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Author : Trevor J. Franklin,George Alan Snow
Publisher : Springer Science & Business Media
Page : 188 pages
File Size : 40,7 Mb
Release : 2006-10-31
Category : Medical
ISBN : 9780387275666
The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.
Author : T. J. Franklin,G. A. Snow
Publisher : Springer Science & Business Media
Page : 173 pages
File Size : 51,6 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781475745993
The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.
Author : T. Franklin
Publisher : Springer
Page : 166 pages
File Size : 40,9 Mb
Release : 2012-05-29
Category : Science
ISBN : 9401091285
The rapid advances made in the study of the synthesis, structure and function of biological macromole cules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of how these substances inhibit cell growth and division. The use of antimicrobial agents as highly specific inhibitors has in turn substantially assisted the investigation of complex biochemical processes. The literature in this field is so extensive, however, that we considered an attempt should be made to draw together in an introductory book the more significant studies of recent years. This book, which is in fact based on lecture courses given by us to undergraduates at Liverpool and Manchester Universities, is therefore intended as an introduction to the biochemistry of antimicrobial action for advanced students in many disciplines. We hope that it may also be useful to established scientists who are new to this area of research. The book is concerned with a discussion of medically important antimicrobial compounds and also a number of agents that, although having no medical uses, have proved invaluable as research tools in bio chemistry. Our aim has been to present the available information in a simple and readable way, empha sizing the established facts rather than more controversial material. Whenever possible, however, we have indicated the gaps in the present knowledge of the subject where further information is required.
Author : Franklin & Snow
Publisher : Unknown
Page : 182 pages
File Size : 48,5 Mb
Release : 2008-01-01
Category : Electronic
ISBN : 8181289242
Author : Trevor John Franklin,G. A. Snow
Publisher : Springer
Page : 235 pages
File Size : 50,8 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489934123
The rapid advances made in the study of the synthesis, structure and function of biological macromolecules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of how these substances inhibit cell growth and division. The use of antimicrobial agents as highly specific inhibitors has in turn substantially assisted the investigation of complex biochemical processes. The literature in this field is so extensive however, that we considered an attempt should be made to draw together in an introductory book the more significant studies of recent years. This book, which is in fact based on lecture courses given by us to undergraduates at Liverpool and Manchester Universities, is therefore intended as an introduction to the biochemistry of antimicrobial action for advanced students in many disciplines. We hope that it may also be useful to established scientists who are new to this area of research. The book is concerned with a discussion of medically important antimicrobial compounds and also a number of agents that, although having no medical uses, have proved invaluable as research tools in biochemistry. Our aim has been to present the available information in a simple and readable way, emphasizing the established facts rather than more controversial material. Whenever possible, however, we have indicated the gaps in the present knowledge of the subject where further information is required.
Author : T. J. Franklin
Publisher : Springer
Page : 216 pages
File Size : 44,9 Mb
Release : 2011-11-03
Category : Science
ISBN : 9401068577
The rapid advances made in the study of the synthesis, structure and function of biological macromolecules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of how these substances inhibit cell growth and division. The use of antimicrobial agents as highly specific inhibitors has in turn substantially assisted the investigation of complex biochemical pro cesses. The literature in Ihis field is so extensive however, that we considered an attempt should be made to draw together in an introductory book the more significant studies of recent years. This book, which is in fact based on lec ture courses given by us to undergraduates at Liverpool and Manchester Universities, is therefore intended as an introduction 'to the biochemistry of antimicrobial action for advanced students in many disciplines. We hope that it may also be useful to established scientists who are new to this area of research. The book is concerned with a discussion of medically important antimicro bial compounds and also a number of agents that, although having no medical uses, have proved invaluable as research tools in biochemistry. Our aim has been to esent pr the available information in a simple and readable way, emphasizing the established facts rather than more controversial material. Whenever possible, however, we have indicated the gaps in the present knowledge of the subject where further information is required.
