Bacterial Genomes And Infectious Diseases

Author : Ricky V.L Chan,Philip M. Sherman,Billy Bourke
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 43,9 Mb
Release : 2007-11-06
Category : Medical
ISBN : 9781597451529

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Bacterial Genomes and Infectious Diseases by Ricky V.L Chan,Philip M. Sherman,Billy Bourke Pdf

The first bacterial genome, Haemophilus influenzae, was completely sequenced, annotated, and published in 1995. Today, more than 200 prokaryotic (archaeal and bacterial) genomes have been completed and over 500 prokaryotic genomes are in va- ous stages of completion. Seventeen eukaryotic genomes plus four eukaryotic chro- somes have been completed. The concept of achieving better understanding of an organism through knowledge of the complete genomic sequence was first demonstrated in 1978 when the first bacteriophage genome, X174, was sequenced. Complete genomic sequences of prokaryotes have led to a better understanding of the biology and evolution of the microbes, and, for pathogens, facilitated identification of new vaccine candidates, putative virulence genes, targets for antibiotics, new strategy for rapid diagnosis, and investigation of bacteria–host interactions and disease mec- nisms. Recent increased interest in microbial pathogens and infectious diseases is largely attributed to the re-emergence of infectious diseases like tuberculosis, emergence of new infectious diseases like AIDS and severe acute respiratory syndrome, the problem of an increasing rate of emergence of antibiotic-resistant variants of pathogens, and the fear of bioterrorism. Microbes are highly diverse and abundant in the biosphere. Less than 1% of these morphologically identified microbes can be cultured in vitro using standard techniques and conditions. With such abundance of microbes in nature, we can expect to see new variants and new species evolve and a small number will emerge as pathogens to humans.

Author : Hilde de Reuse,Stefan Bereswill
Publisher : Karger Medical and Scientific Publishers
Page : 224 pages
File Size : 53,8 Mb
Release : 2009-01-01
Category : Medical
ISBN : 9783805591928

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Microbial Pathogenomics by Hilde de Reuse,Stefan Bereswill Pdf

'Microbial Pathogenomics' contains a unique collection of reviews demonstrating how genomics has revolutionized our understanding of virulence, host-adaptation strategies and the evolution of bacterial pathogens. Current technologies - computational tools and functional approaches to genome analysis - are carefully documented and clearly illustrated. These include visualization tools for genome comparison, databases, in silico metabolic reconstructions and function prediction as well as interactomics for the study of protein-protein interactions. The concepts of pan-genomics and reverse vaccinology are introduced as strategies when addressing the challenge presented by bacterial diversity in the prevention and treatment of infectious diseases. The authors explore individual bacterial pathogens and discuss the mechanisms that have contributed to their evolutionary success. Special cases of host adaptation, for example, are illustrated by Helicobacter pylori and 'Mycobacterium tuberculosis' which are human-specific and highly persistent; further bacteria discussed include 'Escherichia coli, Campylobacter, Pseudomonas, Legionella, Bartonella, Burkholderia' and 'Staphylococcus'.'Microbial Pathogenomics' provides the reader with a global view of key aspects and future trends in bacterial pathogenomics and evaluates their impact on the understanding and treatment of infectious diseases. Well illustrated and accessible to both specialists and nonspecialists, it is recommended not only for researchers in microbiology, genomics and biotechnology, but also for lecturers and teachers.

Author : Michel Tibayrenc
Publisher : Elsevier
Page : 773 pages
File Size : 49,6 Mb
Release : 2010-12-17
Category : Medical
ISBN : 9780123848901

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Genetics and Evolution of Infectious Diseases by Michel Tibayrenc Pdf

Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches. Takes an integrated approach to infectious diseases Includes contributions from leading authorities Provides the latest developments in the field

Author : D. Ashley Robinson,Edward J Feil,Daniel Falush
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 45,7 Mb
Release : 2010-03-16
Category : Science
ISBN : 9780470600115

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Bacterial Population Genetics in Infectious Disease by D. Ashley Robinson,Edward J Feil,Daniel Falush Pdf

This book is a unique synthesis of the major concepts and methods in bacterial population genetics in infectious disease, a field that is now about 35 yrs old. Emphasis is given to explaining population-level processes that shape genetic variation in bacterial populations and statistical methods of analysis of bacterial genetic data. A "how to" of bacterial population genetics, which covers an extremely large range of organisms Expanding area of science due to high-throughput genome sequencing of bacterial pathogens Covers both fundamental approaches to analyzing bacterial population structures with conceptual background in bacterial population biology Detailed treatment of statistical methods

