Concepts In Biochemical Pharmacology

Author : H.S. Ackermann,Bernard B. Brodie,James R. Gillette
Publisher : Springer Science & Business Media
Page : 486 pages
File Size : 43,9 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642650529

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Concepts in Biochemical Pharmacology by H.S. Ackermann,Bernard B. Brodie,James R. Gillette Pdf

This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bioche mical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. BYRON CLARKE, Director of the Pharmacology-Toxicology Program at the National Insti tutes of Health, whose support made possible much of the work described in this volume. Contents Section One: Routes of Drug Administration Chapter 1: Biological Membranes and Their Passage by Drugs. C. A. M. HOGBEN 1 References. . . . . . . . . . . . . . . . . . . . . . . . . . 8 Chapter 2: Absorption of Drugs from the Gastrointestinal Tract. L. S. SCHANKER. With 5 Figures. 9 I. Introduction. . . . . . . . . . . . . . . . . . . . . . . 9 II. Methods of Study. . . . . . . . . . . . . . . . . . . . . 9 III. Absorption from the Stomach . . . . . . . . . . . . . . . 11 IV. Intestinal Absorption of Non-Electrolytes and Weak Electrolytes 15 V. Absorption of Weak Electrolytes from the Colon and Rectum 18 VI. Intestinal Absorption of Organic Ions. . . . . . . . . . 19 VII. Intestinal Absorption of Macromolecules . . . . . . . . . . 19 VIII. Active Transport across the Intestinal Epithelium . . . . . 20 IX. Effect of EDTA on Drug Absorption from the Intestine . . . . . . .

Author : P.S. Randall,James R. Gillette,J.R. Mitchell
Publisher : Springer Science & Business Media
Page : 509 pages
File Size : 50,5 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642463143

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Concepts in Biochemical Pharmacology by P.S. Randall,James R. Gillette,J.R. Mitchell Pdf

Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.

Author : Bernard B. Brodie,James R. Gillette
Publisher : Springer Science & Business Media
Page : 797 pages
File Size : 42,7 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642651779

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Concepts in Biochemical Pharmacology by Bernard B. Brodie,James R. Gillette Pdf

This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bio chemical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. Byron Clark, Director of the Pharmacology-Toxicology Program at the National Institutes of Health whose support made possible much of the work described in this volume. Contents Section Four: Methods 01 Stooging the MetoholiBm 01 Drugs Subsection A. Assay 01 Drugs and Their M etoholites Chapter 22 : Basic Principles in Development of Methods for Drug Assay. B. B. BRODIE. With 2 Figures 1 1 A. Introduction . . . . . . . . . . B. Principles of Developing a Method. . . . . . 1 I. Section of Method of Assay . . . . . . 1 II. Choice of Solvent for Extraction of Drug 2 III. Adsorption of Drugs by Glass Surfaces . . . . . . . . . . . . . . 3 IV. Recoveries of Known Amounts of Compound from Biological Material. 4 V. Assessment of Sensitivity 5 VI. Assessment of Specificity 5 References. . . . . . . . . . .

Author : Bernard Beryl Brodie
Publisher : Unknown
Page : 128 pages
File Size : 43,6 Mb
Release : 1977
Category : Electronic
ISBN : OCLC:1110788374

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Concepts in biochemical pharmacology by Bernard Beryl Brodie Pdf

Author : Bernard B. Brodie,Jerry R. Mitchell,James R. Gillette,Helen S. Ackerman
Publisher : Unknown
Page : 128 pages
File Size : 40,9 Mb
Release : 1971
Category : Drugs
ISBN : LCCN:79135957

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Concepts in Biochemical Pharmacology by Bernard B. Brodie,Jerry R. Mitchell,James R. Gillette,Helen S. Ackerman Pdf

Author : Bernard B. Brodie,James R. Gillette,Jerry R. Mitchell,Helen S. Ackerman
Publisher : Unknown
Page : 518 pages
File Size : 53,5 Mb
Release : 1971
Category : Biochemistry
ISBN : PSU:000058714393

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Concepts in Biochemical Pharmacology by Bernard B. Brodie,James R. Gillette,Jerry R. Mitchell,Helen S. Ackerman Pdf

Author : Anonim
Publisher : Unknown
Page : 480 pages
File Size : 47,9 Mb
Release : 1975
Category : Pharmacology
ISBN : OCLC:15666823

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Concepts in Biochemical Pharmacology by Anonim Pdf

Author : Z. M. Bacq
Publisher : Elsevier
Page : 674 pages
File Size : 55,7 Mb
Release : 2014-05-17
Category : Medical
ISBN : 9781483181622

