Antimicrobials Antibiotic Resistance Antibiofilm Strategies And Activity Methods

Author : Sahra Kırmusaoğlu
Publisher : BoD – Books on Demand
Page : 154 pages
File Size : 41,6 Mb
Release : 2019-04-03
Category : Medical
ISBN : 9781789857894

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Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods by Sahra Kırmusaoğlu Pdf

To prevent bacterial adherence, invasion and infection, antimicrobials such as antibiotics are being used and vastly researched nowdays. Several factors such as natural selection, mutations in genes, the presence of efflux pumps, impermeability of the cell wall, structural changes in enzymes and receptors, biofilm formation, and quorum sensing cause microorganisms to develop resistance against antimicrobials. Isolates that synthesize extended spectrum-β-lactamases (ESBL), induced β-lactamases (IBL), carbapenamases, metallo-β-lactamases (MBLs), and New Delhi metallo-β-lactamases (NDM) have emerged. Determining virulence factors such as biofilms and the level of antimicrobial activities of antimicrobial agents alone and in combination with appropriate doses against microorganisms is very important for the diagnosis, inhibition, and prevention of microbial infection. The goal of this book is to provide information on all these topics.

Author : Sahra Kırmusaoğlu
Publisher : Unknown
Page : 152 pages
File Size : 46,6 Mb
Release : 2019
Category : Microbiology
ISBN : 1789857902

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Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods by Sahra Kırmusaoğlu Pdf

Author : Katharina Richter,Kasper Nørskov Kragh
Publisher : Springer Nature
Page : 569 pages
File Size : 51,8 Mb
Release : 2022-09-28
Category : Science
ISBN : 9783031109928

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Antibiofilm Strategies by Katharina Richter,Kasper Nørskov Kragh Pdf

Bacteria and fungi are able to aggregate together or on surfaces in densely packed microcolonies, facilitated by extracellular polymeric substances for cell protection and stability. These biofilms have proven to be extremely hard to eradicate and remove once established. In chronic infections, this condition can result in a high degree of morbidity and mortality as regular antibiotic treatments are ineffective against biofilms. In industrial facilities, the formation of biofilms can ruin production and result in enormous financial losses. In this book, the current state of antibiofilm research is presented by experts from around the world. Novel, cutting-edge techniques and new optimized strategies based on established methods are discussed in chapters focused on biofilm prevention, treatment and control for the application in clinical, industrial and veterinary settings. Antibiofilm strategies, such as chemical and enzymatic treatments, surface modification and coatings, quorum sensing inhibition and dispersal induction, phage therapy, cold plasma treatment, hyperbaric oxygen treatment, and metal-based nanomedicine are covered, among many others. This book contributes to the UN’s Sustainable Development Goal 3: Good Health and Well-Being and is a valuable resource for healthcare professionals, microbiologists, academics and for educators to inform curricula of universities and colleges.

Author : José-Luis Capelo-Martínez,Gilberto Igrejas
Publisher : John Wiley & Sons
Page : 684 pages
File Size : 41,5 Mb
Release : 2019-08-27
Category : Medical
ISBN : 9781119282556

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Antibiotic Drug Resistance by José-Luis Capelo-Martínez,Gilberto Igrejas Pdf

This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Author : Ola Sköld
Publisher : John Wiley & Sons
Page : 181 pages
File Size : 47,9 Mb
Release : 2011-10-07
Category : Medical
ISBN : 9781118075586

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Antibiotics and Antibiotic Resistance by Ola Sköld Pdf

This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future scientists recognize the problem antibiotics resistance poses for medicinal and drug-related fields, and perhaps trigger more research and discoveries to fight antibiotic resistant strains. Current overviews of the topic are included, along with specific discussions on the individual mechanisms (betalactams, glycopeptides, aminoglycosides, etc) used in various antibacterial agents and explanations of how resistances to those develop. Methods for counteracting resistance development in bacteria are discussed as well.

Author : Kendra P. Rumbaugh,Iqbal Ahmad
Publisher : Springer Science & Business Media
Page : 495 pages
File Size : 51,7 Mb
Release : 2014-05-08
Category : Science
ISBN : 9783642538339

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Antibiofilm Agents by Kendra P. Rumbaugh,Iqbal Ahmad Pdf

This book provides a survey of recent advances in the development of antibiofilm agents for clinical and environmental applications. The fact that microbes exist in structured communities called biofilms has slowly become accepted within the medical community. We now know that over 80% of all infectious diseases are biofilm-related; however, significant challenges still lie in our ability to diagnose and treat these extremely recalcitrant infections. Written by experts from around the globe, this book offers a valuable resource for medical professionals seeking to treat biofilm-related disease, academic and industry researchers interested in drug discovery and instructors who teach courses on microbial pathogenesis and medical microbiology.

