Chemistry Of Antibiotics And Related Drugs

Author : Mrinal K. Bhattacharjee
Publisher : Unknown
Page : 0 pages
File Size : 47,6 Mb
Release : 2022
Category : Electronic
ISBN : 3031075838

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Chemistry of Antibiotics and Related Drugs by Mrinal K. Bhattacharjee Pdf

This textbook builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels. Appropriate for a one-semester course at either the graduate or advanced undergraduate level, the book is self-contained and written in accessible language. It includes all necessary background biochemistry material and a discussion of the latest developments in the field of antibiotics. Original research works are frequently cited and experimental procedures and interpretation of results are emphasized.

Author : Mrinal K. Bhattacharjee
Publisher : Springer Nature
Page : 276 pages
File Size : 50,7 Mb
Release : 2022-08-23
Category : Science
ISBN : 9783031075827

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Chemistry of Antibiotics and Related Drugs by Mrinal K. Bhattacharjee Pdf

This textbook builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels. Appropriate for a one-semester course at either the graduate or advanced undergraduate level, the book is self-contained and written in accessible language. It includes all necessary background biochemistry material and a discussion of the latest developments in the field of antibiotics. Original research works are frequently cited and experimental procedures and interpretation of results are emphasized.

Author : Rosaleen Anderson,Paul W. Groundwater,Adam Todd,Alan Worsley
Publisher : John Wiley & Sons
Page : 379 pages
File Size : 47,6 Mb
Release : 2012-05-30
Category : Science
ISBN : 9781118325445

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Antibacterial Agents by Rosaleen Anderson,Paul W. Groundwater,Adam Todd,Alan Worsley Pdf

Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

Author : José-Luis Capelo-Martínez,Gilberto Igrejas
Publisher : John Wiley & Sons
Page : 730 pages
File Size : 54,8 Mb
Release : 2019-09-24
Category : Medical
ISBN : 9781119282525

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Antibiotic Drug Resistance by José-Luis Capelo-Martínez,Gilberto Igrejas Pdf

This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Author : Trevor J. Franklin,George Alan Snow
Publisher : Springer Science & Business Media
Page : 188 pages
File Size : 50,6 Mb
Release : 2005-03-03
Category : Medical
ISBN : 9780387225548

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Biochemistry and Molecular Biology of Antimicrobial Drug Action by Trevor J. Franklin,George Alan Snow Pdf

The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.

Author : Christopher Walsh,Timothy Wencewicz
Publisher : John Wiley & Sons
Page : 477 pages
File Size : 43,5 Mb
Release : 2020-08-06
Category : Medical
ISBN : 9781555819316

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Antibiotics by Christopher Walsh,Timothy Wencewicz Pdf

A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.

Author : R. M. Evans
Publisher : Unknown
Page : 240 pages
File Size : 46,8 Mb
Release : 1969
Category : Electronic
ISBN : 8210379456XXX

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The Chemistry of the Antibiotics used in medicine by R. M. Evans Pdf

Author : Dev P. Arya
Publisher : John Wiley & Sons
Page : 338 pages
File Size : 53,9 Mb
Release : 2007-06-29
Category : Science
ISBN : 9780471743026

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Aminoglycoside Antibiotics by Dev P. Arya Pdf

Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides. Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.

Author : Ronald Major Evans
Publisher : Unknown
Page : 128 pages
File Size : 48,8 Mb
Release : 1965
Category : Electronic
ISBN : 0080111645

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The Chemistry of the Antibiotics Used in Medicine by Ronald Major Evans Pdf

Author : Gabor Lukacs,Masaji Ohno
Publisher : Springer Science & Business Media
Page : 808 pages
File Size : 54,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642756177

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Recent Progress in the Chemical Synthesis of Antibiotics by Gabor Lukacs,Masaji Ohno Pdf

The use of antibiotics in the treatment by antibacterial and antifungal chemo therapy, has become standard practice since the end of World War Two and has had an enormous impact on healthcare throughout the world. Compounds belonging to this class have also reached an important place in the medical treatment of human cancer. Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies. In fact the antibiotics have represented (and still represent) for a generation of organic chemists an endless source of molecular structures whose varied assemblage of carbon atom backbones and chemical functions was beyond any possibility of imagination. Perhaps a similar repertoire of chemotypes was formerly offered by the natural products, namely the alkaloids, the terpenes, the vitamins and hormones as well as the pigments of the animal and plant kingdoms, albeit the chemical arrange ments of the antibiotic molecules appeared much more surprising and diverse to the admiring eyes of cultivated organic chemists. The idea of this book, certainly a landmark in the field, came during the Symposium of EUCHEM on Chemical Synthesis of Antibiotics, that was held at Aussois in Savoy, France (May 2-6, 1988), the initiative being taken by Gabor Lukacs to whom Masaji Ohno readily associated as a co-editor.

