Bioinformatics And Drug Discovery

Author : Richard S. Larson
Publisher : Humana Press
Page : 374 pages
File Size : 46,9 Mb
Release : 2016-08-23
Category : Science
ISBN : 1493959298

Get Book

Bioinformatics and Drug Discovery by Richard S. Larson Pdf

Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.

Author : William T. Loging
Publisher : Cambridge University Press
Page : 255 pages
File Size : 41,8 Mb
Release : 2016-03-17
Category : Science
ISBN : 9780521768009

Get Book

Bioinformatics and Computational Biology in Drug Discovery and Development by William T. Loging Pdf

A comprehensive overview of the use of computational biology approaches in the drug discovery and development process.

Author : Anna Maria Almerico,Marco Tutone
Publisher : Mdpi AG
Page : 414 pages
File Size : 47,5 Mb
Release : 2022-01-03
Category : Science
ISBN : 3036527796

Get Book

Computational Approaches by Anna Maria Almerico,Marco Tutone Pdf

This book is a collection of original research articles in the field of computer-aided drug design. It reports the use of current and validated computational approaches applied to drug discovery as well as the development of new computational tools to identify new and more potent drugs.

Author : C. Gopi Mohan
Publisher : Springer
Page : 406 pages
File Size : 48,8 Mb
Release : 2019-01-10
Category : Science
ISBN : 9783030052829

Get Book

Structural Bioinformatics: Applications in Preclinical Drug Discovery Process by C. Gopi Mohan Pdf

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery. The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.

Author : John David MacCuish,Norah E. MacCuish
Publisher : CRC Press
Page : 235 pages
File Size : 45,7 Mb
Release : 2010-11-15
Category : Computers
ISBN : 9781439816790

Get Book

Clustering in Bioinformatics and Drug Discovery by John David MacCuish,Norah E. MacCuish Pdf

With a DVD of color figures, Clustering in Bioinformatics and Drug Discovery provides an expert guide on extracting the most pertinent information from pharmaceutical and biomedical data. It offers a concise overview of common and recent clustering methods used in bioinformatics and drug discovery.Setting the stage for subsequent material, the firs

Author : S. Balamurugan,Anand T. Krishnan,Dinesh Goyal,Balakumar Chandrasekaran,Boomi Pandi
Publisher : John Wiley & Sons
Page : 354 pages
File Size : 53,5 Mb
Release : 2021-10-19
Category : Computers
ISBN : 9781119654711

Get Book

Computation in BioInformatics by S. Balamurugan,Anand T. Krishnan,Dinesh Goyal,Balakumar Chandrasekaran,Boomi Pandi Pdf

COMPUTATION IN BIOINFORMATICS Bioinformatics is a platform between the biology and information technology and this book provides readers with an understanding of the use of bioinformatics tools in new drug design. The discovery of new solutions to pandemics is facilitated through the use of promising bioinformatics techniques and integrated approaches. This book covers a broad spectrum of the bioinformatics field, starting with the basic principles, concepts, and application areas. Also covered is the role of bioinformatics in drug design and discovery, including aspects of molecular modeling. Some of the chapters provide detailed information on bioinformatics related topics, such as silicon design, protein modeling, DNA microarray analysis, DNA-RNA barcoding, and gene sequencing, all of which are currently needed in the industry. Also included are specialized topics, such as bioinformatics in cancer detection, genomics, and proteomics. Moreover, a few chapters explain highly advanced topics, like machine learning and covalent approaches to drug design and discovery, all of which are significant in pharma and biotech research and development. Audience Researchers and engineers in computation biology, information technology, bioinformatics, drug design, biotechnology, pharmaceutical sciences.

Author : Jaroslav Koča,Radka Svobodová Vařeková,Lukáš Pravda,Karel Berka,Stanislav Geidl,David Sehnal,Michal Otyepka
Publisher : Springer
Page : 144 pages
File Size : 44,7 Mb
Release : 2017-01-24
Category : Medical
ISBN : 9783319473888

Get Book

Structural Bioinformatics Tools for Drug Design by Jaroslav Koča,Radka Svobodová Vařeková,Lukáš Pravda,Karel Berka,Stanislav Geidl,David Sehnal,Michal Otyepka Pdf

The book describes the individual steps necessary for biomacromolecular fragments analysis, as well as a list of essential software tools. For each step, it also shows corresponding web-based tools in detail and provides practical examples of their use. All tools and databases mentioned in the examples are available free of charge, platform-independent, web-based, user-friendly and do not require a prior IT background to be fully used.

