Cell Encapsulation Technology And Therapeutics

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Cell Encapsulation Technology and Therapeutics

Willem_M. Kühtreiber,Robert P. Lanza,William L. Chick

Author : Willem_M. Kühtreiber,Robert P. Lanza,William L. Chick
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 54,7 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9781461215868

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Cell Encapsulation Technology and Therapeutics by Willem_M. Kühtreiber,Robert P. Lanza,William L. Chick Pdf

The concept of using encapsulation for the immunoprotection of transplanted cells was introduced for the first time in the 1960s. "[Microencapsulated cells] might be protected from destruction and from partici pation in immunological processes, while the enclosing membrane would be permeable to small molecules of specific cellular product which could then enter the general extracellular compartment of the recipient. For instance, encapsulated endocrine cells might survive and maintain an effective supply of hormone." (Chang, Ph. D. Thesis, McGill University, 1965; Chang et aI., Can J Physiol PharmacoI44:115-128, 1966). We asked Connaught Laboratories, Ltd., in Toronto to put this concept into practice. In 1980, Lim and Sun from Connaught Laboratories reported on the successful implantation of poly-I-Iysine-alginate encapsu lated rat islets into a foreign host. [Lim and Sun, Science 210:908-909, 1980]. Now many groups around the world are making tremendous progress in the encapsulation of a multitude of cell types. Kiihtreiber, Lanza, and Chick have invited many cell encapsulation groups from around the world to contribute to this book. The result is a very useful reference book in this rapidly growing area. With so many excellent au thors describing in detail the different areas of cell encapsulation, my role here will be to briefly discuss a few points.

Cell Encapsulation Technology and Therapeutics

Willem M. Kühtreiber,Robert Paul Lanza,William Louis Chick

Author : Willem M. Kühtreiber,Robert Paul Lanza,William Louis Chick
Publisher : Unknown
Page : 450 pages
File Size : 47,9 Mb
Release : 1999
Category : Animal cell biotechnology
ISBN : 376434010X

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Cell Encapsulation Technology and Therapeutics by Willem M. Kühtreiber,Robert Paul Lanza,William Louis Chick Pdf

Encapsulated cells offer enormous potential for the treatment of human disease. This work includes detailed descriptions of chemical properties of encapsulation materials, purification, biocompatibility issues and experimental protocols.

Therapeutic Applications of Cell Microencapsulation

Jose Luis Pedraz,Gorka Orive

Author : Jose Luis Pedraz,Gorka Orive
Publisher : Springer Science & Business Media
Page : 125 pages
File Size : 42,7 Mb
Release : 2010-12-31
Category : Medical
ISBN : 9781441957863

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Therapeutic Applications of Cell Microencapsulation by Jose Luis Pedraz,Gorka Orive Pdf

The advancement of science is ever more contingent upon the interaction of experts vast amount of scientific information being gathered every day that exceeds the ability of any one scientist to acquire. As an illustration of the frantic pace of scientific disc- more acute in the case of scientific fields at the interface of different and seemingly distant areas of study. Amidst these, the field of cell encapsulation brings together an array of diverse disciplines such as molecular biology and biopolymers, gene therapy and inorganic membranes, stem cell biology and physicochemistry, immunology and nanotechnology. Clearly, such range of topics is too broad for any individual scientist the state-of-the-art in the field of cell encapsulation. At the core of this technology, there is an interaction of physicochemical and biological elements forming three distinct layers of complexity. First, the chemistry of the biopolymer dictates the degree of protein adsorption, vascularization, tox- ity and biocompatibility of the microcapsules. Advances in biopolymer science are providing solutions to overcome existing challenges and to improve microcapsules as delivery vehicles. Second, the choice of cells, and more precisely the plethora of in determining the immune response elicited by the host to implanted microcapsules.

Bioencapsulation of Living Cells for Diverse Medical Applications

Eva Maria Brandtner,John Austin Dangerfield

Author : Eva Maria Brandtner,John Austin Dangerfield
Publisher : Bentham Science Publishers
Page : 195 pages
File Size : 54,7 Mb
Release : 2013-05-31
Category : Medical
ISBN : 9781608057207

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Bioencapsulation of Living Cells for Diverse Medical Applications by Eva Maria Brandtner,John Austin Dangerfield Pdf

