Antiprotozoal Drug Discovery A Challenge That Remains

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Antiprotozoal Drug Discovery: A Challenge That Remains

Norma Rivera
Antiprotozoal Drug Discovery A Challenge That Remains Book PDF

Author : Norma Rivera
Publisher : Bentham Science Publishers
Page : 199 pages
File Size : 41,8 Mb
Release : 2016-09-06
Category : Medical
ISBN : 9781681083292

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Antiprotozoal Drug Discovery: A Challenge That Remains by Norma Rivera Pdf

Protozoan infections that are endemic in countries with limited economic resources pose a significant public health challenge to affected communities and some of these diseases are categorized as neglected tropical diseases by the World Health Organization. At the moment, there is an urgent need to identify and develop new antiprotozoal drugs. Antiprotozoal Drug Discovery: A Challenge That Remains brings together research from all scientists (including parasitologists, chemists, biologists among others) involved in the field of antiprotozoal experimental pharmacology, drug design and natural product research. The monograph is a compilation of review chapters written by experts on medical parasitology and pharmacology that covers a wide range of topics such as general characteristics of protozoan diseases (malaria, toxoplasmosis, Chagas’ disease, leishmaniasis, trichomoniasis) prophylaxis, treatments, natural products and rational drug design. The contents of this book are useful to medical microbiologists and pharmaceutical scientists seeking to update their knowledge about antiprotozoal drug design.

Antiprotozoal Drug Development and Delivery

Alane Beatriz Vermelho,Claudiu T. Supuran
Antiprotozoal Drug Development and Delivery Book PDF

Author : Alane Beatriz Vermelho,Claudiu T. Supuran
Publisher : Springer Nature
Page : 333 pages
File Size : 45,7 Mb
Release : 2022-06-24
Category : Science
ISBN : 9783031068508

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Antiprotozoal Drug Development and Delivery by Alane Beatriz Vermelho,Claudiu T. Supuran Pdf

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.

Malaria

Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control
Malaria Book PDF

Author : Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control
Publisher : National Academies Press
Page : 312 pages
File Size : 51,9 Mb
Release : 1991-02-01
Category : Medical
ISBN : 0309045274

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Malaria by Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control Pdf

Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.

Bioassay Methods in Natural Product Research and Drug Development

Lars Bohlin,Jan G. Bruhn
Bioassay Methods in Natural Product Research and Drug Development Book PDF

Author : Lars Bohlin,Jan G. Bruhn
Publisher : Springer Science & Business Media
Page : 203 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401148108

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Bioassay Methods in Natural Product Research and Drug Development by Lars Bohlin,Jan G. Bruhn Pdf

Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Saving Lives, Buying Time

Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
Saving Lives Buying Time Book PDF

Author : Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
Publisher : National Academies Press
Page : 384 pages
File Size : 54,9 Mb
Release : 2004-09-09
Category : Medical
ISBN : 9780309165938

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Saving Lives, Buying Time by Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs Pdf

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

Grand Challenges in Marine Biotechnology

Pabulo H. Rampelotto,Antonio Trincone
Grand Challenges in Marine Biotechnology Book PDF

Author : Pabulo H. Rampelotto,Antonio Trincone
Publisher : Springer
Page : 616 pages
File Size : 44,9 Mb
Release : 2018-05-15
Category : Science
ISBN : 9783319690759

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Grand Challenges in Marine Biotechnology by Pabulo H. Rampelotto,Antonio Trincone Pdf

This book serves as essential reading for research scientists and biotechnologists from both academia and industry working in marine biotechnology and related disciplines. The book discusses recent advances and challenges in terms of science, technology, innovation, and policy for the development of the field; and how marine biotechnology may provide new solutions to some of the grand challenges faced by our society. Written in an accessible language, the book is also recommended as a reference text for decision-makers in government and non-governmental organizations in their efforts to foster the development of a global blue economy. With less than 5 % of the vast and rich marine environment explored, our seas and oceans represent a virtually unexplored resource for the discovery of novel product, processes, and development of bio-inspired synthetic drugs with biotechnological potential. As such, the marine environment has been considered Earth's last frontier of exploration. Recent advances in molecular techniques are providing the necessary tools to access on a larger scale the still-untapped ocean resources and, consequently, unveil the promise of the blue biotechnology. Governments are recognizing the potential of marine biotechnology to provide solutions to some of the Grand Challenges of the 21st Century such as sustainable energy and food sources, identification of novel drugs for improved health treatments, and providing new industrial materials and processes. For this reason, advances in marine biotechnology may foster the much-needed source of innovation and economic growth in many countries, and pave the way towards the development of a global blue economy, i.e. a new economic model based on the sustainable exploration of our ocean ecosystems.

