Basic And Clinical Research On Renal Cell Carcinoma

Author : Gerd Staehler,Sigmund Pomer
Publisher : Springer Science & Business Media
Page : 288 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642768637

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Basic and Clinical Research on Renal Cell Carcinoma by Gerd Staehler,Sigmund Pomer Pdf

Advanced Renal Cell Carcinoma (RCC) cannot be cured by surgery alone. Its resillience to irradiation and chemotherapy demands a new approach to the management of this disease. This book provides an overview of the scientific and clinical developments of RCC, and clarifies the fields ofimmunotherapy and immunobiology. The book contains a compilation of approaches that will enhance the effectiveness of the management of advancedRCC, even in the absence of definitive pre-clinical data. These require additional study and will stimulate the reassessment of preliminary results.Furthermore, preliminary results of already implemented clinical trials withbiological modifiers are presented. Of special interest are the current achievements in the field of immunotherapy using topically and subcutaneously low dosage combinations of cytokines. This concise volume will benefit those seeking a thorough review of the research and the clinical aspects of RCC simultaneously.

Author : Gerd Staehler,Sigmund Pomer
Publisher : Springer
Page : 237 pages
File Size : 42,5 Mb
Release : 1992-04-09
Category : Medical
ISBN : 3540544240

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Basic and Clinical Research on Renal Cell Carcinoma by Gerd Staehler,Sigmund Pomer Pdf

Advanced Renal Cell Carcinoma (RCC) cannot be cured by surgery alone. Its resillience to irradiation and chemotherapy demands a new approach to the management of this disease. This book provides an overview of the scientific and clinical developments of RCC, and clarifies the fields ofimmunotherapy and immunobiology. The book contains a compilation of approaches that will enhance the effectiveness of the management of advancedRCC, even in the absence of definitive pre-clinical data. These require additional study and will stimulate the reassessment of preliminary results.Furthermore, preliminary results of already implemented clinical trials withbiological modifiers are presented. Of special interest are the current achievements in the field of immunotherapy using topically and subcutaneously low dosage combinations of cytokines. This concise volume will benefit those seeking a thorough review of the research and the clinical aspects of RCC simultaneously.

Author : Gerd Staehler,Sigmund Pomer
Publisher : Springer Science & Business Media
Page : 158 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642786099

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Contemporary Research on Renal Cell Carcinoma by Gerd Staehler,Sigmund Pomer Pdf

The management of advanced renal cell carcinoma is still problematic. Surgery, although the therapy of choice for locally advanced renal tumors, is still controversial as the treatment for metastases. The role of surgery in the management of patients with pulmonary, bony, and liver metastasis is one of the subject matters discussed in this book. Our results with series of patients undergoing resection of metastases from the lung, bone, and liver show that surgery may be appropriate in selected patients with a good performance status, although most of them certainly cannot be cured by this procedure alone, i.e., in the absence of effective adjuvant therapies. As recent developments show, new strategies for immunotherapy of renal cell carcinoma represent a modest advance over traditional approaches in the treatment of this cancer, such as chemo- and radiotherapy. Clinical trials employing recombinant interferon-a and interleukin 2 produced response rates in up to 30% of patients treated, as evidenced by the European Immunotherapy Trials Program. The adverse reactions and the lack of efficacy in the majority of patients warrants the search for new immunotherapeutic approaches.

Author : Gerd Staehler,Sigmund Pomer
Publisher : Springer
Page : 158 pages
File Size : 52,8 Mb
Release : 1994-03-18
Category : Medical
ISBN : 3540573755

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Contemporary Research on Renal Cell Carcinoma by Gerd Staehler,Sigmund Pomer Pdf

The management of advanced renal cell carcinoma is still problematic. Surgery, although the therapy of choice for locally advanced renal tumors, is still controversial as the treatment for metastases. The role of surgery in the management of patients with pulmonary, bony, and liver metastasis is one of the subject matters discussed in this book. Our results with series of patients undergoing resection of metastases from the lung, bone, and liver show that surgery may be appropriate in selected patients with a good performance status, although most of them certainly cannot be cured by this procedure alone, i.e., in the absence of effective adjuvant therapies. As recent developments show, new strategies for immunotherapy of renal cell carcinoma represent a modest advance over traditional approaches in the treatment of this cancer, such as chemo- and radiotherapy. Clinical trials employing recombinant interferon-a and interleukin 2 produced response rates in up to 30% of patients treated, as evidenced by the European Immunotherapy Trials Program. The adverse reactions and the lack of efficacy in the majority of patients warrants the search for new immunotherapeutic approaches.

