Bioimaging In Neurodegeneration

Author : Patricia A. Broderick,David N. Rahni,Edwin H. Kolodny
Publisher : Springer Science & Business Media
Page : 314 pages
File Size : 55,8 Mb
Release : 2007-11-05
Category : Medical
ISBN : 9781592598885

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Bioimaging in Neurodegeneration by Patricia A. Broderick,David N. Rahni,Edwin H. Kolodny Pdf

Bioimaging is in the forefront of medicine for the diagnosis and helps to predict the progression of AD via mild cognitive treatment of neurodegenerative disease. Conventional magnetic impairment (MCI) studies. resonance imaging (MRI) uses interactive external magnetic fields Novel neuroimaging technologies, such as neuromolecular and resonant frequencies of protons from water molecules. imaging (NMI) with a series of newly developed BRODERICK ® However, newer sequences, such as magnetization-prepared rapid PROBE sensors, directly image neurotransmitters, precursors, acquisition gradient echo (MPRAGE), are able to seek higher and metabolites in vivo, in real time and within seconds, at separate levels of anatomic resolution by allowing more rapid temporal and selective waveform potentials. NMI, which uses an imaging. Magnetic resonance spectroscopy (MRS) images electrochemical basis for detection, enables the differentiation of metabolic changes, enabling underlying pathophysiologic neurodegenerative diseases in patients who present with mesial dysfunction in neurodegeneration to be deciphered. Neuro- versus neocortical temporal lobe epilepsy. In fact, NMI has some 1 chemicals visible with proton H MRS include N-acetyl aspartate remarkable similarities to MRI insofar as there is technological (NAA), creatine/phosphocreatine (Cr), and choline (Cho); NAA dependence on electron and proton transfer, respectively, and is considered to act as an in vivo marker for neuronal loss and/or further dependence is seen in both NMI and MRI on tissue neuronal dysfunction. By extending imaging to the study of composition such as lipids.

Author : Javier Ramírez,Juan M. Górriz,Stefan Teipel
Publisher : Frontiers Media SA
Page : 168 pages
File Size : 48,6 Mb
Release : 2019-08-12
Category : Electronic
ISBN : 9782889459490

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Multimodal and Longitudinal Bioimaging Methods for Characterizing the Progressive Course of Dementia by Javier Ramírez,Juan M. Górriz,Stefan Teipel Pdf

Author : Luca Saba
Publisher : OUP Oxford
Page : 640 pages
File Size : 47,6 Mb
Release : 2015-01-08
Category : Medical
ISBN : 9780191651403

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Imaging in Neurodegenerative Disorders by Luca Saba Pdf

Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-array profiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. This book is an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology.

Author : Sangam Kanekar
Publisher : Thieme
Page : 1175 pages
File Size : 53,7 Mb
Release : 2015-11-05
Category : Medical
ISBN : 9781638532552

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Imaging of Neurodegenerative Disorders by Sangam Kanekar Pdf

The definitive reference on imaging and diagnosis of neurodegenerative diseases FIVE STARS from Doody's Star Ratings™ Imaging of Neurodegenerative Disorders is a comprehensive, up-to-date reference covering the latest techniques used in neuroimaging as well as the basic structural imaging that facilitates diagnosis of various neurodegenerative disorders. All advanced imaging modalities, including MR spectroscopy, DTI, MRI, and PET scans, are discussed in detail, enabling readers to gain a solid understanding of how to use them to diagnose neurodegenerative diseases. Key Features: Each chapter covers the clinical features, pathology, and imaging of a specific disease/disorder Sections on cerebellar degeneration and dysfunction, motor neuron disorders, post-traumatic cognitive disorders, dementia with extrapyramidal syndromes, and deep brain stimulation A final section discusses the distinctions between preventable, potentially reversible, and irreversible dementia This book provides radiologists and all who care for patients suffering from neurodegenerative diseases with an invaluable reference that will be part of their medical library for many years to come.

Author : Awesh K. Yadav,Rahul Shukla,S.J.S. Flora
Publisher : Academic Press
Page : 284 pages
File Size : 52,6 Mb
Release : 2022-03-10
Category : Medical
ISBN : 9780323898010

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Nanomedical Drug Delivery for Neurodegenerative Diseases by Awesh K. Yadav,Rahul Shukla,S.J.S. Flora Pdf

