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Author : Jianhua Wang,Octavio Luiz Franco,Rustam Aminov,Cesar de la Fuente-Nunez,Guangshun Wang
Publisher : Frontiers Media SA
Page : 322 pages
File Size : 49,7 Mb
Release : 2024-05-29
Category : Science
ISBN : 9782832549810
Author : Claudio O. Gualerzi,Letizia Brandi,Attilio Fabbretti,Cynthia L. Pon
Publisher : John Wiley & Sons
Page : 549 pages
File Size : 51,8 Mb
Release : 2013-09-05
Category : Medical
ISBN : 9783527659708
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
Author : Boyan B. Bonev,Nicholas M. Brown
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 51,9 Mb
Release : 2019-03-14
Category : Science
ISBN : 9781119558200
AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era—when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death—new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics – From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics – From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.
Author : Antonieta De Cal,Maria Del Mar Jimenez-Gasco,Paloma Melgarejo
Publisher : Frontiers Media SA
Page : 465 pages
File Size : 48,9 Mb
Release : 2022-03-09
Category : Science
ISBN : 9782889746231
Paloma Melgarejo is an author on one patent issued in Spain and one patent issued internationally, and has co-obtained plant variety rights for the following strawberry varieties: Aguedilla, Amiga, Carisma, Fontanilla, Fuentepina, Marina, Medina, and Santaclara. Maria Del Mar Jimenez-Gasco is an author on two patents issued in Spain, relating to the identification of Fusarium oxysporum.
Author : Paola Angelini,Ahmed M. Abdel-Azeem,Carolina Elena Girometta
Publisher : Frontiers Media SA
Page : 181 pages
File Size : 44,9 Mb
Release : 2022-03-04
Category : Science
ISBN : 9782889745661
Author : Richard M. Epand
Publisher : Springer
Page : 321 pages
File Size : 50,8 Mb
Release : 2016-05-06
Category : Science
ISBN : 9783319329499
This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this. The chapters, written by leading experts in the field, detail the number and diversity of host defense peptides, and discuss the therapeutic potential not only of antibacterial, but also of antifungal, antiviral, plant antimicrobial and anticancer host defense peptides. The authors provide new insights into their mechanisms of action and their immunomodulatory properties, and review recent advances in the design of novel therapeutic molecules. Lastly, their potential to prevent preterm births and Staphylococcus aureus infections is highlighted. The book is of interest to researchers, industry and clinicians alike.
Author : Tobias Dörr,Partick J. Moynihan,Christoph Mayer
Publisher : Frontiers Media SA
Page : 199 pages
File Size : 48,8 Mb
Release : 2019-12-27
Category : Electronic
ISBN : 9782889631520
Bacterial cells are encased in a cell wall, which is required to maintain cell shape and to confer physical strength to the cell. The cell wall allows bacteria to cope with osmotic and environmental challenges and to secure cell integrity during all stages of bacterial growth and propagation, and thus has to be sufficiently rigid. Moreover, to accommodate growth processes, the cell wall at the same time has to be a highly dynamic structure: During cell enlargement, division, and differentiation, bacteria continuously remodel, degrade, and resynthesize their cell wall, but pivotally need to assure cell integrity during these processes. Finally, the cell wall is also adjusted according to both environmental constraints and metabolic requirements. However, how exactly this is achieved is not fully understood. The major structural component of the bacterial cell wall is peptidoglycan (PG), a mesh-like polymer of glycan chains interlinked by short-chain peptides, constituting a net-like macromolecular structure that has historically also termed murein or murein sacculus. Although the basic structure of PG is conserved among bacteria, considerable variations occur regarding cross-bridging, modifications, and attachments. Moreover, different structural arrangements of the cell envelope exist within bacteria: a thin PG layer sandwiched between an inner and outer membrane is present in Gram-negative bacteria, and a thick PG layer decorated with secondary glycopolymers including teichoic acids, is present in Gram-positive bacteria. Furthermore, even more complex envelope structures exist, such as those found in mycobacteria. Crucially, all bacteria possess a multitude of often redundant lytic enzymes, termed “autolysins”, and other cell wall modifying and synthesizing enzymes, allowing to degrade and rebuild the various structures covering the cells. However, how cell wall turnover and cell wall biosynthesis are coordinated during different stages of bacterial growth is currently unclear. The mechanisms that prevent cell lysis during these processes are also unclear. This Research Topic focuses on the dynamics of the bacterial cell wall, its modifications, and structural rearrangements during cell growth and differentiation. It pays particular attention to the turnover of PG, its breakdown and recycling, as well as the regulation of these processes. Other structures, for example, secondary polymers such as teichoic acids, which are dynamically changed during bacterial growth and differentiation, are also covered. In recent years, our view on the bacterial cell envelope has undergone a dramatic change that challenged old models of cell wall structure, biosynthesis, and turnover. This collection of articles aims to contribute to new understandings of bacterial cell wall structure and dynamics.