Author : Richard S. Larson
Publisher : Humana Press
Page : 0 pages
File Size : 43,8 Mb
Release : 2012-07-21
Category : Science
ISBN : 1617799645

Get Book

Bioinformatics and Drug Discovery by Richard S. Larson Pdf

Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.

Author : Richard S. Larson
Publisher : Humana Press
Page : 444 pages
File Size : 48,8 Mb
Release : 2005-10-01
Category : Medical
ISBN : 1588293467

Get Book

Bioinformatics and Drug Discovery by Richard S. Larson Pdf

A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.

Author : Navneet Sharma,Himanshu Ojha,Pawan Raghav,Ramesh K. Goyal
Publisher : Academic Press
Page : 510 pages
File Size : 41,9 Mb
Release : 2021-05-21
Category : Business & Economics
ISBN : 9780128217474

Get Book

Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences by Navneet Sharma,Himanshu Ojha,Pawan Raghav,Ramesh K. Goyal Pdf

Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences brings together two very important fields in pharmaceutical sciences that have been mostly seen as diverging from each other: chemoinformatics and bioinformatics. As developing drugs is an expensive and lengthy process, technology can improve the cost, efficiency and speed at which new drugs can be discovered and tested. This book presents some of the growing advancements of technology in the field of drug development and how the computational approaches explained here can reduce the financial and experimental burden of the drug discovery process. This book will be useful to pharmaceutical science researchers and students who need basic knowledge of computational techniques relevant to their projects. Bioscientists, bioinformaticians, computational scientists, and other stakeholders from industry and academia will also find this book helpful. Provides practical information on how to choose and use appropriate computational tools Presents the wide, intersecting fields of chemo-bio-informatics in an easily-accessible format Explores the fundamentals of the emerging field of chemoinformatics and bioinformatics

Author : Aman Chandra Kaushik,Ajay Kumar,Shiv Bharadwaj,Ravi Chaudhary,Shakti Sahi
Publisher : Springer
Page : 57 pages
File Size : 48,9 Mb
Release : 2018-04-25
Category : Computers
ISBN : 9783319757322

Get Book

Bioinformatics Techniques for Drug Discovery by Aman Chandra Kaushik,Ajay Kumar,Shiv Bharadwaj,Ravi Chaudhary,Shakti Sahi Pdf

The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data. This work reviews the latest bioinformatics approaches used for drug discovery. The text covers ligand-based and structure-based approaches for computer-aided drug design, 3D pharmacophore modeling, molecular dynamics simulation, the thermodynamics of ligand−receptor and ligand−enzyme association, thermodynamic characterization and optimization, and techniques for computational genomics and proteomics.

Author : Mohini Gore,Umesh B. Jagtap
Publisher : Springer Nature
Page : 357 pages
File Size : 54,7 Mb
Release : 2023-10-09
Category : Medical
ISBN : 9781071634417

Get Book

Computational Drug Discovery and Design by Mohini Gore,Umesh B. Jagtap Pdf

This second edition provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Drug Discovery and Design, Second Edition aims to effectively utilize computational methodologies in discovery and design of novel drugs.

Author : Qing Yan
Publisher : Springer Nature
Page : 618 pages
File Size : 48,7 Mb
Release : 2022-09-06
Category : Medical
ISBN : 9781071625736

Get Book

Pharmacogenomics in Drug Discovery and Development by Qing Yan Pdf

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Author : Larson
Publisher : Unknown
Page : 456 pages
File Size : 43,9 Mb
Release : 2007-12-01
Category : Electronic
ISBN : 8181289099

Get Book

Bioinformatics And Drug Discovery by Larson Pdf

Author : Vivek Chavda,Krishnan Anand,Vasso Apostolopoulos
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 50,5 Mb
Release : 2023-02-09
Category : Medical
ISBN : 9781119865704

Get Book

Bioinformatics Tools for Pharmaceutical Drug Product Development by Vivek Chavda,Krishnan Anand,Vasso Apostolopoulos Pdf

BIOINFORMATICS TOOLS FOR Pharmaceutical DRUG PRODUCT DLEVELOPMENT A timely book that details bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies, for drug development in the pharmaceutical and medical sciences industries. The book contains 17 chapters categorized into 3 sections. The first section presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. The following 2 sections include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall. Readers will find in this book: Applications of bioinformatics tools for pharmaceutical drug product development like process development, pre-clinical development, clinical development, commercialization of the product, etc.; The ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach; The broad and deep background, as well as updates, on recent advances in both medicine and AI/ML that enable the application of these cutting-edge bioinformatics tools. Audience The book will be used by researchers and scientists in academia and industry including drug developers, computational biochemists, bioinformaticians, immunologists, pharmaceutical and medical sciences, as well as those in artificial intelligence and machine learning.