Basic Pharmacokinetics Second Edition

Author : Mohsen A. Hedaya
Publisher : CRC Press
Page : 599 pages
File Size : 47,9 Mb
Release : 2012-02-09
Category : Medical
ISBN : 9781439850732

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Basic Pharmacokinetics, Second Edition by Mohsen A. Hedaya Pdf

Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.

Author : Sara E. Rosenbaum
Publisher : John Wiley & Sons
Page : 589 pages
File Size : 49,6 Mb
Release : 2016-12-27
Category : Medical
ISBN : 9781119143154

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Basic Pharmacokinetics and Pharmacodynamics by Sara E. Rosenbaum Pdf

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Author : Mohsen A. Hedaya
Publisher : CRC Press
Page : 328 pages
File Size : 41,5 Mb
Release : 2007-04-23
Category : Medical
ISBN : 9781420046724

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Basic Pharmacokinetics by Mohsen A. Hedaya Pdf

This volume is a self-instructional computer-assisted medium for active learning. Indeed, the tutorial materials included in the accompanying compact disk have received an award from the American Association of Colleges of Pharmacy for innovation in teaching. This volume and its companion CD are intended for students and practitioners in the health professions who need to comprehend the concepts and principles related to how the body absorbs, distributes, metabolizes, and excretes drugs. "...The author's reliance on active learning, his use of examples illustrating important pharmacokinetic principles, and particularly the thoughtful simulation tools he has developed make this text and its companion CD an extremely effective and enjoyable introduction to the field of pharmacokinetics." From the Foreword, Ronald J. Sawchuk Minneapolis, Minnesota Pharmacokinetics has become an essential component of all the processes involved in drug development, discovery, and preclinical evaluation, as well as with the clinical use of drugs. While this has led to the development of many highly complex techniques, basic pharmacokinetic concepts remain the backbone of all these new developments. Consequently, a thorough understanding of the basic concepts is essential before one can tackle the more involved and applied areas of pharmacokinetics. Basic Pharmacokinetics consists of two parts: textual printed materials and highly interactive computer-based presentations. Together, these provide a useful combination that makes it easy to grasp basic principles. The computer-based information is presented in a self-instructional format, which introduces concepts, utilizing highly interactive graphical presentations and simulations. It visualizes the interplay between the different pharmacokinetic parameters, observing how the change in one or more of these parameters impacts the drug concentration-time profile in the body. Uniquely and carefully designed, the learning modules in the CD closely support and complement the text, providing the learner with an opportunity to reinforce his or her understanding of the principles presented.

Author : Sara E. Rosenbaum
Publisher : John Wiley & Sons
Page : 440 pages
File Size : 55,9 Mb
Release : 2012-09-10
Category : Medical
ISBN : 9781118197783

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Basic Pharmacokinetics and Pharmacodynamics by Sara E. Rosenbaum Pdf

With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 44,5 Mb
Release : 1982
Category : Electronic
ISBN : OCLC:252398052

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Pharmacokinetics by Anonim Pdf

Author : Wolfgang A. Ritschel
Publisher : Unknown
Page : 616 pages
File Size : 53,7 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015028448358

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Handbook of Basic Pharmacokinetics-- Including Clinical Applications by Wolfgang A. Ritschel Pdf

Author : Sunil S. Jambhekar,Pharmaceutical Press,Philip J,Philip J. Breen
Publisher : Unknown
Page : 0 pages
File Size : 40,7 Mb
Release : 2023-04
Category : Electronic
ISBN : 0857114476

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Basic Pharmacokinetics by Sunil S. Jambhekar,Pharmaceutical Press,Philip J,Philip J. Breen Pdf

Author : Wolfgang A. Ritschel,Gregory L. Kearns
Publisher : American Pharmacists Association (APhA)
Page : 456 pages
File Size : 41,9 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015059107733

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Handbook of Basic Pharmacokinetics-- Including Clinical Applications by Wolfgang A. Ritschel,Gregory L. Kearns Pdf

A user-friendly handbook on the principles and techniques involved in the various applications of pharmacokinetics. Provides a concise reference for clinicians who need quick information on the pharmacokinetic characteristics of specific drugs. Thoroughly updated and revised, this book features pharmacokinetic data profiles on more than 600 drugs.

Author : Larry A. Bauer
Publisher : McGraw Hill Professional
Page : 842 pages
File Size : 49,9 Mb
Release : 2007-09-22
Category : Medical
ISBN : 0071593721

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Applied Clinical Pharmacokinetics by Larry A. Bauer Pdf

New sections on dosing strategies in all chapters. New chapter on sirolimus under the Immunosuppressants section. Essential information on drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure. 30% of chapters extensively revised, others lightly updated

Author : Wolfgang A. Ritschel
Publisher : Unknown
Page : 572 pages
File Size : 54,5 Mb
Release : 1986
Category : Medical
ISBN : UOM:39015011640136

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Handbook of Basic Pharmacokinetics-- Including Clinical Applications by Wolfgang A. Ritschel Pdf

Author : Johan Gabrielsson,Daniel Weiner
Publisher : CRC Press
Page : 926 pages
File Size : 46,6 Mb
Release : 2001-11-30
Category : Medical
ISBN : 9186274929

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Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition by Johan Gabrielsson,Daniel Weiner Pdf

This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.

Author : Milo Gibaldi,Donald Perrier
Publisher : Unknown
Page : 329 pages
File Size : 51,9 Mb
Release : 1982
Category : Electronic
ISBN : OCLC:777063461

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Pharmacokinetics by Milo Gibaldi,Donald Perrier Pdf

Author : Donald J. Birkett
Publisher : McGraw Hill Professional
Page : 162 pages
File Size : 52,9 Mb
Release : 2002
Category : Medical
ISBN : 0074710729

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Pharmacokinetics Made Easy by Donald J. Birkett Pdf

Pharmacokinetics Made Easy 1Rpresents the complex subject of pharmacokinetics in a simple, easy-to-understand manner, lending itself to a wide audience including medical practitioners, health professionals and students of pharmacology, medicine and nursing. The physiological approach adopted in the book allows clinical issues in drug therapy to be addressed, making it directly applicable to practice situations. The chapters in this book were initially published as a series of articles inAustralian Prescriberto assist practitioners in drug dosing and therapy. In this revised edition, the book has been updated according to recent developments and a new chapter called 'How to Determine the Pharmacokinetic Parameters of a Drug' added. Each chapter also has a new feature-a list of key points summarising the content to improve accessibility and understanding.

Author : Jim E. Riviere
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 51,9 Mb
Release : 2011-01-14
Category : Medical
ISBN : 0470959886

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Comparative Pharmacokinetics by Jim E. Riviere Pdf

Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.

Author : Younggil Kwon
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 51,8 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306468209

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Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by Younggil Kwon Pdf

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.