Bacterial Resistance To Antimicrobials

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 418 pages
File Size : 41,6 Mb
Release : 2012-09-10
Category : Medical
ISBN : 9780309259361

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Improving Food Safety Through a One Health Approach by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Globalization of the food supply has created conditions favorable for the emergence, reemergence, and spread of food-borne pathogens-compounding the challenge of anticipating, detecting, and effectively responding to food-borne threats to health. In the United States, food-borne agents affect 1 out of 6 individuals and cause approximately 48 million illnesses, 128,000 hospitalizations, and 3,000 deaths each year. This figure likely represents just the tip of the iceberg, because it fails to account for the broad array of food-borne illnesses or for their wide-ranging repercussions for consumers, government, and the food industry-both domestically and internationally. A One Health approach to food safety may hold the promise of harnessing and integrating the expertise and resources from across the spectrum of multiple health domains including the human and veterinary medical and plant pathology communities with those of the wildlife and aquatic health and ecology communities. The IOM's Forum on Microbial Threats hosted a public workshop on December 13 and 14, 2011 that examined issues critical to the protection of the nation's food supply. The workshop explored existing knowledge and unanswered questions on the nature and extent of food-borne threats to health. Participants discussed the globalization of the U.S. food supply and the burden of illness associated with foodborne threats to health; considered the spectrum of food-borne threats as well as illustrative case studies; reviewed existing research, policies, and practices to prevent and mitigate foodborne threats; and, identified opportunities to reduce future threats to the nation's food supply through the use of a "One Health" approach to food safety. Improving Food Safety Through a One Health Approach: Workshop Summary covers the events of the workshop and explains the recommendations for future related workshops.

Author : Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke
Publisher : Springer Science & Business Media
Page : 554 pages
File Size : 50,9 Mb
Release : 2009-10-08
Category : Science
ISBN : 9780387893709

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Antimicrobial Resistance in Developing Countries by Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke Pdf

Avoiding infection has always been expensive. Some human populations escaped tropical infections by migrating into cold climates but then had to procure fuel, warm clothing, durable housing, and crops from a short growing season. Waterborne infections were averted by owning your own well or supporting a community reservoir. Everyone got vaccines in rich countries, while people in others got them later if at all. Antimicrobial agents seemed at first to be an exception. They did not need to be delivered through a cold chain and to everyone, as vaccines did. They had to be given only to infected patients and often then as relatively cheap injectables or pills off a shelf for only a few days to get astonishing cures. Antimicrobials not only were better than most other innovations but also reached more of the world’s people sooner. The problem appeared later. After each new antimicrobial became widely used, genes expressing resistance to it began to emerge and spread through bacterial populations. Patients infected with bacteria expressing such resistance genes then failed treatment and remained infected or died. Growing resistance to antimicrobial agents began to take away more and more of the cures that the agents had brought.

Author : Kateryna Kon,Mahendra Rai
Publisher : Academic Press
Page : 436 pages
File Size : 49,9 Mb
Release : 2016-06-14
Category : Medical
ISBN : 9780128036686

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Antibiotic Resistance by Kateryna Kon,Mahendra Rai Pdf

Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches discusses up-to-date knowledge in mechanisms of antibiotic resistance and all recent advances in fighting microbial resistance such as the applications of nanotechnology, plant products, bacteriophages, marine products, algae, insect-derived products, and other alternative methods that can be applied to fight bacterial infections. Understanding fundamental mechanisms of antibiotic resistance is a key step in the discovery of effective methods to cope with resistance. This book also discusses methods used to fight antibiotic-resistant infection based on a deep understanding of the mechanisms involved in the development of the resistance. Discusses methods used to fight antibiotic-resistant infection based on a deep understanding of mechanisms involved in the development of the resistance Provides information on modern methods used to fight antibiotic resistance Covers a wide range of alternative methods to fight bacterial resistance, offering the most complete information available Discusses both newly emerging trends and traditionally applied methods to fight antibiotic resistant infections in light of recent scientific developments Offers the most up-to-date information in fighting antibiotic resistance Includes involvement of contributors all across the world, presenting questions of interest to readers of both developed and developing countries

