Biochemistry Of Collagens Laminins And Elastin

Author : Morten Karsdal
Publisher : Elsevier
Page : 586 pages
File Size : 40,5 Mb
Release : 2023-11-07
Category : Science
ISBN : 9780443156182

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Biochemistry of Collagens, Laminins and Elastin by Morten Karsdal Pdf

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third Edition provides current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of these proteins can result in altered signaling properties of the original extracellular matrix (ECM). Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions with ties to endocrine function, and how this knowledge may be used to modulate various pathologies, including fibrotic disease. This new edition has been expanded and revised to incorporate recent research advances. Several new chapters explore a range of chronic diseases in which the ECM and collagens, laminin and elastin are central players in disease modulation, including new chapters on lung, skin and intestinal disease, as well as cancers. The new edition also considers emerging analytical technologies that can detect biomarkers of ECM degradation, with discussion of protein quantification and detecting aging of collagens. Provides an updated, comprehensive discussion of collagen and related structural proteins Contains insights into biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function and durability Examines details on how collagens play a key role in a range of chronic diseases Offers approaches for protein quantification and detection of collagen aging

Author : Morten Karsdal
Publisher : Academic Press
Page : 0 pages
File Size : 55,7 Mb
Release : 2019-05-29
Category : Science
ISBN : 0128170689

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Biochemistry of Collagens, Laminins and Elastin by Morten Karsdal Pdf

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease.

Author : Jaroslava Halper
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 47,9 Mb
Release : 2014-01-18
Category : Medical
ISBN : 9789400778931

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Progress in Heritable Soft Connective Tissue Diseases by Jaroslava Halper Pdf

This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.

Author : Robert Mecham
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 41,8 Mb
Release : 2011-02-16
Category : Science
ISBN : 9783642165559

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The Extracellular Matrix: an Overview by Robert Mecham Pdf

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Author : Magnus Hook,Timothy J. Foster
Publisher : Frontiers Media SA
Page : 170 pages
File Size : 51,9 Mb
Release : 2021-07-14
Category : Science
ISBN : 9782889710461

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Cell Surface Proteins of Gram-positive Pathogenic Bacteria by Magnus Hook,Timothy J. Foster Pdf

Author : J. Robin Harris,Viktor I. Korolchuk
Publisher : Springer
Page : 499 pages
File Size : 50,8 Mb
Release : 2019-03-19
Category : Medical
ISBN : 9789811336812

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Biochemistry and Cell Biology of Ageing: Part II Clinical Science by J. Robin Harris,Viktor I. Korolchuk Pdf

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Author : Michael I. Gurr,John L. Harwood,Keith N. Frayn,Denis J. Murphy,Robert H. Michell
Publisher : John Wiley & Sons
Page : 446 pages
File Size : 50,5 Mb
Release : 2016-08-29
Category : Science
ISBN : 9781118501139

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Lipids by Michael I. Gurr,John L. Harwood,Keith N. Frayn,Denis J. Murphy,Robert H. Michell Pdf

For the 6th Edition of this highly regarded textbook devoted to lipids, the title has been modified from Lipid Biochemistry to Lipids to acknowledge the coming together of biological and medical sciences, the increasingly blurred boundaries between them and the growing importance of lipids in diverse aspects of science and technology. The principal aims of this new edition - to inform students and researchers about lipids, to assist teachers and encourage further research – have not changed since previous editions. Significant advances in lipid science have demanded yet another extensive rewriting for this edition, with the addition of two new authors, to cover new knowledge of genes coding for proteins involved in lipid metabolism, the many lipids involved in cell signalling, the roles of lipids in health and disease and new developments in biotechnology in support of agriculture and industry. An introductory chapter summarizes the types of lipids covered and their identification and provides a guide to the contents. Chapters contain boxes illustrating special topics, key point summaries and suggested further reading. Lipids: Sixth Edition provides a huge wealth of information for upper-level students of biological and clinical sciences, food science and nutrition, and for professionals working in academic and industrial research. Libraries in all universities and research establishments where biological, medical and food and nutritional sciences are studied and taught should have copies of this excellent and comprehensive new edition on their shelves.

Author : Eric G. Schmuck,Peiman Hematti,Amish N. Raval
Publisher : Springer
Page : 246 pages
File Size : 52,7 Mb
Release : 2018-09-20
Category : Science
ISBN : 9783319974217

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Cardiac Extracellular Matrix by Eric G. Schmuck,Peiman Hematti,Amish N. Raval Pdf

This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.

Author : C. Ross Ethier,Craig A. Simmons
Publisher : Cambridge University Press
Page : 10 pages
File Size : 49,9 Mb
Release : 2007-03-12
Category : Technology & Engineering
ISBN : 9781139461825

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Introductory Biomechanics by C. Ross Ethier,Craig A. Simmons Pdf

Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.

Author : E.D. Hay
Publisher : Springer Science & Business Media
Page : 478 pages
File Size : 47,5 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781461537700

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Cell Biology of Extracellular Matrix by E.D. Hay Pdf

In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Author : Jay D. Humphrey,Sherry DeLange
Publisher : Springer Science & Business Media
Page : 642 pages
File Size : 48,8 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781489903259

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An Introduction to Biomechanics by Jay D. Humphrey,Sherry DeLange Pdf

Designed to meet the needs of undergraduate students, "Introduction to Biomechanics" takes the fresh approach of combining the viewpoints of both a well-respected teacher and a successful student. With an eye toward practicality without loss of depth of instruction, this book seeks to explain the fundamental concepts of biomechanics. With the accompanying web site providing models, sample problems, review questions and more, Introduction to Biomechanics provides students with the full range of instructional material for this complex and dynamic field.

Author : Aleksander Krag,Torben Hansen
Publisher : Springer
Page : 294 pages
File Size : 40,7 Mb
Release : 2018-11-09
Category : Medical
ISBN : 9783319988900

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The Human Gut-Liver-Axis in Health and Disease by Aleksander Krag,Torben Hansen Pdf

The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere. The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area. The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field.

Author : Miranda A. Farage,Kenneth W. Miller,Howard I. Maibach
Publisher : Springer Science & Business Media
Page : 1255 pages
File Size : 52,6 Mb
Release : 2009-12-02
Category : Medical
ISBN : 9783540896555

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Textbook of Aging Skin by Miranda A. Farage,Kenneth W. Miller,Howard I. Maibach Pdf

This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.

Author : Victor R. Preedy,Vinood B. Patel
Publisher : Springer
Page : 0 pages
File Size : 45,5 Mb
Release : 2017-07-14
Category : Medical
ISBN : 9400776748

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Biomarkers in Liver Disease by Victor R. Preedy,Vinood B. Patel Pdf

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 46,7 Mb
Release : 2018-01-10
Category : Science
ISBN : 0128122978

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Methods in Extracellular Matrix Biology by Anonim Pdf

Methods in Extra Cellular Matrix, Volume 142, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections devoted to Elastin, Quantification of collagen and elastin, Fibrillins, Lysyl oxidase, Fibulins, Matrilins, Hyaluronic Acid, Small leucine-rich proteoglycans, Syndecans, Fibronectin, SPARC, Thrombospondins, Tenascins, Collagen IV, Multi-photon analysis of ECM, Cell-derived extracellular matrices, Laminins, Fibrillar Collagens, Imaging ECM in developing embryos, Analysis of Matrix Degradation, Ultrastructural analysis of ECM, Versican and Large proteoglycans, and an ECM crosslink analysis. This series covers a wide array of topics about the extracellular matrix, including an understanding of crucial proteins and glycoproteins components of ECM.