Author : Isabel Diaz,Colette Broekgaarden,Félix Ortego,George Broufas,Takeshi Suzuki,Guy Smagghe
Publisher : Frontiers Media SA
Page : 272 pages
File Size : 41,7 Mb
Release : 2022-03-09
Category : Science
ISBN : 9782889742875
This eBook comprises Volume I, Volume II and Volume III of the Research Topic Plant-Pest Interactions. Topic Editors Colette Broekgaarden and Martin De Vos are employed by KeyGene N.V.. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Author : Anonim
Publisher : John Wiley & Sons
Page : 2954 pages
File Size : 40,9 Mb
Release : 2020-08-06
Category : Medical
ISBN : 9781555818814
In response to the ever-changing needs and responsibilities of the clinical microbiology field, Clinical Microbiology Procedures Handbook, Fourth Edition has been extensively reviewed and updated to present the most prominent procedures in use today. The Clinical Microbiology Procedures Handbook provides step-by-step protocols and descriptions that allow clinical microbiologists and laboratory staff personnel to confidently and accurately perform all analyses, including appropriate quality control recommendations, from the receipt of the specimen through processing, testing, interpretation, presentation of the final report, and subsequent consultation.
Author : Bo Peng,Xinhua Chen,Hetron M. Munang’andu
Publisher : Frontiers Media SA
Page : 160 pages
File Size : 40,6 Mb
Release : 2022-03-07
Category : Science
ISBN : 9782889745845
Author : Wei Zhang,Jing Wang,Chang Guangjun,Xudong Sun,Haidong Yao,Fabiana Quoos Mayer
Publisher : Frontiers Media SA
Page : 226 pages
File Size : 52,9 Mb
Release : 2022-03-09
Category : Science
ISBN : 9782889746279
Author : Dan Hultmark
Publisher : Unknown
Page : 98 pages
File Size : 40,8 Mb
Release : 1982
Category : Electronic
ISBN : UCAL:B3751538
Author : Sanjeev Kumar Singh
Publisher : Springer Nature
Page : 334 pages
File Size : 42,5 Mb
Release : 2021-02-02
Category : Science
ISBN : 9789811589362
This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic methods and highlights the applications of Molecular Dynamics Simulation in the drug discovery process. It also explores the application of quantum mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing, the book provides illustrative descriptions of major challenges associated with computer-aided drug discovery for the development of therapeutic drugs. Given its scope, it offers a valuable asset for life sciences researchers, medicinal chemists and bioinformaticians looking for the latest information on computer-aided methodologies for drug development, together with their applications in drug discovery.
Author : Borivoj Keil
Publisher : Springer Science & Business Media
Page : 343 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642483806
Specificity of Proteolysis presents a survey and conclusions on the action or proteinases - enzymes which are cleaving proteins or peptides. The specificity of proteinases which is determined as the sequence of amino acids at the cleavage site of a substrate, is an important criteria to choose an enzyme as tool in protein research. Whenever one is looking for an enzyme to act at a defined site or to give defined cleavage products one will find comprehensive information in this work. Comprehensive information about more than 280 endopeptidases which are based on the database LYSIS including a calculation program to determine cleavage sites, is given in the book.
Author : Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Publisher : Springer Science & Business Media
Page : 399 pages
File Size : 52,7 Mb
Release : 2007-09-09
Category : Medical
ISBN : 9781402064012
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.