyloidosis 1990

Jacob B Natvig,Øystein Førre,Gunnar Husby,Anne Husebekk,Bjørn Skogen,Knut Sletten,Per Westermark
Amyloid and Amyloidosis 1990 Book PDF

Author : Jacob B Natvig,Øystein Førre,Gunnar Husby,Anne Husebekk,Bjørn Skogen,Knut Sletten,Per Westermark
Publisher : Springer Science & Business Media
Page : 959 pages
File Size : 44,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401132848

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Amyloid and Amyloidosis 1990 by Jacob B Natvig,Øystein Førre,Gunnar Husby,Anne Husebekk,Bjørn Skogen,Knut Sletten,Per Westermark Pdf

Both scientifically and socially the Vlth International Symposium on Amyloidosis, August 5 - 8, 1990 in Oslo was a great success. There were three and a half intensive days. It started with the Opening Ceremony, particularly highlighted with the Norway-Norway multi media show by David Cochron, and ended with a visit to the Edvard Munch museuro and the Farewell Salmon Dinner on the evening of August 8 (not to forget the "happy birthday" song for Dorothea Zucker-Franklin at the breakfast table the following morning). In between was the intellectual penetration into the science of amyloidosis and amyloid proteins, and a deepening of many friendships among young and old "amyloidologists", together with some of the cultural and historical features of Oslo and Norway. Among the numerous Ietters of thanks and gratitude that we have received, the senior organizer of the previous meeting, Takashi lsobe said it briefly and eloquently: "You have overwhelmed us, you have performed a drama with joy and cheer, you have hosted so nicely with lovely secretariat, you have arranged impressive hospitality in every respect, you certainly did for all of us" Now we are left with the proceedings book for the three coming years until the next symposium in Kingston, Canada, which will be organized by Drs. Robert Kisilevsky and Thomas Muckle from the Department of Pathology at Queens University in 1993. The scientific contributions herein cover all the sessions of the meeting.

Early Stage Protein Misfolding and Amyloid Aggregation

Anonim
Early Stage Protein Misfolding and Amyloid Aggregation Book PDF

Author : Anonim
Publisher : Academic Press
Page : 320 pages
File Size : 47,7 Mb
Release : 2017-02-01
Category : Science
ISBN : 9780128122525

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Early Stage Protein Misfolding and Amyloid Aggregation by Anonim Pdf

Early Stage Protein Misfolding and Amyloid Aggregation, Volume 329, the latest in the International Review of Cell and Molecular Biology series presents comprehensive reviews and current advances in cell and molecular biology, including articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a worldwide readership and maintains a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists. Provides comprehensive reviews and current advances Presents a wide range of perspectives on specific subjects Includes valuable reference material for advanced undergraduates, graduate students, and professional scientists

From Globular Proteins to Amyloids

Irena Roterman-Konieczna
From Globular Proteins to Amyloids Book PDF

Author : Irena Roterman-Konieczna
Publisher : Elsevier
Page : 280 pages
File Size : 53,5 Mb
Release : 2019-10-15
Category : Medical
ISBN : 9780081029824

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From Globular Proteins to Amyloids by Irena Roterman-Konieczna Pdf

From Globular Proteins to Amyloids proposes a model and mechanism for explaining protein misfolding. Concepts presented are based on a model originally intended to show how proteins attain their native conformations. This model is quantitative in nature and founded upon arguments derived from information theory. It facilitates prediction and simulation of the amyloid fibrillation process, also identifying the progressive changes that occur in native proteins that lead to the emergence of amyloid aggregations. Introduces basic rules for protein folding, along with the conditions that result in misfolding Presents research that lies in treating the aqueous environment as a continuum rather than a set of individual water molecules (i.e. the classic representation) Provides practical applications for helping the prevention of amyloidosis and improving drug design

Amyloid, Prions, and Other Protein Aggregates

Anonim
Amyloid Prions and Other Protein Aggregates Book PDF

Author : Anonim
Publisher : Elsevier
Page : 861 pages
File Size : 40,8 Mb
Release : 1999-09-22
Category : Science
ISBN : 9780080496672

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Amyloid, Prions, and Other Protein Aggregates by Anonim Pdf

This volume includes a core of methodologies to attack the unique experimental problems presented by protein misassembly. Emphasis is on human biology applications, the area in which there is the most interest, in which most of the work has already been done, and in which there is the best evidence for the structural sophisitication of the protein aggregates.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Amyloid and Related Disorders

Maria M. Picken,Guillermo A. Herrera,Ahmet Dogan
Amyloid and Related Disorders Book PDF

Author : Maria M. Picken,Guillermo A. Herrera,Ahmet Dogan
Publisher : Humana Press
Page : 542 pages
File Size : 55,9 Mb
Release : 2015-08-17
Category : Medical
ISBN : 9783319192949

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Amyloid and Related Disorders by Maria M. Picken,Guillermo A. Herrera,Ahmet Dogan Pdf

The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.

Amyloid Fibrils and Prefibrillar Aggregates

Daniel Erik Otzen
Amyloid Fibrils and Prefibrillar Aggregates Book PDF

Author : Daniel Erik Otzen
Publisher : John Wiley & Sons
Page : 496 pages
File Size : 49,6 Mb
Release : 2013-06-04
Category : Science
ISBN : 9783527654208

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Amyloid Fibrils and Prefibrillar Aggregates by Daniel Erik Otzen Pdf

Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.