Author : Cheryl A. Nickerson,Michael Schurr
Publisher : Springer Science & Business Media
Page : 657 pages
File Size : 41,5 Mb
Release : 2006-11-28
Category : Science
ISBN : 9780387329017

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Molecular Paradigms of Infectious Disease by Cheryl A. Nickerson,Michael Schurr Pdf

This volume provides an overview of host genetic factors that provide complete or partial resistance to infection, that influence the clinical outcome of infection, or that confer the capacity to remain healthy during infection. This book covers the most recent advances in the field and explores how progress in knowing the genetic basis of infectious diseases could lead to new insights in understanding and combating them.

Author : Jörg Hacker,Ulrich Dobrindt,Reinhard Kurth
Publisher : American Society for Microbiology Press
Page : 547 pages
File Size : 40,6 Mb
Release : 2012-03-22
Category : Medical
ISBN : 9781555817084

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Genome Plasticity and Infectious Diseases by Jörg Hacker,Ulrich Dobrindt,Reinhard Kurth Pdf

Comprehensive examination of the current understanding of pathogen adaptation and microevolution. • Introduces the rapidly evolving field of genome plasticity, presents the latest research findings, and explores the relevance of these findings to infection and infection control. • Compiles and analyzes current investigations on the genome fluidity of pathogenic microbes. • Explores bacteria, viruses, fungi, and parasites from the aspect of host genome plasticity and its impact on infection.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 55,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Marc Jean Struelens,Vitali Sintchenko
Publisher : Frontiers Media SA
Page : 160 pages
File Size : 50,9 Mb
Release : 2020-07-03
Category : Electronic
ISBN : 9782889638222

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Pathogen Genomics: Empowering Infectious Disease Surveillance and Outbreak Investigations by Marc Jean Struelens,Vitali Sintchenko Pdf

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 429 pages
File Size : 41,5 Mb
Release : 2013-05-02
Category : Science
ISBN : 9780309268196

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The Science and Applications of Microbial Genomics by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Over the past several decades, new scientific tools and approaches for detecting microbial species have dramatically enhanced our appreciation of the diversity and abundance of the microbiota and its dynamic interactions with the environments within which these microorganisms reside. The first bacterial genome was sequenced in 1995 and took more than 13 months of work to complete. Today, a microorganism's entire genome can be sequenced in a few days. Much as our view of the cosmos was forever altered in the 17th century with the invention of the telescope, these genomic technologies, and the observations derived from them, have fundamentally transformed our appreciation of the microbial world around us. On June 12 and 13, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to discuss the scientific tools and approaches being used for detecting and characterizing microbial species, and the roles of microbial genomics and metagenomics to better understand the culturable and unculturable microbial world around us. Through invited presentations and discussions, participants examined the use of microbial genomics to explore the diversity, evolution, and adaptation of microorganisms in a wide variety of environments; the molecular mechanisms of disease emergence and epidemiology; and the ways that genomic technologies are being applied to disease outbreak trace back and microbial surveillance. Points that were emphasized by many participants included the need to develop robust standardized sampling protocols, the importance of having the appropriate metadata, data analysis and data management challenges, and information sharing in real time. The Science and Applications of Microbial Genomics summarizes this workshop.

Author : Xiangyu Deng,Henk C. den Bakker,Rene S. Hendriksen
Publisher : Springer
Page : 205 pages
File Size : 42,6 Mb
Release : 2017-01-23
Category : Technology & Engineering
ISBN : 9783319437514

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Applied Genomics of Foodborne Pathogens by Xiangyu Deng,Henk C. den Bakker,Rene S. Hendriksen Pdf

This book provides a timely and thorough snapshot into the emerging and fast evolving area of applied genomics of foodborne pathogens. Driven by the drastic advance of whole genome shot gun sequencing (WGS) technologies, genomics applications are becoming increasingly valuable and even essential in studying, surveying and controlling foodborne microbial pathogens. The vast opportunities brought by this trend are often at odds with the lack of bioinformatics know-how among food safety and public health professionals, since such expertise is not part of a typical food microbiology curriculum and skill set. Further complicating the challenge is the large and ever evolving body of bioinformatics tools that can obfuscate newcomers to this area. Although reviews, tutorials and books are not in short supply in the fields of bioinformatics and genomics, until now there has not been a comprehensive and customized source of information designed for and accessible to microbiologists interested in applying cutting-edge genomics in food safety and public health research. This book fills this void with a well-selected collection of topics, case studies, and bioinformatics tools contributed by experts at the forefront of foodborne pathogen genomics research.

