An Omics Perspective On Cancer Research

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An Omics Perspective on Cancer Research

William C.S. Cho
An Omics Perspective on Cancer Research Book PDF

Author : William C.S. Cho
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 49,7 Mb
Release : 2010-04-07
Category : Medical
ISBN : 9789048126750

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An Omics Perspective on Cancer Research by William C.S. Cho Pdf

Omics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in cancer research. The development of high-throughput technologies that permit the solution of deciphering cancer from higher dimensionality will provide a knowledge base which changes the face of cancer understanding and therapeutics. This is the first book to provide such a comprehensive coverage of a rapidly evolving area written by leading experts in the field of omics. It complies and details cutting-edge cancer research that covers the broad advances in the field and its application from cancer-associated gene discovery to drug target validation. It also highlights the potential of using integration approach for cancer research. This unique and timely book provides a thorough overview of developing omics, which will appeal to anyone involved in cancer research. It will be a useful reference book for graduate students of different subjects (medicine, biology, engineering, etc) and senior scientists interested in the fascinating area of advanced technologies in cancer research. Readership: This is a precious book for all types of readers – cancer researchers, oncologists, pathologists, biologists, clinical chemists, pharmacologists, pharmaceutical specialists, biostatisticians, and bioinformaticists who want to expand their knowledge in cancer research.

An Omics Perspective on Cancer Research

William C. S. Cho
An Omics Perspective on Cancer Research Book PDF

Author : William C. S. Cho
Publisher : Unknown
Page : 280 pages
File Size : 49,5 Mb
Release : 2010-04-18
Category : Cancer
ISBN : 9048126762

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An Omics Perspective on Cancer Research by William C. S. Cho Pdf

Omics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in cancer research. The development of high-throughput technologies that permit the solution of deciphering cancer from higher dimensionality will provide a knowledge base which changes the face of cancer understanding and therapeutics. This is the first book to provide such a comprehensive coverage of a rapidly evolving area written b.

Evolution of Translational Omics

Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Evolution of Translational Omics Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 40,6 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185

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Evolution of Translational Omics by Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials Pdf

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics

Erika Ruiz-Garcia,Horacio Astudillo-de la Vega
Translational Research and Onco Omics Applications in the Era of Cancer Personal Genomics Book PDF

Author : Erika Ruiz-Garcia,Horacio Astudillo-de la Vega
Publisher : Springer Nature
Page : 171 pages
File Size : 51,8 Mb
Release : 2019-11-11
Category : Science
ISBN : 9783030241001

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Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics by Erika Ruiz-Garcia,Horacio Astudillo-de la Vega Pdf

Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.

OMICS

Debmalya Barh,Kenneth Blum,Margaret A. Madigan
OMICS Book PDF

Author : Debmalya Barh,Kenneth Blum,Margaret A. Madigan
Publisher : CRC Press
Page : 625 pages
File Size : 52,5 Mb
Release : 2011-11-21
Category : Medical
ISBN : 9781439850084

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OMICS by Debmalya Barh,Kenneth Blum,Margaret A. Madigan Pdf

A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.

Integration of Multisource Heterogenous Omics Information in Cancer

Victor Jin,Junbai Wang,Binhua Tang
Integration of Multisource Heterogenous Omics Information in Cancer Book PDF

Author : Victor Jin,Junbai Wang,Binhua Tang
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 44,6 Mb
Release : 2020-01-30
Category : Electronic
ISBN : 9782889634484

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Integration of Multisource Heterogenous Omics Information in Cancer by Victor Jin,Junbai Wang,Binhua Tang Pdf

Multisource heterogenous omics data can provide unprecedented perspectives and insights into cancer studies, but also pose great analytical problems for researchers due to the vast amount of data produced. This Research Topic aims to provide a forum for sharing ideas, tools and results among researchers from various computational cancer biology fields such as genetic/epigenetic and genome-wide studies.

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

Nosheen Masood,Saima Shakil Malik
Essentials of Cancer Genomic Computational Approaches and Precision Medicine Book PDF

Author : Nosheen Masood,Saima Shakil Malik
Publisher : Springer Nature
Page : 499 pages
File Size : 52,7 Mb
Release : 2020-03-20
Category : Medical
ISBN : 9789811510670

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'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine by Nosheen Masood,Saima Shakil Malik Pdf

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Cancer Bioinformatics

Sylvia Nagl
Cancer Bioinformatics Book PDF

Author : Sylvia Nagl
Publisher : Unknown
Page : 320 pages
File Size : 41,8 Mb
Release : 2006-03-06
Category : Medical
ISBN : UCSC:32106018649266

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Cancer Bioinformatics by Sylvia Nagl Pdf

"The development and application of bioinformatics tools to basic and translational cancer research is, in fact, a rapidly expanding field that deserves a timely review. Therefore, a publication of this type is needed. The editors have done an excellent job in recruiting well-established scientists to author the various chapters of the book." —Dieter Naf, Jackson Laboratory, USA Cancer bioinformatics is now emerging as a new interdisciplinary field, which is facilitating an unprecedented synthesis of knowledge arising from the life and clinical sciences. This groundbreaking title provides a comprehensive and up-to-date account of the enormous range of bioinformatics for cancer therapy development from the laboratory to clinical trials. It functions as a guide to integrated data exploitation and synergistic knowledge discovery, and support the consolidation of the interdisciplinary research community involved.

