Molecular Defects In Cardiovascular Disease

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Molecular Defects in Cardiovascular Disease

Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal
Molecular Defects in Cardiovascular Disease Book PDF

Author : Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal
Publisher : Springer Science & Business Media
Page : 381 pages
File Size : 48,8 Mb
Release : 2011-08-09
Category : Medical
ISBN : 9781441971302

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Molecular Defects in Cardiovascular Disease by Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal Pdf

Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics. Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment. The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction. The remaining two sections provide a more clinical focus. The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling. It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure. The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end. A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.

Molecular Defects in Cardiovascular Disease

Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal
Molecular Defects in Cardiovascular Disease Book PDF

Author : Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal
Publisher : Springer
Page : 382 pages
File Size : 41,6 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493941151

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Molecular Defects in Cardiovascular Disease by Naranjan S. Dhalla,Makoto Nagano,Bohuslav Ostadal Pdf

Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics. Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment. The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction. The remaining two sections provide a more clinical focus. The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling. It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure. The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end. A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.

Cellular and Molecular Pathobiology of Cardiovascular Disease

Monte Willis,Jonathon W. Homeister,James R. Stone
Cellular and Molecular Pathobiology of Cardiovascular Disease Book PDF

Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Page : 339 pages
File Size : 47,5 Mb
Release : 2013-12-23
Category : Medical
ISBN : 9780124055254

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Cellular and Molecular Pathobiology of Cardiovascular Disease by Monte Willis,Jonathon W. Homeister,James R. Stone Pdf

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Molecular Genetics & Gene Therapy of Cardiovascular Diseases

S. C. Mockrin
Molecular Genetics Gene Therapy of Cardiovascular Diseases Book PDF

Author : S. C. Mockrin
Publisher : CRC Press
Page : 616 pages
File Size : 44,5 Mb
Release : 1996-01-02
Category : Medical
ISBN : 9781482273243

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Molecular Genetics & Gene Therapy of Cardiovascular Diseases by S. C. Mockrin Pdf

Provides detailed discussions of the most recent developments in gene mapping and manipulation to improve the diagnosis, detection, prevention, and treatment of various cardiovascular diseases--including hypertension, arrhythmias, inherited cariomyopathies, hyperlipidemia, aortic aneurysms, Marfan syndrome, and myocardial infarction. Written by nea

Congenital Heart Disease

Maximilian Muenke,Paul S. Kruszka,Craig A. Sable,John W. Belmont
Congenital Heart Disease Book PDF

Author : Maximilian Muenke,Paul S. Kruszka,Craig A. Sable,John W. Belmont
Publisher : Karger Medical and Scientific Publishers
Page : 342 pages
File Size : 45,7 Mb
Release : 2015-06-02
Category : Medical
ISBN : 9783318030037

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Congenital Heart Disease by Maximilian Muenke,Paul S. Kruszka,Craig A. Sable,John W. Belmont Pdf

This new book reviews the latest advances in the embryology, genetics, diagnosis, imaging, and therapy of congenital heart disease. The international cast of authors has combined its talents to produce a unique, expert perspective. This publication arrives at a very exciting time when new genetic, imaging, and therapeutic developments are changing the field. It is relevant to pediatricians, internal medicine specialists, medical geneticists, both pediatric and adult cardiologists, embryologists, imaging physicians, and cardiac surgeons. The reader is taken on a journey that begins with a historical overview of congenital cardiovascular anomalies and ends with developments in stem cell and tissue engineering. In between are chapters on cardiac embryogenesis; epidemiology; genetic syndromes associated with cardiovascular anomalies; single gene disorders; cardiac imaging; surgical and interventional therapies; and ethical considerations.

Principles of Molecular Cardiology

Marschall S. Runge,Cam Patterson
Principles of Molecular Cardiology Book PDF

Author : Marschall S. Runge,Cam Patterson
Publisher : Springer Science & Business Media
Page : 604 pages
File Size : 50,7 Mb
Release : 2007-11-14
Category : Medical
ISBN : 9781592598786

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Principles of Molecular Cardiology by Marschall S. Runge,Cam Patterson Pdf

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

From Molecule to Men

M. Zehender,G. Breithardt,H. Just
From Molecule to Men Book PDF

Author : M. Zehender,G. Breithardt,H. Just
Publisher : Springer Science & Business Media
Page : 264 pages
File Size : 51,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642577246

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From Molecule to Men by M. Zehender,G. Breithardt,H. Just Pdf

From molecule to man: Medical research has indeed taken this direction, and major improvements of our understanding of the pathophysiology and epidemiology of disease have been achieved. The molecular basis of the congenital cardiovascular disorders has been extended from relatively few congenital malformations into everyday illnesses such as diabetes mellitus, hyperlipoproteinaemea, and arterial hypertension. The monogenic and, more difficult, polygenic basis for a vast majority of cardiovascular disorders are being defined more precisely from year to year. This book gives an overview of what has been achieved so far and defines the current position.