Author : J.P. Gustafson,J. Tayler,G. Stacey
Publisher : Springer Science & Business Media
Page : 232 pages
File Size : 51,5 Mb
Release : 2008-02-12
Category : Medical
ISBN : 9780387767239

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Genomics of Disease by J.P. Gustafson,J. Tayler,G. Stacey Pdf

This title develops from the 24th Stadler symposium. It explores the general theme "GENOME EXPLOITATION: Data Mining the Genomes". The idea behind the theme is to discuss and illustrate how scientists are going to characterize and make use of the massive amount of information being accumulated about plant and animal genomes. The book presents a state-of-the-art picture on mining the Genome databases. Its chapters are authored by key stars in the field.

Author : Walter Doerfler,Josep Casadesús
Publisher : Springer
Page : 277 pages
File Size : 48,7 Mb
Release : 2017-05-26
Category : Medical
ISBN : 9783319550213

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Epigenetics of Infectious Diseases by Walter Doerfler,Josep Casadesús Pdf

The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.

Author : Karen Joy Shaw
Publisher : Springer Science & Business Media
Page : 513 pages
File Size : 50,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781592591725

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Pathogen Genomics by Karen Joy Shaw Pdf

Leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to the prevention, diagnosis, and treatment. The authors' cross-disciplinary approach, with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa, reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA micoarrays and the impact of genome sequencing comparisons on the discovery and choices of novel drug targets. The result is a better understanding how genomic information can reveal the fundamentals of microbial pathogenesis and how organisms interact with their host environment.

Author : Rowena Jenkins,Sarah Maddocks
Publisher : Academic Press
Page : 230 pages
File Size : 45,6 Mb
Release : 2019-07-23
Category : Science
ISBN : 9780128152225

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Bacteriology Methods for the Study of Infectious Diseases by Rowena Jenkins,Sarah Maddocks Pdf

Bacteriology Methods for the Study of Infectious Diseases provides knowledge, understanding and experience of contemporary, robust methodologies for studies into the pathogenicity and virulence of human/animal bacterial pathogens. This book presents contemporary, yet widely utilized methodologies, for the study of pathogenicity and virulence in bacterial pathogens of human and/or animal origin. Protocols are clearly outlined, with lists of required equipment and reagents, alongside underpinning theory. This text will provide undergraduate and postgraduate students with practical guidance for dissertation projects with protocols for individual project ideas that can be developed further, hence a starting point for additional literature searches is also provided. Helps users research dissertations and interdisciplinary research projects Presents a valuable resource that enables researchers from diverse backgrounds to undertake research within the field of infectious diseases Summarizes protocols that give a fundamental start to research, but are highly adaptable or can be built upon and integrated into other methodologies Provides knowledge, understanding and experience of contemporary, robust methodologies for studies into the pathogenicity and virulence of human/animal bacterial pathogens

Author : Michael Hensel,Herbert Schmidt
Publisher : Cambridge University Press
Page : 335 pages
File Size : 44,5 Mb
Release : 2008-06-30
Category : Science
ISBN : 9781139472050

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Horizontal Gene Transfer in the Evolution of Pathogenesis by Michael Hensel,Herbert Schmidt Pdf

Horizontal gene transfer is a major driving force in the evolution of many bacterial pathogens. The development of high-throughput sequencing tools and more sophisticated genomic and proteomic techniques in recent years has resulted in a better understanding of this phenomenon. Written by leading experts in the field, this edited volume is aimed at graduate students and researchers and provides an overview of current knowledge relating to the evolution of microbial pathogenicity. This volume provides an overview of the mechanisms and biological consequences of the genome rearrangements resulting from horizontal gene transfer, in both prokaryotes and eukaryotes, as well as overviews of the key mobile genetic elements involved. Subsequent chapters focus on paradigms for the evolution of important bacterial pathogens, including Salmonella enterica, Streptococcus pneumoniae, and Staphylococcus aureus. The influence of socioeconomic parameters in the dissemination of transferable elements, such as antibiotic resistant genes in bacteria, is also discussed.