Biology And Engineering Of Stem Cell Niches

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Biology and Engineering of Stem Cell Niches

Ajaykumar Vishwakarma,Jeffrey M Karp
Biology and Engineering of Stem Cell Niches Book PDF

Author : Ajaykumar Vishwakarma,Jeffrey M Karp
Publisher : Academic Press
Page : 642 pages
File Size : 52,6 Mb
Release : 2017-03-22
Category : Science
ISBN : 9780128027561

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Biology and Engineering of Stem Cell Niches by Ajaykumar Vishwakarma,Jeffrey M Karp Pdf

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Biomaterials as Stem Cell Niche

Krishnendu Roy
Biomaterials as Stem Cell Niche Book PDF

Author : Krishnendu Roy
Publisher : Springer Science & Business Media
Page : 310 pages
File Size : 48,5 Mb
Release : 2010-09-30
Category : Technology & Engineering
ISBN : 9783642138935

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Biomaterials as Stem Cell Niche by Krishnendu Roy Pdf

Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.

Biology in Stem Cell Niche

Kursad Turksen
Biology in Stem Cell Niche Book PDF

Author : Kursad Turksen
Publisher : Springer
Page : 228 pages
File Size : 52,5 Mb
Release : 2015-10-15
Category : Science
ISBN : 9783319217024

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Biology in Stem Cell Niche by Kursad Turksen Pdf

This comprehensive volume explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescence, biomimetics, epigenetics, engineering strategies for emulating, tumorigenesis and more. The chapter authors represent a broad range of international expertise and perspectives. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Biology of Stem Cell Niche is an ideal complementary volume to Tissue-Specific Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

Biology in Stem Cell Niche

Kursad Turksen
Biology in Stem Cell Niche Book PDF

Author : Kursad Turksen
Publisher : Unknown
Page : 128 pages
File Size : 55,5 Mb
Release : 2015
Category : Electronic
ISBN : 3319217038

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Biology in Stem Cell Niche by Kursad Turksen Pdf

This comprehensive volume explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescence, biomimetics, epigenetics, engineering strategies for emulating, tumorigenesis and more. The chapter authors represent a broad range of international expertise and perspectives. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Biology of Stem Cell Niche is an ideal complementary volume to Tissue-Specific Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

Stem Cells

Mary Clarke,Jonathan Frampton
Stem Cells Book PDF

Author : Mary Clarke,Jonathan Frampton
Publisher : Garland Science
Page : 966 pages
File Size : 46,9 Mb
Release : 2020-07-27
Category : Science
ISBN : 9781000062656

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Stem Cells by Mary Clarke,Jonathan Frampton Pdf

Stem cell science, encompassing basic biology to practical application, is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology, tissue structure and physiology, the practicalities of tissue engineering and bioprocessing, and the pathways to clinical implementation—including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers, treating acute damage in conditions such as stroke and myocardial infarction, and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates, first year graduate students, and practitioners in molecular biology, biology, and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.

Stem Cell Engineering

David Schaffer,Joseph D. Bronzino,Donald R. Peterson
Stem Cell Engineering Book PDF

Author : David Schaffer,Joseph D. Bronzino,Donald R. Peterson
Publisher : CRC Press
Page : 233 pages
File Size : 51,7 Mb
Release : 2012-11-20
Category : Medical
ISBN : 9781439872048

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Stem Cell Engineering by David Schaffer,Joseph D. Bronzino,Donald R. Peterson Pdf

While the potential of stem cells is recognized, their proliferation and differentiation must be more precisely controlled to maximize the production of therapeutically relevant cells and for cell replacement therapies to minimize contamination with residual cells that can give rise to side effects. How can engineers make contributions to address these challenges? With contributions from pioneers and experts, Stem Cell Engineering: Principles and Practices highlights recent advances in the understanding of the cellular and molecular composition of the stem cell niche, as well as approaches to build upon this basic information to direct stem cell differentiation into therapeutically valuable lineages. The growing recognition of stem cells as an important and exciting field will continue to draw investigators with diverse backgrounds—from biology, engineering, and the physical sciences—and thereby enable further progress in these and other new directions. This book discusses advances made during the last decade that have led to increasingly defined culture systems for growing stem cells, starting from co-culture with feeder cells in the presence of serum to growth on synthetic substrates in defined medium. In addition to highlighting many recent advances, it underscores the need for future work.

