Angiotensin Ii Receptor Blockade Physiological And Clinical Implications

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Angiotensin II Receptor Blockade Physiological and Clinical Implications

Naranjan S. Dhalla,Peter Zahradka,Ian M.C. Dixon,Robert E. Beamish
Angiotensin II Receptor Blockade Physiological and Clinical Implications Book PDF

Author : Naranjan S. Dhalla,Peter Zahradka,Ian M.C. Dixon,Robert E. Beamish
Publisher : Springer Science & Business Media
Page : 607 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461557432

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Angiotensin II Receptor Blockade Physiological and Clinical Implications by Naranjan S. Dhalla,Peter Zahradka,Ian M.C. Dixon,Robert E. Beamish Pdf

The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such ·as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure. The Manitoba Cardiovascular Forum on Angiotensin Receptor Blockade in Winnipeg was convened October 18-20, 1996 to examine the clinical and basic aspects of angiotensin receptor biology as they apply to hypertension and heart failure. In addition, the potential treatment of these conditions using specific angio tensin receptor antagonists was addressed within the context of their immediate therapeutic application and future potential.

Angiotensin II Receptor Antagonists

Murray Epstein,Hans R. Brunner
Angiotensin II Receptor Antagonists Book PDF

Author : Murray Epstein,Hans R. Brunner
Publisher : Unknown
Page : 408 pages
File Size : 48,7 Mb
Release : 2001
Category : Angiotensin II
ISBN : UOM:39015054248029

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Angiotensin II Receptor Antagonists by Murray Epstein,Hans R. Brunner Pdf

The recent development of several new, non-peptide, orally active angiotensin II receptor antagonists is revolutionizing the treatment of patients with hypertension and various cardiovascular disorders. In this book experts review the current state of angiotensin II antagonists and survey the progress of these diverse applications. Issues relating to angiotensin II and their receptors are examined in relation to their effects on the kidney, non-diabetic renal disease, heart disease, diabetes mellitus, and various other disorders. The combination of AT1 receptor antagonists with other antihypertensive agents is reviewed in depth. The clinical attributes of these drugs are complemented by in-depth reviews of the physiology and pharmacology of angiotensin II peptides. The authors present the most recent findings in ligand recognition, activation, signal coupling, desensitization and functional alterations of vessels, especially small arteries, in patients with hypertension. This book constitutes the only available compendium on the clinical and experimental features of angiotensin II receptor antagonists. The unique features of the rapidly emerging class of drugs are surveyed throughout. Contributions have been made from international experts who have personally contributed to the discovery and development of these novel drugs. Recent cutting-edge physiology and pharmacology studies by renowned international experts provide a platform for considering the clinical applications of these agents.

Angiotensin Vol. II

Thomas Unger,Bernward A. Schölkens
Angiotensin Vol II Book PDF

Author : Thomas Unger,Bernward A. Schölkens
Publisher : Springer Science & Business Media
Page : 603 pages
File Size : 43,9 Mb
Release : 2012-02-02
Category : Medical
ISBN : 9783642184970

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Angiotensin Vol. II by Thomas Unger,Bernward A. Schölkens Pdf

Nearly thirty years ago, in 1974, the volume on Angiotensin edited by Irvine H.Page and F. Merlin Bumpus expanded the Handbook of Experimental Pharmacology. Even after two decades the multiplicity of its actions appears not to have been fully discovered. To call attention to its many functions is one of the purposes of this book. This new edition of the volume on Angiotensin attempts to provide an updated account of the knowledge and findings accumulated since the complexity of angiotensin was so accurately recognized.

Adaptation Biology and Medicine

A. Hargens,N. Takeda,P. K. Singal
Adaptation Biology and Medicine Book PDF

Author : A. Hargens,N. Takeda,P. K. Singal
Publisher : Alpha Science Int'l Ltd.
Page : 366 pages
File Size : 47,9 Mb
Release : 2005-03
Category : Adaptation (Biology)
ISBN : 8173195714

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Adaptation Biology and Medicine by A. Hargens,N. Takeda,P. K. Singal Pdf

Recognition of adaptive processes in biological systems as a discipline is still in its infancy. It is known that repeat exposure to low level stresses such as heat, cold, microgravity, hypoxia, exercise, etc. increases body-resistance to not only the particular stress but also to other conditions. Such a cross-protection can be utilized in a better patient care. This volume describes most current developments in the understanding of the molecular basis of adaptation as well as its application in biological systems including certain disease conditions in humans. The book is based on the presentations made by internationally known experts assembled in San Diego, USA for the 7th World Congress of the International Society for Adaptive Medicine and will be of great interest to experimental biologists as well as clinicians who deal with a wide variety of clinical conditions.

