Bile Acids In Hepatobiliary Disease

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Bile Acids in Hepatobiliary Disease

T.C. Northfield,H. Ahmed,R. Jazwari,P. Zentler-Munro
Bile Acids in Hepatobiliary Disease Book PDF

Author : T.C. Northfield,H. Ahmed,R. Jazwari,P. Zentler-Munro
Publisher : Springer Science & Business Media
Page : 366 pages
File Size : 48,7 Mb
Release : 2000-02-29
Category : Medical
ISBN : 0792387554

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Bile Acids in Hepatobiliary Disease by T.C. Northfield,H. Ahmed,R. Jazwari,P. Zentler-Munro Pdf

This book is the proceedings of the Falk Workshop on `Bile Acids in Hepatobiliary Disease', which took place at the Royal Society of Medicine (RSM) in London, UK, on 29-30 March 1999, and was held in association with the Section of Measurement in Medicine at the RSM. The main interest in bile acid therapy has been recently in cholestatic liver disease. The proceedings of the workshop not only discusses this, but moves on to examine its possible use in alcoholic liver disease, and moves back to re-examine its role in biliary disease. Leading world experts attempt to define its mechanism of action, and the current role of other non-surgical treatments in biliary disease. The physiology and pathogenesis of cholestatic and alcoholic liver disease and cholesterol gallstone disease is also examined.

Bile Acids and Hepatobiliary Diseases - Basic Research and Clinical Application

G. Paumgartner,A. Stiehl,W. Gerok
Bile Acids and Hepatobiliary Diseases Basic Research and Clinical Application Book PDF

Author : G. Paumgartner,A. Stiehl,W. Gerok
Publisher : Springer
Page : 356 pages
File Size : 49,8 Mb
Release : 1997-06-30
Category : Medical
ISBN : UOM:39015040572292

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Bile Acids and Hepatobiliary Diseases - Basic Research and Clinical Application by G. Paumgartner,A. Stiehl,W. Gerok Pdf

Since the last International Bile Acid Meeting in San Diego in 1994, new advances have been made in the understanding of bile acid metabolism and transport. The cytotoxic as well as the therapeutic effects of specific bile acids have been further explored and the beneficial effects of ursodeoxycholic acid in various chronic cholestatic conditions have been substantiated. Much basic and clinical research has been conducted to unravel the underlying mechanisms of action. This volume, the proceedings of Falk Symposium No. 93 (XIV International Bile Acid Meeting), held in Freiburg-im-Breisgau, Germany, October 22-24, 1996, is dedicated to both basic and clinical aspects of bile acid research related to the role of bile acids in hepatobiliary diseases.

Bile Acids in Liver Diseases

G. Paumgartner,U. Beuers
Bile Acids in Liver Diseases Book PDF

Author : G. Paumgartner,U. Beuers
Publisher : Springer
Page : 186 pages
File Size : 41,5 Mb
Release : 1995-12-31
Category : Medical
ISBN : UOM:39015037346742

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Bile Acids in Liver Diseases by G. Paumgartner,U. Beuers Pdf

Bile acid research has attracted increasing attention from both basic scientists and clinical hepatologists over the last decade. Experimental studies have expanded our knowledge of the role of bile acids in liver disease, and well-designed clinical trials have documented beneficial effects of bile acid treatment for a number of hepatobiliary diseases. Bile Acids in Liver Diseases, the proceedings of an International Falk Workshop held in Munich, January 1995, provides insights into current concepts in bile acid chemistry, bile acid synthesis and metabolism, and transport of bile acids across the hepatocyte. The role of bile acids in bile formation, cholestasis and hepatotoxicity are discussed. Finally, the book addresses experimental studies and hypotheses about the putative mechanisms of action of ursodeoxycholic acid in cholestatic liver diseases, and summarizes the clinical applications of bile acid treatment on the basis of controlled clinical trials.

