Atherosclerosis And Oxidant Stress A New Perspective
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Author : Jordan L Holtzman Publisher : Springer Science & Business Media Page : 247 pages File Size : 51,9 Mb Release : 2007-09-26 Category : Medical ISBN : 9780387723471
Atherosclerosis and Oxidant Stress: A New Perspective by Jordan L Holtzman Pdf
Vascular injury is initiated by oxidant injury to the vessel wall. This volume is organized around the role of oxidant damage in this disease process and provides a collection of the most recent studies, representing various disciplines that can serve as the basis for further improvements in our understanding and control of cardiovascular and cerebral vascular disease.
Author : John F. Keaney Jr. Publisher : Springer Science & Business Media Page : 373 pages File Size : 43,5 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461546498
Oxidative Stress and Vascular Disease by John F. Keaney Jr. Pdf
One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.
Oxidative Stress in Heart Diseases by Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit Pdf
This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.
Author : Robert Fitridge,M. M. Thompson Publisher : University of Adelaide Press Page : 589 pages File Size : 55,6 Mb Release : 2011 Category : Medical ISBN : 9781922064004
Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Biomechanics of Coronary Atherosclerotic Plaque by Anonim Pdf
Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient, First Edition, is the first comprehensive text to focus on important biomechanical studies conducted in the last decade that have increased our understanding of coronary atherosclerotic plaque initiation, growth, and rupture, as well as improving the design of medical devices and clinical interventions, including surgical procedures. The book provides students, researchers, engineers, clinicians, and interventional cardiologists with an overview of the main topics related to the biomechanics of atherosclerosis, in a single volume written by several experts in the field. This volume is part of the Biomechanics of Living Organs book series. The biomechanics of human soft tissues and organs has been an emerging research field since the publication of Y.C. Fung’s original book series in the 1990s. The publication of such books entirely dedicated to a specific biomechanical subject is necessary to advance scientific research in the field of biomechanics and to transfer important knowledge to future generations. Therefore, this series of volumes on the biomechanics of living organs has been created. This series began in July 2017 with the publication of a first volume on the fundamentals of Hyperelastic Constitutive Laws for Finite Element Modeling of Living Organs. The current volume on the Biomechanics of Coronary Atherosclerotic Plaque, is the latest in this new series. Presents the main computational fluid dynamic studies performed, describing blood flow in healthy and pathological artery branches, including in coronary bifurcations Highlights the correlation between plaque initiation regions and blood shear stress amplitude Discusses the main biomechanical and mechanobiological models to highlight the importance of quantifying the residual and peak cap stresses and the presence of μ-calcifications to evaluate the risk of plaque rupture Introduces the most recent intravascular imaging biomarker techniques (elastography, palpography and modulography)
Textbook of Vascular Medicine by Rhian M. Touyz,Christian Delles Pdf
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Oxidative Stress in Aging by Satomi Miwa,Kenneth Bruce Beckman,Florian Muller Pdf
Human aging is a complex phenomenon. This state-of-the-art book discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed.
Computational Modeling in Biomechanics by Suvranu De,Farshid Guilak,Mohammad Mofrad Pdf
Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.
Author : John F. Keaney Jr. Publisher : Springer Science & Business Media Page : 404 pages File Size : 53,9 Mb Release : 1999-12-31 Category : Medical ISBN : 0792386787
Oxidative Stress and Vascular Disease by John F. Keaney Jr. Pdf
One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.