Adaptation Biology and Medicine

A.R Hargens
Adaptation Biology and Medicine Book PDF

Author : A.R Hargens
Publisher : ALPHA SCIENCE INTERNATIONAL LIMITED
Page : 362 pages
File Size : 46,5 Mb
Release : 2005-01-01
Category : Medical
ISBN : 9788184872897

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Adaptation Biology and Medicine by A.R Hargens Pdf

Recognition of adaptive processes in biological systems as a discipline is still in its infancy. It is known that repeat exposure to low level stresses such as heat, cold, microgravity, hypoxia, exercise, etc. increases body-resistance to not only the particular stress but also to other conditions. Such a cross-protection can be utilized in a better patient care. This volume describes most current developments in the understanding of the molecular basis of adaptation as well as its application in biological systems including certain disease conditions in humans. The book is based on the presentations made by internationally known experts assembled in San Diego, USA for the 7th World Congress of the International Society for Adaptive Medicine and will be of great interest to experimental biologists as well as clinicians who deal with a wide variety of clinical conditions.

Pharmacology and Therapeutics in the New Millennium

S.K. Gupta
Pharmacology and Therapeutics in the New Millennium Book PDF

Author : S.K. Gupta
Publisher : Springer Science & Business Media
Page : 772 pages
File Size : 43,5 Mb
Release : 2001-09-30
Category : Science
ISBN : 0792370597

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Pharmacology and Therapeutics in the New Millennium by S.K. Gupta Pdf

During the past several years tremendous advancements have been made in the field of pharmacology and therapeutics. While new therapeutic strategies are coming up, old ones are being improved by modifications, or being replaced with newer ones. The major topics covered in this book include: endothelins, current topics in cardiovascular research, molecular pharmacology, recent developments in cancer research, antioxidants, oxidants and human disease, herbal drugs, developments in neuropharmacology, myelin biology and demyelinating disease, pharmacovigilance, role of cytokines in health and disease, ocular pharmacology, detoxification of xenobiotics-biotransformation and transport, and several other topics of current interest. The aim of this book is to fulfill the needs of the basic and clinical researchers as well as the students, particularly related to areas of current interest in pharmacology and therapeutics.

Molecular Defects in Cardiovascular Disease

Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal
Molecular Defects in Cardiovascular Disease Book PDF

Author : Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal
Publisher : Springer Science & Business Media
Page : 381 pages
File Size : 42,8 Mb
Release : 2011-08-09
Category : Medical
ISBN : 9781441971302

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Molecular Defects in Cardiovascular Disease by Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal Pdf

Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics. Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment. The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction. The remaining two sections provide a more clinical focus. The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling. It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure. The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end. A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.

Interstitial Fibrosis in Heart Failure

Francisco Villarreal
Interstitial Fibrosis in Heart Failure Book PDF

Author : Francisco Villarreal
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 50,9 Mb
Release : 2005-12-17
Category : Medical
ISBN : 9780387228259

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Interstitial Fibrosis in Heart Failure by Francisco Villarreal Pdf

Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.

Patients First

Terrence Montague
Patients First Book PDF

Author : Terrence Montague
Publisher : John Wiley & Sons
Page : 268 pages
File Size : 51,6 Mb
Release : 2010-03-18
Category : Medical
ISBN : 9780470675229

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Patients First by Terrence Montague Pdf

PATIENTS FIRST CLOSING THE HEALTH CARE GAP IN CANADA "This book is a must read for those who are interested in our health care system and who want to make it better. Dr. Montague provides an interesting overview of his journey through hospital wards, clinical trials, patient registries, patient health management and chronic disease management programs. Drawing on his diverse and unique background, he gives an important history of the past, analysis of the present and a glimpse of our future." --David Johnstone, MD President, Canadian Cardiovascular Society "Based on significant practice and research experience in the public, private and academic worlds, over many regions of Canada, Dr. Montague reveals to the reader, consumer, decision maker and patient an evolving and, until now, largely overlooked dimension in optimizing care and outcome. This optimization is important not only within the context of an individual's care, but within the scope of an entire practice, community or even nation." --Ross Tsuyuki, PharmD Director, The Epidemiology Coordinating and Research Centre, University of Alberta "Listen to Dr. Montague. He well understands both the problem and the solution, which is to pull out all the stops and to put patients first. He advocates patient health management to close the many care gaps. This will result in improved health for millions of Canadians and then, if we do it right, by emphasizing research and evidence-based health care and not merely budgets, our health care system will become more cost effective and our population healthier and more productive." --Mark Poznansky, PhD President, Robarts Research Institute

Pathophysiology of Cardiovascular Disease

Naranjan S. Dhalla,Heinz Rupp,Aubie Angel,Grant N. Pierce
Pathophysiology of Cardiovascular Disease Book PDF

Author : Naranjan S. Dhalla,Heinz Rupp,Aubie Angel,Grant N. Pierce
Publisher : Springer Science & Business Media
Page : 639 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461504535

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Pathophysiology of Cardiovascular Disease by Naranjan S. Dhalla,Heinz Rupp,Aubie Angel,Grant N. Pierce Pdf

Pathophysiology of Cardiovascular Disease has been divided into four sections that focus on heart dysfunction and its associated characteristics (hypertrophy, cardiomyopathy and failure); vascular dysfunction and disease; ischemic heart disease; and novel therapeutic interventions. This volume is a compendium of different approaches to understanding cardiovascular disease and identifying the proteins, pathways and processes that impact it.