Hepatotoxicity

Hyman J. Zimmerman
Hepatotoxicity Book PDF

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 49,9 Mb
Release : 1999
Category : Medical
ISBN : 0781719526

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Hepatotoxicity by Hyman J. Zimmerman Pdf

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Bile Acids and the Hepatobiliary System

G. Paumgartner,A. Stiehl,W. Gerok
Bile Acids and the Hepatobiliary System Book PDF

Author : G. Paumgartner,A. Stiehl,W. Gerok
Publisher : Springer
Page : 356 pages
File Size : 40,9 Mb
Release : 1993-06-30
Category : Medical
ISBN : UOM:39015029111088

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Bile Acids and the Hepatobiliary System by G. Paumgartner,A. Stiehl,W. Gerok Pdf

Bile acids have recently found application in the treatment of hepatobiliary diseases. Chenodeoxycholic acid and ursodeoxycholic acid have proved to be effective agents for the dissolution of cholesterol gallstones, and ursodeoxycholic acid has been shown to have beneficial effects in patients with chronic cholestatic liver disease such as primary biliary cirrhosis or primary sclerosing cholangitis. The question of the long-term benefit for the patient remains open and the mechanism of action is still unclear. As a consequence, much basic and clinical research is being conducted on bile acid therapy. The XIIth International Bile Acid Meeting brought together researchers and clinicians from around the world, and was dedicated to basic and clinical aspects of the use of bile acids in the therapy of hepatobiliary disease.

Workshops in Bile Acid Research

L. Barbara,R.H. Dowling,A.F. Hofmann,E. Roda
Workshops in Bile Acid Research Book PDF

Author : L. Barbara,R.H. Dowling,A.F. Hofmann,E. Roda
Publisher : Springer Science & Business Media
Page : 137 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400966161

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Workshops in Bile Acid Research by L. Barbara,R.H. Dowling,A.F. Hofmann,E. Roda Pdf

During the 7th International Bile Acid meeting held in Cortina d'Ampezzo. , Italy, during March 1982, there were two important Workshops dealing with recent advances in two areas of bile acid metabolism - Serum Bile Acids i,n Health and Disease and The Pathophysiology of the Enterohepatic Circulation. These Workshops complemented the broad range of topics in bile acid metabolism which were presented formally as part of a Postgraduate Course. The proceedings of these formal presentations have already been pub lished by MTP Press under the title Bile Acids in Gastroenterology but in view of the exciting, important, new information which emerged during both Workshops, the organisers of the meeting felt that it would be valuable to record and edit the proceedings of the Work shops, which form the basis of this volume. The advent of new techniques for measurement of total and indi vidual bile acids in serum now means that accurate and reliable 7 PREFACE measurements of bile acids in peripheral circulation are available to all. This has resulted in a veritable explosion of information in the serum bile acid field and, therefore, the appearance of a critical evalu ation of the technical and basic scientific and clinical aspects of measuring serum bile acids is indeed timely.

The Biliary System

David Q.-H. Wang,Brent A. Neuschwander-Tetri,Piero A. M. Portincasa
The Biliary System Book PDF

Author : David Q.-H. Wang,Brent A. Neuschwander-Tetri,Piero A. M. Portincasa
Publisher : Morgan & Claypool Publishers
Page : 160 pages
File Size : 50,5 Mb
Release : 2012
Category : Science
ISBN : 9781615043606

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The Biliary System by David Q.-H. Wang,Brent A. Neuschwander-Tetri,Piero A. M. Portincasa Pdf

The exponential expansion of knowledge in the field of hepatobiliary diseases makes systematic revisions of current concepts almost mandatory nowadays. This eBook summarizes the progress in understanding the molecular mechanism of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system. By guiding the readers through the various aspects of anatomy, physiology, and biochemistry of all "players" involved in bile formation, this eBook is intended to be a compendium of recent progresses in understanding the molecular mechanisms of cholesterol and bile acid metabolism. Table of Contents: Introduction / Anatomy of the Liver, Biliary Tract, and Gallbladder / Physical Chemistry of Bile / Hepatic Cholesterol Metabolism / Physical Chemistry and Hepatic Metabolism of Bile Acids / The Enterohepatic Circulation of Bile Acids / Hepatic Secretion of Biliary Lipids and Bile Formation / Summary / Acknowledgments / References / Author Biographies

Bile Acids in Gastroenterology

Susumu Tazuma,Hajime Takikawa
Bile Acids in Gastroenterology Book PDF

Author : Susumu Tazuma,Hajime Takikawa
Publisher : Springer
Page : 209 pages
File Size : 43,5 Mb
Release : 2017-04-03
Category : Medical
ISBN : 9784431560623

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Bile Acids in Gastroenterology by Susumu Tazuma,Hajime Takikawa Pdf

This book examines the biological aspects of bile acid analysis and their clinical applications, providing readers with an overview of cutting-edge discussions on Bile Acid research and diseases. It begins with detailed discussions on the biological aspects of bile acid, with chapters examining bile acid from various perspectives, from its metabolism to its use in therapeutic agents. Subsequent chapters focus on diseases involving bile acid abnormalities, and specific applications are addressed concerning gallstones, cholestatic liver disease, NAFLD/NASH, hepatitis, pancreatitis, esophageal cancer and colon cancer. In keeping with the book’s integrated approach, the Editor has gathered a broad range of eminent scholars and practitioners to provide a comprehensive review of modern bile acid research. The book offers clinical physicians, basic researchers and postgraduate students essential insights into cutting-edge research and paves the way for further research.

