Autocrine And Paracrine Mechanisms In Reproductive Endocrinology

Author : L. Krey
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 40,8 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781468457513

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Autocrine and Paracrine Mechanisms in Reproductive Endocrinology by L. Krey Pdf

There is a prov1s10n in the charter of each Study Section of the Division of Research Grants at the National Institutes of Health that stipulates that "workshops" are to be held periodically to aid Study Section members in their appraisals of recent developments in their fields and to identify future challenges worthy of investigation. The Reproductive Endocrinology Study Section was established on December 13, 1985 to review research grants and research training activities relating to reproductive endocrinology, including aspects of management of reproductive endocrine disorders and hormonal imbalances as related to infertility and during pregnancy and puberty, breast cancer and prostate cancer. It held its first workshop, entitled, "Autocrine and Paracrine Mechanisms in Reproductive Endocrinology," in October, 1988 in Shrewsbury, MA at The Worcester Foundation for Experimental Biology. The proceedings of this workshop, which are detailed herein, reflect the fact that autocrine and paracrine interactions are rapidly being accepted as an exciting area of research by scientists investigating the physiological and biochemical mechanisms of hormone action in the male and female reproductive systems. The material covered is novel and wide-ranging, extending from theoretical considerations of mechanisms of growth factor action and the role of cell cycle stage in determining hormone action to investigations of autocrine and paracrine interactions during development to discussions of the potential clinical ramifications of the basic research findings. Such an extensive inventory is necessary for two reasons.

Author : S.S. Nussey,S.A. Whitehead
Publisher : CRC Press
Page : 382 pages
File Size : 46,7 Mb
Release : 2001-06-15
Category : Medical
ISBN : 0203450434

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Endocrinology by S.S. Nussey,S.A. Whitehead Pdf

Traditionally, endocrinology textbooks have been either short notes or multi-author, multi-volume monster, all of which present clinical material last and often only briefly. Endocrinology is different and used real cases to lead readers into the text and then describes the biochemistry, physiology, and anatomy they need to understand the case. The

Author : Tracey J. Woodruff,Sarah J. Janssen,Louis J. Guillette, Jr,Linda C. Giudice
Publisher : Cambridge University Press
Page : 262 pages
File Size : 52,5 Mb
Release : 2010-01-28
Category : Medical
ISBN : 0521519527

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Environmental Impacts on Reproductive Health and Fertility by Tracey J. Woodruff,Sarah J. Janssen,Louis J. Guillette, Jr,Linda C. Giudice Pdf

Many reproductive and developmental health problems are caused by exposure to chemicals that are widely dispersed in our environment. These problems include infertility, miscarriage, poor pregnancy outcomes, abnormal fetal development, early puberty, endometriosis, and diseases and cancers of reproductive organs. The compelling nature of the collective science has resulted in recognition of a new field of environmental reproductive health. Focusing on exposures to environmental contaminants, particularly during critical periods in development and their potential effects on all aspects of future reproductive life-course, this book provides the first comprehensive source of information bringing together the arguments that are spread out among various scientific disciplines in environmental health, clinical and public health fields. It provides a review of the science in key areas of the relationship between environmental contaminants and reproductive health outcomes, and recommendations on efforts toward prevention in clinical care and public policy.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1032 pages
File Size : 42,7 Mb
Release : 1990
Category : Medicine
ISBN : MINN:31951D00422787B

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1024 pages
File Size : 40,8 Mb
Release : 2024-07-01
Category : Medicine
ISBN : UOM:39015020571850

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Current Catalog by National Library of Medicine (U.S.) Pdf

First multi-year cumulation covers six years: 1965-70.

