The Molecular And Cellular Basis Of Neurodegenerative Diseases

Author : Michael S. Wolfe
Publisher : Academic Press
Page : 560 pages
File Size : 49,8 Mb
Release : 2018-03-29
Category : Medical
ISBN : 9780128113059

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The Molecular and Cellular Basis of Neurodegenerative Diseases by Michael S. Wolfe Pdf

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Author : Patrick A. Lewis,Jennifer E. Spillane
Publisher : Academic Press
Page : 274 pages
File Size : 52,7 Mb
Release : 2018-11-16
Category : Science
ISBN : 9780128110706

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The Molecular and Clinical Pathology of Neurodegenerative Disease by Patrick A. Lewis,Jennifer E. Spillane Pdf

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Author : Marie-Francoise Chesselet
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 53,7 Mb
Release : 2000-10-19
Category : Medical
ISBN : 9781592590063

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Molecular Mechanisms of Neurodegenerative Diseases by Marie-Francoise Chesselet Pdf

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Author : Thomas Müller
Publisher : MDPI
Page : 230 pages
File Size : 42,6 Mb
Release : 2019-10-14
Category : Science
ISBN : 9783039215485

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The Molecular and Cellular Basis for Parkinson's Disease by Thomas Müller Pdf

The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research.This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included.The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.

Author : Natalie Theresa
Publisher : American Medical Publishers
Page : 0 pages
File Size : 53,7 Mb
Release : 2023-09-26
Category : Medical
ISBN : 1639278141

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The Molecular and Clinical Pathology of Neurodegenerative Diseases by Natalie Theresa Pdf

A neurodegenerative disease refers to a type of disease caused due to the progressive loss of structure or function of neurons. This whole process is known as neurodegeneration. This process can occur at several levels of neuronal circuitry in the brain, which ranges from molecular to systemic. Various types of neurodegenerative diseases include, Parkinson's disease, multiple system atrophy, Alzheimer's disease, amyotrophic lateral sclerosis, prion diseases, multiple sclerosis and Huntington's disease. A common pathogenic feature of various neurodegenerative diseases is the buildup of aggregated proteins, which can induce cellular dysfunction and ultimately lead to cell death. Neurodegenerative diseases might be categorized on the basis of their primary clinical characteristics, major molecular abnormality or anatomic distribution of neurodegeneration. The understanding of the molecular aspects of a variety of neurodegenerative diseases, like Alzheimer's or Parkinson's disease can help to improve patient management from a basic or clinical standpoint. This book contains some path-breaking studies neurodegenerative diseases. It aims to shed light on molecular and clinical pathology of these diseases. This book will serve as a reference to a broad spectrum of readers.

Author : Ramkumar Mathur,Chetna Soni,Antariksh Tyagi,Xusheng Wang
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 52,6 Mb
Release : 2024-01-25
Category : Science
ISBN : 9782832543498

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The Molecular Basis of Programmed Cell Death and Neuroinflammation in Neurodegenerative Diseases by Ramkumar Mathur,Chetna Soni,Antariksh Tyagi,Xusheng Wang Pdf

Age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuroinflammation as well as neuronal degeneration. Apoptosis, necrosis, and autophagy are all types of programmed cell death that are morphologically distinct from one another. Over the last decade, extensive research has been conducted on necroptosis, resulting in a better understanding of its molecular underpinnings and role in neurodegenerative diseases. A later study investigates the processes of apoptosis and necroptosis, as well as their roles in the activation of inflammatory immune responses. Although there is a distinct mode of cell death with distinct morphological characteristics, its identification and implications in neurological diseases are still unknown. Interestingly, emerging evidence has established a direct link between epigenetic and posttranslational modifications and neurodegenerative disease. Using epigenetic and proteomic methods, researchers uncovered genes and proteins that may play a function in the area of neuroinflammation, a role that has hitherto been overlooked. New pharmacological targets and therapeutic options for neurodegenerative diseases are being investigated in order to gain a better understanding of the disease's origins and progression by using neuronal death and neuroinflammation models that are associated with epigenetic changes.

Author : Patrik Verstreken
Publisher : Academic Press
Page : 330 pages
File Size : 47,6 Mb
Release : 2016-12-19
Category : Science
ISBN : 9780128038055

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Parkinson's Disease by Patrik Verstreken Pdf

Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease

Author : Sikha Saha,Sriharsha Kantamneni
Publisher : Frontiers Media SA
Page : 317 pages
File Size : 53,6 Mb
Release : 2020-01-30
Category : Electronic
ISBN : 9782889634422

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Cerebrovascular and Neurodegenerative Diseases – New Insights into Molecular Cell Biology and Therapeutic Targets by Sikha Saha,Sriharsha Kantamneni Pdf

Author : Akhlaq A. Farooqui,Tahira Farooqui
Publisher : Bentham Science Publishers
Page : 156 pages
File Size : 46,9 Mb
Release : 2011-01-26
Category : Science
ISBN : 9781608050925

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Molecular Aspects of Neurodegeneration and Neuroprotection by Akhlaq A. Farooqui,Tahira Farooqui Pdf

"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Author : K. Beyreuther,Y. Christen,C.L. Masters
Publisher : Springer Science & Business Media
Page : 189 pages
File Size : 43,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662043998

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Neurodegenerative Disorders: Loss of Function Through Gain of Function by K. Beyreuther,Y. Christen,C.L. Masters Pdf

Author : Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante
Publisher : Academic Press
Page : 336 pages
File Size : 48,5 Mb
Release : 2017-01-18
Category : Psychology
ISBN : 9780128025246

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Molecular and Cellular Therapies for Motor Neuron Diseases by Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante Pdf

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Author : Cintia Roodveldt,Tiago F. Outeiro,Janice E. Braun
Publisher : Frontiers Media SA
Page : 182 pages
File Size : 49,9 Mb
Release : 2017-12-06
Category : Electronic book
ISBN : 9782889453429

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Molecular Chaperones and Neurodegeneration by Cintia Roodveldt,Tiago F. Outeiro,Janice E. Braun Pdf

Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.

Author : Anonim
Publisher : Academic Press
Page : 498 pages
File Size : 40,6 Mb
Release : 2012-05-22
Category : Science
ISBN : 9780123858849

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Molecular Biology of Neurodegenerative Diseases by Anonim Pdf

Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson’s, Alzheimer’s and Huntington’s disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. Contributions from leading authorities Informs and updates on all the latest developments in the field

Author : Robert J. Harvey,Kirsten Harvey
Publisher : Frontiers Media SA
Page : 185 pages
File Size : 52,8 Mb
Release : 2017-07-05
Category : Electronic book
ISBN : 9782889451739

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Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease by Robert J. Harvey,Kirsten Harvey Pdf

The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants.

Author : Anonim
Publisher : Academic Press
Page : 222 pages
File Size : 48,7 Mb
Release : 2021-01-14
Category : Science
ISBN : 9780128241448

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Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B by Anonim Pdf

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Part B, Volume 177 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field