Author : Sarfraz Ahmed,Suvash Chandra Ojha,Muhammad Najam-ul-Haq,Muhammad Younus,Muhammad Zaffar Hashmi
Publisher : Springer Nature
Page : 559 pages
File Size : 53,5 Mb
Release : 2021-08-05
Category : Medical
ISBN : 9783030763206
This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included.
Author : Trevor J. Franklin
Publisher : Unknown
Page : 217 pages
File Size : 46,5 Mb
Release : 1985
Category : Electronic
ISBN : OCLC:25425209
Author : Mrinal K. Bhattacharjee
Publisher : Springer Nature
Page : 276 pages
File Size : 49,8 Mb
Release : 2022-08-23
Category : Science
ISBN : 9783031075827
This textbook builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels. Appropriate for a one-semester course at either the graduate or advanced undergraduate level, the book is self-contained and written in accessible language. It includes all necessary background biochemistry material and a discussion of the latest developments in the field of antibiotics. Original research works are frequently cited and experimental procedures and interpretation of results are emphasized.
Author : T. J Franklin
Publisher : Unknown
Page : 228 pages
File Size : 53,8 Mb
Release : 1989-01-19
Category : Electronic
ISBN : 9400908261
Author : Ernest Frederick Gale
Publisher : John Wiley & Sons
Page : 682 pages
File Size : 42,8 Mb
Release : 1981
Category : Medical
ISBN : UOM:39015002430372
Author : R. A. D. Williams,Peter A. Lambert,Paul Singleton
Publisher : Taylor & Francis
Page : 146 pages
File Size : 51,8 Mb
Release : 1996
Category : Science
ISBN : 1872748813
Antimicrobial drugs are of central importance in combating illnesses such as typhoid, malaria, meningitis and influenza. This book describes the mode of action for the major classes of drugs. Where appropriate, the side-effects of the drugs are described together with the mechanisms by which resistance to them may arise. Among the major questions addressed are: How do the major classes of antimicrobial drugs work? What are the significant side-effects? How does resistance to these drugs arise? What strategies are there for overcoming resistance? Are we running out of effective drugs?
Author : David A. Phoenix,Sarah R. Dennison,Frederick Harris
Publisher : John Wiley & Sons
Page : 354 pages
File Size : 54,6 Mb
Release : 2012-12-27
Category : Science
ISBN : 9783527652877
In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers. The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.
Author : G. Tegos,George Tegos and Eleftherios Mylonakis
Publisher : CABI
Page : 369 pages
File Size : 51,7 Mb
Release : 2012
Category : Anti-infective agents
ISBN : 1780640315
Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.
Author : John Mann,M. James C. Crabbe
Publisher : Oxford University Press
Page : 74 pages
File Size : 50,7 Mb
Release : 1996
Category : Science
ISBN : 0716745089
This text is part of the Biochemical and Medicinal Chemistry Series Series Editor: John Mann, Professor of Organic Chemistry, University of Reading The aim of this series of short textbooks is to present full accounts of topics which are at the interface of chemistry and biology, from medicinal chemistry to molecular biology. The topics chosen for inclusion are popular subjects for upper-level undergraduate and postgraduate modular courses, and yet they receive inadequate coverage in traditional textbooks of organic chemistry and of biochemistry. Each text in the series provides a concise and up to date introduction to its subject in an attractive format. Antibiotics are among the most prescribed drugs in the world today, and since their development and commercialization in the early part of this century, they have saved countless millions of lives. Combating bacterial infection has resulted in the development of compounds which include the penecillins, cephalosporins,aminoglycosides and tetracyclins. This concise and up to date textbook uses a wide range of examples to describes the structure, mechanisms of action, synthesis and biosynthetic pathways of the major classes of antibiotics. A serious problem today is the development of microorganisms that are resistant to these 'traditional' antibiotics. This important area is described, with an account of bacterial resistance mechanisms, and the latest advances aimed at overcoming these problems. This textbook is suitable for upper-level undergraduate courses given to chemists, biochemists, microbiologists, pharmacologists and medical students. Postgradates and entrants to the pharmaceutical industry will find it an invaluable introduction to the subject.