Antidiabetic Potential Of Plants In The Era Of Omics

Author : Deepu Pandita,Anu Pandita,Chander Bhanu
Publisher : CRC Press
Page : 443 pages
File Size : 40,5 Mb
Release : 2022-12-30
Category : Medical
ISBN : 9781000574999

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Antidiabetic Potential of Plants in the Era of Omics by Deepu Pandita,Anu Pandita,Chander Bhanu Pdf

Here is an informative overview of diabetes mellitus in conjunction with plant-based treatments. It discusses available methods for studying the antidiabetic activities of scientifically developed plant products, mechanisms of action, their therapeutic superiority, and current genome editing research perspectives and biotechnological approaches. The book begins with an introduction to diabetes, giving a brief overview of the history, diagnosis, classification, pathophysiology, and risk factors. It goes on to review traditional uses of plants for diabetes along with ethnobotanical information. The results of scientific studies on the various modes of action of antidiabetic plants are discussed, such as the molecular aspects of active plantbased antidiabetic drug molecules. A section featuring recent biotechnological advancements of antidiabetic plants and plant-based antidiabetic drugs covers advances in molecular breeding and application of molecular markers, biotechnologically engineered transgenic medicinal plants, and advances in genomic editing tools and techniques.

Author : Sajid Fiaz,Channapatna S. Prakash
Publisher : John Wiley & Sons
Page : 324 pages
File Size : 43,9 Mb
Release : 2024-06-04
Category : Technology & Engineering
ISBN : 9781394209125

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OMICs-based Techniques for Global Food Security by Sajid Fiaz,Channapatna S. Prakash Pdf

Forward-thinking resource discussing how to integrate OMICs and novel genome editing technologies for sustainable crop production OMICS-based Techniques for Global Food Security provides an in-depth understanding of the mechanisms of OMICs techniques for crop improvement, details how OMICs techniques can contribute to identifying genes and traits with economic benefits, and explains how to develop crop plants with improved yield, quality, and resistance to stresses through genome editing technologies, providing evidence on the developments of climate resilient crops via applications of genome editing techniques throughout. The text covers the application of OMICs in crop plants, the integration of bioinformatics and multi-OMICs for precision breeding, de-novo domestication, CRISPR/Cas system for crop improvement, hybrid seed production, transgene free breeding, regulation for genome edit crops, bioinformatics and genome editing, and other topics related OMICs and genome editing. The text also includes a chapter on the global regulations for genome edited crops, and explains how these regulations influence novel plant breeding techniques in their adopted countries. Written by two highly qualified academics, OMICs-based Techniques for Global Food Security covers sample topics such as: Crops genome sequencing and their application for crop improvement, and functional characterization of cereals genome The role of OMICs based technologies in plant sciences and utilization of different multi-OMICs approaches for crop improvement Genomic database and genetic resource of cereals, speed breeding for rapid crop improvement, and evolution of genome editing technologies CRISPR system discovery, history, and future perspective, and CRISPR/Cas system for biotic and abiotic stress resistance in cereals Providing a collection of recent literature focusing on developments and applications of OMICs based technologies for crop improvement, OMICs-based Techniques for Global Food Security is an important read for plant breeders, molecular biologists, researchers, postdoctoral fellows, and students in disciplines for developing crops with high yield and nutritional potential.

Author : Muhammad Zia-Ul-Haq,Arwa Abdulkreem AL-Huqail,Muhammad Riaz,Umar Farooq Gohar
Publisher : Springer Nature
Page : 1216 pages
File Size : 47,9 Mb
Release : 2023-10-09
Category : Technology & Engineering
ISBN : 9783031354038

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Essentials of Medicinal and Aromatic Crops by Muhammad Zia-Ul-Haq,Arwa Abdulkreem AL-Huqail,Muhammad Riaz,Umar Farooq Gohar Pdf

