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Artificial Cells, Cell Engineering and Therapy by S Prakash Pdf
Artificial cells, cell engineering and therapy are emerging technologies which will make a significant impact on the future of medicine and healthcare. However, research within the field is vast. This unique book provides a comprehensive study of the most recent advances in the field and its practical applications. The first part of the book offers the reader an introduction to the basics of artificial cell technology with chapters on its origins, design, current status within medicine and future prospects. Part two covers apoptosis, the use of bone marrow stromal cells in myocardial regeneration together with signalling and tissue engineering. Part three discusses artificial cells for therapy, procedures for various clinical conditions and the current status of the discipline within the field. The book concludes with a final section on the role of artificial cells in medicine with particular focus on the use of artificial cells as blood substitutes and their potential use in myocardial regeneration, drug delivery and in treating kidney and bowel diseases, diabetes and cancer. Artificial cells, cell engineering and therapy is a valuable reference for researchers, students and practitioners within the field. Introduces the basics of artificial cell technology Provides a comprehensive study of the most recent advances in artificial cells, cell engineering and cell therapy Discusses the design, engineering and uses of artificial cells
This is the first book that provides a comprehensive review of the entire area of artificial cells. The author, a pioneer of the field, invented the first artificial cells some 50 years ago and has continued to carry out active research in this field. Since then, there have been explosive research activities around the world on artificial cells, especially in fields related to biotechnology, nanomedicine, cell therapy, blood substitutes, drug delivery and others. However, instead of the term ?artificial cells,? many authors use other terminologies such as blood substitutes, bioencapsulation, liposomes, nanoparticles and so on. Furthermore, papers in this highly interdisciplinary area are published in numerous journals specializing in chemistry, medicine, surgery, bioengineering and others, while books in this area are mostly multi-authored, describing very specific and narrow areas. As a result, any meaningful literature search for a complete idea of the present status of the whole field of artificial cells is impossible. This monograph is written to fill this gap by including all those areas in artificial cells that are disguised under different terminologies. Each chapter begins with a detailed overview, followed by detailed examples of the author's own research and a full description of his methods and procedures. Readers interested in a detailed overview of the whole area can read from cover to cover, omitting the methods section at the end of each chapter; while those entering this area of research will find the detailed methods and procedures very useful.
Author : Thomas Ming Swi Chang Publisher : Charles C. Thomas Publisher Page : 232 pages File Size : 46,6 Mb Release : 1972 Category : Science ISBN : UOM:39015004351121
The first part of the monograph is a consideration of the general characteristics of artificial cells and specific theoretical examples of artificial cell systems. This is followed by examples of typical preparative procedures which have been updated. The biophysical properties of artificial cells are characterized. They are then used in experiments designed to test some of the theoretical examples.
Selected Topics in Nanomedicine by Thomas Ming Swi Chang Pdf
Nanomedicine consists of the use of nanotechnology and nanobiotechnology in medicine. There have been extensive developments in the area of nanomedicine. The scope of this book is first to discuss the origin of nanomedicine. Following this, instead of a general overview of the whole area, 24 chapters on selected topics of important areas are described in detail. Authors are selected from around the world to give a representative and international view of the activities in the area of nanomedicine. Contents:Artificial Cells: The Beginning of Nanomedicine (Thomas Ming Swi Chang)The Clinical Development of Hemopure®: A Selective Commentary (A Gerson Greenburg)Glutaraldehyde Polymerized Porcine Hemoglobin: Preparation, Safety Evaluation and Pharmacodynamics Study (Chao Chen, Hongli Zhu and Kunping Yan)Evidence Regarding Some Pharmacologic Characteristics of Hemoglobin-Based Oxygen Carriers (Enrico Bucci)EAF