Mouse Models In The Study Of Genetic Neurological Disorders

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Mouse Models in the Study of Genetic Neurological Disorders

Brian Popko
Mouse Models in the Study of Genetic Neurological Disorders Book PDF

Author : Brian Popko
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 45,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461548874

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Mouse Models in the Study of Genetic Neurological Disorders by Brian Popko Pdf

The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.

New Animal Models of Human Neurological Diseases

Philippe Poindron,Pascale Piguet
New Animal Models of Human Neurological Diseases Book PDF

Author : Philippe Poindron,Pascale Piguet
Publisher : Karger Medical and Scientific Publishers
Page : 109 pages
File Size : 41,6 Mb
Release : 2008-01-01
Category : Medical
ISBN : 9783805584050

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New Animal Models of Human Neurological Diseases by Philippe Poindron,Pascale Piguet Pdf

This publication describes in detail some animal models of outstanding importance for the study of human neurological diseases. An introductory article provides a definition of animal models, looks at the history and ethics of their use, and highlights the reasons why animal models are so useful in scientific research. The following chapters present some of the newer models which play a key role in the study of amyotrophic lateral sclerosis, multiple sclerosis, stroke and peripheral neuropathy. Their specific features are detailed in the method section of each paper, and their application to the study of human neurological diseases is discussed in a comprehensive manner, i.e. limits and challenges posed by these models are evaluated and potential improvements suggested. A valuable single source of information, this book is recommended reading for neuroscientists as well as for neurologists and neurosurgeons interested in preclinical research on human neurological diseases.

Methods of Behavior Analysis in Neuroscience

Jerry J. Buccafusco
Methods of Behavior Analysis in Neuroscience Book PDF

Author : Jerry J. Buccafusco
Publisher : CRC Press
Page : 341 pages
File Size : 42,6 Mb
Release : 2000-08-29
Category : Medical
ISBN : 9781420041811

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Methods of Behavior Analysis in Neuroscience by Jerry J. Buccafusco Pdf

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Animal Models for Neurodegenerative Disease

Jesus Avila,Jose J Lucas,Felix Hernandez
Animal Models for Neurodegenerative Disease Book PDF

Author : Jesus Avila,Jose J Lucas,Felix Hernandez
Publisher : Royal Society of Chemistry
Page : 306 pages
File Size : 43,6 Mb
Release : 2011-05-30
Category : Science
ISBN : 9781849732758

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Animal Models for Neurodegenerative Disease by Jesus Avila,Jose J Lucas,Felix Hernandez Pdf

In recent years, medical developments have resulted in an increase in human life expectancy. Some developed countries now have a larger population of individuals aged over 64 than those under 14. One consequence of the ageing population is a higher incidence of certain neurodegenerative disorders. In order to prevent these, we need to learn more about them. This book provides up-to-date information on the use of transgenic mouse models in the study of neurodegenerative disorders such as Alzheimer's and Huntington's disease. By reproducing some of the pathological aspects of the diseases, these studies could reveal the mechanism for their onset or development. Some of the transgenic mice can also be used as targets for testing new compounds with the potential to prevent or combat these disorders. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates and academics. The chapters cover disorders including: Alzheimer's disease, Parkinson's disease, Huntington's and other CAG diseases, amyotrophic lateral sclerosis (ALS), recessive ataxias, disease caused by prions, and ischemia.

Animal Models for Neurological Disorders

Anil Kumar
Animal Models for Neurological Disorders Book PDF

Author : Anil Kumar
Publisher : Bentham Science Publishers
Page : 290 pages
File Size : 52,7 Mb
Release : 2021-12-24
Category : Science
ISBN : 9789815039696

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Animal Models for Neurological Disorders by Anil Kumar Pdf

Animal disease models are a vital tool to study diseases and associated conditions. Studies on animal models can, in some cases, be used as a basis for modeling and understanding human diseases. Biomedical scientists face a challenge to choose the correct animal model to study disease pathology, and neurological diseases are no exception to this rule. Animal Models for Neurological Disorders covers different animal models which have been used for studying neurological disorders. 13 topical chapters have been contributed by a group of experts on the subject with an aim to cover emerging experimental models of a range of neurological diseases encountered in the clinic including Alzheimer’s disease, psychosis, Parkinson’s, Huntington’s disease, vascular dementia, schizophrenia, multiple sclerosis and brain tumors, among others. The chapters also inform readers about relevant clinical correlations in each disease model where appropriate. Animal Models for Neurological Disorders is intended for all scholarly researchers and students of biomedical sciences, pharmacology, medicine (oncology, neurology, psychiatry), pharmacy, biochemistry, and biotechnology. The organized contents of the book also serve as a quick reference point for scientists working in applied areas of neuroscience including the study of neurodegenerative diseases and cognitive dysfunction in living organisms.