Nanomedical Drug Delivery for Neurodegenerative Diseases opens the door for promising approaches and advances in the diagnosis and treatment of various neurodegenerative diseases. The contents of the book comprise all the aspects related to the design, synthesis, and application of different nanodrug delivery systems in the treatment of neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and motor neuron diseases. This book explores how nanoparticulate drug carriers can improve therapeutic efficacy by selecting a suitable design strategy. Nanomedical Drug Delivery for Neurodegenerative Diseases is a valuable resource for graduates, clinical researchers, and other scientists working to minimize the challenges to deliver the drugs and genes in a more efficient and targeted manner for the treatment of neurodegenerative diseases. Includes design, synthesis and applications of drug delivery systems Explores the role of nanotechnology in the diagnosis and treatment of neurodegenerative disorders Reviews applications for the management of Parkinson's disease, Alzheimer's disease, Huntington's disease, and motor neuron diseases Discusses extracellular vesicles and mitochondria-targeted bioactive delivery systems Details how nanocarrier-based delivery is useful to improve efficacy and cure

Author : Vishwa Mohan,Amrita Pathak,Chandrakanth Reddy Edamakanti
Publisher : Frontiers Media SA
Page : 134 pages
File Size : 49,7 Mb
Release : 2023-02-27
Category : Science
ISBN : 9782832515297

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Role of Extracellular Matrix in Neurodevelopment and Neurodegeneration by Vishwa Mohan,Amrita Pathak,Chandrakanth Reddy Edamakanti Pdf

Author : Astrid Sigel,Eva Freisinger,Roland K.O. Sigel
Publisher : Walter de Gruyter GmbH & Co KG
Page : 666 pages
File Size : 48,5 Mb
Release : 2021-03-08
Category : Science
ISBN : 9783110685787

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Metal Ions in Bio-Imaging Techniques by Astrid Sigel,Eva Freisinger,Roland K.O. Sigel Pdf

Volume 22, entitled Metal Ions in Bio-Imaging Techniques, of the series Metal Ions in Life Sciences deals with metal ions as tools in imaging. This dates back to the first half of the past century, when barium sulfate was orally given to patients undergoing X-ray examination. The use of contrast agents has since developed into a large interdisciplinary field encompassing not only medicine, but also chemistry, material sciences, physics, biology, engineering, and computer sciences. MILS-22 provides deep and current insights in 17 stimulating chapters on the new research frontiers of this fast growing field on bio-imaging ... and beyond. For example, adding bio-sensing yields theranostic agents, meaning diagnosis and therapy linked in the same molecule; ions of Gd, Mn, Fe, Co, Ir, 99mTc, etc., are involved. Other important topics are, e.g., metal complexes in paramagnetic Chemical Exchange Transfer (paraCEST), radiometals for Positron Emission Tomography (PET) imaging, or paramagnetic metal ion probes for 19F magnetic resonance imaging. MILS-22 is written by 57 internationally recognized experts from 12 countries, that is, from the US via Europe to China. The impact of this vibrant research area is manifested by more than 2300 references and nearly 120 figures, mostly in color, and several informative tables. To conclude, Metal Ions in Bio-Imaging Techniques is an essential resource for scientists working in the wide range from material sciences, enzymology, analytic, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that also excellent information for teaching is provided.

Author : Panagiotis Vlamos,Ilias S. Kotsireas,Ioannis Tarnanas
Publisher : Springer Nature
Page : 1031 pages
File Size : 41,6 Mb
Release : 2023-07-25
Category : Medical
ISBN : 9783319759227

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Handbook of Computational Neurodegeneration by Panagiotis Vlamos,Ilias S. Kotsireas,Ioannis Tarnanas Pdf

The Handbook of Computational Neurodegeneration provides a comprehensive overview of the field and thus bridges the gap between standard textbooks of research on neurodegeneration and dispersed publications for specialists that have a narrowed focus on computational methods to study this complicated process. The handbook reviews the central issues and methodological approaches related to the field for which the reader pursues a thorough overview. It also conveys more advanced knowledge, thus serving both as an introductory text and as a starting point for an in-depth study of a specific area, as well as a quick reference source for the expert by reflecting the state of the art and future prospects. The book includes topics that are usually missing in standard textbooks and that are only marginally represented in the specific literature. The broad scope of this handbook is reflected by five major parts that facilitate an integration of computational concepts, methods and applications in the study of neurodegeneration. Each part is intended to stand on its own, giving an overview of the topic and the most important problems and approaches, which are supported by examples, practical applications, and proposed methodologies. The basic concepts and knowledge, standard procedures and methods are presented, as well as recent advances and new perspectives.

