Biomedical Research Medicine And Disease

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Toward Precision Medicine

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publisher : National Academies Press
Page : 142 pages
File Size : 55,5 Mb
Release : 2012-01-16
Category : Medical
ISBN : 9780309222228

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Toward Precision Medicine by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease Pdf

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Biomedical Research, Medicine, and Disease

Author : RC Sobti,Aastha Sobti
Publisher : CRC Press
Page : 665 pages
File Size : 42,9 Mb
Release : 2023-04-04
Category : Medical
ISBN : 9781000811193

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Biomedical Research, Medicine, and Disease by RC Sobti,Aastha Sobti Pdf

Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics. This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general. The volume comprehensively covers: Emerging technologies for health care Various aspects of biomedical research toward understanding of pathophysiology of the diseases Advances in improvement in diagnostic procedures and therapeutic tools The fundamental role of biomedical research in the development of new medicinal products

Research in the Biomedical Sciences

Author : Michael Williams,Michael Curtis,Kevin Mullane
Publisher : Academic Press
Page : 382 pages
File Size : 45,8 Mb
Release : 2017-10-20
Category : Science
ISBN : 9780128047262

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Research in the Biomedical Sciences by Michael Williams,Michael Curtis,Kevin Mullane Pdf

Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences. Provides a “big picture perspective on the scope of reproducibility issues and covers initiatives that have potential as effective solutions Offers real-world research context for transparent, reproducible experimental design, execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability

The Zebrafish in Biomedical Research

Author : Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders
Publisher : Academic Press
Page : 720 pages
File Size : 53,6 Mb
Release : 2019-11-22
Category : Science
ISBN : 9780128124321

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The Zebrafish in Biomedical Research by Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders Pdf

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

War and Disease

Author : Leo Barney Slater
Publisher : Rutgers University Press
Page : 266 pages
File Size : 47,5 Mb
Release : 2009
Category : History
ISBN : 9780813544380

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War and Disease by Leo Barney Slater Pdf

Fighting around the globe, American soldiers were at high risk for contracting malaria, yet quinine - a natural cure - became hard to acquire. This historical study shows the roots and branches of an enormous drug development project during World War II.

Sourcebook of Models for Biomedical Research

Author : P. Michael Conn
Publisher : Springer Science & Business Media
Page : 756 pages
File Size : 40,9 Mb
Release : 2008
Category : Medical
ISBN : 9781588299338

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Sourcebook of Models for Biomedical Research by P. Michael Conn Pdf

The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.

Advancing the Nation's Health Needs

Author : National Research Council,Policy and Global Affairs,Board on Higher Education and Workforce,Committee for Monitoring the Nation's Changing Needs for Biomedical, Behavioral, and Clinical Personnel
Publisher : National Academies Press
Page : 187 pages
File Size : 55,8 Mb
Release : 2005-08-13
Category : Medical
ISBN : 9780309094276

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Advancing the Nation's Health Needs by National Research Council,Policy and Global Affairs,Board on Higher Education and Workforce,Committee for Monitoring the Nation's Changing Needs for Biomedical, Behavioral, and Clinical Personnel Pdf

This report is the twelfth assessment of the National Institutes of Health National Research Service Awards program. The research training needs of the country in basic biomedical, clinical, and behavioral and social sciences are considered. Also included are the training needs of oral health, nursing, and health services research. The report has been broadly constructed to take into account the rapidly evolving national and international health care needs. The past and present are analyzed, and predictions with regard to future needs are presented.

Nonhuman Primates in Biomedical Research

Author : Christian R. Abee,Keith Mansfield,Suzette D. Tardif,Timothy Morris
Publisher : Academic Press
Page : 868 pages
File Size : 46,5 Mb
Release : 2012-06-07
Category : Medical
ISBN : 9780123978387

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Nonhuman Primates in Biomedical Research by Christian R. Abee,Keith Mansfield,Suzette D. Tardif,Timothy Morris Pdf

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

A Guide to Methods in the Biomedical Sciences

Author : Ronald B. Corley
Publisher : Springer Science & Business Media
Page : 135 pages
File Size : 46,8 Mb
Release : 2006-01-16
Category : Medical
ISBN : 9780387228457

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A Guide to Methods in the Biomedical Sciences by Ronald B. Corley Pdf

Thousands of methods have been developed in the various biomedical disciplines, and those covered in this book represent the basic, essential and most widely used methods in several different disciplines.

Today's Curiosity is Tomorrow's Cure

Author : Steve Caplan
Publisher : CRC Press
Page : 155 pages
File Size : 44,8 Mb
Release : 2021-11-09
Category : Medical
ISBN : 9781000471007

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Today's Curiosity is Tomorrow's Cure by Steve Caplan Pdf

Basic curiosity-driven biomedical science has delivered many of today’s most significant medical advances. This book provides clearly explained examples from recent biomedical history and includes convincing arguments for sustaining a robust portfolio of basic research. Intended as an engaging read, which will delight undergraduate and graduate students, as well as scientific researchers, it is full-throated advocacy of basic science. Illustrations and examples include the discoveries of penicillin and insulin, and the breakthrough elucidation of the genetic code. Providing both compelling rationale in support of basic science, and a fascinating look through the history of modern biomedical research, this book highlights with stirring examples why basic biomedical research is so important, and how so many key advances in medicine are derived from basic research. The book also offers a rationale for scientific inquiry and a broader understanding of the history of modern biomedical research missing from today’s classrooms. Key Features 1) Provides clear explanations of great scientific discoveries 2) Illustrates connections between basic research findings and modern medicine 3) Includes compelling graphics/diagrams/illustrations 4) Accessible to the general public 5) Offers background for more specialized readers, including researchers as well as those with advanced degrees. Related Titles Staddon, J. Scientific Method: How Science Works, Fails to Work, and Pretends to Work (ISBN 978-1-1382-9536-0) Helliwell, J. R. Skills for Scientific Life (ISBN 978-1-4987-6875-7) MacRitchie, F. Scientific Research as a Career (ISBN 978-1-4398-6965-9)