Author : Okio Hino
Publisher : Karger Medical and Scientific Publishers
Page : 137 pages
File Size : 55,5 Mb
Release : 1999-01-01
Category : Medical
ISBN : 9783805569194

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Kidney Cancer by Okio Hino Pdf

Cancer is above all a heritable disorder of somatic cells and gene expression, but environment is also involved in its origin. Hereditary kidney cancer should prove valuable to understand the mechanisms of disease and to the development of therapeutic measures. Recently, scientists have succeeded in cloning and identifying the genes responsible for the following familial kidney cancers: von Hippel-Lindau disease, papillary renal cell carcinoma, tuberous sclerosis and Wilms tumor (all autosomal dominant). This book brings together some of the most recent advances made with respect to kidney cancers: Leading investigators present recent results on VHL, MET, TSC1 and TSC2 and WT1 genes, among others, as well as on environmentally induced kidney cancers (caused by long-term hemodialysis or induced chemically) and their treatments (surgery and gene therapy), providing an excellent survey of this field. This publication will be of interest to both researchers and clinicians concerned with cancer of the kidney.

Author : O. Hino,C. Ronco
Publisher : Unknown
Page : 0 pages
File Size : 44,8 Mb
Release : 1999
Category : Medical
ISBN : 3318004650

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Kidney Cancer by O. Hino,C. Ronco Pdf

Cancer is above all a heritable disorder of somatic cells and gene expression, but environment is also involved in its origin. Hereditary kidney cancer should prove valuable to understand the mechanisms of disease and to the development of therapeutic measures. Recently, scientists have succeeded in cloning and identifying the genes responsible for the following familial kidney cancers: von Hippel-Lindau disease, papillary renal cell carcinoma, tuberous sclerosis and Wilms tumor (all autosomal dominant). This book brings together some of the most recent advances made with respect to kidney cancers: Leading investigators present recent results on VHL, MET, TSC1 and TSC2 and WT1 genes, among others, as well as on environmentally induced kidney cancers (caused by long-term hemodialysis or induced chemically) and their treatments (surgery and gene therapy), providing an excellent survey of this field. This publication will be of interest to both researchers and clinicians concerned with cancer of the kidney.

Author : Ronald M. Bukowski,Robert A. Figlin,Robert J. Motzer
Publisher : Springer
Page : 620 pages
File Size : 55,7 Mb
Release : 2014-11-27
Category : Medical
ISBN : 9781493916221

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Renal Cell Carcinoma by Ronald M. Bukowski,Robert A. Figlin,Robert J. Motzer Pdf

​​ ​The third edition of this critically acclaimed book has updated and expanded the survey of clinical, biological and pathological management of localized and advanced renal cell carcinoma. Internationally renowned editors and contributors explore the latest developments in molecular genetics, focusing on the novel targets that have been discovered in epithelial renal tumors. Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Third Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by leaders of the field.​

Author : Primo N. Lara,Eric Jonasch
Publisher : Springer Science & Business Media
Page : 305 pages
File Size : 44,9 Mb
Release : 2012-01-25
Category : Medical
ISBN : 9783642218576

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Kidney Cancer by Primo N. Lara,Eric Jonasch Pdf

This textbook encompasses all clinically relevant aspects of kidney cancer and is designed to be user-friendly to meet the needs of the busy practitioner. Practice oriented, with brief summary points, patient case studies, high quality images and more.

Author : Gerd Staehler,Sigmund Pomer
Publisher : Unknown
Page : 176 pages
File Size : 54,5 Mb
Release : 1994-03-18
Category : Electronic
ISBN : 3642786103

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Contemporary Research on Renal Cell Carcinoma by Gerd Staehler,Sigmund Pomer Pdf

Author : Rana R. McKay,Eric A. Singer
Publisher : Springer Nature
Page : 418 pages
File Size : 49,8 Mb
Release : 2023-12-03
Category : Medical
ISBN : 9783031409011

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Integrating Multidisciplinary Treatment for Advanced Renal Cell Carcinoma by Rana R. McKay,Eric A. Singer Pdf

The field of kidney cancer has dramatically evolved over the past several years due to notable advances. Most importantly, systemic treatment options have expanded to include combination regimens for advanced disease and expansion of treatment options in the adjuvant setting. Additionally, surgical management has evolved towards nephron-sparing and minimally invasive approaches for treatment of localized disease; the role of surgery and focal therapy are changing for patients with advanced disease. While kidney cancer is a common malignancy in both men and women worldwide, mortality has improved over time given advancements in modern oncology. This book provides a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in kidney cancer. The book reviews new data about systemic treatment options for patients with advanced disease including strategies in the treatment naïve and post frontline setting. It covers new data regarding perioperative and adjuvant treatments for patients with localized disease and will highlight novel targets and treatments under development. Integration of surgery and systemic therapy through cytoreductive and consolidative approaches has yielded provocative data that promises to further advance the field, and major advances in this domain will also be discussed. Additionally, the book discusses the evolving role of alternative focal approaches including radiation therapy for patients with advanced disease. This text serves as a very useful resource for physicians and researchers dealing with and interested in this challenging malignancy. Specifically, urologists, medical oncologists, radiation oncologists, basic science and translational researchers with interest in RCC, fellows in urologic oncology, upper level residents training in urology and medical oncology, and pharmaceutical partners interested in RCC will benefit most significantly. Integrating Multidisciplinary Treatment for Advanced Renal Cell Carcinoma will provide a concise yet comprehensive summary of strategies for sequencing therapies that will help guide patient care and stimulate investigative efforts.