PEG Hemoglobins: Novel Class of Nonhypertensive Resuscitation Fluids: Simplicity and Advantages of Extension Arm Chemistry for PEGylation (Seetharama A Acharya, Amy G Tsai and Marcos Intaglietta)Biocompatibility of a Highly Concentrated Fluid of Hemoglobin-Vesicles as a Transfusion Alternative (Hiromi Sakai)Molecular Basis of Haptoglobin and Hemoglobin Complex Formation and Protection against Oxidative Stress and Damage (Yiping Jia and Abdu I Alayash)Polynitroxylated Hemoglobin as a Multifunctional Therapeutic for Critical Care and Transfusion Medicine (Li Ma and Carleton Jen Chang Hsia)Surface-Mediated Drug Delivery (Benjamin M Wohl, Betina Fejerskov, Siow-Feng Chong and Alexander N Zelikin)Use of Tunable Pores for Accurate Characterization of Micro- and Nanoparticle Systems in Nanomedicine (James Eldridge, Aaron H Colby, Geoff R Willmott, Sam Yu and Mark W Grinstaff)Microfluidic Probes to Process Surfaces, Cells, and Tissues (Mohammad A Qasaimeh, Sebastien G Ricoult and David Juncker)Subcompartmentalized Systems Towards Therapeutic Cell Mimics (Leticia Hosta-Rigau and Brigitte Städler)Soft Magnetic Nanomaterials Towards Nanomedicine: Magnetism Principles, Preparation, Characterization and Potential Applications (G W Qin, S Li, Y P Ren, F Darain and K Dimitrov)GoldMag Composite Particles and Their Applications in Nanomedicine (Mingli Peng, Xu Chao, Chao Chen and Yali Cui)Nanoparticles for Imaging and Therapy: Functionalization, Endocytosis and Characterization (Yu Zhang, Yi Li, Gürer Budak, Mihrimah Ozkan and Cengiz S Ozkan)Noscapines: Novel Carrier Systems to Target Tumor Cells (Ramesh Chandra, J Madan, Prashant Singh, Pradeep Kumar, V Tomar, Sujata K Dass and Ankush Chandra)High-Throughput Methods for Miniaturization of Implantable Artificial Cells (Maryam Mobed-Miremadi)Amphiphilic Core–Shell Nanoparticles Containing Hairy Polyethyleneimine Shells as Effective Nanocarriers for Gene and siRNA Delivery (Pei Li, Yuen Shan Siu, Kin Man Ho and Wei Li)Nano-Chaperones: Nanoparticles Acting as Artificial Chaperones (S Boridy and D Maysinger)Bio-Functional Polymer Vesicles for Applications in Nanomedicine (Hans-Peter M de Hoog, Bo Liedberg and Madhavan Nallani)Carbon Nanotubes in Cancer and Stem Cell Therapeutics (Wei Shao, Arghya Paul and Satya Prakash)Chitosan-Based Nanocarriers for Efficient and Targeted siRNA Delivery (Surendra Nimesh and Ramesh Chandra)Application of Polyethylenimine-Based Nanoparticles for RNA Therapeutics (Surendra Nimesh and Ramesh Chandra)Nanosilver System Technology for Applications in Nanomedicine (Helmut Schmid) Readership: Graduate students and researchers in nanomedicine, nanobiotechnology, nanotechnology, biotechnology and biomedical engineering. Keywords:Nanomedicine;Nanobiotechnology;Nanotechnology;Blood Substitutes;Polyhemoglobin;Oxygen Therapeutics;Antioxidant;Oxygen Radicals;Regenerative Medicine;Nanocapsules;Nanoparticles;Bioencapsulation;Drug Delivery;Magnetic;Conjugated Hemoglobin;Enzymes;Cancer Therapy;Carbon Nanotubule;Microfluidics;Blood;Transfusion;Polyethylene Glycol;Liposome;Polymersomes;Oxidative Stress;Artificial Cells
This is the first book that provides a comprehensive review of the entire area of artificial cells. The author, a pioneer of the field, invented the first artificial cells some 50 years ago and has continued to carry out active research in this field. Since then, there have been explosive research activities around the world on artificial cells, especially in fields related to biotechnology, nanomedicine, cell therapy, blood substitutes, drug delivery and others. However, instead of the term ?artificial cells,? many authors use other terminologies such as blood substitutes, bioencapsulation, liposomes, nanoparticles and so on. Furthermore, papers in this highly interdisciplinary area are published in numerous journals specializing in chemistry, medicine, surgery, bioengineering and others, while books in this area are mostly multi-authored, describing very specific and narrow areas. As a result, any meaningful literature search for a complete idea of the present status of the whole field of artificial cells is impossible.This monograph is written to fill this gap by including all those areas in artificial cells that are disguised under different terminologies. Each chapter begins with a detailed overview, followed by detailed examples of the author's own research and a full description of his methods and procedures. Readers interested in a detailed overview of the whole area can read from cover to cover, omitting the methods section at the end of each chapter; while those entering this area of research will find the detailed methods and procedures very useful.