Medicinal and aromatic crops (MACs) are high-value crops since the natural products obtained from them are low-volume high-value commodities that have numerous applications in various sectors such as the food, beverage, food supplement, flavor and fragrance, perfumery and cosmetics, pharmaceutical and aromatherapy industries. In addition, the plant biomass is used in the production of teas and medical applications in traditional and also modern medicines. MACs are important mainly because they contain plant secondary metabolites such as essential oils, alkaloids, glygosides, saponins, tannins, vitamins and other bioactives. Plant secondary metabolites are differentiated from plant primary metabolites of photosynthesis and respiration since they are directly involved in growth and development of plants. Some MACs are used as spices and culinary herbs since they contain mainly essential oils, and are used as tonic to the digestive system, appetite modification and other systems and may facilitate nutrient uptake and utilization from various foods. A significant amount of MACs and their natural products have also demonstrated antimicrobial, antifungal and bactericidal activity and significant antioxidant capacity. In the past, MACs and their natural products have been used as a source for various medicines, in food and beverage production and in aroma products. Essentials of Medicinal and Aromatic Crops summarizes the current knowledge on medicinal and aromatic crops, including the agronomical practices of important MACs and their products, their beneficial effects and utilization of MAP and their products. The chapters provide a comprehensive guide to the most important and used medicinal and aromatic crops and their use in functional foods, nutraceuticals and as bioactives against various ailments, providing researchers, teachers, chemists, food scientists, agronomists and agroecologists in academia, industry and government a fully up to date singular source on this important topic.

Author : Channa S. Prakash,Sajid Fiaz,Muhammad Azhar Nadeem,Faheem Shehzad Baloch,Abdul Qayyum
Publisher : Springer Nature
Page : 511 pages
File Size : 55,5 Mb
Release : 2023-01-01
Category : Technology & Engineering
ISBN : 9783031155680

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Sustainable Agriculture in the Era of the OMICs Revolution by Channa S. Prakash,Sajid Fiaz,Muhammad Azhar Nadeem,Faheem Shehzad Baloch,Abdul Qayyum Pdf

Access to food with enough calories and nutrients is a fundamental right of every human. The global population has exceeded 7.8 billion and is expected to pass 10 billion by 2055. Such rapid population increase presents a great challenge for food supply. More grain production is needed to provide basic calories for humans. Thus, it is crucial to produce 60-110% more food to fill the gap between food production and the demand of future generations. Meanwhile food nutritional values are of increasing interest to accommodate industrialized modern lives. The instability of food production caused by global climate change presents another great challenge. The global warming rate has become more rapid in recent decades, with more frequent extreme climate change including higher temperatures, drought, and floods. Our world faces various unprecedented scenarios such as rising temperatures, which causes melting glaciers and the resulting various biotic and abiotic stresses, ultimately leading to food scarcity. In these circumstances it is of utmost importance to examine the genetic basis and extensive utilization of germplasm to develop “climate resilient cultivars” through the application of plant breeding and biotechnological tools. Future crops must adapt to these new and unpredictable environments. Crop varieties resistant to biotic and abiotic stresses are also needed as plant disease, insects, drought, high- and low-temperature stresses are expected to be impacted by climate change. Thus, we need a food production system that can simultaneously satisfy societal demands and long-term development. Since the Green Revolution in the 1960s, farming has been heavily dependent on high input of nitrogen and pesticides. This leads to environmental pollution which is not sustainable in the long run. Therefore, a new breeding scheme is urgently needed to enable sustainable agriculture; including new strategies to develop varieties and crops that have high yield potential, high yield stability, and superior grain quality and nutrition while also using less consumption of water, fertilizer, and chemicals in light of environmental protection. While we face these challenges, we also have great opportunities, especially with flourishing developments in omics technologies. High-quality reference genomes are becoming available for a larger number of species, with some species having more than one reference genome. The genome-wide re-sequencing of diverse varieties enables the identification of core- and pan-genomes. An integration of omics data will enable a rapid and high-throughput identification of many genes simultaneously for a relevant trait. This will change our current research paradigm fundamentally from single gene analysis to pathway or network analysis. This will also expand our understanding of crop domestication and improvement. In addition, with the knowledge gained from omics data, in combination with new technologies like targeted gene editing, we can breed new varieties and crops for sustainable agriculture.

Author : Hardeep Singh Tuli,Mükerrem Betül Yerer Aycan
Publisher : Springer Nature
Page : 283 pages
File Size : 52,6 Mb
Release : 2023-06-30
Category : Medical
ISBN : 9789819915293

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Oncology: Genomics, Precision Medicine and Therapeutic Targets by Hardeep Singh Tuli,Mükerrem Betül Yerer Aycan Pdf

This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.