Bioencapsulation (or microencapsulation) of cells and their implantation into a body of immunoprotected cells allows researchers to revive a missing or defective function in the cells. Microencapsulated cells have reached the clinic where they have been shown to be safe and efficacious in numerous clinical trials. Cell types that have been encapsulated for therapeutic purposes include hybridomas, islet cells, "platform" cell lines e.g. HEK293 and CHO cells as well as an increasing focus on the encapsulation of stem cells. This e-book explains the different methods used for achieving cell bioencapsulation based on different polymers e.g. alginate, cellulose sulphate and agarose. Other chapters in this book subsequently describe the use of cell encapsulation in cancer therapy to improve on existing chemotherapies by reducing doses and thus side effects while increasing efficacy for long term in vivo production of (i) tumoricidal or virus neutralising antibodies, (ii) insulin to achieve a self regulating treatment for diabetes and (iii) neuron nurturing factors to treat CNS diseases such as epilepsy, disorders like Parkinson's disease, Alzheimer, Amyotrophic lateral sclerosis, Huntington's disease and pathologies caused by trauma and/or ischemic processes. The book also includes a chapter reviewing the genetic engineering of cells to allow controlled production of biotherapeutics from encapsulated cells. This is a unique and timely book which brings together contributions from some of the leading researchers in the field of cell encapsulation. Interested readers are provided an overview of the exciting developments and clinical experiences of researchers with cell bioencapsulation.

Artificial Cells, Cell Engineering and Therapy

S Prakash

Author : S Prakash
Publisher : Elsevier
Page : 544 pages
File Size : 46,8 Mb
Release : 2007-05-31
Category : Science
ISBN : 9781845693077

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Artificial Cells, Cell Engineering and Therapy by S Prakash Pdf

Artificial cells, cell engineering and therapy are emerging technologies which will make a significant impact on the future of medicine and healthcare. However, research within the field is vast. This unique book provides a comprehensive study of the most recent advances in the field and its practical applications. The first part of the book offers the reader an introduction to the basics of artificial cell technology with chapters on its origins, design, current status within medicine and future prospects. Part two covers apoptosis, the use of bone marrow stromal cells in myocardial regeneration together with signalling and tissue engineering. Part three discusses artificial cells for therapy, procedures for various clinical conditions and the current status of the discipline within the field. The book concludes with a final section on the role of artificial cells in medicine with particular focus on the use of artificial cells as blood substitutes and their potential use in myocardial regeneration, drug delivery and in treating kidney and bowel diseases, diabetes and cancer. Artificial cells, cell engineering and therapy is a valuable reference for researchers, students and practitioners within the field. Introduces the basics of artificial cell technology Provides a comprehensive study of the most recent advances in artificial cells, cell engineering and cell therapy Discusses the design, engineering and uses of artificial cells

Functional Biopolymers

Mohammad Abu Jafar Mazumder,Heather Sheardown,Amir Al-Ahmed

Author : Mohammad Abu Jafar Mazumder,Heather Sheardown,Amir Al-Ahmed
Publisher : Springer
Page : 0 pages
File Size : 55,6 Mb
Release : 2019-04-12
Category : Technology & Engineering
ISBN : 3319959891

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Functional Biopolymers by Mohammad Abu Jafar Mazumder,Heather Sheardown,Amir Al-Ahmed Pdf

This reference work offers a comprehensive overview of the synthesis, properties and biomedical applications of functional biopolymers. Chapters from expert contributors cover topics such as synthetic biopolymers, blood-compatible polymers, ophthalmic polymers and stimuli responsive polymers. An up-to-date review of cell encapsulation strategies and cell surface and tissue engineering is also included in this work, and readers will discover more about hydrogels and polymers from renewable resources. Edited by an international team of experts in the field, this reference work will appeal to researchers, scientists, and practitioners working in this field, or entering this vibrant research area.

Cell Microencapsulation

Emmanuel C. Opara

Author : Emmanuel C. Opara
Publisher : Humana
Page : 0 pages
File Size : 46,9 Mb
Release : 2016-10-14
Category : Science
ISBN : 1493963627

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Cell Microencapsulation by Emmanuel C. Opara Pdf

This volume provides a unique forum to review cell microencapsulation in a broad sense by exploring various cell types that have been encapsulated for different purposes, different approaches and devices used for microencapsulation, the biomaterials used in cell microencapsulation, the challenges to the technology, and the current status of its application in different clinical situations. This book is divided in five sections: Section I is an introductory part that discusses historical developments of the technology and its current challenges, as well as the various applications of cell microencapsulation; Section II discusses the main approaches and devices currently used in cell microencapsulation; Section III presents an overview of the various polymeric materials currently in use for cell microencapsulation and the enabling technologies to either monitor or enhance encapsulated cell function; Section IV gives specific examples of the methods used to encapsulate various cell types; and Section V provides an overview of the different clinical situations in which cell microencapsulation has been applied. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Cell Microencapsulation: Methods and Protocols is a valuable reference for researchers, engineers, clinicians, and other healthcare professionals, as well as food technologists who will find detailed descriptions of methods for the microencapsulation of specific cell types and their current of potential clinical and industrial applications. This volume also includes detailed information about the design and manufacture of different devices including large-scale production devices for use in cell microencapsulation.