Hepatobiliary Diseases

Jesus Prieto,Joan Rodes,David A. Shafritz
Hepatobiliary Diseases Book PDF

Author : Jesus Prieto,Joan Rodes,David A. Shafritz
Publisher : Springer Science & Business Media
Page : 1132 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642768026

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Hepatobiliary Diseases by Jesus Prieto,Joan Rodes,David A. Shafritz Pdf

The last few years have witnessed major developments in molecular biology which have had a significant impact on biomedical knowledge. As a result new concepts in cell biology have emerged, new etiologic agents have been discovered, and new drugs have become available. Furthermore, the world of mediators, cytokines, and humoral factors has enlarged considerably in a relatively short period and this has modified our views of diverse physio pathologic processes as well as opened up new therapeutic prospects. In addition, recent technologic advances have revolutionized our diagnostic methodology and have greatly enhanced the power of our therapeutic resources. All these factors have contributed to a substantial remodeling of both liver science and clinical hepatology, and these changes have generated the motivation for the production of the present book, which attempts to give an account of well-known clinical facts in the light of current thinking. It is the fruit of the coordinated work of experts from different countries in three continents. In a sense, it is a manifestation of the fact that inter national cooperation is becoming increasingly important not only in the expansion of science but also in its exposition. We hope that Hepatobiliary Diseases will be useful to both students and clinicians and that internists, gastroenterologists, and general practitioners will find in its contents a satifactory coverage of their field of interest.

Itch

E. Carstens,Tasuku Akiyama
Itch Book PDF

Author : E. Carstens,Tasuku Akiyama
Publisher : CRC Press
Page : 482 pages
File Size : 52,8 Mb
Release : 2014-02-25
Category : Science
ISBN : 9781466505438

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Itch by E. Carstens,Tasuku Akiyama Pdf

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Liver Disease in Children

Frederick J. Suchy,Ronald J. Sokol,William F. Balistreri
Liver Disease in Children Book PDF

Author : Frederick J. Suchy,Ronald J. Sokol,William F. Balistreri
Publisher : Cambridge University Press
Page : 995 pages
File Size : 41,5 Mb
Release : 2007-05-07
Category : Medical
ISBN : 9781139464031

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Liver Disease in Children by Frederick J. Suchy,Ronald J. Sokol,William F. Balistreri Pdf

Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.

Biology of Bile Acids in Health and Disease

G.P. van Berge Henegouwen,D. Keppler,U. Leuschner,G. Paumgartner,A. Stiehl
Biology of Bile Acids in Health and Disease Book PDF

Author : G.P. van Berge Henegouwen,D. Keppler,U. Leuschner,G. Paumgartner,A. Stiehl
Publisher : Springer Science & Business Media
Page : 364 pages
File Size : 55,8 Mb
Release : 2001-05-31
Category : Medical
ISBN : 0792387686

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Biology of Bile Acids in Health and Disease by G.P. van Berge Henegouwen,D. Keppler,U. Leuschner,G. Paumgartner,A. Stiehl Pdf

Beginning in 1970, the International Bile Acid Meeting has taken place every two years and each time new progress in our understanding of the complex role of bile acids in many metabolic processes of the liver and the intestine has been revealed by a selected group of leading scientists from all over the world. Although originally mainly physiological data on bile acid synthesis and transport were emphasized, and later on also the therapeutic benefit of bile acids in gallstone disease and cholestasis was discovered, we have come now to the molecular biology and genetic era with major discoveries in transport defects and related diseases. This book is the proceedings of Falk Symposium No. 120, held in The Hague, The Netherlands, on October 12-13, 2000 - the 16th International Bile Acid Meeting. One of the main discoveries recently has been the identification of nuclear receptors for bile acids, which gives them a much broader perspective than previously anticipated. It even suggests that bile acids can regulate their biosynthesis and enterohepatic circulation transcriptionally. It will therefore not be surprising that this topic, together with the molecular regulation of cholesterol 7alpha-hydroxylase and cholesterol homeostasis, has a dominant place in these proceedings. Another important topic is the progress in our molecular understanding of hepatic (both at the basolateral and canalicular sites), cholangiocytic and intestinal bile acid transport processes. Further insights into genetic defects causing cholestasis or intestinal malabsorption in animal models and in human diseases are also discussed by a number of well-known authors. Finally the last section deals with new findings on the role of bile acid therapy in cholestatic syndromes or chemoprevention and with the potential benefit of bile acid inhibitors. All contributors provide an update on the most recent developments in their field.