Author : Richard G. Wax,Kim Lewis,Abigail A. Salyers,Harry Taber
Publisher : CRC Press
Page : 530 pages
File Size : 52,6 Mb
Release : 2001-11-21
Category : Science
ISBN : 0824744934

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Bacterial Resistance to Antimicrobials by Richard G. Wax,Kim Lewis,Abigail A. Salyers,Harry Taber Pdf

Focuses on combating bacterial pathogens by understanding their strategies of defense! Each chapter begins with a summary of concepts, so those not actively working in the field gain an overall picture of what follows! Highlights antibiotic resistance in pathogens that poses the greatest threat to human health! Containing nearly 2000 references for additional research, Bacterial Resistance to Antimicrobials discusses the ecology of drug resistance genes, acquired response, and selection in natural bacterial populations describes global response systems that are a basis of resistance details antibiotic modification, inactivation, and host target modification as means of resistance development considers efflux mechanisms, one of the major causes of multidrug resistance covers concepts for developing therapies against multidrug resistant organisms emphasizes the structural basis of lactamases and other enzymes involved in inactivation of antibiotics surveys the epidemiology of methicillin resistance among nosocomial isolates and community-acquired strains outlines molecular detection methods for mainstream diagnostic tests assesses the promise of modern genomics to identify novel targets for drug discovery screening Presenting the molecular basis, methods of detection and identification, and concepts for reducing the development and spread of resistant bacterial strains, Bacterial Resistance to Antimicrobials is an excellent reference for microbiologists, pharmacists, public health officials, infectious disease specialists, organic and medicinal chemists, and upper-level undergraduate and graduate students in these disciplines.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 496 pages
File Size : 40,5 Mb
Release : 2011-01-10
Category : Medical
ISBN : 9780309156110

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Antibiotic Resistance by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Years of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant 'superbugs.' The IOM's Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs.

Author : José-Luis Capelo-Martínez,Gilberto Igrejas
Publisher : John Wiley & Sons
Page : 730 pages
File Size : 47,9 Mb
Release : 2019-09-24
Category : Medical
ISBN : 9781119282525

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Antibiotic Drug Resistance by José-Luis Capelo-Martínez,Gilberto Igrejas Pdf

This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Author : Michael Anderson,Michele Cecchini,Elias Mossialos,Jonathan North
Publisher : Cambridge University Press
Page : 273 pages
File Size : 47,9 Mb
Release : 2020-04-23
Category : Health & Fitness
ISBN : 9781108799454

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Challenges to Tackling Antimicrobial Resistance by Michael Anderson,Michele Cecchini,Elias Mossialos,Jonathan North Pdf

An accessible overview of the challenges in tackling AMR, and the economic and policy responses of the 'One Health' approach. It will appeal to policy-makers seeking to strengthen national and local polices tackling AMR, as well as students and academics who want an overview of the latest scientific evidence regarding effective AMR policies.

Author : National Research Council,Division on Earth and Life Studies,Division of Medical Sciences,Commission on Life Sciences,Committee to Study the Human Health Effects of Subtherapeutic Antibiotic Use in Animal Feeds
Publisher : National Academies Press
Page : 393 pages
File Size : 41,8 Mb
Release : 1980-02-01
Category : Medical
ISBN : 9780309030441

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The Effects on Human Health of Subtherapeutic Use of Antimicrobials in Animal Feeds by National Research Council,Division on Earth and Life Studies,Division of Medical Sciences,Commission on Life Sciences,Committee to Study the Human Health Effects of Subtherapeutic Antibiotic Use in Animal Feeds Pdf

Author : Institute of Medicine,Board on Global Health,Forum on Emerging Infections
Publisher : National Academies Press
Page : 333 pages
File Size : 41,6 Mb
Release : 2003-03-26
Category : Medical
ISBN : 9780309168304

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The Resistance Phenomenon in Microbes and Infectious Disease Vectors by Institute of Medicine,Board on Global Health,Forum on Emerging Infections Pdf

The resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.