Author : Steven C. Campbell,Brian I. Rini
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 41,9 Mb
Release : 2012-09-25
Category : Medical
ISBN : 9781627030625

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Renal Cell Carcinoma by Steven C. Campbell,Brian I. Rini Pdf

Renal Cell Carcinoma: Clinical Management provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in kidney cancer. The volume reviews new data about risk factors for the disease, profiles the new staging system for renal cell carcinoma (RCC), highlights our current understanding of familial syndromes of RCC and their molecular genetics, and provides new perspectives about imaging of renal tumors. For localized disease, a greater appreciation of nephron-sparing approaches and the importance of preservation of renal function is discussed in detail. Advances in surgical techniques are highlighted. For metastatic disease, the molecular biology of kidney cancer is reviewed in a concise and understandable manner, including the data that has fostered novel targeted approaches that have revolutionized management. The several landmark phase III targeted therapy trials published in the last few years are placed in context with respect to current management. Integration of surgery and systemic therapy through cytoreductive and consolidative approaches has yielded provocative data that promises to further advance the field, and major advances in this domain are also be discussed.

Author : Sashi S. Kommu,Inderbir Gill
Publisher : BoD – Books on Demand
Page : 260 pages
File Size : 53,9 Mb
Release : 2020-07-22
Category : Medical
ISBN : 9781838819590

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Evolving Trends in Kidney Cancer by Sashi S. Kommu,Inderbir Gill Pdf

Kidney cancer imposes a significant cancer burden and its incidence continues to rise globally. Mortality in advanced kidney cancer remains high despite oncological, surgical and multimodal optimisation. Genetic associations, heterogeneity and limitations in early diagnosis through lack of optimal biomarkers add to the challenges. Over the last two decades there has been an exponential increase in diagnostic and therapeutic advances in the management of kidney cancer. The coupling of scientific advances in engineering and technology with oncological therapeutics has recently ushered a renewed optimism. The role of minimally invasive approaches through focal therapy and surgical extirpation using the robotic platform has been unprecedented and paramount. Virtual augmentation and mixed reality platforms have proved useful supplementary tools in surgical planning. The role of surgical simulation and training in development of surgeons with the optimal skill set is essential to provide optimal care. This book is the first in a series that explores the evolving trends in kidney cancer. The focus of the book is broad and includes topics ranging from immunotherapy to surgical simulation. Some chapters explore leading edge concepts while others capture the evolving trends and future concepts. The Editors aim to stimulate the readers to explore the key concepts and to encourage research and innovation along the main themes presented.

Author : John A Libertino
Publisher : Springer Science & Business Media
Page : 394 pages
File Size : 46,5 Mb
Release : 2013-06-14
Category : Medical
ISBN : 9781461472360

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Renal Cancer by John A Libertino Pdf

Renal Cancer: Contemporary Management provides a state of the art overview of the major topics in the field of kidney cancer. The material has been collected from the most current evidence based resources to allow for the appropriate care of these patients. The sections of the book have been structured to give an overview of the major issues dealing with renal cell carcinoma and transitional cell carcinoma of the kidney. The text also reviews the new staging system, discusses familial syndromes of renal cell carcinoma, and provides new perspectives with regard to imaging and managing renal tumors. A valuable resource for physicians and researchers dealing with renal cancer, Renal Cancer: Contemporary Management provides a comprehensive summary of the field that will guide patient management and stimulate further clinical and basic science research efforts.

Author : Frans M.J. Debruyne,Ronald M. Bukowski,J. Edson Pontes,Pieter H.M. de Mulder
Publisher : Springer Science & Business Media
Page : 203 pages
File Size : 55,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642758539

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Immunotherapy of Renal Cell Carcinoma by Frans M.J. Debruyne,Ronald M. Bukowski,J. Edson Pontes,Pieter H.M. de Mulder Pdf

With contributions by numerous experts

Author : Eric A. Klein
Publisher : CRC Press
Page : 370 pages
File Size : 52,9 Mb
Release : 1993-04-23
Category : Medical
ISBN : 0824790332

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Renal Cell Carcinoma by Eric A. Klein Pdf

This reference brings together all aspects of renal cell carcinoma, and provides a basis for understanding the disease's origin, progression and responses to immunotherapy.;Examining the current status of cytokine, cell-based and chemotherapeutic methods of treatment, this book: discusses the clinical presentation of advanced renal carcinoma and its therapeutic challenges; reviews prognostic factors and the management of renal cell carcinoma occurring with von Hippel-Landau syndrome; summarizes efforts to identify the tumour suppressor gene deleted from chromosome 3 in most renal cell carcinomas; explicates the role of oncogenes in the progression of renal cell cancer and the molecular correlates of responses to interferon-alpha treatment; details the latest laboratory efforts to establish gene therapy for tumour treatment by transfection of cytokine genes in murine model systems; focuses on biologic response modifier therapy in humans, including cell-mediated immune responses and adoptive immunotherapy; presents preclinical and clinical studies of interleukin-2 alone, in combination with othe cytokines, and with chemothrapeutic agents; and addresses studies on the tumour necrosis factor and low- and high-dose interferon-alpha.