Author : Felice Petraglia,Bart C. Fauser
Publisher : Springer
Page : 0 pages
File Size : 50,9 Mb
Release : 2020-05-29
Category : Medical
ISBN : 3030147819

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Female Reproductive Dysfunction by Felice Petraglia,Bart C. Fauser Pdf

Written by leading international specialists, this book provides a comprehensive, state-of-the-art overview of endocrine-based female reproductive disorders. Particularly focusing on the Hypothalamus – Pituitary – Ovary (HPO) axis as the main driver of reproduction in women, it discusses amenorrhea; chronic anovulation and polycystic ovary syndrome as the most common dysfunctions of the HPO axis; endocrine diseases as possible impacts on the HPO axis; uterine disorders related to estrogen/progesterone; and the impact of endometriosis and uterine fibroids on reproduction. It also addresses infertility and menopause as hormone-related disorders in women and endocrine changes during pregnancy and lactation, and in breast disorders. The book is intended as a major reference for endocrinologists, gynecologists, and obstetricians, as well as basic and clinical scientists. It is published as part of the SpringerReference program, which provides access to live editions constantly updated through a dynamic peer-review publishing process.

Author : Stanley R. Glasser,Joy Mulholland,Alexandre Psychoyos
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 53,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461518815

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Endocrinology of Embryo—Endometrium Interactions by Stanley R. Glasser,Joy Mulholland,Alexandre Psychoyos Pdf

Early embryonic loss is a continuing social and economic global problem. In human populations the estimates of interruptions early in pregnancy range from 35-60%. In animal husbandry (swine, ruminants) fully 30% of pregnancies fail to survive early events of gestation. The futility associated with this persistant high risk is even more unsettling because of advances made in assisted reproductive technology which, although this very selective methodology has added to our knowledge of embryo-endometrial interactions, has resulted in a birth rate of only 14%. These studies have instigated comparisons of the live relative contributions of the embryo and the uterus to the outcome of pregnancy. These analyses have shown that we have learned significantly less about the role of the uterus in deciding the outcome of either natural or assisted pregnancies. In 1979 a quotation by George Corner was used to set the tone of a meeting that was devoted to discussion of the cellular and molecular aspects of implantation. In spite of the proliferation in research activity which occurred in the following 15 years our real understanding of the embryo transfer process has fallen short of our expectations. We use the Corner quotation, once again, to preface this symposium so that we may recall that the fundamental nature of the process which regulates embryo-endometrial interactions still escapes us.

Author : Henry G. Burger,David M. De Kretser
Publisher : Raven Press (ID)
Page : 616 pages
File Size : 55,9 Mb
Release : 1989
Category : Testicular Diseases
ISBN : UCAL:B5036493

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The Testis by Henry G. Burger,David M. De Kretser Pdf

Author : Roger L. Lundblad,Fiona Macdonald
Publisher : CRC Press
Page : 1098 pages
File Size : 55,8 Mb
Release : 2010-05-21
Category : Medical
ISBN : 9781466515154

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Handbook of Biochemistry and Molecular Biology, Fourth Edition by Roger L. Lundblad,Fiona Macdonald Pdf

Edited by renowned protein scientist and bestselling author Roger L. Lundblad, with the assistance of Fiona M. Macdonald of CRC Press, this fourth edition of the Handbook of Biochemistry and Molecular Biology represents a dramatic revision — the first in two decades — of one of biochemistry's most referenced works. This edition gathers a wealth of information not easily obtained, including information not found on the web. Offering a molecular perspective not available 20 years ago, it provides physical and chemical data on proteins, nucleic acids, lipids, and carbohydrates. Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the most frequently used data. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents. Just a small sampling of the wealth of information found inside the handbook: Buffers and buffer solutions Heat capacities and combustion levels Reagents for the chemical modification of proteins Comprehensive classification system for lipids Biological characteristics of vitamins A huge variety of UV data Recommendations for nomenclature and tables in biochemical thermodynamics Guidelines for NMR measurements for determination of high and low pKa values Viscosity and density tables Chemical and physical properties of various commercial plastics Generic source-based nomenclature for polymers Therapeutic enzymes About the Editors: Roger L. Lundblad, Ph.D. Roger L. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his PhD degree in biochemistry at the University of Washington. After postdoctoral work in the laboratories of Stanford Moore and William Stein at the Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill. He joined the Hyland Division of Baxter Healthcare in 1990. Currently Dr. Lundblad is an independent consultant and writer in biotechnology in Chapel Hill, North Carolina. He is an adjunct Professor of Pathology at the University of North Carolina at Chapel Hill and Editor-in-Chief of the Internet Journal of Genomics and Proteomics. Fiona M. Macdonald, Ph.D., F.R.S.C. Fiona M. Macdonald received her BSc in chemistry from Durham University, UK. She obtained her PhD in inorganic biochemistry at Birkbeck College, University of London, studying under Peter Sadler. Having spent most of her career in scientific publishing, she is now at Taylor and Francis and is involved in developing chemical information products.