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Fundamentals of Biochemical Pharmacology by Z. M. Bacq Pdf

Fundamentals of Biochemical Pharmacology explains the molecular aspects of drugs and the changes in bio-chemical systems. The cellular movements that result from such changes are also evaluated. Biochemical lesion is extensively defined in the book. A discussion on electromagnetic radiation is also provided. A chapter of the book is devoted to the principles of electronic and nuclear magnetic resonance. The principles and applications of mass spectrometry and combined gas chromatography are then discussed. The scientific advances made with the use of immunological methods are the focus of a section of the book. Another section provides an introduction to the kinetic properties of reactions made by enzymes. The process called homogenization is clearly explained along with a discussion on the use of electron microscopy. Autoradiography shows the distribution of compounds at the subcellular level. The theoretical background of molecular spectroscopy is presented completely. The book is intended for chemists, biochemists, physicists, micro-biologists, zoologists, and botanists .

Author : James R. Gillette,Jerry R. Mitchell
Publisher : Unknown
Page : 480 pages
File Size : 50,5 Mb
Release : 1975
Category : Biopharmaceutics
ISBN : 038707001X

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Concepts in Biochemical Pharmacology by James R. Gillette,Jerry R. Mitchell Pdf

Author : Michael Palmer
Publisher : John Wiley & Sons
Page : 436 pages
File Size : 51,8 Mb
Release : 2012-03-27
Category : Medical
ISBN : 9780470174456

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Biochemical Pharmacology by Michael Palmer Pdf

"Biochemical abnormalities play a key role in human illness. To pinpoint effective curative solutions, biochemical pharmacologists use drugs to discover new information about biosynthetic pathways and their kinetics. Using a more chemistry- and mechanism-oriented approach than standard pharmacology books, Introduction to Biochemical Pharmacology is a one-stop reference that focuses on how a drug interacts with a target receptor or enzyme at the molecular level. Learning is reinforced through the use of end-of-chapter exercises, PowerPoint slides, and a problem-and-solutions manual"--Provided by publisher.

Author : Thomas Haldane
Publisher : Unknown
Page : 0 pages
File Size : 52,8 Mb
Release : 2016-06-03
Category : Biochemistry
ISBN : 1682860752

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Biochemical Pharmacology by Thomas Haldane Pdf

Biochemical pharmacology is an emerging field which applies the concepts of biochemistry for producing better quality and effective drugs. This book brings forth some ground-breaking research from across the globe which will contribute to further the scope of this field. The theories, models and techniques discussed in this book will prove beneficial to students, chemists, researchers and professionals. It aims to facilitate the growth of this discipline and set ground for new research.

Author : Bernard B. Brodie
Publisher : Unknown
Page : 778 pages
File Size : 53,9 Mb
Release : 1971
Category : Drugs
ISBN : 0387053891

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Concepts in Biochemical Pharmacology by Bernard B. Brodie Pdf

Author : Zénon M. Bacq
Publisher : Unknown
Page : 659 pages
File Size : 41,6 Mb
Release : 1979
Category : Electronic
ISBN : OCLC:749446299

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Fundamentals of Biochemical Pharmacology by Zénon M. Bacq Pdf

Author : Mary Durrant
Publisher : Unknown
Page : 222 pages
File Size : 49,5 Mb
Release : 2019-06-11
Category : Electronic
ISBN : 1632415348

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Biochemical Pharmacology and Toxicology by Mary Durrant Pdf

Pharmacology is a branch of biology. It studies drug action and explores the interactions between living organisms and chemicals that have an influence on normal or abnormal biochemical function. Drugs can be man-made, natural or endogenous. The field of pharmacology studies the design, composition, properties and synthesis of drugs. Toxicology and pharmacology are interrelated areas of study. The field of toxicology studies the adverse reactions of chemical substances on living organisms as well as the diagnosis and treatment of exposures to toxins and toxicants. Dosage, route of exposure, age, sex, species and the environment are significant factors that determine chemical toxicity and its effect. The aim of this book is to present researches that have transformed the disciplines of pharmacology and toxicology and aided their advancement. It also covers in detail some existing theories and innovative concepts of these fields. This book is a vital tool for all researching or studying pharmacology and toxicology as it gives incredible insights into emerging trends and concepts.

Author : Corina Ionescu,Mino R. Caira
Publisher : Springer Science & Business Media
Page : 444 pages
File Size : 50,9 Mb
Release : 2006-02-28
Category : Medical
ISBN : 1402041411

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Drug Metabolism by Corina Ionescu,Mino R. Caira Pdf

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.