Clinical Cardiogenetics

H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt
Clinical Cardiogenetics Book PDF

Author : H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt
Publisher : Springer Science & Business Media
Page : 453 pages
File Size : 52,7 Mb
Release : 2010-12-25
Category : Medical
ISBN : 9781849964715

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Clinical Cardiogenetics by H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt Pdf

Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?

Current Challenges in Cardiovascular Molecular Diagnostics

Matteo Vatta,Valeria Novelli,Luisa Mestroni,Jeffrey A. Towbin,Carlo Napolitano,Guia Guffanti
Current Challenges in Cardiovascular Molecular Diagnostics Book PDF

Author : Matteo Vatta,Valeria Novelli,Luisa Mestroni,Jeffrey A. Towbin,Carlo Napolitano,Guia Guffanti
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 40,6 Mb
Release : 2017-09-12
Category : Electronic book
ISBN : 9782889452811

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Current Challenges in Cardiovascular Molecular Diagnostics by Matteo Vatta,Valeria Novelli,Luisa Mestroni,Jeffrey A. Towbin,Carlo Napolitano,Guia Guffanti Pdf

The field of cardiovascular genetics has tremendously benefited from the recent application of massive parallel sequencing technology also referred to as next generation sequencing (NGS). However, along with the discovery of additional genes associated with human cardiac diseases, the analysis of large dataset of genetic information uncovered a much more complex and variegated landscape, which often departs from the comfort zone of the monogenic Mendelian diseases image that clinical molecular geneticists have been well acquainted with for many decades. It is now clear that, in addition to highly penetrant genetic variants, which in isolation are able to recapitulate the full clinical presentation when expressed in animal models, we are now aware that a small but significant fraction of subjects presenting with cardiac muscle diseases such as cardiomyopathies or primary arrhythmias such as long QT syndrome (LQTS), may harbor at least two deleterious variants in the same gene (compound heterozygous) or in different gene (double heterozygous). Although the clinical presentation in subjects with more than one deleterious variant appears to be more severe and with an earlier disease onset, it somehow changes the viewpoint of clinical molecular geneticists whose aim is to identify all possible genetic contributors to a human condition. In this light, the employment in clinical diagnostics of the NGS technology, allowing the simultaneous interrogation of a DNA target spanning from large panel of genes up to the entire genome, will definitely aid at uncovering all such contributors, which will have to be tested functionally to confirm their role in human cardiac conditions. The uncovering of all clinically relevant deleterious changes associated with a cardiovascular disease would probably increase our understanding of the clinical variability commonly occurring among affected family relatives, and potentially provide with unexpected therapeutic targets for the treatment of symptoms related to the presence of “accessory” deleterious genetic variants other than the key molecular culprit. The objective of this Research Topic is to explore the current challenges presenting to the cardiovascular genetics providers, such as clinical geneticists, genetic counselors, clinical molecular geneticists and molecular pathologists involved in the diagnosis, counseling, testing and interpretation of genetic tests results for the comprehensive management of patients affected by cardiovascular genetic disorders.

Molecular Cardiology in Clinical Practice

Michael R. Sanders,John B. Kostis
Molecular Cardiology in Clinical Practice Book PDF

Author : Michael R. Sanders,John B. Kostis
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 53,6 Mb
Release : 2007-11-23
Category : Medical
ISBN : 9780585381411

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Molecular Cardiology in Clinical Practice by Michael R. Sanders,John B. Kostis Pdf

Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists. With the dawning of the new `molecular' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems. Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients.

Molecular Basis of Cardiovascular Disease

Kenneth R. Chien
Molecular Basis of Cardiovascular Disease Book PDF

Author : Kenneth R. Chien
Publisher : Unknown
Page : 760 pages
File Size : 52,7 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015058250617

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Molecular Basis of Cardiovascular Disease by Kenneth R. Chien Pdf

The 2nd Edition of this heralded companion to Braunwald's Heart Disease explores the molecular mechanisms of cardiology and the scientific advances that are changing the practice of cardiology today. International experts discuss the role of genetics in cardiovascular disease the molecular basis of ischemic disease, thrombosis and hypertension genetic mapping approaches to inherited disorders biologically targeted agents for hypertension and heart failure and much more. Abundant figures and tables illustrate key concepts. Addresses most common cardiovascular problems from a molecular standpoint. Explores developing treatments for cardiovascular problems based on genetics. Provides references to Braunwald's Heart Disease, 6th Edition Examines today's cutting edge advances in molecular cardiology and the future of gene therapy, Examines the implications of cellular cholesterol metabolism in health and disease. . Delivers up-to-date information on understanding the origin of inherited disease.