Author : Jose M. Cuezva,Ana M. Pascual-Leone,Mulchand S. Patel
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 44,5 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781461595670

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Endocrine and Biochemical Development of the Fetus and Neonate by Jose M. Cuezva,Ana M. Pascual-Leone,Mulchand S. Patel Pdf

The annual meeting of the Perinatal Biochemical Group of the Spanish Biochemical Society held in Madrid on December 15-16, 1989, provided an excellent opportunity to bring together a group of distinguished investigators both from Spain and from abroad with a common interest in developmental endocrinology and biochemistry. The aim of the symposium was to present and discuss the most recent developments in the areas of endocrine and biochemical processes critical to normal growth and maturation of the newborn. To achieve a high degree of interaction among the participants, subject reviews as well as short communications were include in the program. The reviews provided in-depth information on selected important topics. The purpose of short communications was two fold: (i) to provide a forum to discuss on-going investigations on related areas; and (ii) to present opportunities for active participation by young investigators. This format proved very successful in generating fruitful discussions among the participants. Taken together the review chapters and the short communications have resulted in a coherent and unified subject presentation. Advances in biochemistry, molecular biology and cell biology have provided not only new and exciting experimental approaches but also have opened up new directions in the investigation of differentiation and developmental processes at cellular, molecular and biochemical levels during the early stages of growth and maturation. In recent years a wealth of information in these areas of development has emerged at a rapid rate.

Author : Adrienne Germain,King K. Holmes,Peter Piot,Judith Wasserheit
Publisher : Springer Science & Business Media
Page : 392 pages
File Size : 52,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489906915

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Reproductive Tract Infections by Adrienne Germain,King K. Holmes,Peter Piot,Judith Wasserheit Pdf

Reproductive tract infections (RTis) have become a silent epidemic that is devastating women's lives. Each year, thousands of women die needlessly from the consequences of these infections, including cervical cancer, ectopic pregnancy, acute and chronic infections of the uterus and the fallopian tubes, and puerperal infections. For many women, this happens because they receive medical attention too late, if at all. The terrible irony of this tragedy is that early diagnosis of and treatment for many RTis do not require high-technology health care. For the hundreds of millions of women with chronic RTis acquired from their sexual partners, life can become a living hell. Infection is a major cause of infertility, and it leads to scorn and rejection in many countries. These women may experience constant pain, have festering lesions of the genital tract, be at enhanced risk of second ary diseases, and endure social ostracism. The problems associated with RT!s have grown even greater in the past decade with the emergence of human immunodeficiency virus (HIV) and AIDS. Preexisting sexually transmitted disease, particularly when associated with genital tract ulcers, raises women's vulnerability to the transmission of HIV 3-5 fold.

