Artemisia Annua

Author : Tariq Aftab,Jorge F.S. Ferreira,M. Masroor A. Khan,M. Naeem
Publisher : Springer Science & Business Media
Page : 288 pages
File Size : 46,9 Mb
Release : 2013-11-26
Category : Science
ISBN : 9783642410277

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Artemisia annua - Pharmacology and Biotechnology by Tariq Aftab,Jorge F.S. Ferreira,M. Masroor A. Khan,M. Naeem Pdf

Artemisinin, a sesquiterpene lactone originally extracted from the medicinal plant Artemisia annua L., is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs. Plant scientists have focused their efforts on A. annua for a higher artemisinin crop yield. With the present volume, we are bringing together the research which is being done on this plant throughout the world and future possibilities for scientists and researchers who want to work on it.

Author : Tariq Aftab,M. Naeem,M. Masroor A. Khan
Publisher : CRC Press
Page : 340 pages
File Size : 48,8 Mb
Release : 2017-12-14
Category : Health & Fitness
ISBN : 9781351802864

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Artemisia annua by Tariq Aftab,M. Naeem,M. Masroor A. Khan Pdf

Artemisia annua is a well-known medicinal plant that has been utilized for a number of purposes, including malaria, for centuries. This is the first comprehensive book to cover the importance of Artemisia annua in the global health crisis and in the treatment against diseases. A component and extract, artemisinin, is the source of other derivatives which are also suitable for pharmaceutical use. The present demand for artemisinin far outpaces its supply. Researchers are working globally towards improving artemisinin content in the plant by various means. Artemisia annua: Prospects, Applications and Therapeutic Uses highlights the different approaches, including ‘omics', that are being used in current research on this immensely important medicinal plant. Providing comprehensive coverage of the agricultural and pharmaceutical uses of this plant, Artemisia annua will be essential reading for botanists, plant scientists, herbalists, pharmacognosists, pharmacologists and natural product chemists.

Author : Colin W. Wright
Publisher : CRC Press
Page : 296 pages
File Size : 40,5 Mb
Release : 2001-10-18
Category : Science
ISBN : 9780203303061

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Artemisia by Colin W. Wright Pdf

A comprehensive overview of this genus, Artemisia examines all aspects of the herbs uses and applications, its mode of action and clinical importance. Following a comprehensive introduction to the genus, the book discusses the botanical, phytochemical and biological aspects of a number of important species of Artemisis. Considering that the discove

Author : Youyou Tu
Publisher : Academic Press
Page : 468 pages
File Size : 48,9 Mb
Release : 2017-07-08
Category : Medical
ISBN : 9780128116562

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From Artemisia annua L. to Artemisinins by Youyou Tu Pdf

From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research. Presents a full view of artemisinin, not only its origin and development, but also chemical structure, chemical properties, extracting mode, derivatives, chromogenic reaction, general pharmacological, and toxicology. Provides many aspects of artemisinin-based drugs Incudes lots of experimental data, such as the X-ray crystallography result—the first application reported in China in determining the absolute molecular configuration utilizing the scattering effects of oxygen atoms by X-ray diffraction technique

Author : Anonim
Publisher : Unknown
Page : 49 pages
File Size : 42,5 Mb
Release : 2006
Category : Antimalarials
ISBN : 9241594438

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WHO Monograph on Good Agricultural and Collection Practices (GACP) for Artemisia Annua L. by Anonim Pdf

Author : Seid Yimer
Publisher : GRIN Verlag
Page : 86 pages
File Size : 48,7 Mb
Release : 2013-01-28
Category : Technology & Engineering
ISBN : 9783656361664

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Extraction of Artemisinin from Artemisia Annua by Seid Yimer Pdf

