Bioinformatics Tools For Pharmaceutical Drug Product Development

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Bioinformatics Tools for Pharmaceutical Drug Product Development

Vivek Chavda,Krishnan Anand,Vasso Apostolopoulos
Bioinformatics Tools for Pharmaceutical Drug Product Development Book PDF

Author : Vivek Chavda,Krishnan Anand,Vasso Apostolopoulos
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 42,5 Mb
Release : 2023-02-09
Category : Medical
ISBN : 9781119865704

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Bioinformatics Tools for Pharmaceutical Drug Product Development by Vivek Chavda,Krishnan Anand,Vasso Apostolopoulos Pdf

BIOINFORMATICS TOOLS FOR Pharmaceutical DRUG PRODUCT DLEVELOPMENT A timely book that details bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies, for drug development in the pharmaceutical and medical sciences industries. The book contains 17 chapters categorized into 3 sections. The first section presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. The following 2 sections include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall. Readers will find in this book: Applications of bioinformatics tools for pharmaceutical drug product development like process development, pre-clinical development, clinical development, commercialization of the product, etc.; The ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach; The broad and deep background, as well as updates, on recent advances in both medicine and AI/ML that enable the application of these cutting-edge bioinformatics tools. Audience The book will be used by researchers and scientists in academia and industry including drug developers, computational biochemists, bioinformaticians, immunologists, pharmaceutical and medical sciences, as well as those in artificial intelligence and machine learning.

CADD and Informatics in Drug Discovery

Mithun Rudrapal,Johra Khan
CADD and Informatics in Drug Discovery Book PDF

Author : Mithun Rudrapal,Johra Khan
Publisher : Springer Nature
Page : 370 pages
File Size : 55,7 Mb
Release : 2023-05-12
Category : Science
ISBN : 9789819913169

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CADD and Informatics in Drug Discovery by Mithun Rudrapal,Johra Khan Pdf

This book updates knowledge on recent advances in computational, biophysical and bioinformatics tools/techniques and their practical applications in modern drug design and discovery paradigm. It also encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas; presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, R&D personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, de novo drug design, pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and systems biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to various stakeholders working in the pharmaceutical and biotechnology industries (R&D), the academic as well as research sectors.

Open Source Software in Life Science Research

Lee Harland,Mark Forster
Open Source Software in Life Science Research Book PDF

Author : Lee Harland,Mark Forster
Publisher : Elsevier
Page : 583 pages
File Size : 49,8 Mb
Release : 2012-10-31
Category : Computers
ISBN : 9781908818249

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Open Source Software in Life Science Research by Lee Harland,Mark Forster Pdf

The free/open source approach has grown from a minor activity to become a significant producer of robust, task-orientated software for a wide variety of situations and applications. To life science informatics groups, these systems present an appealing proposition - high quality software at a very attractive price. Open source software in life science research considers how industry and applied research groups have embraced these resources, discussing practical implementations that address real-world business problems. The book is divided into four parts. Part one looks at laboratory data management and chemical informatics, covering software such as Bioclipse, OpenTox, ImageJ and KNIME. In part two, the focus turns to genomics and bioinformatics tools, with chapters examining GenomicsTools and EBI Atlas software, as well as the practicalities of setting up an ‘omics’ platform and managing large volumes of data. Chapters in part three examine information and knowledge management, covering a range of topics including software for web-based collaboration, open source search and visualisation technologies for scientific business applications, and specific software such as DesignTracker and Utopia Documents. Part four looks at semantic technologies such as Semantic MediaWiki, TripleMap and Chem2Bio2RDF, before part five examines clinical analytics, and validation and regulatory compliance of free/open source software. Finally, the book concludes by looking at future perspectives and the economics and free/open source software in industry. Discusses a broad range of applications from a variety of sectors Provides a unique perspective on work normally performed behind closed doors Highlights the criteria used to compare and assess different approaches to solving problems

Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences

Navneet Sharma,Himanshu Ojha,Pawan Raghav,Ramesh K. Goyal
Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences Book PDF

Author : Navneet Sharma,Himanshu Ojha,Pawan Raghav,Ramesh K. Goyal
Publisher : Academic Press
Page : 510 pages
File Size : 54,8 Mb
Release : 2021-05-21
Category : Business & Economics
ISBN : 9780128217474

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Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences by Navneet Sharma,Himanshu Ojha,Pawan Raghav,Ramesh K. Goyal Pdf

Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences brings together two very important fields in pharmaceutical sciences that have been mostly seen as diverging from each other: chemoinformatics and bioinformatics. As developing drugs is an expensive and lengthy process, technology can improve the cost, efficiency and speed at which new drugs can be discovered and tested. This book presents some of the growing advancements of technology in the field of drug development and how the computational approaches explained here can reduce the financial and experimental burden of the drug discovery process. This book will be useful to pharmaceutical science researchers and students who need basic knowledge of computational techniques relevant to their projects. Bioscientists, bioinformaticians, computational scientists, and other stakeholders from industry and academia will also find this book helpful. Provides practical information on how to choose and use appropriate computational tools Presents the wide, intersecting fields of chemo-bio-informatics in an easily-accessible format Explores the fundamentals of the emerging field of chemoinformatics and bioinformatics

