Biochemical Pharmacology And Toxicology

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 40,7 Mb
Release : 1985
Category : Electronic
ISBN : OCLC:251519647

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Biochemical Pharmacology and Toxicology by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 52,9 Mb
Release : 1980
Category : Electronic
ISBN : OCLC:923221920

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Biochemical Pharmacology and Toxicology by Anonim Pdf

Author : Michael Palmer
Publisher : John Wiley & Sons
Page : 436 pages
File Size : 44,9 Mb
Release : 2012-04-09
Category : Science
ISBN : 9781118230336

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Biochemical Pharmacology by Michael Palmer Pdf

An integrated approach to the study of drug action mechanisms Biochemical Pharmacology is a concise and contemporary textbook on the principles of drug action. It discusses representative drugs by example to explore the range of biochemical targets and mechanisms. The book explains some of the experiments that tell us how drugs work, and it outlines the physiological and pathological context that make those action mechanisms therapeutically useful. Biochemical Pharmacology is intended primarily for students in biology and biochemistry at the advanced undergraduate or graduate levels. For classroom use, the illustrations from the book are separately available as PowerPoint slides. It is written in a conversational, vivid style that readily encourages students to explore this important area of medical science. Biochemical Pharmacology can also serve as an introduction for professionals in biosciences, as well as in pharmaceutical and health sciences. Complete with numerous figures throughout the text, which are also available separately as PowerPoint slides, Biochemical Pharmacology: Explains the role of pharmacodynamics, pharmacokinetics, and drug metabolism in drug action Provides representative examples from the pharmacology of cell excitation, hormones, nitric oxide, chemotherapy, and others Examines emerging applications of ribonucleic acids as drugs and drug targets Discusses what researchers need to know about the problems of drug distribution, elimination, and toxicity Biochemical Pharmacology is an important resource for anyone wishing to gain an in-depth understanding of drug action mechanisms and extremely useful for researchers wishing to explore some of the unanswered questions .

Author : Michael Palmer,Alice Chan,Thorsten Dieckmann,John Honek
Publisher : John Wiley & Sons
Page : 388 pages
File Size : 48,7 Mb
Release : 2013-08-08
Category : Science
ISBN : 9781118819982

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Notes to Biochemical Pharmacology by Michael Palmer,Alice Chan,Thorsten Dieckmann,John Honek Pdf

This book contains lecture notes intended for teaching biochemical pharmacology. The content is based on and best understood as an ancillary with the authors' textbook Biochemical Pharmacology (Wiley, 2012). Most of the figures have been adapted, with enhancements and occasional corrections, whereas the text is new and more condensed -- making it easier to cover most or all of the content in a single term. The focus is on principles, not on comprehensive coverage or clinical relevance. It uses a simple layout, presenting lecture slides in sequence, augmented with the explanatory text below each. This is an ideal format for ebook reading, yielding easier on-screen reading than a traditional book layout.

Author : P.S. Randall,James R. Gillette,J.R. Mitchell
Publisher : Springer Science & Business Media
Page : 509 pages
File Size : 54,6 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642463143

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Concepts in Biochemical Pharmacology by P.S. Randall,James R. Gillette,J.R. Mitchell Pdf

Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.

Author : Bernard B. Brodie,James R. Gillette
Publisher : Springer Science & Business Media
Page : 797 pages
File Size : 42,6 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642651779

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Concepts in Biochemical Pharmacology by Bernard B. Brodie,James R. Gillette Pdf

This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bio chemical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. Byron Clark, Director of the Pharmacology-Toxicology Program at the National Institutes of Health whose support made possible much of the work described in this volume. Contents Section Four: Methods 01 Stooging the MetoholiBm 01 Drugs Subsection A. Assay 01 Drugs and Their M etoholites Chapter 22 : Basic Principles in Development of Methods for Drug Assay. B. B. BRODIE. With 2 Figures 1 1 A. Introduction . . . . . . . . . . B. Principles of Developing a Method. . . . . . 1 I. Section of Method of Assay . . . . . . 1 II. Choice of Solvent for Extraction of Drug 2 III. Adsorption of Drugs by Glass Surfaces . . . . . . . . . . . . . . 3 IV. Recoveries of Known Amounts of Compound from Biological Material. 4 V. Assessment of Sensitivity 5 VI. Assessment of Specificity 5 References. . . . . . . . . . .

Author : H.S. Ackermann,Bernard B. Brodie,James R. Gillette
Publisher : Springer Science & Business Media
Page : 486 pages
File Size : 55,6 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642650529

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Concepts in Biochemical Pharmacology by H.S. Ackermann,Bernard B. Brodie,James R. Gillette Pdf

This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bioche mical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. BYRON CLARKE, Director of the Pharmacology-Toxicology Program at the National Insti tutes of Health, whose support made possible much of the work described in this volume. Contents Section One: Routes of Drug Administration Chapter 1: Biological Membranes and Their Passage by Drugs. C. A. M. HOGBEN 1 References. . . . . . . . . . . . . . . . . . . . . . . . . . 8 Chapter 2: Absorption of Drugs from the Gastrointestinal Tract. L. S. SCHANKER. With 5 Figures. 9 I. Introduction. . . . . . . . . . . . . . . . . . . . . . . 9 II. Methods of Study. . . . . . . . . . . . . . . . . . . . . 9 III. Absorption from the Stomach . . . . . . . . . . . . . . . 11 IV. Intestinal Absorption of Non-Electrolytes and Weak Electrolytes 15 V. Absorption of Weak Electrolytes from the Colon and Rectum 18 VI. Intestinal Absorption of Organic Ions. . . . . . . . . . 19 VII. Intestinal Absorption of Macromolecules . . . . . . . . . . 19 VIII. Active Transport across the Intestinal Epithelium . . . . . 20 IX. Effect of EDTA on Drug Absorption from the Intestine . . . . . . .

