Osteosarcoma

Author : Takafumi Ueda,Akira Kawai
Publisher : Springer
Page : 0 pages
File Size : 47,7 Mb
Release : 2018-04-07
Category : Medical
ISBN : 4431566775

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Osteosarcoma by Takafumi Ueda,Akira Kawai Pdf

This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10–15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis from osteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.

Author : Norman Jaffe,Oyvind S. Bruland,Stefan Bielack
Publisher : Springer Science & Business Media
Page : 591 pages
File Size : 52,8 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9781441902849

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Pediatric and Adolescent Osteosarcoma by Norman Jaffe,Oyvind S. Bruland,Stefan Bielack Pdf

Pediatric and Adolescent Osteosarcoma provides a historical review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in Epidemiology and Etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age group, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of radiation therapy. The volume concludes with a review of differences and similarities in the management of osteosarcoma in adults as compared to pediatrics / adolescents and new laboratory and animal investigations currently in progress to develop effective diagnostic and therapeutic approaches to improve the outcome. In essence the scope and intensive coverage of the book provides a historical perspective of the advances made over the past 30 years and emerging concepts and prospects for new diagnostic and therapeutic approaches. This is based upon past experiences and new discoveries. It also provides a unique opportunity for pediatric and adult medical oncologists, physicians in training, orthopedic surgeons, pathologists, radiologists, radiotherapists, oncology nurses and allied professionals involved in the care of pediatric/adolescent patients with osteosarcoma to become acquainted with prevailing methods of treatment and new and evolving concepts and developments.

Author : Eugenie S. Kleinerman,Richard Gorlick
Publisher : Springer Nature
Page : 233 pages
File Size : 55,9 Mb
Release : 2020-08-07
Category : Medical
ISBN : 9783030430856

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Current Advances in the Science of Osteosarcoma by Eugenie S. Kleinerman,Richard Gorlick Pdf

This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Author : Kanya Honoki,Kurt Weiss
Publisher : BoD – Books on Demand
Page : 256 pages
File Size : 43,7 Mb
Release : 2017-04-26
Category : Medical
ISBN : 9789535130956

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Osteosarcoma by Kanya Honoki,Kurt Weiss Pdf

Osteosarcoma is the most common malignant bone tumor and mainly affects children, adolescents, and young adults. Osteosarcoma shows significant genetic instability, resulting in very complex biology with multifaceted cellular and molecular mechanisms and behavior. Although clinical outcomes, both prognostic and functional, of osteosarcoma dramatically improved in the 1980s, the prognoses of the patients with relapsed and/or metastatic disease remained very poor in spite of our continuous efforts to overcome this difficulty. This book aims to delve into the current advances of basic and clinical sciences in osteosarcoma that are guiding the future directions of its research and clinical practice. The knowledge presented here will lead to further inspiration, ideas, and novel insights into the field of osteosarcoma research. Hopefully, this work will foster improvement of the prognosis for patients suffering from the disease.

Author : Piero Picci,Marco Manfrini,Nicola Fabbri,Marco Gambarotti,Daniel Vanel
Publisher : Springer Science & Business Media
Page : 387 pages
File Size : 52,7 Mb
Release : 2014-01-18
Category : Medical
ISBN : 9783319017488

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Atlas of Musculoskeletal Tumors and Tumorlike Lesions by Piero Picci,Marco Manfrini,Nicola Fabbri,Marco Gambarotti,Daniel Vanel Pdf

This book reflects the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment of musculoskeletal tumor and tumorlike lesions. It presents a wide range of lesions from a multidisciplinary perspective, highlighting pertinent clinical, radiological, and histological correlations. Treatment is briefly reported for each entity. In addition, the more recent biomolecular findings of use for diagnosis, prognosis, and treatment are carefully analyzed. The Rizzoli case archive spans more than a century, the first treated case dating back to 28 September 1900, and contains the original material – clinical charts, imaging, paraffin blocks, and histological slides – of more than 40,000 cases, including about 29,000 bone lesions and 11,000 soft tissue lesions. This book reports the most relevant entities and reflects the improvements in knowledge of musculoskeletal tumors as presented during the yearly international course held at the Rizzoli Institute.​

Author : Matthew Gregory Cable,Robert Lawrence Randall
Publisher : BoD – Books on Demand
Page : 132 pages
File Size : 45,5 Mb
Release : 2019-12-04
Category : Medical
ISBN : 9781839680144

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Osteosarcoma by Matthew Gregory Cable,Robert Lawrence Randall Pdf

This book is titled Osteosarcoma - Diagnosis, Mechanisms, and Translational Developments, and focuses on recent advancements and novel ideas in osteosarcoma research. In a manner of speaking, we have taken the multidisciplinary mindset essential for treating osteosarcoma and broadened it to include other areas of cancer research. By learning from gains in other areas of oncology, such as new lncRNAs, the understanding of cancer metabolism and oxidative phosphorylation, and new chemotherapy agents, we can apply them to the niche of osteosarcoma for treatment development. By drawing more attention to these novel and clever discoveries, we hope to continue this enthusiasm for advancements in basic and translational research in the field of osteosarcoma.

Author : Takafumi Ueda,Akira Kawai
Publisher : Springer
Page : 270 pages
File Size : 52,9 Mb
Release : 2016-02-19
Category : Medical
ISBN : 9784431556961

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Osteosarcoma by Takafumi Ueda,Akira Kawai Pdf

This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10–15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis from osteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.

Author : Manish Agarwal
Publisher : BoD – Books on Demand
Page : 186 pages
File Size : 52,8 Mb
Release : 2012-04-11
Category : Medical
ISBN : 9789535105060

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Osteosarcoma by Manish Agarwal Pdf

This book is aimed at quickly updating the reader on osteosarcoma, a dreaded primary bone cancer. Progress in management of osteosarcoma has been slow after the evolution of chemotherapy and limb salvage surgery. Research is now directed towards identifying molecular targets for systemic therapy. Availability of chemotherapy drugs and low cost implants in developing world have allowed limb salvage surgery to develop. This book looks at current basic knowledge on osteosarcoma and some of the developments in research which have the potential to change the prognosis.

Author : Ian T. Magrath
Publisher : Springer Science & Business Media
Page : 631 pages
File Size : 44,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642834059

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New Directions in Cancer Treatment by Ian T. Magrath Pdf

During the last few decades, there has been a tremendous improvement in the treatment of cancer. There is evidence that this trend is continuing, based on the achievements re sulting from the combined efforts of clinicians and basic re search workers. This book is an example of such interaction and collaboration. It was prepared by authors representing both areas of work. Most of the work reported in this book is not merely theoretical, but has been experimentally successfully tested and sometimes applied clinically. This work has, however, not yet been generalized and practiced on a wide scale. Some of the results reported here relate to new aspects and open new horizons for future progress. This book will be of great value for both clinicians and basic research workers. VICC Treatment and Rehabilitation Programme ISMAIL ELSEBAI Chairman Preface The three main approaches to the treatment of cancer are surgery, radiotherapy, and chemotherapy. Today, all malignant neoplasms are managed by one or more of these modalities, with varying success rates depending on the type of tumor, its degree of spread, and the knowl edge and skill with which the treatment plan has been designed and executed. In the United States of America and in Europe, approximate ly half of all cancer is presently curable, but this has been the case for approximately 20 years.

Author : Eugenie S. Kleinerman,Richard Gorlick
Publisher : Springer Nature
Page : 214 pages
File Size : 51,9 Mb
Release : 2020-06-01
Category : Medical
ISBN : 9783030430320

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Current Advances in Osteosarcoma by Eugenie S. Kleinerman,Richard Gorlick Pdf

This thoroughly revised second edition complied in 2 books is an up-to-date overview of the current clinical advances in sarcoma and osteosarcoma. The new edition features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, these essential volumes also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists focused in sarcoma.

Author : G. Bennett Humphrey,H. Schraffordt Koops,W.M. Molenaar,A. Postma
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461535188

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Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies by G. Bennett Humphrey,H. Schraffordt Koops,W.M. Molenaar,A. Postma Pdf

Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies is the fifth volume in the series `Cancer Treatment, and Research' devoted to pediatric oncology. Like its immediate predecessor, Hodgkin's Disease in Children: Controversies and Current Practice, this volume also deals with the current state of affairs: where do researchers differ in opinions or firmly held beliefs? What does the future hold for research or for the patients who have benefited from research and are now cured? etc. The first part deals with preclinical and clinical issues that relate to the disease and the second part deals with the results of recent trials and in some cases ongoing trials. It could be argued that section B Pharmacology, Section D Radiotherapy and Section E Surgery of part one belong to part two; however in these sections we have tried to focus on one discipline and in part two, we have tried to focus on the results of multidisciplinary trials. A third part includes a few critiques and editorial comments. This volume was prepared and planned for both basic and clinical oncologists. It is hoped that the basic scientists will gain some insight into the problems of their clinical colleagues and that the clinicians will be willing to read to the more basic articles. It is not a text for students (or for that matter physicians) who want all things to be laid out in `black and white'. But it is a text for those students who want to know how vibrant this field of research is and are willing to stand in awe of how much research needs to be done.

Author : Mariarita Romanucci,Leonardo Della Salda,Raffaella De Maria,Emanuela Maria Morello
Publisher : Frontiers Media SA
Page : 110 pages
File Size : 49,8 Mb
Release : 2023-03-03
Category : Medical
ISBN : 9782832516621

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Canine Osteosarcoma as a Model in Comparative Oncology: Advances and Perspective by Mariarita Romanucci,Leonardo Della Salda,Raffaella De Maria,Emanuela Maria Morello Pdf

Author : Eugenie S. Kleinerman, M.D.
Publisher : Springer
Page : 0 pages
File Size : 51,5 Mb
Release : 2016-08-23
Category : Medical
ISBN : 3319344595

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Current Advances in Osteosarcoma by Eugenie S. Kleinerman, M.D. Pdf

Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. To improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. Current Advances in Osteosarcoma summarizes all of these new discoveries in one singular text, which will help move the field forward.

Author : Adam Greenspan,Gernot Jundt,Wolfgang Remagen
Publisher : Lippincott Williams & Wilkins
Page : 552 pages
File Size : 45,5 Mb
Release : 2007
Category : Medical
ISBN : 9780781779302

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Differential Diagnosis in Orthopaedic Oncology by Adam Greenspan,Gernot Jundt,Wolfgang Remagen Pdf

This volume presents both the radiologist's and the pathologist's approach to differential diagnosis of musculoskeletal tumors and tumor-like lesions and details the radiologic and histopathologic features helpful in confirming a diagnosis. The book is illustrated with over 1,200 radiographs, CT and MR images, full-color photomicrographs, and schematic drawings. Tables list important diagnostic features, and schematic drawings summarize both radiologic and pathologic differential diagnoses. This edition includes state-of-the-art information on PET, thin-section CT, 3-D CT, MRI, enzyme histochemistry, immunohistochemistry, flow cytometry, cytogenetics, and molecular cytogenetics. The new co-author, Gernot Jundt, was instrumental in revising the WHO classification of musculoskeletal lesions. Illustrations have been updated, and improved captions begin with the diagnosis.

Author : Anonim
Publisher : ScholarlyEditions
Page : 85 pages
File Size : 48,6 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464903236

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Osteosarcomas: New Insights for the Healthcare Professional: 2011 Edition by Anonim Pdf

Osteosarcomas: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Osteosarcomas in a concise format. The editors have built Osteosarcomas: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Osteosarcomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Osteosarcomas: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.