Author : Lincoln C. Chen,Jaime Sepulveda Amor,Sheldon J. Segal
Publisher : Springer Science & Business Media
Page : 207 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461533542

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AIDS and Women’s Reproductive Health by Lincoln C. Chen,Jaime Sepulveda Amor,Sheldon J. Segal Pdf

Over the past decade, the AIDS pandemic has propagated so widely and exerted such a dev astating impact that one may properly ask the question, Why not concentrate all AIDS efforts on disease control alone? Why link AIDS with women's reproductive health? What is the scientific basis for this linkage? And how might AID~ control and women's health objectives be promot ed simultaneously? These questions constitute the principal themes addressed in this monograph. The 15 chapters in this volume are intended to provide state-of-the-art reviews of key interac tions between AIDS and women's reproductive health for an audience of scientists and policy makers in the AIDS and population fields. Impetus for this monograph comes in pan from what we perceive to be an inadequate global response, thus far, to AIDS and women's health ;>roblems. A common platform has failed to emerge among the disparate professional communities working in the areas of AIDS, STDs, and family planning. As a result, endeavors in these fields have been isolated, and opportunities for joint action have been missed. An enormous and, as yet, unharnessed potential exists for power ful interdisciplinary collaborations that could strengthen policies and programs against these pressing health problems of humankind.

Author : Jerome F. Strauss,Robert L. Barbieri,Antonio R. Gargiulo
Publisher : Elsevier Health Sciences
Page : 952 pages
File Size : 45,7 Mb
Release : 2017-12-23
Category : Medical
ISBN : 9780323582322

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Yen & Jaffe's Reproductive Endocrinology E-Book by Jerome F. Strauss,Robert L. Barbieri,Antonio R. Gargiulo Pdf

Now celebrating its 40th anniversary, Yen & Jaffe’s Reproductive Endocrinology, 8th Edition, by Drs. Jerome F. Strauss III, Robert L. Barbieri, and Antonio R. Gargiulo, keeps you up to date with the latest information on the diagnosis and management of the full range of female and male reproductive disorders. This cornerstone text thoroughly covers both basic science and clinical practice, making it a one-stop reference for all reproductive issues, including impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, and contraception. Every chapter has been completely revised and updated to reflect important changes in this fast-moving field. Provides the knowledge and expertise of global experts who draw on the latest developments in the field to keep you abreast of current science and practice in endocrinology. Coverage includes molecular, cellular, and genetic concepts and their relevance to pathophysiology, diagnosis, and therapy. Features new bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section.

Author : Andrew F. Olshan,Donald R. Mattison
Publisher : Springer Science & Business Media
Page : 401 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461518778

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Male-Mediated Developmental Toxicity by Andrew F. Olshan,Donald R. Mattison Pdf

The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.

Author : Jerome F. Strauss III,C.Richard Lyttle
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461533801

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Uterine and Embryonic Factors in Early Pregnancy by Jerome F. Strauss III,C.Richard Lyttle Pdf

Human reproduction is the most dynamic of processes. The events which lead to the birth of a normal healthy infant have their origin long before actual fertilization. Indeed, the whole process can be looked upon as a continuum. Human fertilization and early development, once sequestered in the protective environment of the fallopian tubes and uterus, have now been exposed in the laboratory. These events have, over time, been extensively observed and catalogued in animal models. The tools of modem morphology and molecular biology have reopened issues long since considered settled as facets of early reproduction are reexplored. This volume, consisting of the proceedings of a workshop on uterine and embryonic factors in early pregnancy, has been designed to enhance that effort. Attention is focused largely on early embryonal development with special attention to the interrelationship between the embryo and the uterus in early pregnancy. Each of the contributing scientists brings with him or her the perspective of one specific discipline or another. The common denominator is the application of emerging techniques in modem molecular biology to problems pertaining to embryonal-uterine interaction. The goal is to consider specific areas of concern in a multidisciplinary way and to reexplore the factors behind early development and implantation. Uterine complement, the function of uterine macrophages immunoregulatory loops in the peri-implantation period, colony stimulating factors and interferon-like factors are reviewed and their interrelationship explored. Uterine angiogenesis factors as well as embryonic growth factors are also considered.