The Use of Drugs in Food Animals

National Research Council,Institute of Medicine,Food and Nutrition Board,Board on Agriculture,Committee on Drug Use in Food Animals,Panel on Animal Health, Food Safety, and Public Health
The Use of Drugs in Food Animals Book PDF

Author : National Research Council,Institute of Medicine,Food and Nutrition Board,Board on Agriculture,Committee on Drug Use in Food Animals,Panel on Animal Health, Food Safety, and Public Health
Publisher : National Academies Press
Page : 276 pages
File Size : 49,7 Mb
Release : 1999-01-12
Category : Medical
ISBN : 9780309175777

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The Use of Drugs in Food Animals by National Research Council,Institute of Medicine,Food and Nutrition Board,Board on Agriculture,Committee on Drug Use in Food Animals,Panel on Animal Health, Food Safety, and Public Health Pdf

The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.

Comprehensive Analysis of Parasite Biology

Sylke Müller,Rachel Cerdan,Ovidiu Radulescu
Comprehensive Analysis of Parasite Biology Book PDF

Author : Sylke Müller,Rachel Cerdan,Ovidiu Radulescu
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 50,8 Mb
Release : 2016-07-19
Category : Medical
ISBN : 9783527694099

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Comprehensive Analysis of Parasite Biology by Sylke Müller,Rachel Cerdan,Ovidiu Radulescu Pdf

Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

Neglected Tropical Diseases and Phytochemicals in Drug Discovery

Muhammad Akram,Chukwuebuka Egbuna,Jonathan Chinenye Ifemeje
Neglected Tropical Diseases and Phytochemicals in Drug Discovery Book PDF

Author : Muhammad Akram,Chukwuebuka Egbuna,Jonathan Chinenye Ifemeje
Publisher : John Wiley & Sons
Page : 624 pages
File Size : 40,6 Mb
Release : 2021-10-25
Category : Science
ISBN : 9781119617150

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Neglected Tropical Diseases and Phytochemicals in Drug Discovery by Muhammad Akram,Chukwuebuka Egbuna,Jonathan Chinenye Ifemeje Pdf

NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

Drug Repurposing and Computational Drug Discovery

Mithun Rudrapal
Drug Repurposing and Computational Drug Discovery Book PDF

Author : Mithun Rudrapal
Publisher : CRC Press
Page : 294 pages
File Size : 53,6 Mb
Release : 2023-10-27
Category : Medical
ISBN : 9781000800012

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Drug Repurposing and Computational Drug Discovery by Mithun Rudrapal Pdf

Drug repurposing is defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates. This new volume presents exciting recent advances in drug repurposing and computational approaches for the discovery and development of drugs against certain difficult-to-treat and life-threatening diseases. With contributions from a global team of experts (academicians, scientists, and researchers), it explores the sophisticated tools and techniques of drug repurposing and computational drug discovery. It delivers valuable information on computational techniques, tools, and databases being utilized for drug repurposing and for identifying the uses of existing drug candidates on different emerging or deadly diseases. Drug repurposing and computational approaches addressed in the book target the discovery and development of drugs for microbial infections (bacterial, fungal, viral, COVID-19), parasitic diseases and neglected tropical diseases (NTDs), malignant diseases (cancer), inflammatory diseases, cardiovascular disorders, diabetes, and aging and neurological (CNS) disorders. In addition, the challenges and regulatory issues encountered in drug repurposing and computational drug discovery programs are looked at, offering perspectives for future directions.

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

Goutam Brahmachari
Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases Book PDF

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 458 pages
File Size : 45,8 Mb
Release : 2019-04-15
Category : Medical
ISBN : 9780128157244

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Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases by Goutam Brahmachari Pdf

Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases

Practicing Biomedicine at the Albert Schweitzer Hospital 1913-1965

Tizian Zumthurm
Practicing Biomedicine at the Albert Schweitzer Hospital 1913 1965 Book PDF

Author : Tizian Zumthurm
Publisher : BRILL
Page : 319 pages
File Size : 49,7 Mb
Release : 2020-08-10
Category : Medical
ISBN : 9789004436978

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Practicing Biomedicine at the Albert Schweitzer Hospital 1913-1965 by Tizian Zumthurm Pdf

Tizian Zumthurm uses the extraordinary hospital of an extraordinary man to produce novel insights into the ordinary practice of biomedicine in colonial Central Africa. His investigation of therapeutic routines in surgery, maternity care, psychiatry, and the treatment of dysentery and leprosy reveals the incoherent nature of biomedicine and not just in Africa. Reading rich archival sources against and along the grain, the author combines concepts that appeal to those interested in the history of medicine and colonialism. Through the microcosm of the hospital, Zumthurm brings to light the social worlds of Gabonese patients as well as European staff. By refusing to easily categorize colonial medical encounters, the book challenges our understanding of biomedicine as solely domineering or interactive.

