Bacterial Lipopolysaccharides

Author : Yuriy A. Knirel,Miguel A. Valvano
Publisher : Springer Science & Business Media
Page : 440 pages
File Size : 43,6 Mb
Release : 2011-07-13
Category : Science
ISBN : 9783709107331

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Bacterial Lipopolysaccharides by Yuriy A. Knirel,Miguel A. Valvano Pdf

The bacterial lipopolysaccharide also known as endotoxin is exhaustively covered in the present work. Central emphasis is placed upon the fine chemical structure of the lipopolysaccharide and its significance for understanding their activity and function. In particular, the role it plays in the interaction of bacteria with other biological systems is examined. New aspects of their physicochemical biology are introduced and updates to the current knowledge concerning the lipopolysaccharide are provided. This important class of biomolecules has recently attracted the attention of many investigators, in particular for understanding its involvement in innate immunity, toll-like receptor recognition and intracellular signaling.

Author : David C. Morrison,John L. Ryan
Publisher : CRC Press
Page : 474 pages
File Size : 42,9 Mb
Release : 1992-08-05
Category : Science
ISBN : 0849367875

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Bacterial Endotoxic Lipopolysaccharides by David C. Morrison,John L. Ryan Pdf

Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.

Author : Helmut Brade
Publisher : CRC Press
Page : 968 pages
File Size : 49,5 Mb
Release : 2020-10-28
Category : Science
ISBN : 9781000110388

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Endotoxin in Health and Disease by Helmut Brade Pdf

Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.

Author : David C. Morrison,John L. Ryan
Publisher : CRC Press
Page : 484 pages
File Size : 54,5 Mb
Release : 1992-09-11
Category : Science
ISBN : 0849367883

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Bacterial Endotoxic Lipopolysaccharides by David C. Morrison,John L. Ryan Pdf

Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.

Author : Solomon Kadis,George Weinbaum,Samuel J. Ajl
Publisher : Elsevier
Page : 526 pages
File Size : 49,9 Mb
Release : 2016-06-14
Category : Medical
ISBN : 9781483215891

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Bacterial Endotoxins by Solomon Kadis,George Weinbaum,Samuel J. Ajl Pdf

Microbial Toxins, Volume V: Bacterial Endotoxins covers the physiology, pathology, and immunology of bacterial endotoxins. The book discusses the relationship of lipopolysaccharide structure to bacterial virulence; the importance of blood-group and Forssman antigenic determinants in interactions between human and microbes; and the chemical modification of endotoxin and inactivation of its biological properties. The text also describes the effects of endotoxic lipopolysaccharides on the complement system; the host-dependent detoxification of bacterial endotoxin; and the metabolic effects of bacterial endotoxins. The release of vasoactive agents and the vascular effects of endotoxin are also considered. The book further tackles the febrile response to endotoxin; some major aspects and the relationship between shock and endotoxemia; as well as the effects of lipopolysaccharides (endotoxins) on the susceptibility to infections. The text also encompasses the role of hypersensitivity and tolerance in reactions to endotoxins. Pathologists, immunologists, physiologists, and microbiologists will find the book invaluable.

Author : Laurens Anderson,Frank M. Unger,American Chemical Society. Division of Carbohydrate Chemistry
Publisher : Unknown
Page : 344 pages
File Size : 40,7 Mb
Release : 1983
Category : Science
ISBN : UCAL:B4530607

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Bacterial Lipopolysaccharides by Laurens Anderson,Frank M. Unger,American Chemical Society. Division of Carbohydrate Chemistry Pdf

Author : Xiaoyuan Wang,Peter J. Quinn
Publisher : Springer Science & Business Media
Page : 415 pages
File Size : 42,7 Mb
Release : 2010-06-30
Category : Medical
ISBN : 9789048190782

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Endotoxins: Structure, Function and Recognition by Xiaoyuan Wang,Peter J. Quinn Pdf

Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

Author : American Chemical Society
Publisher : Unknown
Page : 335 pages
File Size : 42,8 Mb
Release : 1983
Category : Endotoxins
ISBN : 0608030805

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Bacterial Lipopolysaccharides by American Chemical Society Pdf

Author : Loriano Ballarin,Matteo Cammarata
Publisher : Academic Press
Page : 324 pages
File Size : 46,9 Mb
Release : 2016-04-08
Category : Medical
ISBN : 9780128032534

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Lessons in Immunity by Loriano Ballarin,Matteo Cammarata Pdf

Lessons in Immunity: From Single-cell Organisms to Mammals stems from the activity of the Italian Association of Developmental and Comparative Immunobiology (IADCI), represented by the editors. This book is presented as a series of short overviews that report on the current state of various relevant fields of immunobiology from an evolutionary perspective. The overviews are written by authors directly involved in the research, and most are members of the IADCI or have otherwise been involved in the related research for their respective overview. This publication offers scientists and teachers an easy and updated reference tool. Provides simple and updated reviews on the immunobiology of a wide spectrum of organisms, considered in an evolutionary context Focuses on both cells and humoral components of a variety of non-classical model organisms Offers in a single volume many contributions which can help with understanding the evolution of immune responses and the main adaptations in animal phyla Presents a valuable holistic cross-sectional approach for teaching immunology and its applications

Author : Edward H. Kass,Sheldon M. Wolff
Publisher : Unknown
Page : 304 pages
File Size : 43,9 Mb
Release : 1973
Category : Electronic
ISBN : 0226425649

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Bacterial Lipopolysaccharides by Edward H. Kass,Sheldon M. Wolff Pdf