Nano- and Microencapsulation

Nedal Abu-Thabit

Author : Nedal Abu-Thabit
Publisher : BoD – Books on Demand
Page : 292 pages
File Size : 50,5 Mb
Release : 2021-01-27
Category : Science
ISBN : 9781839683480

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Nano- and Microencapsulation by Nedal Abu-Thabit Pdf

Nano- or micro-encapsulation is used in many different fields and industries, including pharmaceuticals, cosmetics, food, and agrochemicals. It offers advantages for various applications, especially drug delivery. Nano-encapsulation can help extend and control the release of drugs as well as increase drug bioavailability and efficacy. It improves the precision of targeted drug delivery and allows for fabricating nano-encapsulated drugs for diagnostic and theranaostic applications. This book covers recent advances in fabricating nano-/micro-capsules using natural carriers for therapeutic and diagnostic drug delivery applications as well as rheology and formulations of micro-emulsions for diverse applications. This book is essential for scientists and researchers with diverse backgrounds in chemistry, engineering, material sciences, pharmaceuticals, and drug delivery.

Fundamentals of Cell Immobilisation Biotechnology

Viktor Nedovic,Ronnie Willaert

Author : Viktor Nedovic,Ronnie Willaert
Publisher : Springer Science & Business Media
Page : 542 pages
File Size : 54,5 Mb
Release : 2013-04-17
Category : Science
ISBN : 9789401716383

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Fundamentals of Cell Immobilisation Biotechnology by Viktor Nedovic,Ronnie Willaert Pdf

Cell Immobilisation Biotechnology Biotechnology is divided into two volumes. The first volume is dedicated to fundamental aspects of cell immobilisation while the second volume deals with the diverse applications of this technology. The first volume, Fundamentals of Cell Immobilisation Biotechnology, comprises 26 chapters arranged into four parts: Materials for cell immobilisation/encapsulation, Methods and technologies for cell immobilisation/encapsulation, Carrier characterisation and bioreactor design, and Physiology of immobilised cells: techniques and mathematical modelling.

Encapsulation of Active Molecules and Their Delivery System

Shirish Sonawane,Bharat A. Bhanvase,Manickam Sivakumar

Author : Shirish Sonawane,Bharat A. Bhanvase,Manickam Sivakumar
Publisher : Elsevier
Page : 379 pages
File Size : 54,6 Mb
Release : 2020-03-24
Category : Technology & Engineering
ISBN : 9780128193648

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Encapsulation of Active Molecules and Their Delivery System by Shirish Sonawane,Bharat A. Bhanvase,Manickam Sivakumar Pdf

Encapsulation of Active Molecules and Their Delivery System covers the key methods of preparation of encapsulation, as well as release mechanisms and their applications in food, biotechnology, metal protection, drug delivery, and micronutrients delivery in agriculture. The book also provides real-life examples of applications in food and other industries. Sections encompasses (i) Synthesis and characterization methods of micro- and nanocarriers as the delivery systems, (ii) Up-to-date encapsulation techniques in the areas of pharmaceuticals, nutraceuticals and corrosion, (iii) The release methods of the encapsulated materials, and (iv) Industry perspectives, including scale up of the processes. Focuses on encapsulation processes in chemical and materials engineering and biotechnology Provides a relevant resource for the pharmaceutical and food industries Presents wide coverage on the entrapment of molecules that scales-up to industrial sized needs

Cell Therapy

Dwaine F. Emerich,Gorka Orive

Author : Dwaine F. Emerich,Gorka Orive
Publisher : Springer
Page : 328 pages
File Size : 42,7 Mb
Release : 2017-08-25
Category : Medical
ISBN : 9783319571539

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Cell Therapy by Dwaine F. Emerich,Gorka Orive Pdf

This volume provides a comprehensive, state-of-the art review of the field of cell therapy. The volume begins with an overview of the breadth of the field and then turns to overviews of imaging technologies that can aid in both safety and efficacy evaluations. The book then turns to numerous contributions detailing the rapidly growing field of stem cell therapies. These sections cover our understanding of the natural roles of stem cells in biology and human disease and then touches on several of the more prominent areas where stem cells are moving rapidly into clinical evaluation including neurodegenerative diseases, muscular dystrophy, cardiac repair, and diabetes. The volume concludes with contributions from experts in oncology, ophthalmology, stem cells, 3-D printing, and biomaterials where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of transplanted and/or endogeneously mobilized cells. Finally, the book provides insights into the pivotal relationship between academic and industrial partnerships. This volume is designed to touch on the major areas where the field will make its greatest and most immediate clinical impacts. This text will provide a useful resource for physicians and researchers interested in the rapidly changing filed of cell therapy.