Mouse Models of Developmental Genetic Disease

Anonim
Mouse Models of Developmental Genetic Disease Book PDF

Author : Anonim
Publisher : Academic Press
Page : 528 pages
File Size : 51,6 Mb
Release : 2011-09-06
Category : Science
ISBN : 9780080922485

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Mouse Models of Developmental Genetic Disease by Anonim Pdf

Approximately three percent of newborn humans have congenital anomalies with significant cosmetic and/or functional consequences. Much of our ability to understand what has gone awry in these birth defects rests with development of animal models for them; the mouse has emerged as the model organism of choice for these studies. This volume reviews mouse models of specific developmental genetic diseases, including neural tube defects; cleft lip and/or palate; congenital heart disease; ciliopathies; hereditary deafness and others to provide conceptual insight into congenital anomalies generally. The interplay between clinical observation and murine model systems is expected to yield deep insight into mammalian developmental processes and the emergence of effective preventive and/or therapeutic strategies. Provides busy clinical and basic science researchers a one-stop overview and synthesis of the latest research findings and contemporary thought in the area Allows researchers to compare and contrast disease models and also to learn about what models have been developed for large-scale distribution Allows researchers to evaluate basic differences in mouse and human biology and propose alternate pathways and possible gene interactions of the disease

Animal Models for the Study of Human Disease

P. Michael Conn
Animal Models for the Study of Human Disease Book PDF

Author : P. Michael Conn
Publisher : Academic Press
Page : 1108 pages
File Size : 49,5 Mb
Release : 2013-05-29
Category : Science
ISBN : 9780124159129

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Animal Models for the Study of Human Disease by P. Michael Conn Pdf

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

The Mouse Nervous System

Charles Watson,George Paxinos,Luis Puelles
The Mouse Nervous System Book PDF

Author : Charles Watson,George Paxinos,Luis Puelles
Publisher : Academic Press
Page : 815 pages
File Size : 55,8 Mb
Release : 2011-11-28
Category : Science
ISBN : 9780123694973

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The Mouse Nervous System by Charles Watson,George Paxinos,Luis Puelles Pdf

The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

Leucine-Rich Repeat Kinase 2 (LRRK2)

Hardy J. Rideout
Leucine Rich Repeat Kinase 2 LRRK2 Book PDF

Author : Hardy J. Rideout
Publisher : Springer
Page : 271 pages
File Size : 53,6 Mb
Release : 2017-03-28
Category : Medical
ISBN : 9783319499697

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Leucine-Rich Repeat Kinase 2 (LRRK2) by Hardy J. Rideout Pdf

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine
Improving the Utility and Translation of Animal Models for Nervous System Disorders Book PDF

Author : Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine
Publisher : National Academies Press
Page : 111 pages
File Size : 47,7 Mb
Release : 2013-04-08
Category : Medical
ISBN : 9780309266345

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Improving the Utility and Translation of Animal Models for Nervous System Disorders by Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine Pdf

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

Animal Models of Cognitive Impairment

Edward D. Levin,Jerry J. Buccafusco
Animal Models of Cognitive Impairment Book PDF

Author : Edward D. Levin,Jerry J. Buccafusco
Publisher : CRC Press
Page : 395 pages
File Size : 49,6 Mb
Release : 2006-06-22
Category : Medical
ISBN : 9781420004335

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Animal Models of Cognitive Impairment by Edward D. Levin,Jerry J. Buccafusco Pdf

The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Mouse Models of Development and Disease

Thomas Gridley,Leif Oxburgh
Mouse Models of Development and Disease Book PDF

Author : Thomas Gridley,Leif Oxburgh
Publisher : Elsevier
Page : 282 pages
File Size : 40,7 Mb
Release : 2022-04-14
Category : Science
ISBN : 9780128171318

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Mouse Models of Development and Disease by Thomas Gridley,Leif Oxburgh Pdf

Mouse Models of Development and Disease, Volume 148 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this volume presenting chapters describing Mouse models of Charcot-Marie-Tooth disease, Mouse models in palate and craniofacial development, Uterine morphogenesis, Improving the translatability of mouse models of Alzheimer's disease, Mouse models for the study of clustered protocadherins, Mechanisms of organ regeneration in the spiny mouse, Comparative studies of organ vascularization, Modeling human urinary tract development and hereditary malformations, Innervation in organogenesis, Between embryo and adult: somatic growth of the kidney, and Mouse models in the study of Notch signaling. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Mouse Models of Development and Disease

Handbook of Animal Models in Neurological Disorders

Colin R Martin,Vinood B. Patel,Victor R Preedy
Handbook of Animal Models in Neurological Disorders Book PDF

Author : Colin R Martin,Vinood B. Patel,Victor R Preedy
Publisher : Elsevier
Page : 708 pages
File Size : 45,6 Mb
Release : 2022-11-29
Category : Medical
ISBN : 9780323898867

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Handbook of Animal Models in Neurological Disorders by Colin R Martin,Vinood B. Patel,Victor R Preedy Pdf

Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction. Summarizes animal models for a variety of neurological conditions Contains chapter abstracts, key facts, a dictionary and a summary Covers both neurodegenerative diseases and other neurological conditions Compares and contrasts different models and experimental systems Includes sections on Alzheimer’s, Parkinson’s, brain injury, migraine, multiple sclerosis, and more

Transgenic Mouse Methods and Protocols

Marten H. Hofker,Jan van Deursen
Transgenic Mouse Methods and Protocols Book PDF

Author : Marten H. Hofker,Jan van Deursen
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 44,7 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592593408

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Transgenic Mouse Methods and Protocols by Marten H. Hofker,Jan van Deursen Pdf

Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.

International Animal Research Regulations

National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
International Animal Research Regulations Book PDF

Author : National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 102 pages
File Size : 51,6 Mb
Release : 2012-06-26
Category : Science
ISBN : 9780309252119

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International Animal Research Regulations by National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.