Pharmaceutical Data Mining

Konstantin V. Balakin
Pharmaceutical Data Mining Book PDF

Author : Konstantin V. Balakin
Publisher : John Wiley & Sons
Page : 584 pages
File Size : 42,9 Mb
Release : 2009-11-19
Category : Medical
ISBN : 9780470567616

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Pharmaceutical Data Mining by Konstantin V. Balakin Pdf

Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover: A general overview of the discipline, from its foundations to contemporary industrial applications Chemoinformatics-based applications Bioinformatics-based applications Data mining methods in clinical development Data mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.

Computation in BioInformatics

Anand T. Krishnan,S. Balamurugan,Dinesh Goyal,Balakumar Chandrasekaran,Boomi Pandi
Computation in BioInformatics Book PDF

Author : Anand T. Krishnan,S. Balamurugan,Dinesh Goyal,Balakumar Chandrasekaran,Boomi Pandi
Publisher : John Wiley & Sons
Page : 352 pages
File Size : 54,6 Mb
Release : 2021-10-05
Category : Computers
ISBN : 9781119654766

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Computation in BioInformatics by Anand T. Krishnan,S. Balamurugan,Dinesh Goyal,Balakumar Chandrasekaran,Boomi Pandi Pdf

COMPUTATION IN BIOINFORMATICS Bioinformatics is a platform between the biology and information technology and this book provides readers with an understanding of the use of bioinformatics tools in new drug design. The discovery of new solutions to pandemics is facilitated through the use of promising bioinformatics techniques and integrated approaches. This book covers a broad spectrum of the bioinformatics field, starting with the basic principles, concepts, and application areas. Also covered is the role of bioinformatics in drug design and discovery, including aspects of molecular modeling. Some of the chapters provide detailed information on bioinformatics related topics, such as silicon design, protein modeling, DNA microarray analysis, DNA-RNA barcoding, and gene sequencing, all of which are currently needed in the industry. Also included are specialized topics, such as bioinformatics in cancer detection, genomics, and proteomics. Moreover, a few chapters explain highly advanced topics, like machine learning and covalent approaches to drug design and discovery, all of which are significant in pharma and biotech research and development. Audience Researchers and engineers in computation biology, information technology, bioinformatics, drug design, biotechnology, pharmaceutical sciences.

Systems Biology in Biotech & Pharma

Ales Prokop,Seth Michelson
Systems Biology in Biotech Pharma Book PDF

Author : Ales Prokop,Seth Michelson
Publisher : Springer Science & Business Media
Page : 137 pages
File Size : 40,8 Mb
Release : 2012-01-05
Category : Medical
ISBN : 9789400728486

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Systems Biology in Biotech & Pharma by Ales Prokop,Seth Michelson Pdf

The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.

Genomic Biomarkers for Pharmaceutical Development

Yihong Yao,Bahija Jallal,Koustubh Ranade
Genomic Biomarkers for Pharmaceutical Development Book PDF

Author : Yihong Yao,Bahija Jallal,Koustubh Ranade
Publisher : Academic Press
Page : 203 pages
File Size : 50,6 Mb
Release : 2013-07-16
Category : Medical
ISBN : 9780123977946

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Genomic Biomarkers for Pharmaceutical Development by Yihong Yao,Bahija Jallal,Koustubh Ranade Pdf

Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development. Provides case studies in applications of pharmacodynamic and predictive markers in drug development in oncology, autoimmunity, respiratory diseases and infectious diseases Shows how to identify potential new therapeutic targets in different diseases and provides examples of potential new disease indications for life cycle management of drugs Authored by leading international experts from industry and academia

Drug Efficacy, Safety, and Biologics Discovery

Sean Ekins,Jinghai J. Xu
Drug Efficacy Safety and Biologics Discovery Book PDF

Author : Sean Ekins,Jinghai J. Xu
Publisher : John Wiley & Sons
Page : 442 pages
File Size : 45,5 Mb
Release : 2009-01-28
Category : Medical
ISBN : 9780470431801

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Drug Efficacy, Safety, and Biologics Discovery by Sean Ekins,Jinghai J. Xu Pdf

Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.

Bioinformatics and Computational Biology in Drug Discovery and Development

William T. Loging
Bioinformatics and Computational Biology in Drug Discovery and Development Book PDF

Author : William T. Loging
Publisher : Cambridge University Press
Page : 255 pages
File Size : 44,8 Mb
Release : 2016-03-17
Category : Science
ISBN : 9780521768009

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Bioinformatics and Computational Biology in Drug Discovery and Development by William T. Loging Pdf

A comprehensive overview of the use of computational biology approaches in the drug discovery and development process.

