The Zebrafish In Biomedical Research

Author : Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders
Publisher : Academic Press
Page : 720 pages
File Size : 48,9 Mb
Release : 2019-11-22
Category : Science
ISBN : 9780128124321

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The Zebrafish in Biomedical Research by Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders Pdf

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

Author : Livia D'Angelo,Paolo de Girolamo
Publisher : Academic Press
Page : 476 pages
File Size : 53,5 Mb
Release : 2021-08-28
Category : Science
ISBN : 9780128212455

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Laboratory Fish in Biomedical Research by Livia D'Angelo,Paolo de Girolamo Pdf

Fish, and particularly zebrafish, have become the fastest-growing segment of the research population. They offer several advantages, in terms of biology and technologies to apply, and thus are employed in numerous research fields. Laboratory Fish in Biomedical Research: Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Swordtail Fish, Cavefish, Stickleback, Goldfish and Danionella Translucida addresses the relevant and increasing need to collect cutting-edge knowledge on husbandry, maintenance, welfare and experimental protocols of the most common freshwater species under standard laboratory conditions. Provides husbandry and management protocols, devices and water systems Shows strength and weakness of breeding Explores potential scientific applications and experimental protocols. with regards to the most used freshwater fish used for scientific purposes

Author : Yusuf Bozkurt
Publisher : Unknown
Page : 128 pages
File Size : 55,9 Mb
Release : 2020-03
Category : Electronic
ISBN : 1789859859

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Zebrafish in Biomedical Research by Yusuf Bozkurt Pdf

Author : Prasan R. Bhandari,Kala Kumar Bharani,Amit Khurana
Publisher : Springer Nature
Page : 493 pages
File Size : 45,6 Mb
Release : 2022-05-30
Category : Medical
ISBN : 9789811652172

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Zebrafish Model for Biomedical Research by Prasan R. Bhandari,Kala Kumar Bharani,Amit Khurana Pdf

This book provides the latest information on the significance of zebrafish as an ideal model for researching the biomedical field, with references. This book also focused on the evidence of zebrafish as a model in cardiovascular, neurologic, psychiatric and metabolic research. In addition, the book also includes the research carried out on zebrafish in hepatic, renal, ophthalmic, and ENT related areas. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish models including specific research in the area of skin disorders, endocrine diseases, nutritional disorders, gastrointestinal, hematological disorders and cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and its suitability for modeling various diseases, providing a critical resource on the potential attributes of the zebrafish as a pharmacological model. In terms of scope, this book is a useful tool for young researchers, professors and pharmaceutical scientists for understanding the significance of zebrafish as an emerging pharmacological model that can significantly aid in the process of drug discovery and development.

Author : P. Michael Conn
Publisher : Springer Science & Business Media
Page : 756 pages
File Size : 47,9 Mb
Release : 2008-03-07
Category : Medical
ISBN : 9781597452854

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Sourcebook of Models for Biomedical Research by P. Michael Conn Pdf

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Author : Allan V. Kalueff
Publisher : Springer
Page : 0 pages
File Size : 49,5 Mb
Release : 2017-02-13
Category : Medical
ISBN : 3319337734

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The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish by Allan V. Kalueff Pdf

Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book “The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling” explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.

Author : Dorte Bratbo Sørensen,Sylvie Cloutier,Brianna N. Gaskill
Publisher : CRC Press
Page : 205 pages
File Size : 43,8 Mb
Release : 2020-10-14
Category : Medical
ISBN : 9780429607578

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Animal-centric Care and Management by Dorte Bratbo Sørensen,Sylvie Cloutier,Brianna N. Gaskill Pdf

The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and management, Animal-centric Care and Management: Enhancing Refinement in Biomedical Research takes Russell and Burch’s definition of Refinement as "elimination of inhumanities" and goes further. Rather than fitting animals into experimental conditions, it encourages readers to adjust conditions to better meet the behavioral, emotional, physical, and physiological needs and preferences of the animals. The team of expert authors, from the fields of laboratory animal science, ethology, biology as well as animal training, provide ideas for creating housing conditions and handling procedures that induce, to the best of current abilities and knowledge, a long-term positive state of mind in the animals under our care. This book is written for animal caretakers, animal health technicians, researchers, animal facility managers, laboratory animal veterinarians, and anyone who engages in work with living experimental animals or is interested in the continuous improvement of laboratory animal welfare. This interdisciplinary guide will act as a catalyst, resulting in multiple viewpoints and fields collaborating to optimize laboratory animal welfare.