Osteosarcoma

Kanya Honoki,Kurt Weiss
Osteosarcoma Book PDF

Author : Kanya Honoki,Kurt Weiss
Publisher : BoD – Books on Demand
Page : 256 pages
File Size : 49,5 Mb
Release : 2017-04-26
Category : Medical
ISBN : 9789535130956

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Osteosarcoma by Kanya Honoki,Kurt Weiss Pdf

Osteosarcoma is the most common malignant bone tumor and mainly affects children, adolescents, and young adults. Osteosarcoma shows significant genetic instability, resulting in very complex biology with multifaceted cellular and molecular mechanisms and behavior. Although clinical outcomes, both prognostic and functional, of osteosarcoma dramatically improved in the 1980s, the prognoses of the patients with relapsed and/or metastatic disease remained very poor in spite of our continuous efforts to overcome this difficulty. This book aims to delve into the current advances of basic and clinical sciences in osteosarcoma that are guiding the future directions of its research and clinical practice. The knowledge presented here will lead to further inspiration, ideas, and novel insights into the field of osteosarcoma research. Hopefully, this work will foster improvement of the prognosis for patients suffering from the disease.

Cancer Evolution

Charles Swanton
Cancer Evolution Book PDF

Author : Charles Swanton
Publisher : Perspectives Cshl
Page : 350 pages
File Size : 47,5 Mb
Release : 2017
Category : Medical
ISBN : 1621821439

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Cancer Evolution by Charles Swanton Pdf

Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

Improving Cancer Diagnosis and Care

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum
Improving Cancer Diagnosis and Care Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Page : 93 pages
File Size : 53,5 Mb
Release : 2019-08-15
Category : Medical
ISBN : 9780309490818

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Improving Cancer Diagnosis and Care by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum Pdf

A hallmark of high-quality cancer care is the delivery of the right treatment to the right patient at the right time. Precision oncology therapies, which target specific genetic changes in a patient's cancer, are changing the nature of cancer treatment by allowing clinicians to select therapies that are most likely to benefit individual patients. In current clinical practice, oncologists are increasingly formulating cancer treatment plans using results from complex laboratory and imaging tests that characterize the molecular underpinnings of an individual patient's cancer. These molecular fingerprints can be quite complex and heterogeneous, even within a single patient. To enable these molecular tumor characterizations to effectively and safely inform cancer care, the cancer community is working to develop and validate multiparameter omics tests and imaging tests as well as software and computational methods for interpretation of the resulting datasets. To examine opportunities to improve cancer diagnosis and care in the new precision oncology era, the National Cancer Policy Forum developed a two-workshop series. The first workshop focused on patient access to expertise and technologies in oncologic imaging and pathology and was held in February 2018. The second workshop, conducted in collaboration with the Board on Mathematical Sciences and Analytics, was held in October 2018 to examine the use of multidimensional data derived from patients with cancer, and the computational methods that analyze these data to inform cancer treatment decisions. This publication summarizes the presentations and discussions from the second workshop.

Integrating Omics Data

George Tseng,Debashis Ghosh,Xianghong Jasmine Zhou
Integrating Omics Data Book PDF

Author : George Tseng,Debashis Ghosh,Xianghong Jasmine Zhou
Publisher : Cambridge University Press
Page : 497 pages
File Size : 53,8 Mb
Release : 2015-09-23
Category : Mathematics
ISBN : 9781107069114

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Integrating Omics Data by George Tseng,Debashis Ghosh,Xianghong Jasmine Zhou Pdf

Tutorial chapters by leaders in the field introduce state-of-the-art methods to handle information integration problems of omics data.

Application of Bioinformatics in Cancers

Chad Brenner
Application of Bioinformatics in Cancers Book PDF

Author : Chad Brenner
Publisher : MDPI
Page : 418 pages
File Size : 40,7 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9783039217885

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Application of Bioinformatics in Cancers by Chad Brenner Pdf

This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.

Omics Approaches in Breast Cancer

Debmalya Barh
Omics Approaches in Breast Cancer Book PDF

Author : Debmalya Barh
Publisher : Springer
Page : 559 pages
File Size : 43,9 Mb
Release : 2014-10-13
Category : Medical
ISBN : 9788132208433

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Omics Approaches in Breast Cancer by Debmalya Barh Pdf

Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology and pharmacy.

Omics in Clinical Practice

Yu Liu
Omics in Clinical Practice Book PDF

Author : Yu Liu
Publisher : CRC Press
Page : 456 pages
File Size : 42,9 Mb
Release : 2014-06-20
Category : Science
ISBN : 9781482262438

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Omics in Clinical Practice by Yu Liu Pdf

This title includes a number of Open Access chapters.This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation t