Analysis And Modeling Of Coordinated Multi Neuronal Activity

Author : Masami Tatsuno
Publisher : Springer
Page : 353 pages
File Size : 40,6 Mb
Release : 2014-11-13
Category : Medical
ISBN : 9781493919697

Get Book

Analysis and Modeling of Coordinated Multi-neuronal Activity by Masami Tatsuno Pdf

Since information in the brain is processed by the exchange of spikes among neurons, a study of such group dynamics is extremely important in understanding hippocampus dependent memory. These spike patterns and local field potentials (LFPs) have been analyzed by various statistical methods. These studies have led to important findings of memory information processing. For example, memory-trace replay, a reactivation of behaviorally induced neural patterns during subsequent sleep, has been suggested to play an important role in memory consolidation. It has also been suggested that a ripple/sharp wave event (one of the characteristics of LFPs in the hippocampus) and spiking activity in the cortex have a specific relationship that may facilitate the consolidation of hippocampal dependent memory from the hippocampus to the cortex. The book will provide a state-of-the-art finding of memory information processing through the analysis of multi-neuronal data. The first half of the book is devoted to this analysis aspect. Understanding memory information representation and its consolidation, however, cannot be achieved only by analyzing the data. It is extremely important to construct a computational model to seek an underlying mathematical principle. In other words, an entire picture of hippocampus dependent memory system would be elucidated through close collaboration among experiments, data analysis, and computational modeling. Not only does computational modeling benefit the data analysis of multi-electrode recordings, but it also provides useful insight for future experiments and analyses. The second half of the book will be devoted to the computational modeling of hippocampus-dependent memory.

Author : Zhe Chen,Sridevi V. Sarma
Publisher : Springer
Page : 327 pages
File Size : 44,7 Mb
Release : 2017-12-27
Category : Technology & Engineering
ISBN : 9783319719764

Get Book

Dynamic Neuroscience by Zhe Chen,Sridevi V. Sarma Pdf

This book shows how to develop efficient quantitative methods to characterize neural data and extra information that reveals underlying dynamics and neurophysiological mechanisms. Written by active experts in the field, it contains an exchange of innovative ideas among researchers at both computational and experimental ends, as well as those at the interface. Authors discuss research challenges and new directions in emerging areas with two goals in mind: to collect recent advances in statistics, signal processing, modeling, and control methods in neuroscience; and to welcome and foster innovative or cross-disciplinary ideas along this line of research and discuss important research issues in neural data analysis. Making use of both tutorial and review materials, this book is written for neural, electrical, and biomedical engineers; computational neuroscientists; statisticians; computer scientists; and clinical engineers.

Author : Asim Roy,Leonid Perlovsky,Tarek Besold,Juyang Weng,Jonathan Edwards
Publisher : Frontiers Media SA
Page : 147 pages
File Size : 50,9 Mb
Release : 2018-09-28
Category : Electronic
ISBN : 9782889455966

Get Book

Representation in the Brain by Asim Roy,Leonid Perlovsky,Tarek Besold,Juyang Weng,Jonathan Edwards Pdf

This eBook contains ten articles on the topic of representation of abstract concepts, both simple and complex, at the neural level in the brain. Seven of the articles directly address the main competing theories of mental representation – localist and distributed. Four of these articles argue – either on a theoretical basis or with neurophysiological evidence – that abstract concepts, simple or complex, exist (have to exist) at either the single cell level or in an exclusive neural cell assembly. There are three other papers that argue for sparse distributed representation (population coding) of abstract concepts. There are two other papers that discuss neural implementation of symbolic models. The remaining paper deals with learning of motor skills from imagery versus actual execution. A summary of these papers is provided in the Editorial.

Author : Richard W. Morris,Aaron Bornstein,Amitai Shenhav
Publisher : Academic Press
Page : 484 pages
File Size : 43,9 Mb
Release : 2018-08-23
Category : Science
ISBN : 9780128120996

Get Book

Goal-Directed Decision Making by Richard W. Morris,Aaron Bornstein,Amitai Shenhav Pdf

Goal-Directed Decision Making: Computations and Neural Circuits examines the role of goal-directed choice. It begins with an examination of the computations performed by associated circuits, but then moves on to in-depth examinations on how goal-directed learning interacts with other forms of choice and response selection. This is the only book that embraces the multidisciplinary nature of this area of decision-making, integrating our knowledge of goal-directed decision-making from basic, computational, clinical, and ethology research into a single resource that is invaluable for neuroscientists, psychologists and computer scientists alike. The book presents discussions on the broader field of decision-making and how it has expanded to incorporate ideas related to flexible behaviors, such as cognitive control, economic choice, and Bayesian inference, as well as the influences that motivation, context and cues have on behavior and decision-making. Details the neural circuits functionally involved in goal-directed decision-making and the computations these circuits perform Discusses changes in goal-directed decision-making spurred by development and disorders, and within real-world applications, including social contexts and addiction Synthesizes neuroscience, psychology and computer science research to offer a unique perspective on the central and emerging issues in goal-directed decision-making

Author : Ahmed El Hady
Publisher : Academic Press
Page : 304 pages
File Size : 49,9 Mb
Release : 2016-09-08
Category : Medical
ISBN : 9780128026410

Get Book

Closed Loop Neuroscience by Ahmed El Hady Pdf

Closed Loop Neuroscience addresses the technical aspects of closed loop neurophysiology, presenting the implementation of these approaches spanning several domains of neuroscience, from cellular and network neurophysiology, through sensory and motor systems, and then clinical therapeutic devices. Although closed-loop approaches have long been a part of the neuroscientific toolbox, these techniques are only now gaining popularity in research and clinical applications. As there is not yet a comprehensive methods book addressing the topic as a whole, this volume fills that gap, presenting state-of-the-art approaches and the technical advancements that enable their application to different scientific problems in neuroscience. Presents the first volume to offer researchers a comprehensive overview of the technical realities of employing closed loop techniques in their work Offers application to in-vitro, in-vivo, and hybrid systems Contains an emphasis on the actual techniques used rather than on specific results obtained Includes exhaustive protocols and descriptions of software and hardware, making it easy for readers to implement the proposed methodologies Encompasses the clinical/neuroprosthetic aspect and how these systems can also be used to contribute to our understanding of basic neurophysiology Edited work with chapters authored by leaders in the field from around the globe – the broadest, most expert coverage available

Author : Matthias Bethge,Philipp Berens,Jakob Macke
Publisher : Frontiers E-books
Page : 209 pages
File Size : 40,8 Mb
Release : 2012-01-01
Category : Electronic
ISBN : 9782889190126

Get Book

Statistical analysis of multi-cell recordings: linking population coding models to experimental data by Matthias Bethge,Philipp Berens,Jakob Macke Pdf

Modern recording techniques such as multi-electrode arrays and 2-photon imaging are capable of simultaneously monitoring the activity of large neuronal ensembles at single cell resolution. This makes it possible to study the dynamics of neural populations of considerable size, and to gain insights into their computations and functional organization. The key challenge with multi-electrode recordings is their high-dimensional nature. Understanding this kind of data requires powerful statistical techniques for capturing the structure of the neural population responses and their relation with external stimuli or behavioral observations. Contributions to this Research Topic should advance statistical modeling of neural populations. Questions of particular interest include: 1. What classes of statistical methods are most useful for modeling population activity? 2. What are the main limitations of current approaches, and what can be done to overcome them? 3. How can statistical methods be used to empirically test existing models of (probabilistic) population coding? 4. What role can statistical methods play in formulating novel hypotheses about the principles of information processing in neural populations? This Research Topic is connected to a one day workshop at the Computational Neuroscience Meeting 2009 in Berlin (http://www.cnsorg.org/2009/workshops.shtml and http://www.kyb.tuebingen.mpg.de/bethge/workshops/cns2009/)

Author : Tobias A. Mattei
Publisher : Frontiers Media SA
Page : 273 pages
File Size : 55,5 Mb
Release : 2016-10-31
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 9782889199969

Get Book

Nonlinear Analysis in Neuroscience and Behavioral Research by Tobias A. Mattei Pdf

Although nonlinear dynamics have been mastered by physicists and mathematicians for a long time (as most physical systems are inherently nonlinear in nature), the recent successful application of nonlinear methods to modeling and predicting several evolutionary, ecological, physiological, and biochemical processes has generated great interest and enthusiasm among researchers in computational neuroscience and cognitive psychology. Additionally, in the last years it has been demonstrated that nonlinear analysis can be successfully used to model not only basic cellular and molecular data but also complex cognitive processes and behavioral interactions. The theoretical features of nonlinear systems (such unstable periodic orbits, period-doubling bifurcations and phase space dynamics) have already been successfully applied by several research groups to analyze the behavior of a variety of neuronal and cognitive processes. Additionally the concept of strange attractors has lead to a new understanding of information processing which considers higher cognitive functions (such as language, attention, memory and decision making) as complex systems emerging from the dynamic interaction between parallel streams of information flowing between highly interconnected neuronal clusters organized in a widely distributed circuit and modulated by key central nodes. Furthermore, the paradigm of self-organization derived from the nonlinear dynamics theory has offered an interesting account of the phenomenon of emergence of new complex cognitive structures from random and non-deterministic patterns, similarly to what has been previously observed in nonlinear studies of fluid dynamics. Finally, the challenges of coupling massive amount of data related to brain function generated from new research fields in experimental neuroscience (such as magnetoencephalography, optogenetics and single-cell intra-operative recordings of neuronal activity) have generated the necessity of new research strategies which incorporate complex pattern analysis as an important feature of their algorithms. Up to now nonlinear dynamics has already been successfully employed to model both basic single and multiple neurons activity (such as single-cell firing patterns, neural networks synchronization, autonomic activity, electroencephalographic measurements, and noise modulation in the cerebellum), as well as higher cognitive functions and complex psychiatric disorders. Similarly, previous experimental studies have suggested that several cognitive functions can be successfully modeled with basis on the transient activity of large-scale brain networks in the presence of noise. Such studies have demonstrated that it is possible to represent typical decision-making paradigms of neuroeconomics by dynamic models governed by ordinary differential equations with a finite number of possibilities at the decision points and basic heuristic rules which incorporate variable degrees of uncertainty. This e-book has include frontline research in computational neuroscience and cognitive psychology involving applications of nonlinear analysis, especially regarding the representation and modeling of complex neural and cognitive systems. Several experts teams around the world have provided frontline theoretical and experimental contributions (as well as reviews, perspectives and commentaries) in the fields of nonlinear modeling of cognitive systems, chaotic dynamics in computational neuroscience, fractal analysis of biological brain data, nonlinear dynamics in neural networks research, nonlinear and fuzzy logics in complex neural systems, nonlinear analysis of psychiatric disorders and dynamic modeling of sensorimotor coordination. Rather than a comprehensive compilation of the possible topics in neuroscience and cognitive research to which non-linear may be used, this e-book intends to provide some illustrative examples of the broad range of

Author : Hermann Haken
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 44,5 Mb
Release : 2006-11-22
Category : Science
ISBN : 9783540462842

Get Book

Brain Dynamics by Hermann Haken Pdf

This book addresses a large variety of models in mathematical and computational neuroscience. It is written for the experts as well as for graduate students wishing to enter this fascinating field of research. The author studies the behaviour of large neural networks composed of many neurons coupled by spike trains. An analysis of phase locking via sinusoidal couplings leading to various kinds of movement coordination is included.

Author : Vieri Giuliano Santucci,Pierre-Yves Oudeyer,Andrew Barto,Gianluca Baldassarre
Publisher : Frontiers Media SA
Page : 286 pages
File Size : 41,6 Mb
Release : 2020-02-19
Category : Electronic
ISBN : 9782889634859

Get Book

Intrinsically Motivated Open-Ended Learning in Autonomous Robots by Vieri Giuliano Santucci,Pierre-Yves Oudeyer,Andrew Barto,Gianluca Baldassarre Pdf

Author : A. Ravishankar Rao,Guillermo A. Cecchi,Ehud Kaplan
Publisher : Frontiers Media SA
Page : 266 pages
File Size : 52,7 Mb
Release : 2016-03-17
Category : Electronic book
ISBN : 9782889197620

Get Book

Towards an Integrated Approach to Measurement, Analysis and Modeling of Cortical Networks by A. Ravishankar Rao,Guillermo A. Cecchi,Ehud Kaplan Pdf