Author : Yunpeng Cao,Hui Song,Muhammad Abdullah,Xiaoxu Li,Muhammad Aamir Manzoor
Publisher : Frontiers Media SA
Page : 353 pages
File Size : 52,7 Mb
Release : 2024-02-13
Category : Science
ISBN : 9782832544709

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Multi-omics and Computational Biology in Horticultural Plants: From Genotype to Phenotype, Volume II by Yunpeng Cao,Hui Song,Muhammad Abdullah,Xiaoxu Li,Muhammad Aamir Manzoor Pdf

This Research Topic is part of the article collection series - Multi-omics and Computational Biology in Horticultural Plants: From Genotype to Phenotype. Horticultural plants play an important role for humans by providing herbal medicines, beverages, vegetables, fruits, and ornamentals. High-throughput technologies have revolutionised the time scale and power of detecting insights into physiological changes and biological mechanisms in plants. All sequencing data and tools have helped us better understand the evolutionary histories of horticultural plants and provide genotype and phenotype resources for molecular studies on economically important traits. The integration of these -omics technologies (e.g., genomics, transcriptomics, proteomics, metabolomics, lipidomics, ionomics, and redoxomics) is currently at the forefront of plant research. The genomes of horticultural plants are highly diverse and complex, often with a high degree of heterozygosity and polyploidy. Novel computational methods need to be developed to take advantage of state-of-the-art genomic technologies. As a result, the mining of multi-omics data and the development of new computational biology approaches for the reliable and efficient analysis of plant traits is necessary.

Author : Altaf Ahmad,Ambreen Asif
Publisher : CRC Press
Page : 467 pages
File Size : 49,8 Mb
Release : 2023-02-21
Category : Health & Fitness
ISBN : 9781000822861

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Omics Studies of Medicinal Plants by Altaf Ahmad,Ambreen Asif Pdf

Herbal drugs play a pivotal role in modern medicine and pharmaceutical care; however, only limited biotechnology applications have been seen in medicinal plants. Revolutions in high-throughput approaches emphasize omics approaches, such as genomics, transcriptomics, proteomics, and metabolomics. A volume in the Exploring Medicinal Plants series, this book provides a comprehensive and in-depth analysis of breakthroughs in high-throughput approaches for the research of medicinal plants. Exploring the principles and applications of omics technologies, this book is essential for those working on or are involved in the modern research of medicinal and aromatic plants. There is also a strong focus on practical implications of these technologies through exploring the safety aspects and conservation strategies of various plants. From informative discussions on the latest research to a holistic evaluation of their potential applications, this book appeals to students, researchers and professionals working with medicinal and aromatic plants, as well as healthcare professionals interested in the area.

Author : Deepu Pandita,Anu Pandita
Publisher : CRC Press
Page : 323 pages
File Size : 54,9 Mb
Release : 2023-10-27
Category : Science
ISBN : 9781000852172

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Plant-Derived Anticancer Drugs in the OMICS Era by Deepu Pandita,Anu Pandita Pdf

The current anti-cancer synthetic medicines are deemed inefficient and unsafe, state the editors of this new book. Plant-based lead molecules, however, such as taxol, camptothecin, podophyllotoxins, vinblastine, vincristine, homoharringtonine, and numerous other anticancer compounds from nature’s arsenal, are potentially safe and can be powerful alternatives that effectively fight against cancer. The volume looks at a variety of medicinal plants and approaches that have shown beneficial results against cancer. Topics in the book include Unani approaches of anticancer plants, genetic engineering and CRISPR/CAS-mediated editing to enhance a plant’s anticancer potential, computational approaches used in anticancer plants, and more. The volume also examines the metabolomics of plants that give them anti-cancer properties.

