Anticancer Drug Discovery And Development Natural Products And New Molecular Models

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Anticancer Drug Discovery and Development: Natural Products and New Molecular Models

Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker

Author : Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker
Publisher : Springer Science & Business Media
Page : 289 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461526100

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Anticancer Drug Discovery and Development: Natural Products and New Molecular Models by Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker Pdf

With the publication of these proceedings from the Second Drug Discovery and Development Symposium, this forum has become the main mechanism for bringing together the principal groups involved in both discovering and developing new approaches to the treatment of cancer. This Second Symposium emphasized the types of materials being discovered and their therapeutic activity. This is especially evident in the natural product discovery programs, where unique and active structures are being identified. The major contributors to the meeting were the investigators participating in the National Cooperative (Natural Products) Drug Discovery Groups [NC(NP)DDG]. These groups reflect an association among researchers at universities or cancer centers, pharmaceutical companies and the National Cancer Institute. Their sources of materials are varied, reflecting chemical inventories of pharmaceutical companies, organic synthetic compounds from the laboratory, cytotoxics as well as biologics and their hybrids, and natural products obtained from plants, marine organisms and microorganisms. The models employed in the discovery systems vary from broadly cellular based to specific enzymes to defined cellular functions. Each of them is believed important to the malignant state and will allow for the discovery of compounds which will have efficacy in cancer therapy. The goal of the participants is both to discover new anticancer agents and to develop them as efficiently as possible into clinically useful additions to treatment. Of importance is the fact that there are a number of promising leads which will soon be moving into the clinic thereby testing the effectiveness of this NC (NP) DDG approach.

Natural Products and Cancer Drug Discovery

Frank E. Koehn

Author : Frank E. Koehn
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 54,6 Mb
Release : 2012-11-09
Category : Medical
ISBN : 9781461446545

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Natural Products and Cancer Drug Discovery by Frank E. Koehn Pdf

This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Natural Products and Cancer Drug Discovery

Farid A. Badria

Author : Farid A. Badria
Publisher : BoD – Books on Demand
Page : 318 pages
File Size : 42,6 Mb
Release : 2017-07-05
Category : Medical
ISBN : 9789535133131

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Natural Products and Cancer Drug Discovery by Farid A. Badria Pdf

This book, Natural Products and Cancer Drug Discovery, is written by leading experts in natural products in cancer therapy. The first two sections describe new applications of common herbs and foods for treatment of cancer. Section 3 deals with the development of new chemotherapeutics from Cannabis and endophytic fungi. Section 4 presented formulations of natural products for treatment of malignant melanoma. Made-to-order anticancer therapy from natural products using computational and tissue engineering approaches is addressed in the fifth section. It is our hope that this book may motivate readers to approach the evidence of anticancer natural products with an open mind and thereby spark an interest in making further contributions to the cancer treatment efforts.

Anticancer Agents from Natural Products, Second Edition

Gordon M. Cragg,David G. I. Kingston,David J. Newman

Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publisher : CRC Press
Page : 786 pages
File Size : 43,7 Mb
Release : 2011-10-10
Category : Science
ISBN : 9781439813829

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Anticancer Agents from Natural Products, Second Edition by Gordon M. Cragg,David G. I. Kingston,David J. Newman Pdf

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Anticancer Drug Development

Bruce C. Baguley,David J. Kerr

Author : Bruce C. Baguley,David J. Kerr
Publisher : Elsevier
Page : 397 pages
File Size : 49,6 Mb
Release : 2001-11-17
Category : Medical
ISBN : 9780080490441

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Anticancer Drug Development by Bruce C. Baguley,David J. Kerr Pdf

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Anticancer Drug Development Guide

Beverly A. Teicher,Paul A. Andrews

Author : Beverly A. Teicher,Paul A. Andrews
Publisher : Springer Science & Business Media
Page : 514 pages
File Size : 46,8 Mb
Release : 2004-02-01
Category : Medical
ISBN : 9781592597390

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Anticancer Drug Development Guide by Beverly A. Teicher,Paul A. Andrews Pdf

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.

Drug Discovery and Development

Omboon Vallisuta,Suleiman Olimat

Author : Omboon Vallisuta,Suleiman Olimat
Publisher : BoD – Books on Demand
Page : 332 pages
File Size : 44,7 Mb
Release : 2015-06-03
Category : Medical
ISBN : 9789535121282

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Drug Discovery and Development by Omboon Vallisuta,Suleiman Olimat Pdf

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Cancer Drug Discovery

Kyu-Won Kim,Jae Kyung Roh,Hee-Jun Wee,Chan Kim

Author : Kyu-Won Kim,Jae Kyung Roh,Hee-Jun Wee,Chan Kim
Publisher : Springer
Page : 276 pages
File Size : 53,6 Mb
Release : 2016-11-14
Category : Medical
ISBN : 9789402408447

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Cancer Drug Discovery by Kyu-Won Kim,Jae Kyung Roh,Hee-Jun Wee,Chan Kim Pdf

The reader will discover a comprehensive and multifaceted overview of the history of the development of anticancer drugs deeply influenced by the cell concept of cancer and future directions for the development of new anticancer drugs. First, this book documents the scientific progress in biological science over the last 70 years and the influence this progress had in cancer research. Summaries and charts of important discoveries complete this overview. Furthermore, this book outlines the process of anticancer drug development with a focus on the characteristic drug groups of each era, related to advancements of chemistry and biological sciences. This book also provides brief mechanism of action of drugs, illustrated by comprehensive timelines and conceptual cartoons. This book finally sums up the limitations of the current anticancer drug development and seeks new directions for anticancer drug discovery, considering under the systemic view of cancer.

Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker

Author : Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 41,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461534921

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Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development by Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker Pdf

The focus of the 22nd Annual Detroit Cancer Symposium was the presentation and discussion of cytotoxic agents, with a significant portion of the symposium including the exciting frontiers of drug discovery being explored by the National Cooperative Drug Discovery Groups (NCDDG) Program. The symposium brought together a large number of investigators from government, universities and pharmaceutical companies involved in the discovery and development of new anticancer agents. Exciting new leads were presented and the status of others presently under development was discussed. Of particular significance has been the initiation of renewed efforts in the area of natural product drug discovery, where the discovery of new cytotoxics is very promising at the moment. A number of major changes have occurred during the last decade in research on drug discovery of cytotoxic agents. Critical reviews of a number of the models and concepts underlying drug discovery represented a continuous thread throughout the meeting, being constantly discussed in terms of their advantages, disadvantages and capabilities of discovering solid tumor active anticancer agents. A recent development which is to be much applauded and which portends to great discoveries is the new relationship formed between Government, University of Industry. The NCDDG mechanism which stimulates this interaction is an inexpensive manner to greatly magnify the drug discovery and development effort nationally. Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development represents a forum which will become the major mode for bringing together these three different components in the equation to regularly discuss new results and ideas.

Frontiers in Anti-Cancer Drug Discovery

Atta-ur-Rahman,M. Iqbal Choudhary

Author : Atta-ur-Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 280 pages
File Size : 50,6 Mb
Release : 2015-05-05
Category : Medical
ISBN : 9781681080581

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Frontiers in Anti-Cancer Drug Discovery by Atta-ur-Rahman,M. Iqbal Choudhary Pdf

“Frontiers in Anti-Cancer Drug Discovery” is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The fifth volume of the series features chapters on the following topics: -Nutraceuticals and natural food products for cancer treatment -Pharmacogenomics in Anti-cancer treatment -Cancer stem cells -Potassium channel targeting for brain tumor treatment -Sorafenib in the management of hepatocellular carcinoma …and more.

New Approaches to Natural Anticancer Drugs

Soodabeh Saeidnia

Author : Soodabeh Saeidnia
Publisher : Springer
Page : 117 pages
File Size : 43,5 Mb
Release : 2015-02-05
Category : Medical
ISBN : 9783319140278

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New Approaches to Natural Anticancer Drugs by Soodabeh Saeidnia Pdf

This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.

Discovery and Development of Anti-Breast Cancer Agents from Natural Products

Goutam Brahmachari

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 386 pages
File Size : 51,6 Mb
Release : 2021-06-24
Category : Science
ISBN : 9780128212783

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Discovery and Development of Anti-Breast Cancer Agents from Natural Products by Goutam Brahmachari Pdf

Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields. Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. Highlights active agents from natural sources for development as novel anti-cancer agents Features contributions from active researchers and leading experts working in the field Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines

Principles of Anticancer Drug Development

Elizabeth Garrett-Mayer,Manuel Hidalgo,S. Gail Eckhardt,Neil J. Clendeninn

Author : Elizabeth Garrett-Mayer,Manuel Hidalgo,S. Gail Eckhardt,Neil J. Clendeninn
Publisher : Springer Science & Business Media
Page : 673 pages
File Size : 54,9 Mb
Release : 2010-12-29
Category : Medical
ISBN : 9781441973580

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Principles of Anticancer Drug Development by Elizabeth Garrett-Mayer,Manuel Hidalgo,S. Gail Eckhardt,Neil J. Clendeninn Pdf

A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Drug Discovery and Development, Third Edition

James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell

Author : James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell
Publisher : CRC Press
Page : 697 pages
File Size : 44,6 Mb
Release : 2019-11-21
Category : Medical
ISBN : 9781351625142

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Drug Discovery and Development, Third Edition by James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell Pdf

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

Anticancer Agents from Natural Products

Gordon M. Cragg,David G. I. Kingston,David J. Newman

Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publisher : CRC Press
Page : 610 pages
File Size : 52,5 Mb
Release : 2005-06-13
Category : Medical
ISBN : 9781420039658

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Anticancer Agents from Natural Products by Gordon M. Cragg,David G. I. Kingston,David J. Newman Pdf

Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Anticancer Drug Discovery And Development Natural Products And New Molecular Models

Anticancer Drug Discovery and Development: Natural Products and New Molecular Models by Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker Pdf

Natural Products and Cancer Drug Discovery by Frank E. Koehn Pdf

Natural Products and Cancer Drug Discovery by Farid A. Badria Pdf

Anticancer Agents from Natural Products, Second Edition by Gordon M. Cragg,David G. I. Kingston,David J. Newman Pdf

Anticancer Drug Development by Bruce C. Baguley,David J. Kerr Pdf

Anticancer Drug Development Guide by Beverly A. Teicher,Paul A. Andrews Pdf

Drug Discovery and Development by Omboon Vallisuta,Suleiman Olimat Pdf

Cancer Drug Discovery by Kyu-Won Kim,Jae Kyung Roh,Hee-Jun Wee,Chan Kim Pdf

Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development by Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker Pdf

Frontiers in Anti-Cancer Drug Discovery by Atta-ur-Rahman,M. Iqbal Choudhary Pdf

New Approaches to Natural Anticancer Drugs by Soodabeh Saeidnia Pdf

Discovery and Development of Anti-Breast Cancer Agents from Natural Products by Goutam Brahmachari Pdf

Principles of Anticancer Drug Development by Elizabeth Garrett-Mayer,Manuel Hidalgo,S. Gail Eckhardt,Neil J. Clendeninn Pdf

Drug Discovery and Development, Third Edition by James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell Pdf

Anticancer Agents from Natural Products by Gordon M. Cragg,David G. I. Kingston,David J. Newman Pdf

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