Applied Biopharmaceutics Pharmacokinetics Fifth Edition

Author : Leon Shargel,Susanna Wu-Pong,Andrew Yu
Publisher : McGraw Hill Professional
Page : 914 pages
File Size : 53,5 Mb
Release : 2004-09-09
Category : Medical
ISBN : 9780071501873

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Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition by Leon Shargel,Susanna Wu-Pong,Andrew Yu Pdf

The most comprehensive text on the practical applications of biopharmaceuticals and pharmacokinetics! 4 STAR DOODY'S REVIEW! "The updated edition provides the reader with a solid foundation in the basic principles of pharmacokinetics and biopharmaceutics. Students will be able to apply the information to their clinical practice and researchers will find this to be a valuable reference. This modestly priced book should be the gold standard for student use."--Doody's Review Service The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Author : Leon Shargel,Susanna Wu-Pong,Andrew B. C. Yu
Publisher : McGraw-Hill Medical Publishing
Page : 920 pages
File Size : 50,7 Mb
Release : 2005
Category : Medical
ISBN : UOM:39015059132483

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Applied Biopharmaceutics & Pharmacokinetics by Leon Shargel,Susanna Wu-Pong,Andrew B. C. Yu Pdf

Annotation The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Author : Leon Shargel,Andrew Yu,Susanna Wu-Pong
Publisher : McGraw Hill Professional
Page : 831 pages
File Size : 54,9 Mb
Release : 2012-04-11
Category : Medical
ISBN : 9780071603935

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Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition by Leon Shargel,Andrew Yu,Susanna Wu-Pong Pdf

A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics The field’s leading text for more than three decades Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to: Understand the basic concepts in biopharmaceutics and pharmacokinetics. Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

Author : Leon Shargel,Susanna Wu-Pong,Andrew Yu
Publisher : McGraw Hill Professional
Page : 915 pages
File Size : 50,7 Mb
Release : 2004-08-19
Category : Medical
ISBN : 9780071375504

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Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition by Leon Shargel,Susanna Wu-Pong,Andrew Yu Pdf

The most comprehensive text on the practical applications of biopharmaceuticals and pharmacokinetics! 4 STAR DOODY'S REVIEW! "The updated edition provides the reader with a solid foundation in the basic principles of pharmacokinetics and biopharmaceutics. Students will be able to apply the information to their clinical practice and researchers will find this to be a valuable reference. This modestly priced book should be the gold standard for student use."--Doody's Review Service The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Author : Leon Shargel,Andrew B. C. Yu
Publisher : McGraw-Hill/Appleton & Lange
Page : 656 pages
File Size : 51,7 Mb
Release : 1993
Category : Medical
ISBN : UOM:39015029461012

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Applied Biopharmaceutics and Pharmacokinetics by Leon Shargel,Andrew B. C. Yu Pdf

The third edition of this introductory text covers the factors which influence the release of the drug from the drug product and how the body handles the drug. A stronger focus has been placed on the basics with clear explanations and illustrated examples. There is also more information on statistics and population pharmacokinetics and new chapters on drug distribution, computer applications, enzyme kinetics and pharmacokinetics models.

Author : Leon Shargel,Andrew B. C. Yu
Publisher : McGraw Hill Professional
Page : 928 pages
File Size : 53,9 Mb
Release : 2015-11-22
Category : Medical
ISBN : 9780071829649

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Applied Biopharmaceutics & Pharmacokinetics, Seventh Edition by Leon Shargel,Andrew B. C. Yu Pdf

The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics—now fully updated. Explains how to detect clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Helps you critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Chapters have been revised to reflect the latest clinical perspectives on drug performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy The field’s leading text for more than three decades, Applied Biopharmaceutics & Pharmacokinetics gets you up to speed on the basics of the discipline like no other resource. Practical problems and clinical examples with discussions are integrated within each chapter to help you apply principles to patient care and drug consultation situations. In addition, outstanding pedagogy, including chapter objectives, chapter summaries, and FAQs, plus additional application questions, identify and focus on key concepts. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics shows you how to use raw data and formulate the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination. The book also helps you work with pharmacokinetic and biopharmaceutic parameters to design and evaluate dosage regimens of drugs. In the seventh edition of this must-have interactive learning tool, most of the chapters are updated to reflect our current understanding of complex issues associated with safe and efficacious drug therapy.

