Applied Biophysics

Author : Thomas Andrew Waigh
Publisher : John Wiley & Sons
Page : 437 pages
File Size : 52,9 Mb
Release : 2007-09-11
Category : Science
ISBN : 9780470017173

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Applied Biophysics by Thomas Andrew Waigh Pdf

This book presents the fundamentals of molecular biophysics, and highlights the connection between molecules and biological phenomena, making it an important text across a variety of science disciplines. The topics covered in the book include: Phase transitions that occur in biosystems (protein crystallisation, globule-coil transition etc) Liquid crystallinity as an example of the delicate range of partially ordered phases found with biological molecules How molecules move and propel themselves at the cellular level The general features of self-assembly with examples from proteins The phase behaviour of DNA The physical toolbox presented within this text will form a basis for students to enter into a wide range of pure and applied bioengineering fields in medical, food and pharmaceutical areas.

Author : Donald Huddler,Edward R. Zartler
Publisher : John Wiley & Sons
Page : 148 pages
File Size : 48,7 Mb
Release : 2017-10-02
Category : Science
ISBN : 9781119099482

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Applied Biophysics for Drug Discovery by Donald Huddler,Edward R. Zartler Pdf

Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: • Design considerations in biophysical-based lead screening • Thermodynamic characterization of protein-compound interactions • Characterizing targets and screening reagents with HDX-MS • Microscale thermophoresis methods (MST) • Screening with Weak Affinity Chromatography • Methods to assess compound residence time • 1D-NMR methods for hit identification • Protein-based NMR methods for SAR development • Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.

Author : Donald Huddler,Edward R. Zartler
Publisher : John Wiley & Sons
Page : 312 pages
File Size : 51,7 Mb
Release : 2017-07-14
Category : Science
ISBN : 9781119099499

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Applied Biophysics for Drug Discovery by Donald Huddler,Edward R. Zartler Pdf

Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: • Design considerations in biophysical-based lead screening • Thermodynamic characterization of protein-compound interactions • Characterizing targets and screening reagents with HDX-MS • Microscale thermophoresis methods (MST) • Screening with Weak Affinity Chromatography • Methods to assess compound residence time • 1D-NMR methods for hit identification • Protein-based NMR methods for SAR development • Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.

Author : Vladimir I Vysotskii,Alla A Kornilova,Igor V Smirnov
Publisher : World Scientific
Page : 340 pages
File Size : 53,8 Mb
Release : 2009-07-06
Category : Science
ISBN : 9789814630733

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Applied Biophysics of Activated Water by Vladimir I Vysotskii,Alla A Kornilova,Igor V Smirnov Pdf

This book provides a detailed review of the modern theories dealing with the structure and properties of water. It also presents an analysis of the research on the effect of activated water on biological systems such as animals, microorganisms, and plants. The results of experiments on the influence of activated water on “pure” microbiological cultures and their natural associations are described, the studies being carried out under both aerobic and anaerobic conditions. The results demonstrate a significant influence of activated water on higher plants (vegetable crops), sterile plants, and callus tissues. It is shown that the activation of water under definite conditions gives rise to the appearance of very strong bactericidal properties: activated water inhibits the development of pathogenic microbiological cultures by tens and hundreds of times more strongly, and can be used for sterilization. In addition, a potent positive effect of activated water on the prevention and treatment of cancer in mice has been observed, and its efficacy compared to that of chemotherapy is discussed in the book. The information provided in this book is supported by intensive experimental data and developed theories. The research programs were conducted at the authors' laboratories in Ukraine and Russia as well as at research facilities located in the USA. Contents:Introduction to the Theory of Water Memory and General Principles of Water ActivationMolecular Resonance Effect Technology as the Basic Method for Activation of Liquid SubstancesStudy of the Physical Properties of MRET Activated WaterInfluence of MRET Activated Water on the Growth of Higher PlantsEffects of MRET Activated Water on Microbial Culture and Natural Microbial AssociationsExamination of the Influence of MRET Activated Water on Prophylaxis and Treatment of OncologyEffect of MRET Activated Water on Staphylococcal Infection in vivo in Animal Model (on the Cells of Immune System) and in vitro on the Culture of Staphylococcus aureus Wood-46The Possible Mechanisms of Effects of Activated Water on Biological SystemsConclusions and Recommendations Readership: Biophysicists; physicists; medical doctors; researchers in molecular physics, hydrodynamics, optics, electrodynamics, condensed matter physics, microbiology, epidemiology and agriculture. Key Features:Presents the results of complex experimental and theoretical studies of the characteristics of activated water obtained under a controlled action of the specific non-ionizing low-frequency electromagnetic emission on ordinary waterProvides a comprehensive overview of the authors' work that includes innovative discoveries related to the effect of subtle, low-frequency, random magnetic fields on the molecular structure and physical properties of waterGives the results of the theoretical analysis of a possible mechanism of water memory and methods of its stimulationKeywords:Activated Water;Water Memory;Biophysics;Bioengineering;Biotechnology;Treatment in Oncology;Inhibition of Pathogenic Culture Growth

