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Background to Discovery recounts the great voyages of discovery, from Dampier to Cook, that excited such fervent political and popular interest in eighteenth-century Europe. Perhaps this book's greatest strength lies in its remarkable synthesis of both the achievements of European maritime exploration and the political, economic, and scientific motives behind it. Writing essays on the literary and artistic response to the voyages as well, the contributors collectively provide a rich source for historians, geographers, and anyone interested in the history of voyage and travel. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1990.
The Discovery of Global Warming by Spencer R. Weart Pdf
In 2001 a panel representing virtually all the world's governments and climate scientists announced that they had reached a consensus: the world was warming at a rate without precedent during at least the last ten millennia, and that warming was caused by the buildup of greenhouse gases from human activity. The consensus itself was at least a century in the making. The story of how scientists reached their conclusion--by way of unexpected twists and turns and in the face of formidable intellectual, financial, and political obstacles--is told for the first time in The Discovery of Global Warming. Spencer R. Weart lucidly explains the emerging science, introduces us to the major players, and shows us how the Earth's irreducibly complicated climate system was mirrored by the global scientific community that studied it. Unlike familiar tales of Science Triumphant, this book portrays scientists working on bits and pieces of a topic so complex that they could never achieve full certainty--yet so important to human survival that provisional answers were essential. Weart unsparingly depicts the conflicts and mistakes, and how they sometimes led to fruitful results. His book reminds us that scientists do not work in isolation, but interact in crucial ways with the political system and with the general public. The book not only reveals the history of global warming, but also analyzes the nature of modern scientific work as it confronts the most difficult questions about the Earth's future. Table of Contents: Preface 1. How Could Climate Change? 2. Discovering a Possibility 3. A Delicate System 4. A Visible Threat 5. Public Warnings 6. The Erratic Beast 7. Breaking into Politics 8. The Discovery Confirmed Reflections Milestones Notes Further Reading Index Reviews of this book: A soberly written synthesis of science and politics. --Gilbert Taylor, Booklist Reviews of this book: Charting the evolution and confirmation of the theory [of global warming], Spencer R. Weart, director of the Center for the History of Physics of the American Institute of Physics, dissects the interwoven threads of research and reveals the political and societal subtexts that colored scientists' views and the public reception their work received. --Andrew C. Revkin, New York Times Book Review Reviews of this book: It took a century for scientists to agree that gases produced by human activity were causing the world to warm up. Now, in an engaging book that reads like a detective story, physicist Weart reports the history of global warming theory, including the internal conflicts plaguing the research community and the role government has had in promoting climate studies. --Publishers Weekly Reviews of this book: It is almost two centuries since the French mathematician Jean Baptiste Fourier discovered that the Earth was far warmer than it had any right to be, given its distance from the Sun...Spencer Weart's book about how Fourier's initially inconsequential discovery finally triggered urgent debate about the future habitability of the Earth is lucid, painstaking and commendably brief, packing everything into 200 pages. --Fred Pearce, The Independent Reviews of this book: [The Discovery of Global Warming] is a well-written, well-researched and well-balanced account of the issues involved...This is not a sermon for the faithful, or verses from Revelation for the evangelicals, but a serious summary for those who like reasoned argument. Read it--and be converted. --John Emsley, Times Literary Supplement Reviews of this book: This is a terrific book...Perhaps the finest compliment I could give this book is to report that I intend to use it instead of my own book...for my climate class. The Discovery of Global Warming is more up-to-date, better balanced historically, beautifully written and, not least important, short and to the point. I think the [Intergovernmental Panel on Climate Change] needs to enlist a few good historians like Weart for its next assessment. --Stephen H. Schneider, Nature Reviews of this book: This short, well-written book by a science historian at the American Institute of Physics adds a serious voice to the overheated debate about global warming and would serve as a great starting point for anyone who wants to better understand the issue. --Maureen Christie, American Scientist Reviews of this book: I was very pleasantly surprised to find that Spencer Weart's account provides much valuable and interesting material about how the discipline developed--not just from the perspective