Animal Models For Neurodegenerative Disease

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Animal Models for Neurodegenerative Disease

Jesus Avila,Jose J Lucas,Felix Hernandez
Animal Models for Neurodegenerative Disease Book PDF

Author : Jesus Avila,Jose J Lucas,Felix Hernandez
Publisher : Royal Society of Chemistry
Page : 306 pages
File Size : 42,6 Mb
Release : 2011-05-30
Category : Science
ISBN : 9781849732758

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Animal Models for Neurodegenerative Disease by Jesus Avila,Jose J Lucas,Felix Hernandez Pdf

In recent years, medical developments have resulted in an increase in human life expectancy. Some developed countries now have a larger population of individuals aged over 64 than those under 14. One consequence of the ageing population is a higher incidence of certain neurodegenerative disorders. In order to prevent these, we need to learn more about them. This book provides up-to-date information on the use of transgenic mouse models in the study of neurodegenerative disorders such as Alzheimer's and Huntington's disease. By reproducing some of the pathological aspects of the diseases, these studies could reveal the mechanism for their onset or development. Some of the transgenic mice can also be used as targets for testing new compounds with the potential to prevent or combat these disorders. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates and academics. The chapters cover disorders including: Alzheimer's disease, Parkinson's disease, Huntington's and other CAG diseases, amyotrophic lateral sclerosis (ALS), recessive ataxias, disease caused by prions, and ischemia.

Handbook of Animal Models in Alzheimer’s Disease

G. Casadesus
Handbook of Animal Models in Alzheimer s Disease Book PDF

Author : G. Casadesus
Publisher : IOS Press
Page : 352 pages
File Size : 40,8 Mb
Release : 2011-07-05
Category : Medical
ISBN : 9781607507338

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Handbook of Animal Models in Alzheimer’s Disease by G. Casadesus Pdf

Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals – including transgenic animals – has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.

Handbook of Animal Models in Alzheimer's Disease

Gemma Casadesus
Handbook of Animal Models in Alzheimer s Disease Book PDF

Author : Gemma Casadesus
Publisher : ADVANCES IN ALZHEIMERS DISEASE
Page : 340 pages
File Size : 52,9 Mb
Release : 2011
Category : Medical
ISBN : 1607507323

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Handbook of Animal Models in Alzheimer's Disease by Gemma Casadesus Pdf

Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals - including transgenic animals - has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram
Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America Book PDF

Author : Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram
Publisher : Frontiers Media SA
Page : 217 pages
File Size : 47,5 Mb
Release : 2018-06-21
Category : Electronic
ISBN : 9782889454945

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Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America by Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram Pdf

Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Animal Models for Neurological Disorders

Anil Kumar
Animal Models for Neurological Disorders Book PDF

Author : Anil Kumar
Publisher : Bentham Science Publishers
Page : 290 pages
File Size : 44,7 Mb
Release : 2021-12-24
Category : Science
ISBN : 9789815039696

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Animal Models for Neurological Disorders by Anil Kumar Pdf

Animal disease models are a vital tool to study diseases and associated conditions. Studies on animal models can, in some cases, be used as a basis for modeling and understanding human diseases. Biomedical scientists face a challenge to choose the correct animal model to study disease pathology, and neurological diseases are no exception to this rule. Animal Models for Neurological Disorders covers different animal models which have been used for studying neurological disorders. 13 topical chapters have been contributed by a group of experts on the subject with an aim to cover emerging experimental models of a range of neurological diseases encountered in the clinic including Alzheimer’s disease, psychosis, Parkinson’s, Huntington’s disease, vascular dementia, schizophrenia, multiple sclerosis and brain tumors, among others. The chapters also inform readers about relevant clinical correlations in each disease model where appropriate. Animal Models for Neurological Disorders is intended for all scholarly researchers and students of biomedical sciences, pharmacology, medicine (oncology, neurology, psychiatry), pharmacy, biochemistry, and biotechnology. The organized contents of the book also serve as a quick reference point for scientists working in applied areas of neuroscience including the study of neurodegenerative diseases and cognitive dysfunction in living organisms.

