Anti Neutrophil Cytoplasmic Antibody Anca Associated Vasculitis

Author : Renato Alberto Sinico,Loïc Guillevin
Publisher : Springer Nature
Page : 336 pages
File Size : 46,7 Mb
Release : 2019-09-13
Category : Medical
ISBN : 9783030022396

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Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis by Renato Alberto Sinico,Loïc Guillevin Pdf

This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.

Author : Anonim
Publisher : Unknown
Page : 334 pages
File Size : 55,5 Mb
Release : 2020
Category : Vasculitis
ISBN : 3030022404

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Anti-neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis by Anonim Pdf

This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer's series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.

Author : Wolfgang L. Gross
Publisher : Springer Science & Business Media
Page : 531 pages
File Size : 44,5 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781475791822

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ANCA-Associated Vasculitides by Wolfgang L. Gross Pdf

Proceedings of the Fourth International Workshop on ANCA and the Second International Colloquium on Wegener's Granulomatosis and Vasculitic Disorders held in Lubeck, Germany, May 28-30, 1992

Author : Maria Weiner
Publisher : Linköping University Electronic Press
Page : 82 pages
File Size : 49,8 Mb
Release : 2019-11-04
Category : Electronic
ISBN : 9789176850008

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The Importance of Demographic and Geographical Factors on the Incidence and Outcome of Systemic Small Vessel Vasculitis Associated with Anti-Neutrophil Cytoplasmic Antibodies by Maria Weiner Pdf

The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) comprise microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Two serotypes are recognized: myeloperoxidase (MPO)-ANCA and proteinase 3 (PR3)-ANCA. Renal involvement is a common and severe manifestation associated with increased mortality. The incidence varies geographically, but studies are difficult to compare due to heterogeneous methodology and inclusion criteria. AAV is commonly found in the elderly, but there are little data on outcome and optimal treatment in the highest age groups. This thesis focuses on the epidemiology of AAV: incidence, geographical distribution, and outcome. In Paper I annual incidence rates and outcome were compared between nephritis in AAV and nephritis in systemic lupus erythematosus (SLE) in two geographically defined populations in Sweden. Even though SLE is twice as common as AAV, ANCA-associated nephritis outnumbered lupus nephritis by three to one, and was significantly more severe in terms of mortality and development of end stage renal disease. In Paper II associations between ANCA serotype and geographical and demographic factors were investigated in a large multi-centre study of 1408 patients with renal biopsy-proven AAV. PR3-ANCA was associated with male gender, younger age and higher glomerular filtration rate. PR3-ANCA was also associated with higher latitude and lower ultraviolet radiation levels, but analyses of subgroups suggested that genetic rather than environmental explanations might be more important for this geographical gradient. In Paper III a consecutive cohort of 151 elderly patients with MPA and GPA was studied with a focus on treatment, mortality and renal survival. Patients who had received immunosuppressive treatment with cyclophosphamide or rituximab had better survival rates compared to less intensively treated or untreated patients. Severely impaired renal function at diagnosis was associated with worse outcome in terms of both patient and renal survival. In Paper IV the elderly cohort was extended to 202 patients. In this study we found that treatment with cyclophosphamide or rituximab was associated with the development of less permanent organ damage, and not with higher utilization of in-hospital care. However, high doses of glucocorticoids were associated with fatal infections and treatment-related damage.

Author : Lesley Rees,Paul A. Brogan,Detlef Bockenhauer,Nicholas J.A. Webb
Publisher : Oxford University Press
Page : 657 pages
File Size : 48,6 Mb
Release : 2012-06-28
Category : Medical
ISBN : 9780199601370

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Paediatric Nephrology by Lesley Rees,Paul A. Brogan,Detlef Bockenhauer,Nicholas J.A. Webb Pdf

Rev. ed. of: Paediatric nephrology / Lesley Rees, Nicolas J.A. Webb, Paul A. Brogan. 2007.

Author : Barrie J. Fessler,S. Louis Bridges
Publisher : Clinics: Internal Medicine
Page : 0 pages
File Size : 47,6 Mb
Release : 2010
Category : Medical
ISBN : 1437724930

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ANCA-associated Vasculitis by Barrie J. Fessler,S. Louis Bridges Pdf

This issue of the Rheumatic Disease Clinics of North America provides the rheumatologist with the latest information on diagnosis and treatment of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis. Topics covered inlucde epidemiology; history; pathogenesis; autoantibodies in ANCA-associated vasculitis (including drug-induced ANCAs); pauci-immune renal disease; ocular manifestations; diagnostic approach (including mimickers); Wegener's Granulomatosis; Churg-Strauss Syndrome; microscopic polyangiitis; outcome measures; and the future of ANCA-Associated Vasculitis.