of climate science but also within the context of the field's relation to other scientific disciplines, the media, political trends, and even 20th-century history (particularly the Cold War). In addition, Weart has done a valuable service by recording for posterity background information on some of the key discoveries and historical figures who contributed to our present understanding of the global warming problem. --Thomas J. Crowley, Science Reviews of this book: Weart has done us all a service by bringing the discovery of global warming into a short, compendious and persuasive book for a general readership. He is especially strong on the early days and the scientific background. --Crispin Tickell, Times Higher Education Supplement A Capricious Beast Ever since the days when he had trudged around fossil lake basins in Nevada for his doctoral thesis, Wally Broecker had been interested in sudden climate shifts. The reported sudden jumps of CO2 in Greenland ice cores stimulated him to put this interest into conjunction with his oceanographic interests. The result was a surprising and important calculation. The key was what Broecker later described as a "great conveyor belt'"of seawater carrying heat northward. . . . The energy carried to the neighborhood of Iceland was "staggering," Broecker realized, nearly a third as much as the Sun sheds upon the entire North Atlantic. If something were to shut down the conveyor, climate would change across much of the Northern Hemisphere' There was reason to believe a shutdown could happen swiftly. In many regions the consequences for climate would be spectacular. Broecker was foremost in taking this disagreeable news to the public. In 1987 he wrote that we had been treating the greenhouse effect as a 'cocktail hour curiosity,' but now 'we must view it as a threat to human beings and wildlife.' The climate system was a capricious beast, he said, and we were poking it with a sharp stick. I found the book enjoyable, thoughtful, and an excellent introduction to the history of what may be one of the most important subjects of the next one hundred years. --Clark Miller, University of Wisconsin The Discovery of Global Warming raises important scientific issues and topics and includes essential detail. Readers should be able to follow the discussion and emerge at the end with a good understanding of how scientists have developed a consensus on global warming, what it is, and what issues now face human society. --Thomas R. Dunlap, Texas A&M University
Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive. Books on drug discovery will play vital role in the new era of disease treatment using natural products.
Perception and Discovery by Norwood Russell Hanson Pdf
Norwood Russell Hanson was one of the most important philosophers of science of the post-war period. Hanson brought Wittgensteinian ordinary language philosophy to bear on the concepts of science, and his treatments of observation, discovery, and the theory-ladenness of scientific facts remain central to the philosophy of science. Additionally, Hanson was one of philosophy’s great personalities, and his sense of humor and charm come through fully in the pages of Perception and Discovery. Perception and Discovery, originally published in 1969, is Hanson’s posthumous textbook in philosophy of science. The book focuses on the indispensable role philosophy plays in scientific thinking. Perception and Discovery features Hanson’s most complete and mature account of theory-laden observation, a discussion of conceptual and logical boundaries, and a detailed treatment of the epistemological features of scientific research and scientific reasoning. This book is of interest to scholars of philosophy of science, particularly those concerned with Hanson’s thought and the development of the discipline in the middle of the 20th century. However, even fifty years after Hanson’s early death, Perception and Discovery still has a great deal to offer all readers interested in science.
The Privileged Planet by Guillermo Gonzalez,Jay W. Richards Pdf
Earth. The Final Frontier Contrary to popular belief, Earth is not an insignificant blip on the universe’s radar. Our world proves anything but average in Guillermo Gonzalez and Jay W. Richards’ The Privileged Planet: How Our Place in the Cosmos Is Designed for Discovery. But what exactly does Earth bring to the table? How does it prove its worth among numerous planets and constellations in the vastness of the Milky Way? In The Privileged Planet, you’ll learn about the world’s life-sustaining capabilities, water and its miraculous makeup, protection by the planetary giants, and how our planet came into existence in the first place.
No one can operate effectively in the court rooms of tomorrow without a good understanding of wheres, hows and whys of digital evidence. As a cover-to-cover read to learn more about the hot topics and latest case law in e-discovery, this book can provide that understanding. After a read through, this book can be used again and again as a reference, with its appendix of useful reference materials to look up cases and arguments to use in daily practice. It's written in an easy-to-read style, making it perfect for anyone interested in e-discovery. Book jacket.