Drugs & Pharmaceutical Technology Handbook

NIIR Board
Drugs Pharmaceutical Technology Handbook Book PDF

Author : NIIR Board
Publisher : ASIA PACIFIC BUSINESS PRESS Inc.
Page : 636 pages
File Size : 40,8 Mb
Release : 2004-01-01
Category : Electronic
ISBN : 9788178330549

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Drugs & Pharmaceutical Technology Handbook by NIIR Board Pdf

Drugs and pharmaceutical industry plays a vital role in the economic development of a nation. It is one of the largest and most advanced sectors in the world, acting as a source for various drugs, medicines and their intermediates as well as other pharmaceutical formulations. India has come a long way in this field, from a country importing more than 95% of its requirement of drugs and pharmaceuticals; India now is exporting it even to developed countries. Being the intense knowledge driven industry, it offers innumerable business opportunities for the investors/ corporate the world over. The existence of well defined and strong pharmaceutical industry is important for promoting and sustaining research and developmental efforts and initiatives in an economy as well as making available the quality medicines to all at affordable prices. That is, it is essential to improve the health status of the individuals as well as the society as a whole, so that positive contributions could be made to the economic growth and regional development of a country. On the global platform, India holds fourth position in terms of volume and thirteenth position in terms of value of production in pharmaceuticals. The pharmaceutical industry has been producing bulk drugs belonging to all major therapeutic groups requiring complicated manufacturing processes as well as a wide range of pharmaceutical machinery and equipments. The modern Indian Pharmaceutical Industry is recent and its foundation was laid in the beginning of the current century. The pharmaceutical industry can be broadly categorised as bulk drugs, formulations, IV fluids and pharmaceutical aids (such as medical equipment, hospital disposables, capsules, etc.). Special feature of the pharmaceutical industry is a large number of manufacturers in the small scale sector. The government is also encouraging the SSI sector providing some incentives. The recent developments in the technology and R & D work in this field have led to the increased growth rate of industries and have established Indian Pharmaceutical industries in the international market. The content of the book includes information about properties, general methods of analysis, methods of manufacture, of different types of drugs and pharmaceuticals. Some of the fundamentals of the book are polymeric materials used in drug delivery systems , theoretical aspects of friction and lubrication , a convenient method for conversion of quinine to quinidine, formulation and evaluation of bio-available enteric-coated erythromycin and metronidazole tablets, extraction of virginiamycin, antipyretics and analgesics, column chromatographic assay of aspirin tablets, differentiating titration of phenacetin and caffeine, infrared spectra of some compounds of pharmaceutical interest etc. This book covers an intensive study on manufacturing, production, formulation and quality control of drugs and pharmaceuticals with technology involved in it. This book is an invaluable resource for technologists, professionals and those who want to venture in this field.

WHO Global Report on Traditional and Complementary Medicine 2019

World Health Organization
WHO Global Report on Traditional and Complementary Medicine 2019 Book PDF

Author : World Health Organization
Publisher : World Health Organization
Page : 228 pages
File Size : 48,9 Mb
Release : 2019-05-16
Category : Business & Economics
ISBN : 9789241515436

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WHO Global Report on Traditional and Complementary Medicine 2019 by World Health Organization Pdf

This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).

Traditional Medicines for Modern Times

Amala Soumyanath
Traditional Medicines for Modern Times Book PDF

Author : Amala Soumyanath
Publisher : CRC Press
Page : 331 pages
File Size : 52,8 Mb
Release : 2005-11-02
Category : Health & Fitness
ISBN : 9781420019001

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Traditional Medicines for Modern Times by Amala Soumyanath Pdf

The increasing prevalence of diabetes mellitus world-wide is an issue of major socio-economic concern. Scientific interest in plant-derived medicine is steadily rising, yet there is often a wide disparity in the caliber of information available. A detailed compilation of scientific information from across the globe, Traditional Medicines for Modern