Animal Models for the Study of Human Disease

Angela L. Shamchuk,Keith B. Tierney
Animal Models for the Study of Human Disease Book PDF

Author : Angela L. Shamchuk,Keith B. Tierney
Publisher : Elsevier Inc. Chapters
Page : 1108 pages
File Size : 40,5 Mb
Release : 2013-05-29
Category : Medical
ISBN : 9780128072172

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Animal Models for the Study of Human Disease by Angela L. Shamchuk,Keith B. Tierney Pdf

Olfactory dysfunction, although caused by many factors including physical damage and genetic abnormalities, is an early stage symptom of several neurodegenerative diseases. Not only is the olfactory system subject to the specific histological abnormalities but patients also lose the capacities to detect, identify, and discriminate among odors. In addition to olfactory deficits, motor dysfunction is another prominent manifestation of these conditions. Recent studies have begun to create zebrafish (Danio rerio) models for neurodegenerative diseases. Despite successful execution, there remains a great deal of potential in testing the models using established methods of olfactory and motion assessment. This chapter discusses the current zebrafish models and suggests olfactory and motor endpoints for Parkinson's, Alzheimer's, Huntington's, multiple system atrophy, and amyotrophic lateral sclerosis.

Drosophila Models for Human Diseases

Masamitsu Yamaguchi
Drosophila Models for Human Diseases Book PDF

Author : Masamitsu Yamaguchi
Publisher : Springer
Page : 308 pages
File Size : 41,9 Mb
Release : 2018-06-27
Category : Medical
ISBN : 9789811305290

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Drosophila Models for Human Diseases by Masamitsu Yamaguchi Pdf

Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.

Animal Models of Neurological Disorders

Puneet Kumar Bansal,Rahul Deshmukh
Animal Models of Neurological Disorders Book PDF

Author : Puneet Kumar Bansal,Rahul Deshmukh
Publisher : Springer
Page : 343 pages
File Size : 43,5 Mb
Release : 2018-01-17
Category : Medical
ISBN : 9789811059810

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Animal Models of Neurological Disorders by Puneet Kumar Bansal,Rahul Deshmukh Pdf

This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Animal Models of Neurological Disease, I

Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Animal Models of Neurological Disease I Book PDF

Author : Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Publisher : Humana Press
Page : 368 pages
File Size : 49,8 Mb
Release : 2013-08-18
Category : Medical
ISBN : 1489940227

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Animal Models of Neurological Disease, I by Alan A. Boulton,Glen B. Baker,Roger F. Butterworth Pdf

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neu- psychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further research using animals is necessary and why animal models of psychi- ric and neurologic disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out.

Animal Models of Dementia

Peter Paul De Deyn,Debby Van Dam
Animal Models of Dementia Book PDF

Author : Peter Paul De Deyn,Debby Van Dam
Publisher : Humana Press
Page : 732 pages
File Size : 55,5 Mb
Release : 2010-12-01
Category : Medical
ISBN : 1607618974

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Animal Models of Dementia by Peter Paul De Deyn,Debby Van Dam Pdf

With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Methods of Behavior Analysis in Neuroscience

Jerry J. Buccafusco
Methods of Behavior Analysis in Neuroscience Book PDF

Author : Jerry J. Buccafusco
Publisher : CRC Press
Page : 341 pages
File Size : 45,7 Mb
Release : 2000-08-29
Category : Medical
ISBN : 9781420041811

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Methods of Behavior Analysis in Neuroscience by Jerry J. Buccafusco Pdf

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Toxin-Induced Models of Neurological Disorders

A.J. Nonneman,M.L. Woodruff
Toxin Induced Models of Neurological Disorders Book PDF

Author : A.J. Nonneman,M.L. Woodruff
Publisher : Springer Science & Business Media
Page : 357 pages
File Size : 44,6 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489914477

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Toxin-Induced Models of Neurological Disorders by A.J. Nonneman,M.L. Woodruff Pdf

Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro degenerative disorders and assessing risk factors associated with neurotoxin ex posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia.

Central Nervous System Diseases

Dwaine F. Emerich,Reginald L. Dean III,Paul R. Sanberg
Central Nervous System Diseases Book PDF

Author : Dwaine F. Emerich,Reginald L. Dean III,Paul R. Sanberg
Publisher : Springer Science & Business Media
Page : 511 pages
File Size : 47,5 Mb
Release : 1999-11-24
Category : Medical
ISBN : 9781592596911

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Central Nervous System Diseases by Dwaine F. Emerich,Reginald L. Dean III,Paul R. Sanberg Pdf

Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.

Mouse Models in the Study of Genetic Neurological Disorders

Brian Popko
Mouse Models in the Study of Genetic Neurological Disorders Book PDF

Author : Brian Popko
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461548874

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Mouse Models in the Study of Genetic Neurological Disorders by Brian Popko Pdf

The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.

Guidance for the Description of Animal Research in Scientific Publications

National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research
Guidance for the Description of Animal Research in Scientific Publications Book PDF

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research
Publisher : National Academies Press
Page : 42 pages
File Size : 52,6 Mb
Release : 2011-09-16
Category : Science
ISBN : 9780309219549

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Guidance for the Description of Animal Research in Scientific Publications by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research Pdf

The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.