Author : World Health Organization
Publisher : Unknown
Page : 232 pages
File Size : 52,9 Mb
Release : 2014
Category : Medical
ISBN : 9241564741

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Antimicrobial Resistance by World Health Organization Pdf

Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.

Author : Boyan B. Bonev,Nicholas M. Brown
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 51,9 Mb
Release : 2019-03-14
Category : Science
ISBN : 9781119558200

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Bacterial Resistance to Antibiotics by Boyan B. Bonev,Nicholas M. Brown Pdf

AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era—when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death—new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics – From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics – From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.

Author : Indranil Samanta,Samiran Bandyopadhyay
Publisher : Academic Press
Page : 392 pages
File Size : 48,5 Mb
Release : 2019-09-25
Category : Medical
ISBN : 9780128165232

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Antimicrobial Resistance in Agriculture by Indranil Samanta,Samiran Bandyopadhyay Pdf

Antimicrobial Resistance in Agriculture: Perspective, Policy and Mitigation is a valuable industrial resource that addresses complex, multi-factorial topics regarding farm, wild, companion animals, fish, and how the environment plays an important role in amplification and transmission of resistant bugs into the human food chain. Information of phenotypical and genotypical properties of each bacterial genus associated with antimicrobial resistance, transmission dynamics from different reservoirs (food animals, poultry, fishes) and control measures with alternative therapy, such as phytobiotics and nanomaterials are provided. Researchers, scientists and practitioners will find this an essential resource on the judicial use of antibiotics in animals and humans. Explores all the genera of livestock and fish originated pathogenic bacteria associated with antimicrobial resistance Presents cutting-edge research on epigenetics, nanotechnology and intervention technologies Discusses transmission dynamics of resistance gene pools from different reservoirs, including food animals, poultry, fishes and the environment

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 53,7 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689

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Treating Infectious Diseases in a Microbial World by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials Pdf

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Author : The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada
Publisher : Council of Canadian Academies
Page : 268 pages
File Size : 49,5 Mb
Release : 2019-11-12
Category : Medical
ISBN : 9781926522753

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When Antibiotics Fail by The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada Pdf

When Antibiotics Fail examines the current impacts of AMR on our healthcare system, projects the future impact on Canada’s GDP, and looks at how widespread resistance will influence the day-to-day lives of Canadians. The report examines these issues through a One Health lens, recognizing the interconnected nature of AMR, from healthcare settings to the environment to the agriculture sector. It is the most comprehensive report to date on the economic impact of AMR in Canada.

Author : Muhammad Zaffar Hashmi
Publisher : Elsevier
Page : 434 pages
File Size : 55,5 Mb
Release : 2019-11-22
Category : Science
ISBN : 9780128188835

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Antibiotics and Antimicrobial Resistance Genes in the Environment by Muhammad Zaffar Hashmi Pdf

Antibiotics and Antimicrobial Resistance Genes (AMR) in the Environment summarizes and updates information on antibiotic producing organisms and their resistance and entry routes in soil, air, water and sediment. As antibiotic use continues to rise in healthcare, their fate, bioavailability and biomonitoring, and impacts on environment and public health are becoming increasingly important. The book addresses the impact of antibiotics and AMR to environment and public health and risk assessment. Moreover, it focused on the metagenomics and molecular techniques for the detection of antibiotics and antimicrobial genes. Lastly, it introduces management strategies, such as treatment technologies for managing antibiotics and AMR/ARGs-impacted environment, and bioremediation approaches. Summarizes and updates information on antibiotics and AMR/ARGs production and its fate and transport in the environment Includes phytoremediation and bioremediation technologies for environmental management Provides analysis of risk assessment of antibiotic resistance genes to help understand the environmental and socioeconomic impacts of antibiotics and AMR/ARGs