Background to Discovery recounts the great voyages of discovery, from Dampier to Cook, that excited such fervent political and popular interest in eighteenth-century Europe. Perhaps this book's greatest strength lies in its remarkable synthesis of both the achievements of European maritime exploration and the political, economic, and scientific motives behind it. Writing essays on the literary and artistic response to the voyages as well, the contributors collectively provide a rich source for historians, geographers, and anyone interested in the history of voyage and travel. Background to Discovery recounts the great voyages of discovery, from Dampier to Cook, that excited such fervent political and popular interest in eighteenth-century Europe. Perhaps this book's greatest strength lies in its remarkable synthesis of both the achievements of European maritime exploration and the political, economic, and scientific motives behind it. Writing essays on the literary and artistic response to the voyages as well, the contributors collectively provide a rich source for historians, geographers, and anyone interested in the history of voyage and travel.
The search -- Discoveries -- Observation -- Detection, recognition, and classification of cosmic phenomena -- The fringes of legitimacy : the need for enlightened planning.
E-discovery and Data Privacy by Catrien W. Noorda,Stefan Hanloser Pdf
"This book deals with the dilemma faced by multinational corporations when a United States court demands discovery of ESI that is protected in other countries. In fine detail the authors cover the full spectrum of possible responses, from evaluating the comparative costs of legal sanctions in a variety of major global jurisdictions to recognizing when to avoid litigation entirely. The tone throughout is eminently practical, specifying the precise nature and degree of risk involved and offering optimal solutions to all the conflicts likely to arise. On the theoretical side, the rationales of both the US e-discovery model and data privacy laws (focusing on the European data protection directive) are clearly explained"--P. [4] of cover.
Drug Discovery for Psychiatric Disorders by Zoran Rankovic,Richard Hargreaves,Matilda Bingham Pdf
The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment of psychiatric patients and even our social perception of mental illnesses cannot be underestimated. However, there is still an urgent medical need for even more effective, safe and well-tolerated treatments. For example, currently available treatments for schizophrenia address mainly the positive symptoms and largely neglect the negative symptoms and cognitive disfunction which greatly impact overall morbidity. Similarly, whilst the current first line antidepressants show significantly improved side effect profiles compared to the first generation therapies, there still up to 40% of patients who are treatment resistant, and even in the patient population which responds well, the onset of action is slow at typically 2-3 weeks. The aim of this book is to provide the first point of call for those involved or just interested in this rapidly expanding and increasingly fragmented field of research and drug discovery. The editors will combine their wide ranging experience and extensive network of contacts with leading scientists and opinion leaders in this field to provide an authoritative reference text covering the evolution, major advances, challenges and future directions in drug discovery and medicinal chemistry for major psychiatric disorders, such as schizophrenia, depression, anxiety, ADHD, bipolar disorder, addiction and autism.
Discovery Science by Jean-Francois Boulicaut,Michael R. Berthold,Tamás Horváth Pdf
It is our pleasure to present the proceedings of Discovery Science 2008, the 11th International Conference on Discovery Science held in Budapest, Hungary, October 13-16, 2008. It was co-located with ALT 2008, the 19th International Conference on Algorithmic Learning Theory, whose proceedings are available in the twin volume LNAI 5254. This combination of DS and ALT conferences has been successfully organized each year since 2002. It provides a forum for the researchersworking on many di?erent aspects of scienti?c discovery. Indeed, ALT/DS 2008 covered both the possibility to automate part of the scienti?c discoveryandthenecessarysupporttothehumanprocessofdiscoveryinscience. Interestingly, this co-location also provided the opportunity for an exciting joint program of tutorials and invited talks. The number of submitted papers was 58, i.e., slightly more than the previous year. The Program Committee members were involved in a rigorous selection process based on three reviews per paper. At the end, we selected 26 long papers thanks to the recommendations of the experts based on relevance, novelty, signi?cance, technical quality, and clarity. Although some short papers were submitted, none of them was selected.
Drug Discovery in Cancer Epigenetics by Gerda Egger,Paola Arimondo Pdf
Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation
Comprehensive Biomarker Discovery and Validation for Clinical Application by Péter Horvatovich,Rainer Bischoff Pdf
This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks.