Immobilization of Enzymes and Cells

Jose M. Guisan

Author : Jose M. Guisan
Publisher : Humana
Page : 0 pages
File Size : 49,7 Mb
Release : 2016-08-27
Category : Science
ISBN : 1493959883

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Immobilization of Enzymes and Cells by Jose M. Guisan Pdf

For most of industrial applications, enzymes and cells have to be immobilized, via very simple and cost-effective protocols, in order to be re-used for very long periods of time. From this point of view, immobilization, simplicity and stabilization have to be strongly related concepts. The third edition of Immobilization of Enzymes and Cells expands upon and updates the previous editions with current, detailed protocols for immobilization. With new chapters on protocols for immobilization of enzymes and cells which may be useful to greatly improve the functional properties of enzymes and cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immobilization of Enzymes and Cells, Third Edition demonstrates simple and efficient protocols for the preparation, characterization, and utilization of immobilized enzymes and cells.

Immobilization of Enzymes and Cells

Jose M. Guisan,Juan M. Bolivar,Fernando López-Gallego,Javier Rocha-Martín

Author : Jose M. Guisan,Juan M. Bolivar,Fernando López-Gallego,Javier Rocha-Martín
Publisher : Humana
Page : 495 pages
File Size : 53,9 Mb
Release : 2021-01-29
Category : Science
ISBN : 1071602179

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Immobilization of Enzymes and Cells by Jose M. Guisan,Juan M. Bolivar,Fernando López-Gallego,Javier Rocha-Martín Pdf

This fourth edition volume expands on the previous editions with new insights on important aspects to take into accounting when immobilizing enzymes and cells, illustrating outstanding examples that support those aspects, and exploring ways to fabricate and characterize heterogeneous biocatalysts including both immobilized enzymes and cells. The transformation of soluble and usually instable enzymes into heterogeneous and highly stable biocatalysts is strongly emphasized. The chapters in this book cover topics such as the importance of enzyme orientation on the support surface; application and characterization of immobilized enzymes; different functionalization chemistries for the modulation of the immobilized enzyme properties; co-immobilization of multi-enzyme systems; new analytical techniques for the characterization of heterogeneous biocatalysts; protocols for cell entrapment in alginate; preparation and characterization of biofilms; and cell encapsulation technologies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Immobilization of Enzymes and Cells: Methods and Protocols, Fourth Edition is a valuable resource for researchers interested in expanding their knowledge of this developing field.

Nanotechnologies in Preventive and Regenerative Medicine

Vuk Uskokovic

Author : Vuk Uskokovic
Publisher : Elsevier
Page : 616 pages
File Size : 52,9 Mb
Release : 2017-11-22
Category : Medical
ISBN : 9780323480642

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Nanotechnologies in Preventive and Regenerative Medicine by Vuk Uskokovic Pdf

Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage Explains how nanomaterials can be manipulated to create more effective drug treatments Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments

Challenges in Delivery of Therapeutic Genomics and Proteomics

Ambikanandan Misra

Author : Ambikanandan Misra
Publisher : Elsevier
Page : 686 pages
File Size : 44,6 Mb
Release : 2010-09-09
Category : Science
ISBN : 9780123849656

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Challenges in Delivery of Therapeutic Genomics and Proteomics by Ambikanandan Misra Pdf

Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed

Cell Encapsulation Technology And Therapeutics

Cell Encapsulation Technology and Therapeutics by Willem_M. Kühtreiber,Robert P. Lanza,William L. Chick Pdf

Cell Encapsulation Technology and Therapeutics by Willem M. Kühtreiber,Robert Paul Lanza,William Louis Chick Pdf

Therapeutic Applications of Cell Microencapsulation by Jose Luis Pedraz,Gorka Orive Pdf

Bioencapsulation of Living Cells for Diverse Medical Applications by Eva Maria Brandtner,John Austin Dangerfield Pdf

Artificial Cells, Cell Engineering and Therapy by S Prakash Pdf

Functional Biopolymers by Mohammad Abu Jafar Mazumder,Heather Sheardown,Amir Al-Ahmed Pdf

Cell Microencapsulation by Emmanuel C. Opara Pdf

Nano- and Microencapsulation by Nedal Abu-Thabit Pdf

Fundamentals of Cell Immobilisation Biotechnology by Viktor Nedovic,Ronnie Willaert Pdf

Encapsulation of Active Molecules and Their Delivery System by Shirish Sonawane,Bharat A. Bhanvase,Manickam Sivakumar Pdf

Cell Therapy by Dwaine F. Emerich,Gorka Orive Pdf

Immobilization of Enzymes and Cells by Jose M. Guisan Pdf

Immobilization of Enzymes and Cells by Jose M. Guisan,Juan M. Bolivar,Fernando López-Gallego,Javier Rocha-Martín Pdf

Nanotechnologies in Preventive and Regenerative Medicine by Vuk Uskokovic Pdf

Challenges in Delivery of Therapeutic Genomics and Proteomics by Ambikanandan Misra Pdf

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