Author : Jack L. Cronenwett,K. Wayne Johnston Publisher : Elsevier Health Sciences Page : 3288 pages File Size : 51,6 Mb Release : 2014-03-12 Category : Medical ISBN : 9780323243063
Rutherford's Vascular Surgery E-Book by Jack L. Cronenwett,K. Wayne Johnston Pdf
Published in association with the Society for Vascular Surgery, Rutherford’s Vascular Surgery presents state-of-the-art updates on all aspects of vascular health care. Extensively revised by many new authors to meet the needs of surgeons, interventionalists, and vascular medicine specialists, this medical reference book incorporates medical, endovascular and surgical treatment, as well as diagnostic techniques, decision making and fundamental vascular biology. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more. View clinical and physical findings and operative techniques more vividly with a full-color layout and images. Get answers you can depend on. Rutherford's delivers the world’s most trusted information on all major areas of vascular health care, is written by international experts, and includes up-to-date bibliographies and annotated recommended references. Discover emerging techniques in rapidly advancing topics, with special emphasis on endovascular coverage, vascular imaging, angiography, CT and MRI. Explore brand new chapters on dialysis catheters, renovascular disease, and management of branches during endovascular aneurysm. Stay up-to-date with the latest coverage of endovascular procedures that reflects the changing practices and techniques in vascular surgery. Access videos at Expert Consult.
Author : Jack L. Cronenwett,K. Wayne Johnston Publisher : Elsevier Health Sciences Page : 8124 pages File Size : 51,6 Mb Release : 2010-03-09 Category : Medical ISBN : 9781455706327
Rutherford's Vascular Surgery, 2-Volume Set by Jack L. Cronenwett,K. Wayne Johnston Pdf
Rutherford's Vascular Surgery - the most acclaimed comprehensive reference in its field - presents definitive, state-of-the-art guidance on every aspect of vascular health care, equipping you to make the best clinical decisions and optimize outcomes. Extensively revised by many new, international authors - led by Drs. Jack Cronenwett and K. Wayne Johnston - and now published in association with the Society for Vascular Surgery, this 7th Edition provides the authoritative answers that surgeons, interventionalists, and vascular medicine specialists need to provide effective care for vascular surgery patients. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you’re using or where you’re located. Get answers you can depend on. Now published in association with the Society for Vascular Surgery, Rutherford's delivers the world’s most trusted information on all major areas of vascular health care, written by international experts, with up-to-date bibliographies and annotated recommended references. Overcome any clinical challenge with in-depth sections on Fundamental Considerations, Patient Evaluation, Atherosclerotic Risk Factors, Perioperative Care, Bleeding and Clotting, Complications, Venous Disease, Lymphedema, Arteriovenous Anomalies, Hemodialysis Access, Miscellaneous Technique, Grafts and Devices, Cerebrovascular Disease, Lower Extremity Arterial Disease, Upper Extremity Arterial Disease, Arterial Aneurysms, Renal and Mesenteric Disease, and Trauma and Acute Limb Ischemia. Choose the best management option for each patient with discussions of operative, endovascular, and non-operative approaches for vascular conditions. Access the complete contents of Rutherford's Vascular Surgery online at www.expertconsult.com - with monthly updates from the Journal of Vascular Surgery and the European Journal of Vascular and Endovascular Surgery, plus videos of procedures, an image library, review questions, and more. Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more. View clinical and physical findings and operative techniques more vividly with a new full-color layout and more full-color images.
Textbook of Cardiology: a Clinical and Historical Perspective by H. K. Chopra,Navin C. Nanda Pdf
Performedin the cardiac catheterization laboratory is also included in this section. The next section deals with all aspects of cardiac surgery. Surgery for ischemic heart disease, valve surgery, aortic surgery, robotically assisted cardiac surgery, surgery for congenital heart disease and cardiac transplantation are covered by well-known experts. The last section points to expected refinements and future developments in cardiology, such as stem cell therapy, newer thrombolytics, new frontiers in balloon valvotomy and cardiac transplantation and artificial hearts. This book includes more than 300 full coloured images and illustration. It can be used as a reference book in every library, hospitals, medical colleges and research institutions.
Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.
Molecular Mechanisms of Atherosclerosis by Joseph Loscalzo Pdf
Atherosclerosis is the most common cardiovascular disorder in western societies and is rapidly becoming similarly prevalent in the underdeveloped world. Written by notable authorities and providing text rich in illustrative figures, Molecular Mechanisms in Atherosclerosis addresses the fundamental mechanisms underlying atherothrombosis and delineat
Nutraceuticals: New Perspectives and Approaches in Human Health and Disease by Antimo Cutone,Maria Carmela Bonaccorsi Di Patti,Luigi Rosa,Vadim B. Vasilyev Pdf