The Hypertrophied Heart

Nobuakira Takeda,Makoto Nagano,Naranjan S. Dhalla
The Hypertrophied Heart Book PDF

Author : Nobuakira Takeda,Makoto Nagano,Naranjan S. Dhalla
Publisher : Springer Science & Business Media
Page : 490 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461544234

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The Hypertrophied Heart by Nobuakira Takeda,Makoto Nagano,Naranjan S. Dhalla Pdf

Whenever the heart is challenged with an increased work load for a prolonged period, it responds by increasing its muscle mass--a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situa tions such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss), and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy. Various hormones such as catecholamines, thyroid hormones, angiotensin II, endothelin, and growth factors have also been shown to induce cardiac hypertrophy. Although the exact mechanisms underlying or pathological forrns of cardiac hypertrophy are poorly under the physiological stood, an increase in the intraventricular pressure is believed to represent the major stimulus for the development of cardiac hypertrophy. In this regard, stretching of the cardiac muscle has been shown to induce the hypertrophic response, but the role of metabolic influences in this process cannot be ruled out. Furthermore, different hormones and other interventions in the absence of stretch have been observed to stimulate protein synthesis in both isolated cardiomyocyte and vascular myocyte preparations. Nonetheless, it is becoming dear that receptor as well as phospholipid linked signal transduction pathways are activated in some specific manner depend ing upon the initial hypertrophic stimulus, and these then result in an increase in the size and mass of cardiomyocytes.

Frontiers in Cardiovascular Health

Naranjan S. Dhalla,Arun Chockalingam,H. Ivan Berkowitz,Pawan K. Singal
Frontiers in Cardiovascular Health Book PDF

Author : Naranjan S. Dhalla,Arun Chockalingam,H. Ivan Berkowitz,Pawan K. Singal
Publisher : Springer Science & Business Media
Page : 587 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461504559

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Frontiers in Cardiovascular Health by Naranjan S. Dhalla,Arun Chockalingam,H. Ivan Berkowitz,Pawan K. Singal Pdf

The Frontiers in Cardiovascular Health varies between and within nations, depend ing upon the level at which the battle is fought for better cardiovascular health. According to the 1997 World Health Report, 15 million deaths (i. e. 30% of the total number of deaths) were attributable to cardiovascular diseases and this number is on the rise. The projection for the year 2020 is quite alarming with an expected cardiovascular mortality reaching 50 million. Much of this burden is projected to occur in developing countries, more specifically in the most populous countries of the world, namely China and India. These countries are already burdened with infectious and parasitic diseases and are trying to eradicate such diseases. With increasing life expectancies people all over the world, especially in developing coun tries, are exposed to degenerative atherosclerosis resulting in increased cardiovascu lar mortality and morbidity. In developing countries, resources available for health care are very limited. For example many of the African countries spend less than $10 per person per year on his/her entire health care let alone cardiovascular health. The average health care budget for nearly two thirds of the global population is well below $100 per year, on a per capita basis. Therefore, in developing countries health promotion and primary prevention are the frontiers by necessity. Improving awareness and health education is not only a matter of choice but is an absolute necessity.

Holland-Frei Cancer Medicine

Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Holland Frei Cancer Medicine Book PDF

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 50,7 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Oxford Textbook of Clinical Nephrology Volume 3

Alex M. Davison
Oxford Textbook of Clinical Nephrology Volume 3 Book PDF

Author : Alex M. Davison
Publisher : Oxford University Press, USA
Page : 1156 pages
File Size : 54,8 Mb
Release : 2005
Category : Medical
ISBN : 0198567987

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Oxford Textbook of Clinical Nephrology Volume 3 by Alex M. Davison Pdf

Authoritative, well-written, and comprehensive textbook of clinical nephrology, combining the clinical aspects of renal disease important for daily clinical practice while giving extensive information about the underlying basic science and current evidence available. This new edition highlights the numerous changes in clinical management that have arisen as a result of recently concluded clinical trials and there are now specific formal guidelines for optimal treatment of patients. Each section of the textbook has been critically and comprehensively edited under the auspices of one of the leading experts in the field. The emphasis throughout is on marrying advances in scientific research with clinical managment. Where possible treatment algorithms are included to aid patient care.

The Protective Arm of the Renin Angiotensin System (RAS)

Thomas Unger,U. Muscha Steckelings,Robson Augusto Souza dos Santos
The Protective Arm of the Renin Angiotensin System RAS Book PDF

Author : Thomas Unger,U. Muscha Steckelings,Robson Augusto Souza dos Santos
Publisher : Academic Press
Page : 316 pages
File Size : 53,8 Mb
Release : 2015-04-18
Category : Medical
ISBN : 9780128014851

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The Protective Arm of the Renin Angiotensin System (RAS) by Thomas Unger,U. Muscha Steckelings,Robson Augusto Souza dos Santos Pdf

The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.