Author : Shargel
Publisher : Unknown
Page : 128 pages
File Size : 43,8 Mb
Release : 2003-01
Category : Electronic
ISBN : 0071240055

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Applied Biopharmaceutics and Pharmacokinetics by Shargel Pdf

Emphasizing on the application and understanding of concepts, this book provides basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Author : Leon Shargel,Murray P. Ducharme,Andrew B. C. Yu
Publisher : McGraw Hill Professional
Page : 1035 pages
File Size : 41,9 Mb
Release : 2022-01-24
Category : Medical
ISBN : 9781260143003

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Shargel and Yu's Applied Biopharmaceutics & Pharmacokinetics, 8th Edition by Leon Shargel,Murray P. Ducharme,Andrew B. C. Yu Pdf

The authoritative textbook on the principles and practical applications of biopharmaceutics and pharmacokinetics Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics has been the standard textbook in its field for over 40 years. This eighth edition includes recent scientific developments in the field and embodies the collective contribution of experts with deep knowledge and experience in the selected subject areas. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition provides the reader with a fundamental understanding of biopharmaceutics and pharmacokinetics principles that can be applied to patient drug therapy and rational drug product development. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition has been expanded and revised to include advancements in biopharmaceutics and pharmacokinetics. The chapter sequence has been reorganized into four main sections, providing a more logical sequence for students. The textbook starts with fundamental concepts, followed by application of these principles to optimize drug therapy and to the rational development of drug products. Each chapter includes theoretical concepts with practical examples and clinical applications. Frequently asked questions provide a discussion of overall concepts. Features: Expanded and revised chapters to include scientific advances in biopharmaceutics and pharmacokinetics Four main sections providing a natural buildup of knowledge: introduction to biopharmaceutics and pharmacokinetics, fundamentals of biopharmaceutics, pharmacokinetic calculations, clinical pharmacokinetics and pharmacodynamics, and biopharmaceutics and pharmacokinetics in drug product development Additional chapters for this edition include: o Physiological factors related to drug absorption o Approaches to pharmacokinetics and pharmacodynamics calculations o Novel and complex dosage Forms o Clinical Development and Therapeutic Equivalence of Generic Drug and Biosimilar Products o Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development Additional information on drug therapy, drug product performance, and other related topics Frequently asked questions, practice problems, clinical examples and learning questions

Author : Andrew B.C. Yu,Leon Shargel
Publisher : McGraw-Hill Education / Medical
Page : 864 pages
File Size : 45,8 Mb
Release : 2020-12-06
Category : Medical
ISBN : 126014299X

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Applied Biopharmaceutics & Pharmacokinetics, Eigth Edition by Andrew B.C. Yu,Leon Shargel Pdf

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. This authoritative guide has been updated with important new findings about drug therapy, product performance, and other need-to-know topics Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition delivers the knowledge and skills you need to succeed. The authors provide practical problems with specific examples of clinical solutions to help you apply principles to patient care and drug consultation situations. Each chapter includes objectives, summaries, and FAQs highlighting that help you understand and retain key concepts. You’ll learn how to derive models/parameters to describe drug absorption, distribution, and elimination processes; evaluate biopharmaceutic studies involving drug product equivalency and unequivalency; design and evaluate dosage regimens of drugs; detect and solve clinical pharmacokinetic problems; and much more.

Author : Johan Gabrielsson,Daniel Weiner
Publisher : CRC Press
Page : 926 pages
File Size : 52,9 Mb
Release : 2001-11-30
Category : Medical
ISBN : 9186274929

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Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition by Johan Gabrielsson,Daniel Weiner Pdf

This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.

Author : SHARGEL
Publisher : Unknown
Page : 0 pages
File Size : 52,8 Mb
Release : 2022-03-18
Category : Electronic
ISBN : 1260469603

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APPLIED BIOPHARMACEUTICS and PHARMACOKINET by SHARGEL Pdf

Author : Thomas N. Tozer,Malcolm Rowland
Publisher : Lippincott Williams & Wilkins
Page : 342 pages
File Size : 43,6 Mb
Release : 2006
Category : Medical
ISBN : 0781751497

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Introduction to Pharmacokinetics and Pharmacodynamics by Thomas N. Tozer,Malcolm Rowland Pdf

This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

Author : Hartmut Derendorf,Stephan Schmidt
Publisher : Lippincott Williams & Wilkins
Page : 864 pages
File Size : 55,6 Mb
Release : 2019-07-11
Category : Medical
ISBN : 9781496385895

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Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications by Hartmut Derendorf,Stephan Schmidt Pdf

Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.

Author : Sara E. Rosenbaum
Publisher : John Wiley & Sons
Page : 440 pages
File Size : 44,8 Mb
Release : 2012-09-10
Category : Medical
ISBN : 9781118197783

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Basic Pharmacokinetics and Pharmacodynamics by Sara E. Rosenbaum Pdf

With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.

Author : Michael E. Aulton,Kevin Taylor
Publisher : Elsevier Health Sciences
Page : 909 pages
File Size : 41,5 Mb
Release : 2013
Category : Medical
ISBN : 9780702042904

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Aulton's Pharmaceutics by Michael E. Aulton,Kevin Taylor Pdf

"Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.