An Investigation Of Microrna Target Regulation Mechanisms Using An Integrative Approach

Author : Ulf Schmitz
Publisher : Logos Verlag Berlin GmbH
Page : 192 pages
File Size : 55,9 Mb
Release : 2015-06-29
Category : MicroRNA.
ISBN : 9783832540050

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An investigation of microRNA target regulation mechanisms using an integrative approach by Ulf Schmitz Pdf

This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.

Author : Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 43,7 Mb
Release : 2013-02-03
Category : Medical
ISBN : 9789400755901

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MicroRNA Cancer Regulation by Ulf Schmitz,Olaf Wolkenhauer,Julio Vera Pdf

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

Author : Shang-Qian Xie,Jiang Libo,Lidan Sun,Yuehua Cui
Publisher : Frontiers Media SA
Page : 342 pages
File Size : 50,5 Mb
Release : 2022-05-06
Category : Science
ISBN : 9782889761357

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The Development and Application of Multi-Omics Integration Approaches to Dissecting Complex Traits in Plants by Shang-Qian Xie,Jiang Libo,Lidan Sun,Yuehua Cui Pdf

Author : Srinivas Aluru
Publisher : CRC Press
Page : 1108 pages
File Size : 48,7 Mb
Release : 2005-12-21
Category : Computers
ISBN : 9781420036275

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Handbook of Computational Molecular Biology by Srinivas Aluru Pdf

The enormous complexity of biological systems at the molecular level must be answered with powerful computational methods. Computational biology is a young field, but has seen rapid growth and advancement over the past few decades. Surveying the progress made in this multidisciplinary field, the Handbook of Computational Molecular Biology of

Author : Amit Kumar Yadav,Sanjay Kumar Banerjee,Kumardeep Chaudhary,Bhabatosh Das
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 43,7 Mb
Release : 2022-05-03
Category : Science
ISBN : 9782889760787

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Systems Biology and Omics Approaches to Understand Complex Diseases Biology by Amit Kumar Yadav,Sanjay Kumar Banerjee,Kumardeep Chaudhary,Bhabatosh Das Pdf

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Page : 716 pages
File Size : 55,5 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015047449171

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Epigenetic Mechanisms of Gene Regulation by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs Pdf

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Author : Helge Großhans
Publisher : Springer Science & Business Media
Page : 175 pages
File Size : 45,5 Mb
Release : 2010-12-10
Category : Science
ISBN : 9781441978233

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Regulation of microRNAs by Helge Großhans Pdf

Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.

Author : Anonim
Publisher : ScholarlyEditions
Page : 337 pages
File Size : 40,8 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464970092

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Ovarian Cancer: New Insights for the Healthcare Professional: 2012 Edition by Anonim Pdf

Ovarian Cancer: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Ovarian Cancer. The editors have built Ovarian Cancer: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ovarian Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Ovarian Cancer: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Geng Chen,Zhichao Liu,Cheng Peng
Publisher : Frontiers Media SA
Page : 116 pages
File Size : 40,8 Mb
Release : 2021-04-07
Category : Science
ISBN : 9782889666683

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Multimodal and Integrative Analysis of Single-Cell or Bulk Sequencing Data by Geng Chen,Zhichao Liu,Cheng Peng Pdf

Author : Anonim
Publisher : Academic Press
Page : 450 pages
File Size : 53,9 Mb
Release : 2019-02-06
Category : Business & Economics
ISBN : 9780128145142

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Computational Epigenetics and Diseases by Anonim Pdf

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Author : Stefan de Folter
Publisher : Humana Press
Page : 363 pages
File Size : 41,6 Mb
Release : 2019-01-31
Category : Science
ISBN : 1493990411

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Plant MicroRNAs by Stefan de Folter Pdf

This detailed volume provides a collection of protocols for the study of miRNA functions in plants. Beginning with coverage of miRNA function, biogenesis, activity, and evolution in plants, the book continues by guiding readers through methods on the identification and detection of plant miRNAs, bioinformatic analyses, and strategies for functional analyses of miRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Plant MicroRNAs: Method and Protocols aims to ensure successful results in the further study of this vital area of plant science.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
Publisher : National Academies Press
Page : 300 pages
File Size : 43,6 Mb
Release : 2007-11-19
Category : Science
ISBN : 9780309178891

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology Pdf

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Author : Bruce Spiegelman
Publisher : Springer
Page : 108 pages
File Size : 40,7 Mb
Release : 2018-03-07
Category : Science
ISBN : 9783319727905

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Hormones, Metabolism and the Benefits of Exercise by Bruce Spiegelman Pdf

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

Author : Diego A. Forero
Publisher : CRC Press
Page : 374 pages
File Size : 48,8 Mb
Release : 2021-12-22
Category : Science
ISBN : 9781000405675

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Bioinformatics and Human Genomics Research by Diego A. Forero Pdf

Advances in high-throughput biological methods have led to the publication of a large number of genome-wide studies in human and animal models. In this context, recent tools from bioinformatics and computational biology have been fundamental for the analysis of these genomic studies. The book Bioinformatics and Human Genomics Research provides updated and comprehensive information about multiple approaches of the application of bioinformatic tools to research in human genomics. It covers strategies analysis of genome-wide association studies, genome-wide expression studies and genome-wide DNA methylation, among other topics. It provides interesting strategies for data mining in human genomics, network analysis, prediction of binding sites for miRNAs and transcription factors, among other themes. Experts from all around the world in bioinformatics and human genomics have contributed chapters in this book. Readers will find this book as quite useful for their in silico explorations, which would contribute to a better and deeper understanding of multiple biological processes and of pathophysiology of many human diseases.

Author : Richard Chbeir,Yannis Manolopoulos,Rajendra Prasath
Publisher : Springer Nature
Page : 248 pages
File Size : 47,5 Mb
Release : 2022-12-14
Category : Computers
ISBN : 9783031215179

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Mining Intelligence and Knowledge Exploration by Richard Chbeir,Yannis Manolopoulos,Rajendra Prasath Pdf

This book constitutes revised selected papers from the refereed proceedings of the 9th International Conference on Mining Intelligence and Knowledge Exploration, MIKE 2021, which took place in Hammamet, Tunisia, in November 2021. The 22 full papers included in this book were carefully reviewed and selected from 61 submissions. They deal with topics such as evolutionary computation, knowledge exploration in IoT, artificial intelligence, machine learning, data mining and information retrieval, medical image analysis, pattern recognition and computer vision, speech / signal processing, text mining and natural language processing, intelligent security systems, Smart and Intelligent Systems, etc.