Author : Thomas Ming Swi Chang,Binglan Yu Publisher : Frontiers Media SA Page : 148 pages File Size : 50,8 Mb Release : 2023-11-28 Category : Medical ISBN : 9782832540022
Innovative Medical Technology Based on Artificial Cells, Including its Different Configurations by Thomas Ming Swi Chang,Binglan Yu Pdf
Artificial Cells are not to reproduce biological cells but to prepare an artificial system for possible uses in medicine and other areas. Many of the ideas on artificial cells are being extensively applied and extended by researchers worldwide, resulting in rapid and exciting progress and discoveries. Different configurations include using emulsion methods and microfluidizers to form microscopic or nano dimension cells called artificial cells, synthetic cells, microcapsules, nanocapsules, liposomes, microparticles, nanoparticles, polymersomes, etc. Macro dimensions artificial cells are used for bioencapsulated cells. Soluble nanobiotherapeutics can be formed by crosslinking proteins and enzymes or by PEG conjugation. The principle of artificial cell has now evolved into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, cell/stem cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic cells, cell encapsulation, biosorbent/immunosorbent hemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, COVID_19 vaccine, COVID_19 therapy, nanobiotechnology, nanotechnology and other areas.
Teams of scientists around the world are racing to create protocells--microscopic, self-organizing entities that spontaneously assemble from simple organic and inorganic materials. The creation of fully autonomous protocells--a technology that can, for all intents and purposes, be considered literally alive--is only a matter of time. This book examines the pressing social and ethical issues raised by the creation of life in the laboratory. Protocells might offer great medical and social benefits and vast new economic opportunities, but they also pose potential risks and threaten cultural and moral norms against tampering with nature and "playing God." The Ethics of Protocells offers a variety of perspectives on these concerns.
Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomes Highlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development
Microcapsules and Nanoparticles in Medicine and Pharmacy by Max Donbrow Pdf
First published in 1992: This book provides a comprehensive look at the design and production of microcapsules, microspheres, and nanoparticles. It discusses the diverse aspects and skills that must be mastered to prepare and test products that will work correctly and be clinically acceptable for human or animal use.
Cell Encapsulation Technology and Therapeutics by Willem_M. Kühtreiber,Robert P. Lanza,William L. Chick Pdf
The concept of using encapsulation for the immunoprotection of transplanted cells was introduced for the first time in the 1960s. "[Microencapsulated cells] might be protected from destruction and from partici pation in immunological processes, while the enclosing membrane would be permeable to small molecules of specific cellular product which could then enter the general extracellular compartment of the recipient. For instance, encapsulated endocrine cells might survive and maintain an effective supply of hormone." (Chang, Ph. D. Thesis, McGill University, 1965; Chang et aI., Can J Physiol PharmacoI44:115-128, 1966). We asked Connaught Laboratories, Ltd., in Toronto to put this concept into practice. In 1980, Lim and Sun from Connaught Laboratories reported on the successful implantation of poly-I-Iysine-alginate encapsu lated rat islets into a foreign host. [Lim and Sun, Science 210:908-909, 1980]. Now many groups around the world are making tremendous progress in the encapsulation of a multitude of cell types. Kiihtreiber, Lanza, and Chick have invited many cell encapsulation groups from around the world to contribute to this book. The result is a very useful reference book in this rapidly growing area. With so many excellent au thors describing in detail the different areas of cell encapsulation, my role here will be to briefly discuss a few points.
This book describes advanced studies in cell-free synthetic biology, an emerging biotechnology that focuses on cell-free protein synthesis and cell-free systems for fundamental and industrial research in areas such as genetic circuit design, small-molecule synthesis, complicated-macromolecule synthesis, unnatural-macromolecule synthesis, high-throughput screening, artificial cells, and biomaterials. Cell-free synthetic biology is now an integral part of developing fields like nanotechnology, materials science, and personalized medicine. The book discusses the main research directions in the development of cell-free systems, as well as a number of applications of cell-free synthetic biology, ranging from structural biology to the human health industry. It is intended for students and researchers in life sciences, synthetic biology, bioengineering, and chemical engineering.
