Anti Aging Drug Discovery On The Basis Of Hallmarks Of Aging

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Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

Sandeep Kumar Singh,Chih Li Lin,Shailendra Kumar Mishra
Anti Aging Drug Discovery on the Basis of Hallmarks of Aging Book PDF

Author : Sandeep Kumar Singh,Chih Li Lin,Shailendra Kumar Mishra
Publisher : Academic Press
Page : 411 pages
File Size : 44,6 Mb
Release : 2022-07-19
Category : Medical
ISBN : 9780323902366

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Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging by Sandeep Kumar Singh,Chih Li Lin,Shailendra Kumar Mishra Pdf

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals. Covers different aspects of anti-aging research, from foundational knowledge to future perspectives Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

Anti-aging Drugs

Alexander M Vaiserman
Anti aging Drugs Book PDF

Author : Alexander M Vaiserman
Publisher : Royal Society of Chemistry
Page : 592 pages
File Size : 54,6 Mb
Release : 2017-02-01
Category : Aging
ISBN : 9781782624356

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Anti-aging Drugs by Alexander M Vaiserman Pdf

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.

Stem Cells and Aging

Surajit Pathak,Antara Banerjee
Stem Cells and Aging Book PDF

Author : Surajit Pathak,Antara Banerjee
Publisher : Academic Press
Page : 322 pages
File Size : 55,5 Mb
Release : 2021-03-17
Category : Science
ISBN : 9780128204139

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Stem Cells and Aging by Surajit Pathak,Antara Banerjee Pdf

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

The Vagus-Immune Connection

J.P. Errico
The Vagus Immune Connection Book PDF

Author : J.P. Errico
Publisher : Simon and Schuster
Page : 223 pages
File Size : 43,7 Mb
Release : 2024-03-12
Category : Health & Fitness
ISBN : 9781646046386

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The Vagus-Immune Connection by J.P. Errico Pdf

A Simon & Schuster eBook. Simon & Schuster has a great book for every reader.

Aging

Paulo J. Oliveira,Joao O. Malva
Aging Book PDF

Author : Paulo J. Oliveira,Joao O. Malva
Publisher : Academic Press
Page : 821 pages
File Size : 53,7 Mb
Release : 2022-09-22
Category : Science
ISBN : 9780128241318

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Aging by Paulo J. Oliveira,Joao O. Malva Pdf

Aging: From Fundamental Biology to Societal Impact examines the interconnection of the cellular and molecular basis of aging and societal-based challenges and innovative interventions. Sections take a societal-based angle on aging, describing several flagship initiatives for healthy living and active aging in different regions, cover the biology of aging which includes the hallmarks of aging, explain the pathophysiology of aging, describing different comorbidities associated with aging and possible interventions to decrease the impact of aging, and envision future and innovative measures to tackle aging-related morbidities. Contributions from an interdisciplinary panel of experts cover such topics as the biology of aging to physical activity, nutrition, psychology, pharmacology, health care, social care and urban planning. Provides a cross-disciplinary approach to aging at both the biological and societal level Highlights frontline scientific knowledge in the biology of aging and its translation into societal interventions Offers insights on the value of aging research and its future impact from a fundamental and translation point-of-view

The Molecular and Cellular Basis of Neurodegenerative Diseases

Michael S. Wolfe
The Molecular and Cellular Basis of Neurodegenerative Diseases Book PDF

Author : Michael S. Wolfe
Publisher : Academic Press
Page : 560 pages
File Size : 42,7 Mb
Release : 2018-03-29
Category : Medical
ISBN : 9780128113059

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The Molecular and Cellular Basis of Neurodegenerative Diseases by Michael S. Wolfe Pdf

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Anti-Aging Pharmacology

Vitaly Koltover
Anti Aging Pharmacology Book PDF

Author : Vitaly Koltover
Publisher : Academic Press
Page : 400 pages
File Size : 54,5 Mb
Release : 2022-12-07
Category : Medical
ISBN : 9780128236802

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Anti-Aging Pharmacology by Vitaly Koltover Pdf

Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice. Includes updated information about current developments in anti-aging pharmacology Offers practical advice on the applicability of certain healthspan-promoting medications Discusses potential challenges related to the translation of anti-aging drugs in clinical practice

Geriatric Gastroenterology

C. S. Pitchumoni,T. Dharmarajan
Geriatric Gastroenterology Book PDF

Author : C. S. Pitchumoni,T. Dharmarajan
Publisher : Springer Science & Business Media
Page : 660 pages
File Size : 50,8 Mb
Release : 2012-07-26
Category : Medical
ISBN : 9781441916235

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Geriatric Gastroenterology by C. S. Pitchumoni,T. Dharmarajan Pdf

As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.

Centenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan

Annibale Puca,Calogero Caruso
Centenarians A Model to Study the Molecular Basis of Lifespan and Healthspan Book PDF

Author : Annibale Puca,Calogero Caruso
Publisher : MDPI
Page : 204 pages
File Size : 49,9 Mb
Release : 2021-06-15
Category : Science
ISBN : 9783036509808

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Centenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan by Annibale Puca,Calogero Caruso Pdf

People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine.

Aging of the Genome

Jan Vijg
Aging of the Genome Book PDF

Author : Jan Vijg
Publisher : OUP Oxford
Page : 384 pages
File Size : 47,7 Mb
Release : 2007-01-25
Category : Science
ISBN : 9780191524585

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Aging of the Genome by Jan Vijg Pdf

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

Oxford Textbook of Oncology

David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Oxford Textbook of Oncology Book PDF

Author : David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Publisher : Oxford University Press
Page : 832 pages
File Size : 52,9 Mb
Release : 2016-01-28
Category : Medical
ISBN : 9780191065118

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Oxford Textbook of Oncology by David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann Pdf

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Gerontology

Grazia D’Onofrio,Daniele Sancarlo,Antonio Greco
Gerontology Book PDF

Author : Grazia D’Onofrio,Daniele Sancarlo,Antonio Greco
Publisher : BoD – Books on Demand
Page : 278 pages
File Size : 54,9 Mb
Release : 2018-07-04
Category : Psychology
ISBN : 9781789232523

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Gerontology by Grazia D’Onofrio,Daniele Sancarlo,Antonio Greco Pdf

Aging well and actively is the real objective of human being. This book is an up-to-date and realistic view on physiopathological mechanisms of aging and age-related diseases. The book includes topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality.

Telomeres in Health and Disease

Anonim
Telomeres in Health and Disease Book PDF

Author : Anonim
Publisher : Academic Press
Page : 205 pages
File Size : 40,7 Mb
Release : 2014-06-26
Category : Science
ISBN : 9780123979094

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Telomeres in Health and Disease by Anonim Pdf

This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field. Contributions from specialists in telomere diseases Informs and updates on how telomere dysfunction may cause disease in humans

Aging and Age-Related Disorders

Stephen Bondy,Kenneth Maiese
Aging and Age Related Disorders Book PDF

Author : Stephen Bondy,Kenneth Maiese
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 43,8 Mb
Release : 2010-09-02
Category : Medical
ISBN : 9781607616023

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Aging and Age-Related Disorders by Stephen Bondy,Kenneth Maiese Pdf

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.

How Tobacco Smoke Causes Disease

Anonim
How Tobacco Smoke Causes Disease Book PDF

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 45,6 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.