Author : James G. Fox,Bennett J. Cohen,Franklin M. Loew
Publisher : Academic Press
Page : 766 pages
File Size : 43,8 Mb
Release : 2013-10-02
Category : Technology & Engineering
ISBN : 9781483269160

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Laboratory Animal Medicine by James G. Fox,Bennett J. Cohen,Franklin M. Loew Pdf

Laboratory Animal Medicine is a compilation of papers that deals with the diseases and biology of major species of animals used in medical research. The book discusses animal medicine, experimental methods and techniques, design and management of animal facilities, and legislation on laboratory animals. Several papers discuss the biology and diseases of mice, hamsters, guinea pigs, and rabbits. Another paper addresses the dog and cat as laboratory animals, including sourcing of these animals, housing, feeding, and their nutritional needs, as well as breeding and colony management. The book also describes ungulates as laboratory animals, including topics on sourcing, husbandry, preventive medical treatments, and housing facilities. One paper addresses primates as test animals, covering the biology and diseases of old world primates, Cebidae, and ferrets. Some papers pertain to the treatment, diseases, and needed facilities for birds, amphibians, and fish. Other papers then deal with techniques of experimentation, anesthesia, euthanasia, and some factors (spontaneous diseases) that complicate animal research. The text can prove helpful for scientists, clinical assistants, and researchers whose work involves laboratory animals.

Author : Claudia Harper,Christian Lawrence
Publisher : CRC Press
Page : 260 pages
File Size : 48,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439807446

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The Laboratory Zebrafish by Claudia Harper,Christian Lawrence Pdf

Like other books in the Laboratory Animal Pocket Reference Series, this guide covers all aspects pertaining to the use of these organisms including their basic biology, humane care and management, husbandry, life support systems, regulatory compliance, technical procedures, veterinary care, and water quality management. In the relatively brief span

Author : Joseph A. Holden,Lester L. Layfield,Jennifer L. Matthews
Publisher : Cambridge University Press
Page : 157 pages
File Size : 44,8 Mb
Release : 2013-01-21
Category : Science
ISBN : 9781139620635

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The Zebrafish by Joseph A. Holden,Lester L. Layfield,Jennifer L. Matthews Pdf

The zebrafish (Danio rerio) is a valuable and common model for researchers working in the fields of genetics, oncology and developmental sciences. This full-color atlas will aid experimental design and interpretation in these areas by providing a fundamental understanding of zebrafish anatomy. Over 150 photomicrographs are included and can be used for direct comparison with histological slides, allowing quick and accurate identification of the anatomic structures of interest. Hematoxylin and eosin stained longitudinal and transverse sections demonstrate gross anatomic relationships and illustrate the microscopic anatomy of major organs. Unlike much of the current literature, this book is focused exclusively on the zebrafish, eliminating the need for researchers to exclude structures that are only found in other fish.

Author : Allan V. Kalueff,Adam Michael Stewart
Publisher : Humana Press
Page : 0 pages
File Size : 55,8 Mb
Release : 2012-06-06
Category : Medical
ISBN : 1617795968

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Zebrafish Protocols for Neurobehavioral Research by Allan V. Kalueff,Adam Michael Stewart Pdf

Zebrafish (Danio rerio) play an integral role in biomedical research, enabling researchers to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. That, along with their low cost, easy manipulation, short reproductive cycles, and physiological homology to humans, has made zebrafish a vital model organism for neuroscience research. Zebrafish Protocols for Neurobehavioral Research addresses protocols for both larval and adult models, written by the leading experts in the field of zebrafish research. Part I of this book takes advantage of the high-throughput nature of larval models to offer protocols for research requiring high output, easily manipulated screens. The second half of the book focuses on the robust and sophisticated behaviors of adult zebrafish, suitable for the neurophenotyping of complex traits and multi-domain disorders. Importantly, these models complement each other, working together to provide researchers with valuable insights into neurobiology of normal and pathological behavior. Thorough and cutting-edge, this volume is a useful, authoritative reference guide that should hold a coveted spot in zebrafish laboratories across the globe.