Author : Saheed Sabiu
Publisher : Bentham Science Publishers
Page : 446 pages
File Size : 51,8 Mb
Release : 2022-09-15
Category : Medical
ISBN : 9789815050639

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Therapeutic Use of Plant Secondary Metabolites by Saheed Sabiu Pdf

The book is an evidence-based reference about biochemical mechanisms of action of plant secondary metabolites. It conveys an understanding about how plant-based therapies work, and explains their role in the treatment of diabetes, cancer, neurodegenerative disorders, and microbial infections. The 15 chapters in the book are written by eminent scholars, lecturers, and experts in indigenous knowledge systems (IKS), industrial and medicinal plants, phytotherapeutics, and phytoinformatics. Reports on health benefits of specific phytochemicals are also highlighted. In addition to basic concepts in medicinal chemistry and ethnopharmacology, the book covers the role of modern computer techniques in developing new pharmaceuticals from plant sources. Therapeutic Uses of Plant Secondary Metabolites is a timely and valuable reference for both undergraduate and postgraduate students in medicinal chemistry, as well as researchers and professionals in IKS, phytomedicine, ethnopharmacology, phytopharmacology, plant biotechnology, drug discovery and development, and phytotherapeutics.

Author : Jen-Tsung Chen
Publisher : MDPI
Page : 542 pages
File Size : 54,6 Mb
Release : 2021-08-18
Category : Medical
ISBN : 9783036512945

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Phytochemical Omics in Medicinal Plants by Jen-Tsung Chen Pdf

Medicinal plants are used to treat diseases and provide health benefits, and their applications are increasing around the world. A huge array of phytochemicals have been identified from medicinal plants, belonging to carotenoids, flavonoids, lignans, and phenolic acids, and so on, with a wide range of biological activities. In order to explore our knowledge of phytochemicals with the assistance of modern molecular tools and high-throughput technologies, this book collects recent innovative original research and review articles on subtopics of mechanistic insights into bioactivities, treatment of diseases, profiling, extraction and identification, and biotechnology.

Author : Khalid Rehman Hakeem,Hüseyin Tombuloğlu,Güzin Tombuloğlu
Publisher : Springer
Page : 514 pages
File Size : 50,7 Mb
Release : 2016-08-23
Category : Science
ISBN : 9783319317038

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Plant Omics: Trends and Applications by Khalid Rehman Hakeem,Hüseyin Tombuloğlu,Güzin Tombuloğlu Pdf

To comprehend the organizational principle of cellular functions at diff erent levels, an integrative approach with large-scale experiments, the so-called ‘omics’ data including genomics, transcriptomics, proteomics, and metabolomics, is needed. Omics aims at the collective characterization and quantifi cation of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms. Currently, omics is an essential tool to understand the molecular systems that underlie various plant functions. Furthermore, in several plant species, the development of omicsresources has progressed to address the particular biological properties of individual species. Integration of knowledge from omics-based research is an emerging issue as researchers seek to identify significance, gain biological insights and promote translational research. From these perspectives, we intend to provide the emerging aspects of plant systems research based on omics and bioinformatics analyses together with their associated resources and technological advances. Th e present book covers a wide range of omics topics, and discusses the latest trends and application area of plant sciences. In this volume, we have highlighted the working solutions as well as open problems and future challenges in plant omics studies. We believe that this book will initiate and introduce readers to state-of-the-art developments and trends in omics-driven research.

Author : Subhash C. Mandal,Raja Chakraborty,Saikat Sen
Publisher : Springer Nature
Page : 1135 pages
File Size : 51,7 Mb
Release : 2021-01-18
Category : Medical
ISBN : 9789811581274

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Evidence Based Validation of Traditional Medicines by Subhash C. Mandal,Raja Chakraborty,Saikat Sen Pdf

The demand for traditional medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements and herbal cosmetics etc. is increasing globally due to the growing recognition of these products as mainly non-toxic, having lesser side effects, better compatibility with physiological flora, and availability at affordable prices. In the last century, medical science has made incredible advances all over the globe. In spite of global reorganization and a very sound history of traditional uses, the promotion of traditional medicine faces a number of challenges around the globe, primarily in developed nations. Regulation and safety is the high concern for the promotion of traditional medicine. Quality issues and quality control, pharmacogivilane, scientific investigation and validation, intellectual property rights, and biopiracy are some key issues that restrain the advancement of traditional medicine around the globe. This book contains diverse and unique chapters, explaining in detail various subsections like phytomolecule, drug discovery and modern techniques, standardization and validation of traditional medicine, and medicinal plants, safety and regulatory issue of traditional medicine, pharmaceutical excipients from nature, plants for future. The contents of the book will be useful for the academicians, researchers and people working in the area of traditional medicine.