Bachelor Thesis from the year 2008 in the subject Engineering - Chemical Engineering, grade: A, Bahir Dar University (Bahir Dar University Engineering Faculity), course: Chemical Engineering, language: English, abstract: Abstract Malaria disease is endemic in least developed countries like Ethiopia. The rapid development of drug-resistant malaria parasite strain leaves the need for new effective anti-malarial drugs. Artemisinin is a sesquiterpene lactone found in the leaves and flowers of plants Artemisia annua L and have different chemical structures and higher efficacy than others. The content of artemisinin is very small and from 0.5 to 1.2 % of dry weight of plants in Ethiopia. Extraction of artemisinin from Artemisia annua is mainly performed using hydrocarbon extraction processes. Extraction with Supercritical CO2, ethanol, ionic liquids, hydroflourocarbon HFC-134a and hexane extraction are extraction technologies and compared majorly in terms of their extraction efficiency, cost and drawback to environment. Since artemisinin is only present in the epidermis of the leaves, leaves were only washed on the outside by stirring appeared to be the most appropriate method and the first step in this research was solvent extraction using hexane. Step followed purify by repeated crystallization. Laboratory scale production data and procedures were listed for aremisinin extraction process. By using those data large scale production method was designed. And did material and energy balance calculations for large scale production process carried out by taking scientific approach followed by feasibility study. As a result my extractor was very large and it has 14.37m3 capacities it wasn’t found in market. So I designed the required larger extractor that should fulfill the target of the project i.e. with simple, rapid, cost effective, environmental friendly and practical method for the isolation of artemisinin from Artemisia annua. The design the extractor I used the optimum ratio between solvent and leaves, optimum extraction time, optimum extraction temperature and optimum design of the stirrer paddles. In these thesis work extractor design, skirt design, bolt design, reinforcement calculations, preliminary equipment design (sizing), economic analysis calculations were included. In the profitability analysis Return on investment, payback period and net present worth calculated and the project was checked its feasibility. The payback period is 1.22yrs and it is economically acceptable that means this market is promising in Ethiopia in addition to save millions of Ethiopian and African from killer malaria. Key words: artemisinin, sesquiterpene lactone, hexane extraction

Author : Tomasz Czechowski,Ian A. Graham,Pamela J. Weathers,Peter E. Brodelius,Geoffrey Duncan Brown
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 51,9 Mb
Release : 2020-12-04
Category : Science
ISBN : 9782889661589

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Artemisinin - From Traditional Chinese Medicine to Artemisinin Combination Therapies; Four Decades of Research on the Biochemistry,Physiology, and Breeding of Artemisia annua by Tomasz Czechowski,Ian A. Graham,Pamela J. Weathers,Peter E. Brodelius,Geoffrey Duncan Brown Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Mahendra Rai,Kateryna Kon
Publisher : Academic Press
Page : 291 pages
File Size : 45,7 Mb
Release : 2013-05-24
Category : Science
ISBN : 9780124017085

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Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components by Mahendra Rai,Kateryna Kon Pdf

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more

Author : Dana G. Dalrymple
Publisher : Unknown
Page : 253 pages
File Size : 55,5 Mb
Release : 2013
Category : Malaria
ISBN : 0615615996

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Artemisia Annua, Artemisinin, ACTs & Malaria Control in Africa by Dana G. Dalrymple Pdf

This book is a comprehensive review and analysis of the origin, development and use of the most effective drug treatment for malaria in Africa.

Author : Jack M. Roe
Publisher : Nova Science Publishers
Page : 122 pages
File Size : 40,8 Mb
Release : 2020
Category : Science
ISBN : 1536181013

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Artemisia by Jack M. Roe Pdf

"Artemisia: Classification, Cultivation and Uses reviews the fundamental traits that make A. monosperma a keystone species in sandy ecosystems, as well as the current experiences in A. monosperma management. Following this, the authors investigate the biological interactions of flavonoids and artemisinin and its derivatives, possibly leading to synergistic effects and consequently enhanced effectiveness in the treatment of cancer. The concluding study outlines the main dependencies obtained from plant development, morphogenesis, physiological status and the profile of essential oils and non-volatile phenolics accumulated"--

Author : Tilahun Hailu,Elias Gebremariam,Balcha Abera
Publisher : LAP Lambert Academic Publishing
Page : 80 pages
File Size : 53,7 Mb
Release : 2012
Category : Electronic
ISBN : 3838379330

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Micropropagation of Artemisia Annua Anamed by Tilahun Hailu,Elias Gebremariam,Balcha Abera Pdf

Artemisia annua is a highly demanded medicinal herb. It is a crop for the production of artemisinin, an important natural sesquiterpene lactone with anti-malarial effect against susceptible and multi-drug resistant Plasmodium species. A-3 is a hybrid cultivar that has been organically grown on ANAMED farm in Germany and contains 20 times more the usual content (0.01-0.42% of dry mass) of artemisinin in wild type. It is especially important for the natural treatment of malaria, because it is adapted for the warmer climates where malaria is endemic. This book could serve an indispensible input to advanced students in the field of Plant Bio-technology, Botanical Sciences, Horticulture etc. and commercial growers as well as pharmaceutical firms as it provides the reader with efficient and reproducible in vitro techniques and procedures (protocol) that enables large scale production of plant materials true-to-type for anamed (A-3) cultivar of A. annua. Packed with compelling pictures and tables it offers up to date comprehensive information on origin and distribution, botany, medicinal importance and propagation (conventional propagation and micropropagation) of the plant.