Hepatobiliary Transport in Health and Disease

Dieter Häussinger,Verena Keitel,Ralf Kubitz
Hepatobiliary Transport in Health and Disease Book PDF

Author : Dieter Häussinger,Verena Keitel,Ralf Kubitz
Publisher : Walter de Gruyter
Page : 312 pages
File Size : 46,6 Mb
Release : 2012-05-29
Category : Science
ISBN : 9783110279344

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Hepatobiliary Transport in Health and Disease by Dieter Häussinger,Verena Keitel,Ralf Kubitz Pdf

One major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. Furthermore, new research has shown that bile acids, whose function in digestion is long known, also behave as signal molecules in a variety of organs, including the intestinal and biliary epithelia, sinusoidal endothelial and immune cells. This book provides indepth surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease, the mechanisms of bile salt-induced apoptosis and hepatocyte protection, and the role of transporter mutations as causes and modifiers of liver diseases. The book will be of interest not only for biochemists, structural chemists and biologists, but also for clinicians.

Bile Acids and Pregnancy

U. Leuschner,P.A. Berg,J. Holtmeier
Bile Acids and Pregnancy Book PDF

Author : U. Leuschner,P.A. Berg,J. Holtmeier
Publisher : Springer Science & Business Media
Page : 106 pages
File Size : 51,6 Mb
Release : 2002-12-31
Category : Medical
ISBN : 0792387821

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Bile Acids and Pregnancy by U. Leuschner,P.A. Berg,J. Holtmeier Pdf

Pregnancy represents an allograft in so far that half of the antigens are foreign to the mother. Therefore, a bidirectional interaction between the maternal and the fetal immune systems must exist, which could be disturbed by preexisting autoimmune liver diseases. Since nowadays autoimmune liver diseases are increasingly detected as early stage diseases due to modern diagnostic procedures, e.g. in women of childbearing age, and since the number of posttransplant pregnancies has become an issue due to improved survival, questions concerning regnancy, autoimmune liver disease and treatment options with bile acids and/or immunosuppressants are of an ever-increasing interest. This book, the proceedings of a Falk Workshop held in Freiburg, Germany, on June 2, 2002, is certainly unable to give any definite answers to any of the hundreds of still remaining questions in this fascinating field, but hopefully it will help to stimulate and initiate cooperation among immunologists, bile acid researchers, gynaecologists and internists.

Bile Acids in Gastroenterology: Basic and Clinical Advances

A.F. Hofmann,G. Paumgartner,A. Stiehl
Bile Acids in Gastroenterology Basic and Clinical Advances Book PDF

Author : A.F. Hofmann,G. Paumgartner,A. Stiehl
Publisher : Springer Science & Business Media
Page : 428 pages
File Size : 50,6 Mb
Release : 1995-06-30
Category : Medical
ISBN : 0792388801

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Bile Acids in Gastroenterology: Basic and Clinical Advances by A.F. Hofmann,G. Paumgartner,A. Stiehl Pdf

This book contains the proceedings of the XIIIth International Bile Acid Meeting (Falk Symposium 80), an official satellite meeting of the World Congress of Gastroenterology, held in San Diego, California, U.S.A., September 30--October 2, 1994. It begins with presentations of major advances in bile acid chemistry, biology and pharmacology. The new structure proposed for the mixed micelles present in bile is reviewed, as are the properties of new synthetic analogues of bile acids. The mechanisms by which bile acids interact with cell membranes are discussed in order to provide insight into the hepatotoxic effects of bile acids in cholestatic liver disease. The book further shows the exciting progress in the molecular biology of bile acid transport by the hepatocyte and enterocyte, and concludes with a consensus on the use of ursodeoxycholic acid in cholestatic liver disease and as an adjunct to immunosuppressive therapy after liver transplantation, and to interferon therapy in chronic viral hepatitis.