Author : Anonim
Publisher : Academic Press
Page : 436 pages
File Size : 52,8 Mb
Release : 2022-08-09
Category : Medical
ISBN : 9780323911108

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Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary by Anonim Pdf

Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450. Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 43,5 Mb
Release : 1968
Category : Electronic
ISBN : OCLC:252486453

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Biochemical Pharmacology by Anonim Pdf

Author : Edward Majchrowicz
Publisher : Springer
Page : 367 pages
File Size : 52,9 Mb
Release : 2012-10-20
Category : Medical
ISBN : 1468475304

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Biochemical Pharmacology of Ethanol by Edward Majchrowicz Pdf

A number of excellent symposia, reviews and monographs on the biology of ethanol have been published during the last decade. Al though it may appear that another such publication may be superflu ous, the subject of alcohol abuse is still open for further explora tion and the field of the biochemical pharmacology of ethanol is in its infancy. This is evidenced, for example, by the unavailability of any drugs that are designed specifically for the treatment of alcohol intoxication or alcohol addiction. The impetus for this publication was generated by a spontane ous enthusiasm following the symposium on BiochemicaZ Ph~acoZogy of EthanoZ that was organized at the annual meeting of the American Chemical Society, Division of Biological Chemistry in August 1973 in Chicago. It was the first symposium on such a topic ever in cluded in the program of that large society of American chemists. The original aim of the symposium was to acquaint the members of the society with some basic facts about the biological chemistry of ethanol. The symposium included seven papers and covered a rela tively narrow range of ethanol biochemistry. In view of the enthu siasm shown at the Chemical Society meeting, the panelists decided to publish the program and to amplify it by inclusion of additional topics which have remained relatively unexplored in earlier publica tions. In addition, reviews have been included which discuss old topics from a new perspective.

Author : Doris Clouet
Publisher : Springer Science & Business Media
Page : 527 pages
File Size : 43,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468418699

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Narcotic Drugs by Doris Clouet Pdf

The riddle of the biochemical nature of drug dependence of the opiate type has stimulated many studies directed toward understanding the molecular basis of the action of opiates, and, particularly, the phenomena of tolerance, physical dependence, and drug-seeking behavior-phenomena exhibited by man and experimental animals exposed persistently to these drugs. The results of these studies provided a substantial body of information which has been published in the scientific and medical literature. The purely pharma cological responses in man and animals to the opiates have been described and evaluated in many monographs and text-books of pharmacology. However, there is no single source for specific and detailed information on the responses of the body and its tissues to narcotic analgesic drugs at the level of biochemical pharmacology; that is, the molecular history of the drug in the body and the biochemical consequences of its presence in tissue. This volume has been prepared in an effort to repair the deficiency. Two factors have contributed a special urgency to making this infor mation available in convenient form: (1) the current need for a better under standing of the biochemical mechanisms underlying addiction to narcotic drugs, and (2) the progress made in molecular biology which promises that significant advances in the elucidation of fundamental processes in the central nervous system and their drug-induced aberrations may soon be possible.

Author : William A. Creasey,Montague Lane,Alan C. Sartorelli
Publisher : Elsevier
Page : 242 pages
File Size : 47,5 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483139401

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Symposium on Clinical Pharmacology by William A. Creasey,Montague Lane,Alan C. Sartorelli Pdf

Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.

Author : Abraham Lincoln Professor of Political Philosophy Michael Palmer
Publisher : Unknown
Page : 0 pages
File Size : 43,8 Mb
Release : 2012-05
Category : Drug interactions
ISBN : 1118230426

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Biochemical Pharmacology by Abraham Lincoln Professor of Political Philosophy Michael Palmer Pdf

An integrated approach to the study of drug action mechanisms Biochemical Pharmacology is a concise and contemporary textbook on the principles of drug action. It discusses representative drugs by example to explore the range of biochemical targets and mechanisms. The book explains some of the experiments that tell us how drugs work, and it outlines the physiological and pathological context that make those action mechanisms therapeutically useful. Biochemical Pharmacology is intended primarily for students in biology and biochemistry at the advanced undergraduate or graduate levels. For c.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 46,8 Mb
Release : 2024-06-13
Category : Electronic
ISBN : OCLC:714207818

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Biochemical pharmacology by Anonim Pdf

Author : P. Hlavica,L.A. Damani
Publisher : Springer Science & Business Media
Page : 487 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401131124

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N-Oxidation of Drugs by P. Hlavica,L.A. Damani Pdf