Cell and Molecular Biology and Imaging of Stem Cells

Heide Schatten
Cell and Molecular Biology and Imaging of Stem Cells Book PDF

Author : Heide Schatten
Publisher : John Wiley & Sons
Page : 304 pages
File Size : 48,8 Mb
Release : 2014-08-04
Category : Science
ISBN : 9781118285077

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Cell and Molecular Biology and Imaging of Stem Cells by Heide Schatten Pdf

Cell and Molecular Biology and Imaging of Stem Cells features original and review articles written by experts who have made significant contributions to stem cell biology and imaging. Chapters cover a broad spectrum of aspects of the field, including Stem cells from the Amniotic Fluid and Placenta, Biomaterials as Artificial Niches for Pluripotent Stem Cell Engineering, Low-Intensity Ultrasound in Stem Cells and Tissue Engineering, Mammalian Neo-Oogenesis from Ovarian Stem Cells, Oct4-EGFP Transgenic Pigs as a New Tool for Visualization of Pluripotent and Reprogrammed Cells, Regulation of Adult Intestinal Stem Cells, Stem Cell Therapy for Veterinary Orthopedic Lesions, Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases, Hair Follicle Stem Cells, The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases, Mitochondrial Differentiation in Early Embryo Cells and Pluripotent Stem Cells, and The Role of Centrosomes in Cancer Stem Cell Functions. Cell and Molecular Biology and Imaging of Stem Cells addresses a wide variety of cell and molecular topics in unprecedented detail, and is a must-read for graduate students and academic and industry professionals in the expanding field of stem cell biology. Reviews new imaging tools and markers for cell and molecular imaging in stem cell biology. Covers novel aspects of stem cell imaging in reproductive biology and stem cell niches Includes chapters on the developing area of centrosome biology as it applies to embryonic and adult stem differentiation

Tissue-Specific Stem Cell Niche

Kursad Turksen
Tissue Specific Stem Cell Niche Book PDF

Author : Kursad Turksen
Publisher : Springer
Page : 333 pages
File Size : 42,5 Mb
Release : 2015-10-05
Category : Science
ISBN : 9783319217055

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Tissue-Specific Stem Cell Niche by Kursad Turksen Pdf

This timely volume explores tissue-derived stem cells, summarizing and evaluating the current body of knowledge. Sixteen chapters cover hematopoietic, osteoblast, skeletal, cardiac, pancreatic, epithelial, corneal, hepatic, renal, testicular, ovarian, fingernail, hair follicle and other stem cells- discussing their individual development, functions and pathologies, as well as the commonalities and interdependence between niches. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Tissue-Specific Stem Cell Niche is an ideal complementary volume to Biology of Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

Stem Cells

Suchandra Chowdhury,Shyamasree Ghosh
Stem Cells Book PDF

Author : Suchandra Chowdhury,Shyamasree Ghosh
Publisher : Springer Nature
Page : 271 pages
File Size : 50,7 Mb
Release : 2021-07-24
Category : Science
ISBN : 9789811616389

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Stem Cells by Suchandra Chowdhury,Shyamasree Ghosh Pdf

Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and plant sciences.

Stem Cells

Michal K. Stachowiak,Emmanuel S. Tzanakakis
Stem Cells Book PDF

Author : Michal K. Stachowiak,Emmanuel S. Tzanakakis
Publisher : World Scientific
Page : 394 pages
File Size : 45,6 Mb
Release : 2012
Category : Science
ISBN : 9789814317702

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Stem Cells by Michal K. Stachowiak,Emmanuel S. Tzanakakis Pdf

Advances in stem cell biology and biotechnology have sparked hopes that therapies will soon be available for maladies which were considered incurable before. However, realization of the clinical potential of stem cells will require better understanding of stem cell physiology and the development of advanced technologies for their efficient differentiation in medically relevant quantities. Resolving these issues necessitates synergistic approaches from multiple fields. Systems biology can be employed to dissect the mechanisms regulating the genome and proteome of stem cells during self-renewal and commitment. Microfluidic platforms can be used to recreate aspects of the stem cell niche and obtain a better understanding of the interactions among stem cells and with their environment. The milieu of stem cells and their progeny can be shaped with appropriately designed biomaterials for the engineering of tissues to replace, reconstitute or regenerate damaged organs. To that end, enabling bioreactor technologies will be necessary for the generation of large quantities of stem cells and their derivatives in a robust and cost-efficient manner. This book invites world-renowned experts in the above fields to discuss the latest advances in their respective areas and to provide insights on the future challenges and achievements in the area of stem cells.