Author : Dibyajit Lahiri,Moupriya Nag,Rina Rani Ray,Sougata Ghosh
Publisher : CRC Press
Page : 391 pages
File Size : 50,6 Mb
Release : 2023-12-01
Category : Science
ISBN : 9781003801436

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Biofilm Associated Antimicrobial Resistance and Its Recovery by Dibyajit Lahiri,Moupriya Nag,Rina Rani Ray,Sougata Ghosh Pdf

A biofilm is a collection of microbial cells that have adhered to biotic surfaces such as plant cuticles or animal epithelia, as well as abiotic surfaces such as rocky substratum or catheter exteriors. The life cycle of a microorganism includes the fundamental process of biofilm formation for survival in diverse and harsh environments since it is a protected mode of growth allowing colonisation of new habitats by dispersal of microbes from the microbial clusters. The biofilm bound microorganisms remain embedded in an extracellular polymeric matrix that protects the indwelling cells from surfactants, biocides, several invaders like protozoans, and defences offered by the hosts like phagocytic cells. The biofilm bound recalcitrant microbes induce chronic and nosocomial diseases, posing a serious threat to public health. It has been observed that various antimicrobial drugs are able to successfully remove the planktonic (freely suspended) states of microbes as compared to the sessile (substrate-bound) forms, thus resulting in the development of antimicrobial resistance. Modern pharmacological strategies targeting the biofilm matrix differ from the conventional methods of antibiotic usage. This includes the use of natural compounds such as plant bioactive molecules, antimicrobial peptides, green synthesised nanoparticles, or secondary metabolites from other organisms that not only prevent the rise of antimicrobial resistance but are also safe for the host tissues. Biofilm Associated Antimicrobial Resistance and Its Recovery provides a detailed and systematic review of alternative pharmacological developments in the field of biofilm research. Features: A narrative overview of the mechanism of biofilm formation and its role in the emergence of antimicrobial resistance. Recent research in the development of antibiofilm remedies involving biogenic compounds. Advancements in biofilm detection methodologies with cutting-edge technologies. This book serves as a resource for researchers who need to understand and analyze the progression of events during microbial biofilm formation, as well as design safer methodologies for its successful eradication. It may also be used as a textbook for a graduate level course in microbiology or microbial biotechnology.

Author : Tony Romeo
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 53,8 Mb
Release : 2008-02-26
Category : Medical
ISBN : 9783540754183

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Bacterial Biofilms by Tony Romeo Pdf

Throughout the biological world, bacteria thrive predominantly in surface-attached, matrix-enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical, and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume focuses on the biology of biofilms that affect human disease, although it is by no means comprehensive. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental, and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth.

Author : Marina Pana
Publisher : BoD – Books on Demand
Page : 590 pages
File Size : 40,8 Mb
Release : 2012-04-04
Category : Medical
ISBN : 9789535104728

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Antibiotic Resistant Bacteria by Marina Pana Pdf

Antibiotic-resistant bacterial strains remain a major global threat, despite the prevention, diagnosis and antibiotherapy, which have improved considerably. In this thematic issue, the scientists present their results of accomplished studies, in order to provide an updated overview of scientific information and also, to exchange views on new strategies for interventions in antibiotic-resistant bacterial strains cases and outbreaks. As a consequence, the recently developed techniques in this field will contribute to a considerable progress in medical research.

Author : Ian M. Gould,Jos W.M. van der Meer
Publisher : Springer Science & Business Media
Page : 286 pages
File Size : 50,7 Mb
Release : 2007-09-12
Category : Medical
ISBN : 9780387708409

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Antibiotic Policies: Fighting Resistance by Ian M. Gould,Jos W.M. van der Meer Pdf

This volume examines many of the crucial issues of resistance in a clinical context, with an emphasis on MRSA; surely the greatest challenge to our antibiotic and infection control policies that modern health care systems have ever seen. Other chapters explore the psychology of prescribing, modern management techniques as an adjunct to antibiotic policies, and the less obvious downsides of antibiotic use.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 496 pages
File Size : 44,8 Mb
Release : 2011-01-10
Category : Medical
ISBN : 9780309156110

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Antibiotic Resistance by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Years of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant 'superbugs.' The IOM's Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs.