The amount of data being produced by neuroscientists is increasing rapidly, driven by advances in neuroimaging and recording techniques spanning multiple scales of resolution. The availability of such data poses significant challenges for their processing and interpretation. To gain a deeper understanding of the surrounding issues, the Editors of this e-Book reached out to an interdisciplinary community, and formed the Cortical Networks Working Group, and the genesis of this e-Book thus began with the formation of this Working Group, which was supported by the National Institute for Mathematical and Biological Synthesis in the USA. The Group consisted of scientists from neuroscience, physics, psychology and computer science, and meetings were held in person. (A detailed list of the group members is presented in the Editorial that follows.) At the time we started, in 2010, the term “big data” was hardly in existence, though the volume of data we were handling would certainly have qualified. Furthermore, there was significant interest in harnessing the power of supercomputers to perform large scale neuronal simulations, and in creating specialized hardware to mimic neural function. We realized that the various disciplines represented in our Group could and should work together to accelerate progress in Neuroscience. We searched for common threads that could define the foundation for an integrated approach to solve important problems in the field. We adopted a network-centric perspective to address these challenges, as the data are derived from structures that are themselves network-like. We proposed three inter-twined threads, consisting of measurement of neural activity, analysis of network structures deduced from this activity, and modeling of network function, leading to theoretical insights. This approach formed the foundation of our initial call for papers. When we issued the call for papers, we were not sure how many papers would fall into each of these threads. We were pleased that we found significant interest in each thread, and the number of submissions exceeded our expectations. This is an indication that the field of neuroscience is ripe for the type of integration and interchange that we had anticipated. We first published a special topics issue after we received a sufficient number of submissions. This is now being converted to an e-book to strengthen the coherence of its contributions. One of the strong themes emerging in this e-book is that network-based measures capture better the dynamics of brain processes, and provide features with greater discriminative power than point-based measures. Another theme is the importance of network oscillations and synchrony. Current research is shedding light on the principles that govern the establishment and maintenance of network oscillation states. These principles could explain why there is impaired synchronization between different brain areas in schizophrenics and Parkinson’s patients. Such research could ultimately provide the foundation for an understanding of other psychiatric and neurodegenerative conditions. The chapters in this book cover these three main threads related to cortical networks. Some authors have combined two or more threads within a single chapter. We expect the availability of related work appearing in a single e-book to help our readers see the connection between different research efforts, and spur further insights and research.

Author : Jose Luis Perez Velazquez,Richard Wennberg
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 46,8 Mb
Release : 2009-05-28
Category : Medical
ISBN : 9780387937977

Get Book

Coordinated Activity in the Brain by Jose Luis Perez Velazquez,Richard Wennberg Pdf

Increasing interest in the study of coordinated activity of brain cell ensembles reflects the current conceptualization of brain information processing and cognition. It is thought that cognitive processes involve not only serial stages of sensory signal processing, but also massive parallel information processing circuitries, and therefore it is the coordinated activity of neuronal networks of brains that give rise to cognition and consciousness in general. While the concepts and techniques to measure synchronization are relatively well characterized and developed in the mathematics and physics community, the measurement of coordinated activity derived from brain signals is not a trivial task, and is currently a subject of debate. Coordinated Activity in the Brain: Measurements and Relevance to Brain Function and Behavior addresses conceptual and methodological limitations, as well as advantages, in the assessment of cellular coordinated activity from neurophysiological recordings. The book offers a broad overview of the field for investigators working in a variety of disciplines (neuroscience, biophysics, mathematics, physics, neurology, neurosurgery, psychology, biomedical engineering, computer science/computational biology), and introduces future trends for understanding brain activity and its relation to cognition and pathologies. This work will be valuable to professional investigators and clinicians, graduate and post-graduate students in related fields of neuroscience and biophysics, and to anyone interested in signal analysis techniques for studying brain function.