Author : M.P. Manns,Marianne Manns,G. Paumgartner,U. Leuschner
Publisher : Springer Science & Business Media
Page : 426 pages
File Size : 51,6 Mb
Release : 2000-08-31
Category : Medical
ISBN : 0792387597

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Immunology and Liver by M.P. Manns,Marianne Manns,G. Paumgartner,U. Leuschner Pdf

In 1992, the Falk Symposium No. 70 dealt with the topic `Immunology and Liver'. At that time basic mechanisms of immunology as well as immunopathogenetic mechanisms in viral and autoimmune liver diseases were discussed. Now, 7 years later, the Falk Symposium No. 114, held in Basel, Switzerland, October 20-21 1999 (Part I of the Basel Liver Week 1999), focused on immunology in autoimmune liver diseases. In the first section basic mechanisms of autoimmunity are presented, including the relevance of superantigens and the role of apoptosis. A further topic is the latest developments concerning animal models for autoimmune diseases. Recently the International Autoimmune Hepatitis Group newly defined and reclassified the syndrome of autoimmune hepatitis. Autoimmune hepatitis is now identified and studied in all parts of the world, including Asia and South America. A special variant of autoimmune hepatitis was identified as one organ manifestation of the autoimmune polyendocrine syndrome type 1, a genetic disease caused by mutations in a single transcription factor. Drug- and hepatitis-virus induced immune mediated liver diseases may serve as models for nonhepatic immune mediated disorders. DNA technology has increased our knowledge of the immunogenetic background of autoimmune liver diseases. Among the cholestatic immune mediated liver diseases, significant progress has been made concerning primary biliary cirrhosis, in particular regarding the identification of mitochondrial antigens and the characterisation of the immune reactions directed at them. The involvement of infectious agents in PBC as well as the definition of overlap syndromes is a particular focus for basic and clinical research in this area. Concerning the therapy of autoimmune liver diseases, corticosteroids and azathioprin remain the state of the art for autoimmune hepatitis, while bile acids have become well established in treatment of primary biliary cirrhosis as well as primary sclerosing cholangitis. New drugs in the future will include topical steroids such as budesonide and new immunosuppressive agents like mofetil/mycophenolate. Liver transplantation is the treatment of choice for end stage liver diseases; all autoimmune liver diseases are among the best candidates for liver transplantation. Hopefully, new therapeutic strategies based on the results obtained from experimental models will become everyday clinical practice in the next decade. Therefore this symposium concludes with a discussion.

Author : Gleb Slobodin,Yehuda Shoenfeld
Publisher : Springer Nature
Page : 391 pages
File Size : 43,6 Mb
Release : 2020-05-25
Category : Medical
ISBN : 9783030442347

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Rheumatic Disease in Geriatrics by Gleb Slobodin,Yehuda Shoenfeld Pdf

This book provides a practical guide to the diagnosis and management of rheumatic disease in geriatric patients. It details information on the effect of ageing on musculoskeletal and immune systems and specifies impact of a variety of inflammatory and degenerative rheumatic disorders on the elderly. The clinical diagnostic approach to an older individual with musculoskeletal complaints is a cornerstone of this book, which includes also insights into the most important comorbidities for this age and discusses in depth available treatments and rehabilitation tools. The symptoms, imaging features and recommendations on the interpretation of specific laboratory tests for rheumatic diseases in geriatrics are also covered. This book encompasses traditionally associated with older age conditions including temporal arteritis, polymyalgia rheumatica, osteoarthritis, as well as common systemic autoimmune diseases that can produce atypical manifestations in the elderly. It will enable the readers to develop a thorough understanding of how to deal with these patients in their clinical practice. Rheumatic Disease in Geriatrics: Diagnosis and Management systematically describes how to diagnose and treat geriatric patients with a variety of rheumatic conditions and is a valuable resource for all medical professionals involved.

Author : Julien Bogousslavsky,Louis R. Caplan
Publisher : Cambridge University Press
Page : 418 pages
File Size : 47,9 Mb
Release : 2001-05-24
Category : Medical
ISBN : 0521771455

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Uncommon Causes of Stroke by Julien Bogousslavsky,Louis R. Caplan Pdf

An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.