Author : Francisco Torrens,Debarshi Kar Mahapatra,A. K. Haghi
Publisher : CRC Press
Page : 211 pages
File Size : 52,5 Mb
Release : 2020-04-07
Category : Medical
ISBN : 9781000008326

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Biochemistry, Biophysics, and Molecular Chemistry by Francisco Torrens,Debarshi Kar Mahapatra,A. K. Haghi Pdf

Biochemistry, Biophysics, and Molecular Chemistry: Applied Research and Interactions provides the background needed in biophysics and molecular chemistry and offers a great deal of advanced biophysical knowledge. It emphasizes the growing interrelatedness of molecular chemistry and biochemistry, and acquaints one with experimental methods of both disciplines. This book addresses some of the enormous advances in biochemistry, particularly in the areas of structural biology and bioinformatics, by providing a solid biochemical foundation that is rooted in chemistry. Topics include scientific integrity and ethics in the field; clinical translational research in cancer, diabetes, and cardiovascular disease; emerging drugs to treat neurodegenerative diseases; swine, avian, and human flu; the use of big data in artificial knowledge in the field; bioinformatic insights on molecular chemistry; and much more.

Author : Jack A. Tuszynski,Michal Kurzynski
Publisher : CRC Press
Page : 579 pages
File Size : 52,5 Mb
Release : 2003-02-26
Category : Science
ISBN : 9780203009963

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Introduction to Molecular Biophysics by Jack A. Tuszynski,Michal Kurzynski Pdf

Molecular biophysics is a rapidly growing field of research that plays an important role in elucidating the mysteries of life's molecules and their assemblies, as well as the relationship between their structure and function. Introduction to Molecular Biophysics fills an existing gap in the literature on this subject by providing the reader with th

Author : Norman Howard-Jones
Publisher : Unknown
Page : 322 pages
File Size : 51,9 Mb
Release : 1949
Category : Biophysics
ISBN : UOM:39015003384974

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Applied Biophysics by Norman Howard-Jones Pdf

Author : Antonio Maffucci,Sergey A. Maksimenko
Publisher : Springer
Page : 290 pages
File Size : 52,6 Mb
Release : 2016-04-08
Category : Science
ISBN : 9789401774789

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Fundamental and Applied Nano-Electromagnetics by Antonio Maffucci,Sergey A. Maksimenko Pdf

This book presents the most relevant and recent results in the study of “Nanoelectromagnetics”, a recently born fascinating research discipline, whose popularity is fast arising with the intensive penetration of nanotechnology in the world of electronics applications. Studying nanoelectromagnetics means describing the interaction between electromagnetic radiation and quantum mechanical low-dimensional systems: this requires a full interdisciplinary approach, the reason why this book hosts contributions from the fields of fundamental and applied electromagnetics, of chemistry and technology of nanostructures and nanocomposites, of physics of nano-structures systems, etc. The book is aimed at providing the reader with the state of the art in Nanoelectromagnetics, from theoretical modelling to experimental characterization, from design to synthesis, from DC to microwave and terahertz applications, from the study of fundamental material properties to the analysis of complex systems and devices, from commercial thin-film coatings to metamaterials to circuit components and nanodevices. The book is intended as a reference in advanced courses for graduate students and as a guide for researchers and industrial professionals involved in nanoelectronics and nanophotonics applications.

Author : Georges Limbert
Publisher : Springer
Page : 303 pages
File Size : 51,7 Mb
Release : 2019-05-28
Category : Technology & Engineering
ISBN : 9783030132798

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Skin Biophysics by Georges Limbert Pdf

This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented. The book focusses especially on: 1. Basic physiology, molecular biology, microstructural and material properties of the skin. 2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches. 3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing). 4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology. This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions.