Author : Frank H. Eeckman
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 54,9 Mb
Release : 2012-02-02
Category : Computers
ISBN : 9781461540106

Get Book

Analysis and Modeling of Neural Systems by Frank H. Eeckman Pdf

I - Analysis and Modeling Tools and Techniques.- Section 1: Analysis.- Assembly Connectivity and Activity: Methods, Results, Interpretations.- Visualization of Cortical Connections With Voltage Sensitive Dyes.- Channels, Coupling, and Synchronized Rhythmic Bursting Activity.- Sparse-stimulation and Wiener Kernels.- Quantitative Search for Stimulus-Specific Patterns in the Human Electroencephalogram (EEG) During a Somatosensory Task.- Section 2: Modeling.- Functional Insights About Synaptic Inputs to Dendrites.- Dendritic Control of Hebbian Computations.- Low Threshold Spikes and Rhythmic Oscil.

Author : Sonja Grün,Stefan Rotter
Publisher : Springer Science & Business Media
Page : 447 pages
File Size : 48,7 Mb
Release : 2010-08-18
Category : Medical
ISBN : 9781441956750

Get Book

Analysis of Parallel Spike Trains by Sonja Grün,Stefan Rotter Pdf

Solid and transparent data analysis is the most important basis for reliable interpretation of experiments. The technique of parallel spike train recordings using multi-electrode arrangements has been available for many decades now, but only recently gained wide popularity among electro physiologists. Many traditional analysis methods are based on firing rates obtained by trial-averaging, and some of the assumptions for such procedures to work can be ignored without serious consequences. The situation is different for correlation analysis, the result of which may be considerably distorted if certain critical assumptions are violated. The focus of this book is on concepts and methods of correlation analysis (synchrony, patterns, rate covariance), combined with a solid introduction into approaches for single spike trains, which represent the basis of correlations analysis. The book also emphasizes pitfalls and potential wrong interpretations of data due to violations of critical assumptions.

Author : Tatjana Tchumatchenko,Ruben Moreno-Bote
Publisher : Frontiers E-books
Page : 237 pages
File Size : 40,9 Mb
Release : 2014-12-03
Category : Brain function
ISBN : 9782889193578

Get Book

Correlated neuronal activity and its relationship to coding, dynamics and network architecture by Tatjana Tchumatchenko,Ruben Moreno-Bote Pdf

Correlated activity in populations of neurons has been observed in many brain regions and plays a central role in cortical coding, attention, and network dynamics. Accurately quantifying neuronal correlations presents several difficulties. For example, despite recent advances in multicellular recording techniques, the number of neurons from which spiking activity can be simultaneously recorded remains orders magnitude smaller than the size of local networks. In addition, there is a lack of consensus on the distribution of pairwise spike cross correlations obtained in extracellular multi-unit recordings. These challenges highlight the need for theoretical and computational approaches to understand how correlations emerge and to decipher their functional role in the brain.

Author : Metin Akay
Publisher : John Wiley & Sons
Page : 681 pages
File Size : 53,6 Mb
Release : 2007-01-09
Category : Medical
ISBN : 9780470068281

Get Book

Handbook of Neural Engineering by Metin Akay Pdf

An important new work establishing a foundation for future developments in neural engineering The Handbook of Neural Engineering provides theoretical foundations in computational neural science and engineering and current applications in wearable and implantable neural sensors/probes. Inside, leading experts from diverse disciplinary groups representing academia, industry, and private and government organizations present peer-reviewed contributions on the brain-computer interface, nano-neural engineering, neural prostheses, imaging the brain, neural signal processing, the brain, and neurons. The Handbook of Neural Engineering covers: Neural signal and image processing--the analysis and modeling of neural activity and EEG-related activities using the nonlinear and nonstationary analysis methods, including the chaos, fractal, and time-frequency and time-scale analysis methods--and how to measure functional, physiological, and metabolic activities in the human brain using current and emerging medical imaging technologies Neuro-nanotechnology, artificial implants, and neural prosthesis--the design of multi-electrode arrays to study how the neurons of human and animals encode stimuli, the evaluation of functional changes in neural networks after stroke and spinal cord injuries, and improvements in therapeutic applications using neural prostheses Neurorobotics and neural rehabilitation engineering--the recent developments in the areas of biorobotic system, biosonar head, limb kinematics, and robot-assisted activity to improve the treatment of elderly subjects at the hospital and home, as well as the interactions of the neuron chip, neural information processing, perception and neural dynamics, learning memory and behavior, biological neural networks, and neural control