Enhancing the Vitality of the National Institutes of Health

Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Organizational Structure of the National Institutes of Health
Publisher : National Academies Press
Page : 165 pages
File Size : 42,7 Mb
Release : 2003-08-29
Category : Medical
ISBN : 9780309089678

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Enhancing the Vitality of the National Institutes of Health by National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Organizational Structure of the National Institutes of Health Pdf

The report says that important organizational changes are needed at the National Institutes of Health to ensure the agency meets future challenges effectively. In particular, the report advises NIH to devote additional resources to innovative interdisciplinary research that reflects its strategic objectives and cuts across all agency's institutes and centers. The report recommends that Congress should establish a formal process for determining how specific proposals for changes in the number of NIH agencies and centers should be addressed.

Biomedical Sciences

Author : Raymond Iles,Suzanne Docherty
Publisher : John Wiley & Sons
Page : 450 pages
File Size : 54,8 Mb
Release : 2012-01-30
Category : Science
ISBN : 9780470997741

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Biomedical Sciences by Raymond Iles,Suzanne Docherty Pdf

Biomedical Sciences is an indispensable, all encompassing core textbook for first/ second year biomedical science students that will support them throughout their undergraduate career. The book includes the key components of the IBMS accredited degree programmes, plus sections on actual practice in UK hospital laboratories (including the compilation of a reflective portfolio). The book is visually exciting, and written in an interesting and accessible manner while maintaining scientific rigour. Highlighted boxes within the text link the theory to actual clinical laboratory practice for example, the histopathology chapter includes a photographically illustrated flow chart of the progress of a specimen through the histopathology lab, so that students can actually see how the specimen reception/inking/cut-up/cassette/block/section/stain system works, with an emphasis on the safety procedures that ensure specimens are not confused).

Biomedical Models and Resources

Author : National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on New and Emerging Models in Biomedical and Behavioral Research
Publisher : National Academies Press
Page : 85 pages
File Size : 48,5 Mb
Release : 1998-02-16
Category : Science
ISBN : 9780309060356

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Biomedical Models and Resources by National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on New and Emerging Models in Biomedical and Behavioral Research Pdf

Printbegrænsninger: Der kan printes 10 sider ad gangen og max. 40 sider pr. session.

Integrative Approaches for Health

Author : Bhushan Patwardhan,Gururaj Mutalik,Girish Tillu
Publisher : Academic Press
Page : 383 pages
File Size : 46,6 Mb
Release : 2015-03-31
Category : Technology & Engineering
ISBN : 9780128014349

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Integrative Approaches for Health by Bhushan Patwardhan,Gururaj Mutalik,Girish Tillu Pdf

Despite spectacular advances, modern medicine faces formidable global challenges in several key areas—notably the persistence of major killer diseases such as malaria, tuberculosis, leprosy, and newer threats including HIV/AIDS, resistant infections, and Ebola. As such, modern medicine has not led to a significant decrease in chronic diseases like diabetes, obesity, and other degenerative and autoimmune diseases. The authors believe that modern medicine needs to experience a paradigm shift, an integration of traditions—in particular from the ancient systems like Ayurveda and Yoga. Integrative Approaches for Health: Biomedical Research, Ayurveda and Yoga brings together the basic principles of interdisciplinary systems approach for an evolving construct of future medicine. Such an approach is already emerging at the cutting edge of current research in omics, bioinformatics, computational and systems biology. Several leading institutions of medicine have adopted Yoga and complementary medicine to widen their reach, and deepen effectiveness in therapeutic practices. The amalgam of modern medicine, with its strengths in scientific rigor, blended with the basic principles of life drawn from Ayurveda and Yoga might evolve into a medicine of tomorrow. Integrative approaches are no longer alternative, perhaps taking these approaches is the only possible way to heal our sick planet. This book introduces important trends and tools for biomedical researchers and physicians alike, to innovate the practice of medicine for the better. Contains a harmonious confluence of ancient and modern concepts, historical perspectives, philosophical underpinnings, and a relevant review of literature supported by worldwide case studies. Provides a critical analysis of ancient wisdom, pointing to potential areas for future research, which provide food for thought for public debate on integrative health care for the twenty-first century. Explains Ayurveda knowledge, and its relevance to drug discovery, nutrition, genomics, epigenetics, regenerative biology, longevity and personalized medicine. Shares Yoga knowledge insights, and explains its relevance to body–mind complex relationships, psychology, neurobiology, immunoendocrinology, bioenergetics, consciousness, and cognitive sciences. Offers illustrations and logic diagrams for enhanced understanding of the concepts presented.

The Common Marmoset in Captivity and Biomedical Research

Author : Robert P. Marini,Lynn M. Wachtman,Suzette D. Tardif,Keith Mansfield,James G. Fox
Publisher : Academic Press
Page : 572 pages
File Size : 43,7 Mb
Release : 2018-11-19
Category : Science
ISBN : 9780128118306

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The Common Marmoset in Captivity and Biomedical Research by Robert P. Marini,Lynn M. Wachtman,Suzette D. Tardif,Keith Mansfield,James G. Fox Pdf

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the AmericanCollege of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset(Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such asmacaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. Themarmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primatemodel to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series