Basic Pharmacokinetics

Author : Mohsen A. Hedaya
Publisher : CRC Press
Page : 599 pages
File Size : 50,9 Mb
Release : 2012-02-09
Category : Medical
ISBN : 9781439850732

Get Book

Basic Pharmacokinetics, Second Edition by Mohsen A. Hedaya Pdf

Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.

Author : Sunil S. Jambhekar,Pharmaceutical Press,Philip J,Philip J. Breen
Publisher : Unknown
Page : 0 pages
File Size : 49,7 Mb
Release : 2023-04
Category : Electronic
ISBN : 0857114476

Get Book

Basic Pharmacokinetics by Sunil S. Jambhekar,Pharmaceutical Press,Philip J,Philip J. Breen Pdf

Author : Sara E. Rosenbaum
Publisher : John Wiley & Sons
Page : 440 pages
File Size : 41,7 Mb
Release : 2012-09-10
Category : Medical
ISBN : 9781118197783

Get Book

Basic Pharmacokinetics and Pharmacodynamics by Sara E. Rosenbaum Pdf

With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.

Author : Mohsen A. Hedaya
Publisher : CRC Press
Page : 328 pages
File Size : 50,8 Mb
Release : 2007-04-23
Category : Medical
ISBN : 9781420046724

Get Book

Basic Pharmacokinetics by Mohsen A. Hedaya Pdf

This volume is a self-instructional computer-assisted medium for active learning. Indeed, the tutorial materials included in the accompanying compact disk have received an award from the American Association of Colleges of Pharmacy for innovation in teaching. This volume and its companion CD are intended for students and practitioners in the health professions who need to comprehend the concepts and principles related to how the body absorbs, distributes, metabolizes, and excretes drugs. "...The author's reliance on active learning, his use of examples illustrating important pharmacokinetic principles, and particularly the thoughtful simulation tools he has developed make this text and its companion CD an extremely effective and enjoyable introduction to the field of pharmacokinetics." From the Foreword, Ronald J. Sawchuk Minneapolis, Minnesota Pharmacokinetics has become an essential component of all the processes involved in drug development, discovery, and preclinical evaluation, as well as with the clinical use of drugs. While this has led to the development of many highly complex techniques, basic pharmacokinetic concepts remain the backbone of all these new developments. Consequently, a thorough understanding of the basic concepts is essential before one can tackle the more involved and applied areas of pharmacokinetics. Basic Pharmacokinetics consists of two parts: textual printed materials and highly interactive computer-based presentations. Together, these provide a useful combination that makes it easy to grasp basic principles. The computer-based information is presented in a self-instructional format, which introduces concepts, utilizing highly interactive graphical presentations and simulations. It visualizes the interplay between the different pharmacokinetic parameters, observing how the change in one or more of these parameters impacts the drug concentration-time profile in the body. Uniquely and carefully designed, the learning modules in the CD closely support and complement the text, providing the learner with an opportunity to reinforce his or her understanding of the principles presented.

Author : Biswajit Mukherjee
Publisher : Springer Nature
Page : 354 pages
File Size : 46,5 Mb
Release : 2022-03-17
Category : Medical
ISBN : 9789811689505

Get Book

Pharmacokinetics: Basics to Applications by Biswajit Mukherjee Pdf

This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.

Author : Sara E. Rosenbaum
Publisher : John Wiley & Sons
Page : 589 pages
File Size : 45,8 Mb
Release : 2016-12-27
Category : Medical
ISBN : 9781119143154

Get Book

Basic Pharmacokinetics and Pharmacodynamics by Sara E. Rosenbaum Pdf

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Author : Thorsteinn Loftsson
Publisher : Academic Press
Page : 178 pages
File Size : 42,9 Mb
Release : 2015-03-25
Category : Medical
ISBN : 9780128014912

Get Book

Essential Pharmacokinetics by Thorsteinn Loftsson Pdf

Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes Illustrates how to write and evaluate drug registration files

Author : Soraya Dhillon,Andrzej Kostrzewski
Publisher : Pharmaceutical Press
Page : 284 pages
File Size : 49,7 Mb
Release : 2006
Category : Chemotherapy
ISBN : 0853695717

Get Book

Clinical Pharmacokinetics by Soraya Dhillon,Andrzej Kostrzewski Pdf

Pharmacokinetics is the study of the process of drug absorption, distribution, metabolism and elimination. The aim of applying pharmacokinetic principles is to individualise the dose of drug, and optimise the outcome achieved in each patient. Its application reduces the chance of under-treatment, inadvertent poisoning, and dose related adverse effects. This new edition is specifically aimed at supporting undergraduate studies in pharmacokinetics, and has a strong emphasis on the application of pharmacokinetics in routine clinical practice. Clinical Pharmacokinetics also includes several case studies and 'questions and answers' to further aid understanding and revision.