Congenital Heart Diseases: The Broken Heart

Silke Rickert-Sperling,Robert G. Kelly,David J. Driscoll
Congenital Heart Diseases The Broken Heart Book PDF

Author : Silke Rickert-Sperling,Robert G. Kelly,David J. Driscoll
Publisher : Springer
Page : 765 pages
File Size : 55,8 Mb
Release : 2015-12-18
Category : Science
ISBN : 9783709118832

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Congenital Heart Diseases: The Broken Heart by Silke Rickert-Sperling,Robert G. Kelly,David J. Driscoll Pdf

This book provides comprehensive insights into congenital heart disease from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. It is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and related animal models and pathways. Taken together these chapters, which were written by and for clinicians and researchers, provide an integrated and cutting-edge resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.

Molecular Mechanisms of Cardiac Hypertrophy and Failure

Richard A. Walsh
Molecular Mechanisms of Cardiac Hypertrophy and Failure Book PDF

Author : Richard A. Walsh
Publisher : CRC Press
Page : 812 pages
File Size : 47,5 Mb
Release : 2005-11-29
Category : Medical
ISBN : 9780203503249

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Molecular Mechanisms of Cardiac Hypertrophy and Failure by Richard A. Walsh Pdf

This title reviews current knowledge of the mechanisms contributing to heart failure. Editor Richard Walsh and an internationally renowned team of contributors discuss key advances in molecular and cell biology, biochemistry, and pharmacology, focusing on advances that have a direct bearing on current clinical studies. It highlights developments across a broad range of disciplines, with in-depth coverage of each topic providing background and perspective on current literature. By setting new advances in a broader context, this text allows readers to compare different ideas and evaluate their importance in their own areas of research or clinical practice.

Molecular Cardiology

Zhongjie Sun
Molecular Cardiology Book PDF

Author : Zhongjie Sun
Publisher : Springer Science & Business Media
Page : 410 pages
File Size : 42,8 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592598793

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Molecular Cardiology by Zhongjie Sun Pdf

The aim of Molecular Cardiology: Methods and Protocols is to document state-of-the-art molecular and genetic techniques in the area of cardiology. These modern approaches enable researchers to readily study heart diseases at the molecular level and will promote the development of new therapeutic str- egies. Methods for genetic dissection, signal transduction, and microarray analysis are excellent tools for the study of the molecular mechanisms of cardiovascular diseases. Protocols for transgenesis take advantage of recent advances in many areas of molecular and cell biology. Transgenic models of heart diseases (cardiac hypertrophy, cardiac dysfunction, and so on. ) are powerful tools for the study of heart disease pathogenesis. Methods for gene transfer to heart tissue using viral and nonviral vectors form the basis of gene therapy for heart diseases. Heart-specific promoters containing a hypox- inducible cardioprotective gene switch are key for protection of the heart from ischemia. Gene and stem cell therapies open novel and exciting avenues for the prevention and treatment of heart diseases. Molecular Cardiology: Methods and Protocols consists of 26 chapters de- ing with various aspects of molecular cardiology, including gene transfer and gene therapy for cardiovascular disease, stem cell therapy for cardiovascular disease, gene analysis in the injured and hypertrophied heart, and transgenesis in cardiovascular research. This book provides step-by-step methods for the successful completion of experimental procedures, and would be useful for both experienced and new investigators in the field of molecular cardiology.

Genes and Cardiovascular Function

Bohuslav Ostadal,Makoto Nagano,Naranjan S. Dhalla
Genes and Cardiovascular Function Book PDF

Author : Bohuslav Ostadal,Makoto Nagano,Naranjan S. Dhalla
Publisher : Springer Science & Business Media
Page : 264 pages
File Size : 55,5 Mb
Release : 2011-08-09
Category : Medical
ISBN : 9781441972071

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Genes and Cardiovascular Function by Bohuslav Ostadal,Makoto Nagano,Naranjan S. Dhalla Pdf

Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology. In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression. The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management. The wide variety of gene expressions proffers excellent targets for novel therapeutics. Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus. This book is based on two international Mendel symposia on “Genes and the Heart,” joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences. Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.