Author : Merlin Willcox,Gerard Bodeker,Philippe Rasoanaivo,Jonathan Addae-Kyereme
Publisher : CRC Press
Page : 464 pages
File Size : 44,6 Mb
Release : 2004-06-28
Category : Health & Fitness
ISBN : 9780203502327

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Traditional Medicinal Plants and Malaria by Merlin Willcox,Gerard Bodeker,Philippe Rasoanaivo,Jonathan Addae-Kyereme Pdf

Malaria is an increasing worldwide threat, with more than three hundred million infections and one million deaths every year. The worlds poorest are the worst affected, and many treat themselves with traditional herbal medicines. These are often more available and affordable, and sometimes are perceived as more effective than conventional antimala

Author : Ákos Máthé,Irfan Ali Khan
Publisher : Springer Nature
Page : 305 pages
File Size : 55,8 Mb
Release : 2023-12-02
Category : Science
ISBN : 9783031449147

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Medicinal and Aromatic Plants of India Vol. 2 by Ákos Máthé,Irfan Ali Khan Pdf

This book is the 9th volume in the series Medicinal and Aromatic Plants of the World. India being one of the countries with the longest and richest past/present/future of Medicinal and Aromatic Plant (MAP) production and utilization has accumulated more than sufficient knowledge to fill two volumes. This is shown by the vivid interest of Indian colleagues to contribute. Similar to the previous volumes, this one deals with the various important aspects (from botanical through phytochemical to pharmacological) of MAPs', famous or simply known of India. Scientific and technological achievements will be equally presented. In addition to the first volume, India V1, this volume is aimed to look carefully at our present knowledge of this vas interdisciplinary domain with an Indian focus. In the era of global climate change and pandemics, building on the huge Indian traditions, this book is expected to make an important contribution to the better knowledge and understanding of MAPs.

Author : Mansour Ghorbanpour,Ajit Varma
Publisher : Springer
Page : 413 pages
File Size : 42,6 Mb
Release : 2017-10-31
Category : Medical
ISBN : 9783319687179

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Medicinal Plants and Environmental Challenges by Mansour Ghorbanpour,Ajit Varma Pdf

This book sheds new light on the role of various environmental factors in regulating the metabolic adaptation of medicinal and aromatic plants. Many of the chapters present cutting-edge findings on the contamination of medicinal plants through horizontal transfer, as well as nanomaterials and the biosynthesis of pharmacologically active compounds. In addition, the book highlights the impacts of environmental factors (e.g., high and low temperature, climate change, global warming, UV irradiation, intense sunlight and shade, ozone, carbon dioxide, drought, salinity, nutrient deficiency, agrochemicals, waste, heavy metals, nanomaterials, weeds, pests and pathogen infections) on medicinal and aromatic plants, emphasizing secondary metabolisms. In recent years, interest has grown in the use of bioactive compounds from natural sources. Medicinal and aromatic plants constitute an important part of the natural environment and agro-ecosystems, and contain a wealth of chemical compounds known as secondary metabolites and including alkaloids, glycosides, essential oils and other miscellaneous active substances. These metabolites help plants cope with environmental and/or external stimuli in a rapid, reversible and ecologically meaningful manner. Additionally, environmental factors play a crucial role in regulating the metabolic yield of these biologically active molecules. Understanding how medicinal plants respond to environmental perturbations and climate change could open new frontiers in plant production and in agriculture, where successive innovation is urgently needed due to the looming challenges in connection with global food security and climate change. Readers will discover a range of revealing perspectives and the latest research on this vital topic.

Author : Toshiyuki Nagata,Yutaka Ebizuka
Publisher : Springer Science & Business Media
Page : 364 pages
File Size : 53,7 Mb
Release : 2013-11-11
Category : Science
ISBN : 9783662086162

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Medicinal and Aromatic Plants XII by Toshiyuki Nagata,Yutaka Ebizuka Pdf

Medicinal and Aromatic Plants XII comprises 18 chapters. It deals with the distribution, importance, conventional propagation, micropropagation, tissue culture studies, and the in vitro production of important medicinal and pharmaceutical compounds in the following plants: Artemisia annua, Coriandrum sativum, Crataegus, Dionaea muscipula, Hyoscyamus reticulatus, Hypericum canariense, Leguminosae, Malva, Ocimum, Pergularia tomentosa, Phellodendron amurense, Sempervivum, Solanum aculeatissimum, S. chrysotrichum, S. kasianum, Stephania, Trigonella, and Vaccinium. It is tailored to the needs of advanced students, teachers, and research scientists in the fields of pharmacy, plant tissue culture, phytochemistry, biomedical engineering, and plant biotechnology in general.