Bioinformatics Techniques for Drug Discovery

Aman Chandra Kaushik,Ajay Kumar,Shiv Bharadwaj,Ravi Chaudhary,Shakti Sahi
Bioinformatics Techniques for Drug Discovery Book PDF

Author : Aman Chandra Kaushik,Ajay Kumar,Shiv Bharadwaj,Ravi Chaudhary,Shakti Sahi
Publisher : Springer
Page : 57 pages
File Size : 53,7 Mb
Release : 2018-04-25
Category : Computers
ISBN : 9783319757322

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Bioinformatics Techniques for Drug Discovery by Aman Chandra Kaushik,Ajay Kumar,Shiv Bharadwaj,Ravi Chaudhary,Shakti Sahi Pdf

The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data. This work reviews the latest bioinformatics approaches used for drug discovery. The text covers ligand-based and structure-based approaches for computer-aided drug design, 3D pharmacophore modeling, molecular dynamics simulation, the thermodynamics of ligand−receptor and ligand−enzyme association, thermodynamic characterization and optimization, and techniques for computational genomics and proteomics.

Computer Applications in Pharmaceutical Research and Development

Sean Ekins
Computer Applications in Pharmaceutical Research and Development Book PDF

Author : Sean Ekins
Publisher : John Wiley & Sons
Page : 840 pages
File Size : 42,6 Mb
Release : 2006-07-11
Category : Medical
ISBN : 9780470037225

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Computer Applications in Pharmaceutical Research and Development by Sean Ekins Pdf

A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.

Quantitative Methods in Pharmaceutical Research and Development

Olga V. Marchenko,Natallia V. Katenka
Quantitative Methods in Pharmaceutical Research and Development Book PDF

Author : Olga V. Marchenko,Natallia V. Katenka
Publisher : Springer Nature
Page : 445 pages
File Size : 53,7 Mb
Release : 2020-09-24
Category : Medical
ISBN : 9783030485559

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Quantitative Methods in Pharmaceutical Research and Development by Olga V. Marchenko,Natallia V. Katenka Pdf

This contributed volume presents an overview of concepts, methods, and applications used in several quantitative areas of drug research, development, and marketing. Chapters bring together the theories and applications of various disciplines, allowing readers to learn more about quantitative fields, and to better recognize the differences between them. Because it provides a thorough overview, this will serve as a self-contained resource for readers interested in the pharmaceutical industry, and the quantitative methods that serve as its foundation. Specific disciplines covered include: Biostatistics Pharmacometrics Genomics Bioinformatics Pharmacoepidemiology Commercial analytics Operational analytics Quantitative Methods in Pharmaceutical Research and Development is ideal for undergraduate students interested in learning about real-world applications of quantitative methods, and the potential career options open to them. It will also be of interest to experts working in these areas.

Chemoinformatics

Jürgen Bajorath
Chemoinformatics Book PDF

Author : Jürgen Bajorath
Publisher : Springer Science & Business Media
Page : 530 pages
File Size : 51,7 Mb
Release : 2008-02-04
Category : Medical
ISBN : 9781592598021

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Chemoinformatics by Jürgen Bajorath Pdf

In the literature, several terms are used synonymously to name the topic of this book: chem-, chemi-, or chemo-informatics. A widely recognized de- nition of this discipline is the one by Frank Brown from 1998 (1) who defined chemoinformatics as the combination of “all the information resources that a scientist needs to optimize the properties of a ligand to become a drug. ” In Brown’s definition, two aspects play a fundamentally important role: de- sion support by computational means and drug discovery, which distinguishes it from the term “chemical informatics” that was introduced at least ten years earlier and described as the application of information technology to ch- istry (not with a specific focus on drug discovery). In addition, there is of course “chemometrics,” which is generally understood as the application of statistical methods to chemical data and the derivation of relevant statistical models and descriptors (2). The pharmaceutical focus of many developments and efforts in this area—and the current popularity of gene-to-drug or si- lar paradigms—is further reflected by the recent introduction of such terms as “discovery informatics” (3), which takes into account that gaining kno- edge from chemical data alone is not sufficient to be ultimately successful in drug discovery. Such insights are well in accord with other views that the boundaries between bio- and chemoinformatics are fluid and that these d- ciplines should be closely combined or merged to significantly impact b- technology or pharmaceutical research (4).

Advances in Bioinformatics

Vijai Singh,Ajay Kumar
Advances in Bioinformatics Book PDF

Author : Vijai Singh,Ajay Kumar
Publisher : Springer Nature
Page : 446 pages
File Size : 43,7 Mb
Release : 2021-07-31
Category : Science
ISBN : 9789813361911

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Advances in Bioinformatics by Vijai Singh,Ajay Kumar Pdf

This book presents the latest developments in bioinformatics, highlighting the importance of bioinformatics in genomics, transcriptomics, metabolism and cheminformatics analysis, as well as in drug discovery and development. It covers tools, data mining and analysis, protein analysis, computational vaccine, and drug design. Covering cheminformatics, computational evolutionary biology and the role of next-generation sequencing and neural network analysis, it also discusses the use of bioinformatics tools in the development of precision medicine. This book offers a valuable source of information for not only beginners in bioinformatics, but also for students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of bioinformatics in many areas.