Author : Robert L. Jarret,Kevin McCluskey
Publisher : CRC Press
Page : 282 pages
File Size : 41,6 Mb
Release : 2019-07-16
Category : Science
ISBN : 9781351587778

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The Biological Resources of Model Organisms by Robert L. Jarret,Kevin McCluskey Pdf

This book discusses 14 model organisms and are used by thousands of researchers, teachers, and students each year in laboratories and classrooms, around the globe. Though acknowledged in innumerable scientific journal articles, little is generally known about the origin of these collections, how the organisms contained within them have been acquired, and how they are maintained and distributed. While some collections such as Drosophila have long histories others, such as the collection of Brachionus, are relatively new. They vary greatly in size. Yet, all have contributed and are continuing to contribute to global research efforts in many areas of scientific research as diverse as tissue regeneration, skin cancer, evolution, water purity, gene function, and hundreds of others. In addition to providing the raw materials for national and international research programs, these collections also provide educational tools used by colleges and high schools. The chapters in this book attempt to provide a brief look at the individual organisms, how they came to be accepted as model organisms, the history of the individual collections, examples of how the organisms have been and are being used in scientific research, and a description of the facilities and procedures used to maintain them. Features: • Provides an in-depth look at the collections of 14 model organisms that have enabled innumerable scientific breakthroughs over decades, and that continue to do so. • Includes detailed descriptions of the operating procedures used for the maintenance of each model organism collection. • Discusses the holdings of the collections of model organisms and its relevance to past, current and future scientific research. • Written by the leaders in the field of the management of model organisms.

Author : Hajime Kojima,Troy Seidle,Horst Spielmann
Publisher : Springer
Page : 130 pages
File Size : 43,7 Mb
Release : 2018-12-27
Category : Medical
ISBN : 9789811324475

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Alternatives to Animal Testing by Hajime Kojima,Troy Seidle,Horst Spielmann Pdf

This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.

Author : Anonim
Publisher : Academic Press
Page : 468 pages
File Size : 53,9 Mb
Release : 2010-06-23
Category : Science
ISBN : 0080961371

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Fish Physiology: Zebrafish by Anonim Pdf

This cutting-edge resource includes up-to-date information on zebrafish physiology and the tools used to study it, not only as a model species for studies of other vertebrates but with application for studies of human disease and aquatic toxicology. The utility of zebrafish for physiological research is based on several key features including i) a "fully" sequenced genome, ii) rapid (~3 month) generation times), iii) their capacity to produce large numbers of externally fertilized eggs, iv) optical transparency of embryos and larvae, and v) the applicability of reverse and forward genetics to assess gene function. Gene knockdown in embryos and the production of transgenic strains are now standard techniques being used to assess physiology. This book will be of keen interest not only to the typical readers of Fish Physiology but also to biomedical researchers, toxicologists and developmental biologists. Integrates and synthesizes the biology of the zebrafish under one cover Features contributions from the leading researchers in their fields Reaches a wider audience of researchers and biologists with its broad inclusion of subjects relating to zebrafish physiology

Author : Christiane Nusslein-Volhard,Ralf Dahm
Publisher : Oxford University Press
Page : 342 pages
File Size : 53,7 Mb
Release : 2002-09-19
Category : Science
ISBN : 019963808X

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Zebrafish by Christiane Nusslein-Volhard,Ralf Dahm Pdf

The zebrafish has become one of the most important model organisms to study biological processes within a living body. As a vertebrate that has many of the strengths of invertebrate model systems, it offers numerous advantages to researchers interested in many aspects of embryonic development, physiology and disease. This book not only provides a complete set of instructions that will allow researchers to establish the zebrafish in their laboratory. It also gives a broad overview of commonly used methods and a comprehensive collection of protocols describing the most powerful techniques.