Author : William Bialek
Publisher : Princeton University Press
Page : 640 pages
File Size : 45,8 Mb
Release : 2012-12-17
Category : Science
ISBN : 9781400845576

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Biophysics by William Bialek Pdf

Interactions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology--from the discovery of DNA's structure to imaging of the human brain--have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students. Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles--the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life. Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos. Featuring numerous problems and exercises throughout, Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems. Covers a range of biological phenomena from the physicist's perspective Features 200 problems Draws on statistical mechanics, quantum mechanics, and related mathematical concepts Includes an annotated bibliography and detailed appendixes Instructor's manual (available only to teachers)

Author : W. Hoppe,W. Lohmann,H. Markl,H. Ziegler
Publisher : Springer Science & Business Media
Page : 967 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642688775

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Biophysics by W. Hoppe,W. Lohmann,H. Markl,H. Ziegler Pdf

What is biophysics? As with all subjects which straddle traditional boundaries between fields, it eludes a precise definition. Furthermore, it is impossible to do biophysics without having a certain foundation of knowledge in biology, physics, physical chemistry, chemistry and biochemistry. One approach to a biophysics textbook would be to refer the student to the literature of these neighboring fields, and to leave the selection of the appropriate supplementary material up to the student. The editors of this volume are of the opinion that it is more useful and less time-consuming to present a selection of the supplementary knowledge, in concentrated form, together with the subject matter specific to biophysics. The reader will thus find in this book introductions to such subjects as the structure and function of the cell, the chemical structure of biogenic macromolecules, and even theoretical chemistry. What, indeed, is biophysics? Must we consider it to include physiology, electromedicine, radiation medicine, etc. ? The field has evolved continuously in recent years. Molecular understanding oflife processes has come more and more to the fore. Just as the field of molecular physics has developed to describe structures and processes in the realm of non-living systems, there has been a corresponding development of molecular biophysics.

Author : Christof Koch
Publisher : Oxford University Press
Page : 587 pages
File Size : 46,9 Mb
Release : 2004-10-28
Category : Medical
ISBN : 9780195181999

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Biophysics of Computation by Christof Koch Pdf

Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation.Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 47,9 Mb
Release : 1949
Category : Electronic
ISBN : OCLC:727162683

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Applied Biophysics; Survey of Physical Methods Used in Medicine, a Symposium by Anonim Pdf

Author : William C. Parke
Publisher : Springer Nature
Page : 703 pages
File Size : 48,5 Mb
Release : 2020-08-17
Category : Science
ISBN : 9783030441463

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Biophysics by William C. Parke Pdf

This comprehensive and extensively classroom-tested biophysics textbook is a complete introduction to the physical principles underlying biological processes and their applications to the life sciences and medicine. The foundations of natural processes are placed on a firm footing before showing how their consequences can be explored in a wide range of biosystems. The goal is to develop the readers’ intuition, understanding, and facility for creative analysis that are frequently required to grapple with problems involving complex living organisms. Topics cover all scales, encompassing the application of statics, fluid dynamics, acoustics, electromagnetism, light, radiation physics, thermodynamics, statistical physics, quantum biophysics, and theories of information, ordering, and evolutionary optimization to biological processes and bio-relevant technological implementations. Sound modeling principles are emphasized throughout, placing all the concepts within a rigorous framework. With numerous worked examples and exercises to test and enhance the reader’s understanding, this book can be used as a textbook for physics graduate students and as a supplementary text for a range of premedical, biomedical, and biophysics courses at the undergraduate and graduate levels. It will also be a useful reference for biologists, physicists, medical researchers, and medical device engineers who want to work from first principles.

Author : Thomas Jue
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 53,6 Mb
Release : 2009-04-20
Category : Science
ISBN : 9781597453974

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Fundamental Concepts in Biophysics by Thomas Jue Pdf

In the first volume, Fundamental Concepts in Biophysics, the authors lay down a foundation for biophysics study. Rajiv Singh opens the book by pointing to the central importance of “Mathematical Methods in Biophysics”. William Fink follows with a discussion on “Quantum Mechanics Basic to Biophysical Methods”. Together, these two chapters establish some of the principles of mathematical physics underlying many biophysics techniques. Because computer modeling forms an intricate part of biophysics research, Subhadip Raychaudhuri and colleagues introduce the use of computer modeling in “Computational Modeling of Receptor–Ligand Binding and Cellular Signaling Processes”. Yin Yeh and coworkers bring to the reader’s attention the physical basis underlying the common use of fluorescence spectroscopy in biomedical research in their chapter “Fluorescence Spectroscopy”. Electrophysiologists have also applied biophysics techniques in the study of membrane proteins, and Tsung-Yu Chen et al. explore stochastic processes of ion transport in their “Electrophysiological Measurements of Membrane Proteins”. Michael Saxton takes up a key biophysics question about particle distribution and behavior in systems with spatial or temporal inhomogeneity in his chapter “Single–Particle Tracking”. Finally, in “NMR Measurement of Biomolecule Diffusion”, Thomas Jue explains how magnetic resonance techniques can map biomolecule diffusion in the cell to a theory of respiratory control. This book thus launches the Handbook of Modern Biophysics series and sets up for the reader some of the fundamental concepts underpinning the biophysics issues to be presented in future volumes.