Author : Sadik Dincer,Melis Sümengen Özdenefe,Afet Arkut
Publisher : BoD – Books on Demand
Page : 362 pages
File Size : 52,8 Mb
Release : 2020-10-07
Category : Science
ISBN : 9781789858990

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Bacterial Biofilms by Sadik Dincer,Melis Sümengen Özdenefe,Afet Arkut Pdf

This book examines biofilms in nature. Organized into four parts, this book addresses biofilms in wastewater treatment, inhibition of biofilm formation, biofilms and infection, and ecology of biofilms. It is designed for clinicians, researchers, and industry professionals in the fields of microbiology, biotechnology, ecology, and medicine as well as graduate and postgraduate students.

Author : Nadeem Akhtar,Kumar Siddharth Singh,Prerna,Dinesh Goyal
Publisher : Springer Nature
Page : 569 pages
File Size : 43,5 Mb
Release : 2022-01-31
Category : Medical
ISBN : 9783030841263

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Emerging Modalities in Mitigation of Antimicrobial Resistance by Nadeem Akhtar,Kumar Siddharth Singh,Prerna,Dinesh Goyal Pdf

Antimicrobial resistance (AMR) is one of the deadliest threats to global public health. This book focuses on dynamics in the landscape of AMR while informing about the latest technologies and strategies to mitigate it. The menace of AMR in different niches, routes of penetration across various domains, socio-economic impact, and the need for a 'One Health' approach in mitigating AMR has been emphasized. Factors involved in AMR, underlying mechanisms, and pharmacometrics in developing antimicrobials are highlighted. Emphasis is given to emerging technologies that are sustainable, scalable, and applicable to the global community, such as big data analytics, bioactive agents, phage therapy, and nanotechnology. The book also explores current and alternative treatment strategies to combat AMR, emphasizing the use of nanoparticles to target pathogens and as a viable alternative to antibiotics.

Author : Dharumadurai Dhanasekaran,Nooruddin Thajuddin
Publisher : BoD – Books on Demand
Page : 526 pages
File Size : 44,8 Mb
Release : 2016-07-13
Category : Medical
ISBN : 9789535124351

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Microbial Biofilms by Dharumadurai Dhanasekaran,Nooruddin Thajuddin Pdf

In the book Microbial Biofilms: Importance and applications, eminent scientists provide an up-to-date review of the present and future trends on biofilm-related research. This book is divided with four subdivisions as biofilm fundamentals, applications, health aspects, and their control. Moreover, this book also provides a comprehensive account on microbial interactions in biofilms, pyocyanin, and extracellular DNA in facilitating Pseudomonas aeruginosa biofilm formation, atomic force microscopic studies of biofilms, and biofilms in beverage industry. The book comprises a total of 21 chapters from valued contributions from world leading experts in Australia, Bulgaria, Canada, China, Serbia, Germany, Italy, Japan, the United Kingdom, the Kingdom of Saudi Arabia, Republic of Korea, Mexico, Poland, Portugal, and Turkey. This book may be used as a text or reference for everyone interested in biofilms and their applications. It is also highly recommended for environmental microbiologists, soil scientists, medical microbiologists, bioremediation experts, and microbiologists working in biocorrosion, biofouling, biodegradation, water microbiology, quorum sensing, and many other related areas. Scientists in academia, research laboratories, and industry will also find it of interest.

Author : Sabu Thomas
Publisher : Springer Nature
Page : 238 pages
File Size : 52,6 Mb
Release : 2020-07-20
Category : Medical
ISBN : 9789811536588

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Antimicrobial Resistance by Sabu Thomas Pdf

Antimicrobial resistance is a major global public health problem. This book focuses on the clinical implications of multi-drug resistant pathogens; tracking AMR and its evolutionary significance; antifungal resistance; and current and alternative treatment strategies for AMR, including antivirulent, antibiofilm and antimicrobial resistance breakers, repurposing of drugs, and probiotic therapy. Advances in antimicrobial stewardship, antibiotic policies from a global perspective and their impacts are also discussed. The book also explores the use of omics approaches to gain insights into antibacterial resistance, and includes chapters on the potential benefits of a ‘One Health approach’ describing the environmental and zoonotic sources of resistant genes and their effects on the global resistance pool.