The Extracellular Matrix An Overview

Author : Robert Mecham
Publisher : Springer Science & Business Media
Page : 426 pages
File Size : 48,5 Mb
Release : 2011-02-16
Category : Science
ISBN : 9783642165559

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The Extracellular Matrix: an Overview by Robert Mecham Pdf

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Author : Nikos Karamanos
Publisher : Walter de Gruyter
Page : 940 pages
File Size : 49,7 Mb
Release : 2012-08-31
Category : Science
ISBN : 9783110258776

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Extracellular Matrix: Pathobiology and Signaling by Nikos Karamanos Pdf

Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden

Author : E.D. Hay
Publisher : Springer Science & Business Media
Page : 478 pages
File Size : 50,5 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781461537700

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Cell Biology of Extracellular Matrix by E.D. Hay Pdf

In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Author : Richard O. Hynes,Kenneth M. Yamada
Publisher : Unknown
Page : 0 pages
File Size : 45,9 Mb
Release : 2012
Category : Cell interaction
ISBN : 1936113384

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Extracellular Matrix Biology by Richard O. Hynes,Kenneth M. Yamada Pdf

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis. Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.

Author : Francesco Travascio
Publisher : BoD – Books on Demand
Page : 376 pages
File Size : 47,7 Mb
Release : 2016-06-15
Category : Science
ISBN : 9789535124153

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Composition and Function of the Extracellular Matrix in the Human Body by Francesco Travascio Pdf

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Author : Roy Zent,Ambra Pozzi
Publisher : Springer Science & Business Media
Page : 314 pages
File Size : 54,9 Mb
Release : 2010-01-23
Category : Medical
ISBN : 9781441908148

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Cell-Extracellular Matrix Interactions in Cancer by Roy Zent,Ambra Pozzi Pdf

Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 44,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Charles Boyd
Publisher : Elsevier
Page : 287 pages
File Size : 53,6 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323157667

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Extracellular Matrix Genes by Charles Boyd Pdf

Extracellular Matrix Genes provides some of the interesting complexities of the structure of the entire family of extracellular matrix genes. This book illustrates the permanent role that molecular biology and molecular genetics play in the detailed understanding of the normal biology of extracellular matrix. Organized into 10 chapters, this book begins with an overview of the structural and sequence aspects of the entire family of genomic sequences with a view to establishing common functional domains among collagens and their genes. This text then examines the status of the literature concerning human types. III and V. Other chapters consider the FACIT collagen gene family. This book discusses as well the development in understanding the structure of small proteoglycan core proteins and their role in proteoglycan biosynthesis and function as a result of their molecular cloning and expression. The final chapter deals with mutations in collagen genes. This book is a valuable resource for biochemists.

Author : Robert Mecham
Publisher : Springer
Page : 426 pages
File Size : 42,6 Mb
Release : 2011-03-25
Category : Science
ISBN : 3642165567

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The Extracellular Matrix: an Overview by Robert Mecham Pdf

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Author : Julia Thom Oxford
Publisher : MDPI
Page : 357 pages
File Size : 49,9 Mb
Release : 2019-02-21
Category : Electronic
ISBN : 9783038975700

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Extracellular Matrix in Development and Disease by Julia Thom Oxford Pdf

This book is a printed edition of the Special Issue "Extracellular Matrix in Development and Disease" that was published in IJMS

Author : Shirley Ayad,Ray Boot-Handford,Martin Humphries,Karl Kadler,Adrian Shuttleworth
Publisher : Elsevier
Page : 314 pages
File Size : 48,9 Mb
Release : 1998-03-27
Category : Science
ISBN : 9780080531519

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The Extracellular Matrix Factsbook by Shirley Ayad,Ray Boot-Handford,Martin Humphries,Karl Kadler,Adrian Shuttleworth Pdf

The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references. Key Features * Compiled by members of one of the foremost centers of matrix biochemistry in the world * Contains over 30 new entries, with all previous entries being revised and updated * Includes new entries on proteinases involved in the deposition of the extracellular matrix * Presents 3D ribbon diagrams in cases where the protein structure is now known

Author : Takashi Hoshiba,Tetsuji Yamaoka
Publisher : Royal Society of Chemistry
Page : 368 pages
File Size : 48,5 Mb
Release : 2019-12-05
Category : Science
ISBN : 9781788014670

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Decellularized Extracellular Matrix by Takashi Hoshiba,Tetsuji Yamaoka Pdf

Using this book, the reader will gain a good foundation to the field complemented with a broad overview of characterisation, microfabrication and applications.

Author : Douglas W. DeSimone,Robert Mecham
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 45,7 Mb
Release : 2013-03-15
Category : Science
ISBN : 9783642359354

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Extracellular Matrix in Development by Douglas W. DeSimone,Robert Mecham Pdf

Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Author : Eric Wong
Publisher : Axolotl Academic Publishing
Page : 283 pages
File Size : 54,6 Mb
Release : 2009
Category : Biology
ISBN : 9780985226114

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Cells: Molecules and Mechanisms by Eric Wong Pdf

"Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.

Author : William C. Parks,Robert Mecham
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 44,9 Mb
Release : 2011-04-07
Category : Science
ISBN : 9783642168611

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Extracellular Matrix Degradation by William C. Parks,Robert Mecham Pdf

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.