Stem Cells in Development and Disease

Anonim
Stem Cells in Development and Disease Book PDF

Author : Anonim
Publisher : Academic Press
Page : 503 pages
File Size : 48,9 Mb
Release : 2014-01-15
Category : Medical
ISBN : 9780123914354

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Stem Cells in Development and Disease by Anonim Pdf

This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging Covers the area of Stem Cells in Development and Disease International board of authors Provides a comprehensive set of reviews covering such topics as Intestinal Stem Cells, Nephron Stem Cells/Progenitors, Skin epithelial Stem Cells and Lung Stem Cells

Cell Biology and Translational Medicine, Volume 6

Kursad Turksen
Cell Biology and Translational Medicine Volume 6 Book PDF

Author : Kursad Turksen
Publisher : Springer Nature
Page : 228 pages
File Size : 48,7 Mb
Release : 2020-01-09
Category : Science
ISBN : 9783030328238

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Cell Biology and Translational Medicine, Volume 6 by Kursad Turksen Pdf

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the sixth volume of a continuing series.

Stem Cell Engineering

Gerhard M. Artmann,Stephen Minger,Jürgen Hescheler
Stem Cell Engineering Book PDF

Author : Gerhard M. Artmann,Stephen Minger,Jürgen Hescheler
Publisher : Springer Science & Business Media
Page : 566 pages
File Size : 44,5 Mb
Release : 2010-10-29
Category : Technology & Engineering
ISBN : 9783642118654

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Stem Cell Engineering by Gerhard M. Artmann,Stephen Minger,Jürgen Hescheler Pdf

The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.

Stem Cells and Extracellular Matrices

Lakshmi Kiran Chelluri
Stem Cells and Extracellular Matrices Book PDF

Author : Lakshmi Kiran Chelluri
Publisher : Morgan & Claypool Publishers
Page : 87 pages
File Size : 54,5 Mb
Release : 2012
Category : Science
ISBN : 9781615043767

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Stem Cells and Extracellular Matrices by Lakshmi Kiran Chelluri Pdf

Stem cells have great potential in regenerative medicine and tissue injury. Regulation of stem cell homeostasis in a 3D microenvironment is controlled by the niche components that influence stem cell fate, regulation, and function. It is therefore necessary to understand the mechanisms of cell-cell interaction, molecular cross talk between stem cells and their extracellular matrix (ECM) environment. The adhesion molecules play a pivotal role in establishing the cell-cell contact and subsequent integration with the ECM. This understanding is the basis for establishing design criteria for biomimetic. The integrated approach by biologists, material science engineers, biomedical engineers, and clinicians is the key in the development of tissue engineered constructs for effective translation to clinics. Table of Contents: Abbreviations / Introduction to Stem Cell Biology and Niche Components / ECM-Structure and Organization / ECM Control, Regulation on Stem Cell Fate and Function / ECM and Stem Cell Cultures / Acknowledgments / Bibliography / Author Biography / Titles of Related Interest

Stem Cells and Revascularization Therapies

Hyunjoon Kong,Andrew J. Putnam,Lawrence B. Schook
Stem Cells and Revascularization Therapies Book PDF

Author : Hyunjoon Kong,Andrew J. Putnam,Lawrence B. Schook
Publisher : CRC Press
Page : 345 pages
File Size : 40,7 Mb
Release : 2011-12-13
Category : Medical
ISBN : 9781439803233

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Stem Cells and Revascularization Therapies by Hyunjoon Kong,Andrew J. Putnam,Lawrence B. Schook Pdf

In the last few decades, significant advancements in the biology and engineering of stem cells have enabled progress in their clinical application to revascularization therapies. Some strategies involve the mobilization of endogenous stem cell populations, and others employ cell transplantation. However, both techniques have benefited from multidisciplinary efforts to create biomaterials and other biomedical tools that can improve and control the fate of stem cells, and advance our understanding of them. Stem Cells and Revascularization Therapies focuses on the fundamentals and applied studies in stem cell biology, and provides perspectives associated with the development of revascularization strategies. To help readers understand the multidisciplinary issues associated with this topic, this book has been divided into four sections: Section 1: Explores how to define, isolate, and characterize various stem and progenitor cell populations for neovascularization Section 2: Summarizes some especially useful model systems and approaches used to regulate angiogenesis, vasculogenesis, and arteriogenesis, and explores their impact on formation of functional vessels in vivo Section 3: Focuses on stem cell homing to sites of injury and inflammation, as well as strategies to exploit this mobilization phenomenon Section 4: Covers stem cell transplantation topics, including recreating features of endogenous stem cell niches to maintain the multipotency of transplanted cells and combinatorial delivery of cells and molecular factors Intended to inspire new contributions to improve the therapeutic efficacy, Stem Cells and Revascularization Therapies outlines emergent findings and challenges regarding the use of stem cells in revascularization therapies. Overcoming the significant hurdles to our understanding of stem cell biology will enhance their utility in promoting new blood vessel formation.