Author : George Weinbaum,Solomon Kadis,Samuel J. Ajl
Publisher : Elsevier
Page : 494 pages
File Size : 55,6 Mb
Release : 2016-01-21
Category : Health & Fitness
ISBN : 9781483215884

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Bacterial Endotoxins by George Weinbaum,Solomon Kadis,Samuel J. Ajl Pdf

Microbial Toxins, Volume IV: Bacterial Endotoxins covers a general introduction of bacterial endotoxins, as well as research concerning structure (both morphological and physical), chemistry, immunology, biosynthesis, and genetics of bacterial endotoxins. The book describes the general characteristics of bacterial endotoxins; the anatomy and chemistry of Gram-negative cell envelopes; and the physical structure of bacterial lipopolysaccharides. The text also discusses the isolation and chemical and immunological characterization of bacterial lipopolysaccharides; the chemistry of the unique carbohydrates of bacterial lipopolysaccharides; and the relation of bacteriophage attachment to lipopolysaccharide structure. The chemical and biological heterogeneity of endotoxins, as well as the biosynthesis of the core region of lipopolysaccharide are also considered. The book further tackles the biosynthesis of O-antigens and the genetic aspects of biosynthesis and structure of Salmonella lipopolysaccharide. Microbiologists, biochemists, bacteriologists, immunologists, and people involved in biochemical research will find the book useful.

Author : Juan M. Tomás
Publisher : MDPI
Page : 390 pages
File Size : 54,8 Mb
Release : 2020-01-24
Category : Science
ISBN : 9783039282562

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Lipopolysaccharides (LPSs) by Juan M. Tomás Pdf

The cytoplasm of Gram-negative bacteria is bound by three layers: an inner membrane, a layer of peptidoglycan, and an outer membrane. The outer membrane is an asymmetric lipidic bilayer, with phospholipids on its inner surface and lipopolysaccharides (LPSs) on the outside, with the latter being the major component of the outer leaflet and covering nearly three-quarters of the total outer cell surface. All LPSs possess the same general chemical architecture independently of bacterial activity (pathogenic, symbiotic, commensal), ecological niche (human, animal, soil, plant, water), or growth conditions. Endotoxins are large amphiphilic molecules consisting of a hydrophilic polysaccharide component and a covalently bound hydrophobic and highly conserved lipid component, termed lipid A (the endotoxin subunit). The polysaccharide component can be divided into two subdomains: the internal and conserved core region as well as the more external and highly variable O-specific chain, also referred to as the O-antigen due to its immunogenic properties. LPSs are endotoxins, one of the most potent class of activators of the mammalian immune system; they can be released from cell surfaces of bacteria during multiplication, lysis, and death. LPS can act through its biological center (lipid A component) on various cell types, of which macrophages and monocytes are the most important.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 55,8 Mb
Release : 1973
Category : Endotoxins
ISBN : OCLC:1342434105

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Bacterial Lipopolysaccharides by Anonim Pdf

Author : Bernhard Urbaschek,Renate Urbaschek,Erwin Neter
Publisher : Springer Science & Business Media
Page : 524 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783709183960

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Gram-Negative Bacterial Infections and Mode of Endotoxin Actions by Bernhard Urbaschek,Renate Urbaschek,Erwin Neter Pdf

The relevance of international symposia and congresses has been questioned with increasing frequency. All too often, presentations at such meetings are meaningful only for very few members of the audience; fundamental scientific principles and relationships between disciplines are not always taken into account. Under present conditions rapid sharing of new information is highly desirable. However, many journals do not lend themselves to speedy exchange of information, nor do many provide the opportunity for the publication of discussion by various specialists of problems arising from different disciplines. Symposia may lend themselves, perhaps more readily, to the identification of current knowledge and the exchange of thoughts between scientists from various fields. It was particularly opportune to have the present symposium held in Vienna, where as early as 1365 the University was founded and where the medical sciences have played a dominant role in the investigation of the nature of diseases. It was the aim of the organizer to provide in this city the opportunity for the exchange of information and of thoughts between scientists from different disciplines and different countries. One of the many current, important problems relates to the fundamental basis of the pathogenesis of gram-negative infections. Information on immune mechanisms against these infections is in adequate; the relative role of non-specific resistance and specific immunity has not been fully elucidated. Problems regarding active immunization and the effectiveness of passively administered immuno globulins still exist even today.

Author : Andreas Kuhn
Publisher : Springer
Page : 501 pages
File Size : 54,9 Mb
Release : 2019-06-18
Category : Science
ISBN : 9783030187682

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Bacterial Cell Walls and Membranes by Andreas Kuhn Pdf

This book provides an up-to-date overview of the architecture and biosynthesis of bacterial and archaeal cell walls, highlighting the evolution-based similarities in, but also the intriguing differences between the cell walls of Gram-negative bacteria, the Firmicutes and Actinobacteria, and the Archaea. The recent major advances in this field, which have brought to light many new structural and functional details, are presented and discussed. Over the past five years, a number of novel systems, e.g. for lipid, porin and lipopolysaccharide biosynthesis have been described. In addition, new structural achievements with periplasmic chaperones have been made, all of which have revealed amazing details on how bacterial cell walls are synthesized. These findings provide an essential basis for future research, e.g. the development of new antibiotics. The book’s content is the logical continuation of Volume 84 of SCBI (on Prokaryotic Cytoskeletons), and sets the stage for upcoming volumes on Protein Complexes.