Author : Younggil Kwon
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 47,5 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306468209

Get Book

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by Younggil Kwon Pdf

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Author : Michael E. Winter
Publisher : Applied Therapeutics, Incorporated
Page : 440 pages
File Size : 44,6 Mb
Release : 1988
Category : Medical
ISBN : UOM:39015035784183

Get Book

Basic Clinical Pharmacokinetics by Michael E. Winter Pdf

Basic Clinical Pharmacokinetics was designed to simplify pharmacokinetics to help busy practitioners understand and visualize basic principles. An easy-to-read, case-study format has made the text a favorite among clinical professors, students, and practitioners. Part One provides a basic review of pharmacokinetic principles. Extensive explanations, graphic illustrations, and detailed algorithms teach the principles of bioavailability, volume of distribution, clearance, elimination rate constant, and half-life. Part Two explains the clinical applications of these principles. Solutions to problems commonly encountered in the practice setting are discussed for specific drugs. New to this edition are chapters on tricyclic antidepressants and cyclosporine, an expanded chapter on dialysis, and updated information on choosing equations and interpreting plasma drug concentrations.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 54,7 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

Get Book

Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Wolfgang A. Ritschel
Publisher : Unknown
Page : 572 pages
File Size : 49,6 Mb
Release : 1986
Category : Medical
ISBN : UOM:39015011640136

Get Book

Handbook of Basic Pharmacokinetics-- Including Clinical Applications by Wolfgang A. Ritschel Pdf

Author : Beringer, Paul
Publisher : Lippincott Williams & Wilkins
Page : 732 pages
File Size : 54,7 Mb
Release : 2023-09-19
Category : Medical
ISBN : 9781975195250

Get Book

Winter's Basic Clinical Pharmacokinetics by Beringer, Paul Pdf

Popular among students and clinicians for its easy-to-read, case-study format, Winter’s Basic Clinical Pharmacokinetics, 7th Edition, clarifies complex concepts to help you confidently apply pharmacokinetics and therapeutic drug monitoring to patient care. This straightforward text is divided into two parts, reviewing basic pharmacokinetic principles in Part I and illustrating the clinical application of these principles to the most commonly encountered problems in Part II. The significantly updated and expanded 7th Edition adds essential coverage of the use of pharmacokinetics in managing obesity, pregnancy, as well as anticoagulation

Author : Michael E. Winter,Brian S. Katcher,Mary Anne Koda-Kimble
Publisher : Applied Therapeutics, Incorporated
Page : 254 pages
File Size : 46,7 Mb
Release : 1980
Category : Medical
ISBN : UOM:39015000844376

Get Book

Basic Clinical Pharmacokinetics by Michael E. Winter,Brian S. Katcher,Mary Anne Koda-Kimble Pdf

Basic Clinical Pharmacokinetics was designed to simplify pharmacokinetics to help busy practitioners understand and visualize basic principles. An easy-to-read, case-study format has made the text a favorite among clinical professors, students, and practitioners. Part One provides a basic review of pharmacokinetic principles. Extensive explanations, graphic illustrations, and detailed algorithms teach the principles of bioavailability, volume of distribution, clearance, elimination rate constant, and half-life. Part Two explains the clinical applications of these principles. Solutions to problems commonly encountered in the practice setting are discussed for specific drugs. New to this edition are chapters on tricyclic antidepressants and cyclosporine, an expanded chapter on dialysis, and updated information on choosing equations and interpreting plasma drug concentrations.

Author : John Kolthammer
Publisher : Inst of Clinical Research
Page : 52 pages
File Size : 41,7 Mb
Release : 2007
Category : Pharmacokinetics
ISBN : 9781905238415

Get Book

Pharmacokinetics, a Beginner's Guide by John Kolthammer Pdf

Everything you ever wanted to know about basic pharmacokinetics.