Author : Tangchun Zheng,Pervaiz Tariq,Penghui Li
Publisher : Frontiers Media SA
Page : 310 pages
File Size : 43,5 Mb
Release : 2023-07-04
Category : Science
ISBN : 9782832528785

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Application of multi-omics to important traits of ornamental and beverage plants by Tangchun Zheng,Pervaiz Tariq,Penghui Li Pdf

Author : Deepu Pandita,Anu Pandita,Chander Bhanu
Publisher : CRC Press
Page : 355 pages
File Size : 46,8 Mb
Release : 2022-12-29
Category : Health & Fitness
ISBN : 9781000575118

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Antidiabetic Plants for Drug Discovery by Deepu Pandita,Anu Pandita,Chander Bhanu Pdf

This volume takes an in-depth look at the potential pharmacological applications of 11 important antidiabetic plants, examining their antihyperglycemic, hypoglycemic, and anti-lipidemic properties along with current genome editing research perspectives. Plant natural products, or phytoconstituents, are promising candidates for antidiabetic pharmacological actions. The phytoconstituents, such as fl avonoids, terpenoids, saponins, carotenoids, alkaloids and glycosides, play vital roles in the current and future potent antidiabetic drug development programs Each chapter reviews a particular plant with antidiabetic properties, explaining the therapeutic aspects, its active antidiabetic compounds, and relevant genome editing technology. The specific plants discussed include Azadirachta indica (commonly known as neem, nimtree or Indian lilac), Gymnema sylvestre (commonly called gymnema, Australian cowplant, and Periploca of the woods), Syzygium cumini (commonly known as Malabar plum, Java plum, black plum, jamun or jambolana), Ceylon cinnamon (or true cinnamon, as opposed to cassia cinnamon), insulin plant (or Costus pictus), Trigonella foenum-graecum (better known as fenugreek), Mulberry, Nigella sativa L. (black caraway, also known as black cumin, nigella, kalojeera, kalonji or kalanji), Aegle marmelos (L.) (commonly known as bael (or bili or bhel), also Bengal quince, golden apple, Japanese bitter orange, stone apple or wood apple), Ficus benghalensis (the banyan, banyan fig and Indian banyan), and of course, garlic (Allium sativum). Antidiabetic Plants for Drug Discovery: Pharmacology, Secondary Metabolite Profiling, and Ingredients with Insulin Mimetic Activity will serve as a valuable source of information for students, drug researchers, medical practitioners, diabetic patients, and many others in the effort to gain understand of how these plant drug molecules can help fight diabetes.

Author : Dinesh Chandra Agrawal,Hsin-Sheng Tsay,Lie-Fen Shyur,Yang-Chang Wu,Sheng-Yang Wang
Publisher : Springer
Page : 547 pages
File Size : 55,7 Mb
Release : 2017-11-03
Category : Science
ISBN : 9789811059780

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Medicinal Plants and Fungi: Recent Advances in Research and Development by Dinesh Chandra Agrawal,Hsin-Sheng Tsay,Lie-Fen Shyur,Yang-Chang Wu,Sheng-Yang Wang Pdf

This book highlights the latest international research on different aspects of medicinal plants and fungi. Studies over the last decade have demonstrated that bioactive compounds isolated from medicinal fungi have promising antitumor, cardiovascular, immunomodulatory, anti-allergic, anti-diabetic, and hepatoprotective properties. In the light of these studies, the book includes chapters (mostly review articles) by eminent researchers from twelve countries across the globe working in different disciplines of medicinal plants and fungi. It discusses topics such as the prevention of major neurodegenerative and neurotoxic mechanisms by Centella asiatica; the medicinal properties and therapeutic applications of several mushrooms species found in different parts of the world; and fungal endophytes as a source of bioactive metabolites including anticancer and cardioprotective agents. There are also chapters on strategies for identifying bioactive secondary metabolites of fungal origin; the use of genomic information to explore the biotechnological potential of medicinal mushrooms; and solid state fermentation of agro-industrial and forestry residues for the production of medicinal mushrooms. It is a valuable resource for the researchers, professionals and students working in the area of medicinal plants and fungi.