Author : T. Franklin
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 51,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401091275

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Biochemistry and Molecular Biology of Antimicrobial Drug Action by T. Franklin Pdf

The rapid advances made in the study of the synthesis, structure and function of biological macromole cules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of how these substances inhibit cell growth and division. The use of antimicrobial agents as highly specific inhibitors has in turn substantially assisted the investigation of complex biochemical processes. The literature in this field is so extensive, however, that we considered an attempt should be made to draw together in an introductory book the more significant studies of recent years. This book, which is in fact based on lecture courses given by us to undergraduates at Liverpool and Manchester Universities, is therefore intended as an introduction to the biochemistry of antimicrobial action for advanced students in many disciplines. We hope that it may also be useful to established scientists who are new to this area of research. The book is concerned with a discussion of medically important antimicrobial compounds and also a number of agents that, although having no medical uses, have proved invaluable as research tools in bio chemistry. Our aim has been to present the available information in a simple and readable way, empha sizing the established facts rather than more controversial material. Whenever possible, however, we have indicated the gaps in the present knowledge of the subject where further information is required.

Author : C. R. Ganellin,Stanley M. Roberts
Publisher : Academic Press
Page : 332 pages
File Size : 47,9 Mb
Release : 1993-02-26
Category : Medical
ISBN : UOM:39015029520718

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Medicinal Chemistry by C. R. Ganellin,Stanley M. Roberts Pdf

This new edition aims to introduce students to the mechanisms of action of drugs and the approaches adopted in designing new drugs. It also contains chapters on individual successful drugs written by their discoverers or developers, tracing their history to the present day.

Author : Jian Wang,James D. MacNeil,Jack F. Kay
Publisher : John Wiley & Sons
Page : 378 pages
File Size : 51,6 Mb
Release : 2011-11-29
Category : Science
ISBN : 9781118067192

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Chemical Analysis of Antibiotic Residues in Food by Jian Wang,James D. MacNeil,Jack F. Kay Pdf

An insightful exploration of the key aspects concerning the chemical analysis of antibiotic residues in food The presence of excess residues from frequent antibiotic use in animals is not only illegal, but can pose serious health risks by contaminating products for human consumption such as meat and milk. Chemical Analysis of Antibiotic Residues in Food is a single-source reference for readers interested in the development of analytical methods for analyzing antibiotic residues in food. It covers themes that include quality assurance and quality control, antibiotic chemical properties, pharmacokinetics, metabolism, distribution, food safety regulations, and chemical analysis. In addition, the material presented includes background information valuable for understanding the choice of marker residue and target animal tissue to use for regulatory analysis. This comprehensive reference: Includes topics on general issues related to screening and confirmatory methods Presents updated information on food safety regulation based on routine screening and confirmatory methods, especially LC-MS Provides general guidance for method development, validation, and estimation of measurement uncertainty Chemical Analysis of Antibiotic Residues in Food is written and organized with a balance between practical use and theory to provide laboratories with a solid and reliable reference on antibiotic residue analysis. Thorough coverage elicits the latest scientific findings to assist the ongoing efforts toward refining analytical methods for producing safe foods of animal origin.

Author : G. Tegos,George Tegos and Eleftherios Mylonakis
Publisher : CABI
Page : 369 pages
File Size : 42,7 Mb
Release : 2012
Category : Anti-infective agents
ISBN : 1780640315

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Antimicrobial Drug Discovery by G. Tegos,George Tegos and Eleftherios Mylonakis Pdf

Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.

Author : Barrie W. Bycroft,David J. Payne
Publisher : CRC Press
Page : 2117 pages
File Size : 45,8 Mb
Release : 2013-08-09
Category : Medical
ISBN : 9781482282153

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Dictionary of Antibiotics and Related Substances by Barrie W. Bycroft,David J. Payne Pdf

Bacterial and parasitic diseases are the second leading cause of death worldwide, according to a report by the London School of Economics. Due to the emergence of drug-resistant "superbugs," like methicillin-resistant Staphylococcus aureus (MRSA), traditional antibiotics such as penicillin and its derivatives are in danger of becoming obsolete. In