Author : Lazaros Sakkas,Christina Katsiari
Publisher : BoD – Books on Demand
Page : 286 pages
File Size : 50,9 Mb
Release : 2013-02-20
Category : Medical
ISBN : 9789535110088

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Updates in the Diagnosis and Treatment of Vasculitis by Lazaros Sakkas,Christina Katsiari Pdf

Vasculitis, an inflammation of blood vessels, can be idiopathic or secondary to other conditions. Infections may also mimic idiopathic vasculitis, and the differential diagnosis is of paramount importance for the practicing physician. Vasculitides are not rare diseases. In fact, some vasculitides, such as giant cell arteritis, cutaneous vasculitis, and ANCA-associated vasculitis are relatively common in everyday practice. Vasculitis may rapidly lead to organ failure, and put patient's life in danger. Therefore, physicians of different specialties should diagnose vasculitis early, because early institution of treatment is crucial for the favorable outcome. In recent years progress has been made in the pathophysiology and treatment of vasculitis. This book reflects all new advances in pathogenetic mechanisms, diagnosis, and treatment of different types of vasculitis. The international panel of authors helps in achieving a balanced view on different aspects of vasculitis.

Author : A. R. Bradwell,R. P. Stokes,G. P. Mead
Publisher : Unknown
Page : 112 pages
File Size : 51,8 Mb
Release : 1999
Category : Autoantibodies
ISBN : 0704485109

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Advanced Atlas of Autoantibody Patterns by A. R. Bradwell,R. P. Stokes,G. P. Mead Pdf

Author : Anonim
Publisher : ScholarlyEditions
Page : 52 pages
File Size : 55,9 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464975684

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Vasculitis: New Insights for the Healthcare Professional: 2012 Edition by Anonim Pdf

Vasculitis: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Vasculitis in a concise format. The editors have built Vasculitis: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Vasculitis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Vasculitis: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Richard A. Watts,David G. I. Scott,Chetan Mukhtyar
Publisher : Springer
Page : 220 pages
File Size : 49,8 Mb
Release : 2015-05-26
Category : Medical
ISBN : 9783319148717

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Vasculitis in Clinical Practice by Richard A. Watts,David G. I. Scott,Chetan Mukhtyar Pdf

This book focuses on clinical presentation, diagnostic processes and current management of systematic vasculitis, and for this second edition the Editors have updated the treatment approach and nomenclature in line with current practice. Systemic vasculitides are a group of disorders which are of increasing importance. Many of these conditions are only rarely encountered by general physicians and often present significant diagnostic challenges. The Editors aim to provide easily accessible information in a pocket sized format. In doing so they hope to help both the generalist but also rheumatologists who only encounter these problems occasionally.

Author : Anonim
Publisher : Academic Press
Page : 294 pages
File Size : 53,9 Mb
Release : 2018-11-24
Category : Medical
ISBN : 9780128138335

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Translational Inflammation by Anonim Pdf

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

Author : W.J. van Venrooij,Ravinder N. Maini
Publisher : Springer Science & Business Media
Page : 711 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401116701

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Manual of Biological Markers of Disease by W.J. van Venrooij,Ravinder N. Maini Pdf

A comprehensive reference work: This looseleaf work is an authoritative compilation of methods for the detection of autoantibodies (Section A: Methods of Autoantibody Detection); the structure, function, and molecular and biochemical concepts of autoantigens (Section B: Autoantigens); and the clinical significance of measuring autoantibodies in patients with rheumatic, connective tissue and autoimmune diseases (Section C: Clinical Significance of Autoantibodies). This unique work brings together all the molecular and medical information - very difficult to retrieve otherwise - in ONE publication. The Editors and contributors are leading experts in the immunological, molecular biological, and clinical fields. The format of this looseleaf publication allows regular updating of data as well as inclusion of new advances in research on autoimmunity. Until now, the work (Basic work including Supplement 1) included Section A, and the larger part of Section B, both in an attractive and robust ringbinder. Audience: By nature and design of this exciting reference work, it is especially aimed at scientists, including immunologists, pathologists and molecular biologists, and clinical chemists, as well as clinicians specializing in rheumatic diseases and autoimmune disorders, inflammation or clinical immunology. Supplement 2: This supplement primarily contains Section C (Clinical Significance of Autoantibodies). As in the other sections, the contents are presented in a consistently structured manner, beautifully illustrated with photos and schematic figures. Extensive literature references are provided. Also, this supplement includes an addition to Section B (Autoantigens), being chapter B.1.5: The Antigens Defined by Antikeratin Antibodies (AKA).