Author : Cláudio M. Gomes,Wolfgang Hoyer,Jinghui Luo
Publisher : Frontiers Media SA
Page : 153 pages
File Size : 53,5 Mb
Release : 2022-02-02
Category : Science
ISBN : 9782889742516

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The Biochemistry of Amyloids in Neurodegenerative Diseases, Volume I by Cláudio M. Gomes,Wolfgang Hoyer,Jinghui Luo Pdf

Author : Nick Van Bruggen,Timothy P.L. Roberts
Publisher : CRC Press
Page : 368 pages
File Size : 53,9 Mb
Release : 2002-12-23
Category : Medical
ISBN : 9781420042153

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Biomedical Imaging in Experimental Neuroscience by Nick Van Bruggen,Timothy P.L. Roberts Pdf

Recent years have seen an explosion of activity in the field of biomedical imaging in an attempt to understand the behavior of the brain in healthy and disease states. With the emergence of genetically manipulated laboratory mice and the knowledge of the mouse genome, we are entering an exciting new era with revolutionary tools for experimental research. Noninvasive imaging techniques capable of providing both anatomical and functional descriptions of the brain have become essential. Among the various imaging methodologies, magnetic resonance imaging (MRI) stands in the forefront by virtue of its contrast versatility and pathophysiological specificity. Emphasizing the relationship between physiological microenvironment and macroscopic imaging signal changes, Biomedical Imaging in Experimental Neuroscience presents a comprehensive review of the noninvasive biomedical imaging techniques available for laboratory animal research. Focusing on MRI, but recognizing the multiple forms of imaging information, this book outlines the scope and limitations of these methods and analyzes their impact on in vivo neuroscience research. The book is intended for the biologist who may not have a background in the physical sciences. This applied guide also provides a concise theoretical description of the pertinent physics. Noninvasive imaging offers the obvious benefits of reducing sample sizes and identifying new and unanticipated behaviors. Biomedical Imaging in Experimental Neuroscience presents detailed information for biologists interested in how biomedical imaging may augment their in vivo research and for clinical practitioners seeking deeper insights into the association between imaging findings and disease pathophysiology.

Author : Peter Morris
Publisher : Elsevier
Page : 367 pages
File Size : 43,5 Mb
Release : 2014-02-19
Category : Technology & Engineering
ISBN : 9780857097477

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Biomedical Imaging by Peter Morris Pdf

Biomedical Imaging: Applications and Advances discusses the technologies and latest developments in the increasingly important field of imaging techniques for the diagnosis of disease, monitoring of medical implants, and strategies for personalized medicine. Chapters in part one explore the full range of imaging technologies from atomic force microscopy (AFM) to positron emission tomography (PET), as well as the next-generation techniques that could provide the basis for personalized medicine. Part two highlights application-specific biomedical imaging methods, including ophthalmic imaging of ocular circulation, imaging methods for detection of joint degeneration, neural brain activation imaging, and the use of brain imaging to assess post-therapy responses. Further chapters review intravascular, cardiovascular, and whole-body magnetic resonance imaging (MRI). Biomedical Imaging is a technical resource for those concerned with imaging and diagnosis, including materials scientists and engineers as well as clinicians and academics. Explores the full range of imaging technologies from atomic force microscopy (AFM) to positron emission tomography (PET), as well as next-eneration techniques for personalized medicine Highlights application-specific biomedical imaging methods, including ophthalmic imaging of ocular circulation, imaging methods for detection of joint degeneration, neural brain activation imaging, and the use of brain imaging to assess post therapy responses Reviews intravascular, cardiovascular, and whole-body magnetic resonance imaging (MRI)

Author : Anonim
Publisher : ScholarlyEditions
Page : 340 pages
File Size : 54,6 Mb
Release : 2013-07-22
Category : Medical
ISBN : 9781481654555

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Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition by Anonim Pdf

Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Ray Hashman Hashemi,William G. Bradley,Christopher J. Lisanti
Publisher : Lippincott Williams & Wilkins
Page : 400 pages
File Size : 48,8 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9781451148718

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MRI: The Basics by Ray Hashman Hashemi,William G. Bradley,Christopher J. Lisanti Pdf

Now in its updated Third Edition, MRI: The Basics is an easy-to-read, clinically relevant introduction to the physics behind MR imaging. The book features large-size, legible equations, state-of-the-art images, instructive diagrams, and questions and answers that are ideal for board review. The American Journal of Radiology praised the previous edition as "an excellent text for introducing the basic concepts to individuals interested in clinical MRI." This edition spans the gamut from basic physics to multi-use MR options to specific applications, and has dozens of new images. Coverage reflects the latest advances in MRI and includes completely new chapters on k-space, parallel imaging, cardiac MRI, and MR spectroscopy.

Author : Robert Crichton,Roberta Ward
Publisher : John Wiley & Sons
Page : 628 pages
File Size : 42,5 Mb
Release : 2013-09-04
Category : Medical
ISBN : 9781118553510

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Metal-Based Neurodegeneration by Robert Crichton,Roberta Ward Pdf

Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.

Author : Vijay Kumar,Manoj Kumar Jaiswal
Publisher : Academic Press
Page : 272 pages
File Size : 51,6 Mb
Release : 2021-10-23
Category : Medical
ISBN : 9780128204405

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TDP-43 and Neurodegeneration by Vijay Kumar,Manoj Kumar Jaiswal Pdf

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside