Biostatistics For Human Genetic Epidemiology

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Biostatistics for Human Genetic Epidemiology

Author : Bertram K. C. Chan
Publisher : Springer
Page : 355 pages
File Size : 40,8 Mb
Release : 2018-10-24
Category : Medical
ISBN : 9783319937915

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Biostatistics for Human Genetic Epidemiology by Bertram K. C. Chan Pdf

The book illustrates how biostatistics may numerically summarize human genetic epidemiology using R, and may be used successfully to solve problems in quantitative Genetic Epidemiology Biostatistics for Human Genetic Epidemiology provides statistical methodologies and R recipes for human genetic epidemiologic problems. It begins by introducing all the necessary probabilistic and statistical foundations, before moving on to topics related human genetic epidemiology, with R codes illustrations for various examples. This clear and concise book covers human genetic epidemiology, using R in data analysis, including multivariate data analysis. It examines probabilistic and statistical theories for modeling human genetic epidemiology – leading the readers through an effective epidemiologic model, from simple to advanced levels. Classical mathematical, probabilistic, and statistical theory are thoroughly discussed and presented. This book also presents R as a calculator and using R in data analysis. Additionally, it covers Advanced Human Genetic Data Concepts, the Study of Human Genetic Variation, Manhattan Plots, as well as the Procedures for Multiple Comparison. Numerous Worked Examples are provided for illustrations of concepts and real-life applications. Biostatistics for Human Genetic Epidemiology is an ideal reference for professionals and students in Medicine (particularly in Preventive Medicine and Public Health Medical Practices), as well as in Genetics, Epidemiology, and Biostatistics.

Statistical Methods in Genetic Epidemiology

Author : Duncan C. Thomas
Publisher : Oxford University Press
Page : 458 pages
File Size : 45,6 Mb
Release : 2004-01-29
Category : Medical
ISBN : 9780199748051

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Statistical Methods in Genetic Epidemiology by Duncan C. Thomas Pdf

This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

Biostatistics for Human Genetic Epidemiology

Author : Bertram Kim-Cheong Chan
Publisher : Unknown
Page : 355 pages
File Size : 43,6 Mb
Release : 2018
Category : HEALTH & FITNESS
ISBN : 3319937928

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Biostatistics for Human Genetic Epidemiology by Bertram Kim-Cheong Chan Pdf

"Biostatistics for Human Genetic Epidemiology provides statistical methodologies and R recipes for human genetic epidemiologic problems. It begins by introducing all the necessary probabilistic and statistical foundations, before moving on to topics related human genetic epidemiology, with R codes illustrations for various examples. This clear and concise book covers human genetic epidemiology, using R in data analysis, including multivariate data analysis. It examines probabilistic and statistical theories for modeling human genetic epidemiology – leading the readers through an effective epidemiologic model, from simple to advanced levels. Classical mathematical, probabilistic, and statistical theory are thoroughly discussed and presented. This book also presents R as a calculator and using R in data analysis. Additionally, it covers Advanced Human Genetic Data Concepts, the Study of Human Genetic Variation, Manhattan Plots, as well as the Procedures for Multiple Comparison. Numerous Worked Examples are provided for illustrations of concepts and real-life applications"--Publisher's description.

Biostatistical Genetics and Genetic Epidemiology

Author : Robert C. Elston,Jane M. Olson,Lyle Palmer
Publisher : John Wiley & Sons
Page : 860 pages
File Size : 48,7 Mb
Release : 2002-04-22
Category : Medical
ISBN : 0471486310

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Biostatistical Genetics and Genetic Epidemiology by Robert C. Elston,Jane M. Olson,Lyle Palmer Pdf

"Human Genetics and Genetic Epidemiology" ist der 3. Band aus der sehr erfolgreichen Reihe 'Wiley Biostatistics Reference Series', die auf Artikeln der "Encyclopedia of Biostatistics" basiert. Dieser Band gibt einen topaktuellen und umfassenden Überblick über ein Forschungsgebiet, das insbesondere im Zuge des Human-Genomprojekts eine regelrechte Explosion an Forschungsaktivitäten erlebt hat. Enthalten sind komplett aktualisierte Artikel aus der "Encyclopedia of Biostatistics" sowie über 25% neue Artikel. Mit einem komplexen System an Querverweisen, die das Auffinden der gewünschten Information erheblich erleichtern. Eine interessante Lektüre für Genetiker, Epidemiologen, Biostatistiker und Forscher in diesen Bereichen.

Fundamentals of Genetic Epidemiology

Author : Muin J. Khoury,Terri H. Beaty,Bernice H. Cohen
Publisher : Monographs in Epidemiology and
Page : 394 pages
File Size : 40,8 Mb
Release : 1993
Category : Medical
ISBN : 9780195052886

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Fundamentals of Genetic Epidemiology by Muin J. Khoury,Terri H. Beaty,Bernice H. Cohen Pdf

This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.

Biostatistics and Epidemiology

Author : Sylvia Wassertheil-Smoller
Publisher : Springer Science & Business Media
Page : 244 pages
File Size : 47,5 Mb
Release : 2006-05-10
Category : Medical
ISBN : 9780387218298

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Biostatistics and Epidemiology by Sylvia Wassertheil-Smoller Pdf

For the new edition of Biostatistics and Epidemiology, Dr. Wassertheil-Smoller has included several new chapters (genetic statistics, molecular epidemiology, scientific integrity and research ethics) and a new appendix on the basic concepts of genetics and a glossary of genetic terminology. She has also expanded the coverage of multi-center trials (an important aspect of implementation of the standards of evidence-based medicine), controversies in screening for prostate, colon, breast, and other cancers.

Basic Biostatistics for Geneticists and Epidemiologists

Author : Robert C. Elston,William Johnson
Publisher : John Wiley & Sons
Page : 384 pages
File Size : 46,9 Mb
Release : 2008-11-20
Category : Medical
ISBN : 9780470024911

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Basic Biostatistics for Geneticists and Epidemiologists by Robert C. Elston,William Johnson Pdf

Anyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures. This Book: Surveys basic statistical methods used in the genetics and epidemiology literature, including maximum likelihood and least squares. Introduces methods, such as permutation testing and bootstrapping, that are becoming more widely used in both genetic and epidemiological research. Is illustrated throughout with simple examples to clarify the statistical methodology. Explains Bayes’ theorem pictorially. Features exercises, with answers to alternate questions, enabling use as a course text. Written at an elementary mathematical level so that readers with high school mathematics will find the content accessible. Graduate students studying genetic epidemiology, researchers and practitioners from genetics, epidemiology, biology, medical research and statistics will find this an invaluable introduction to statistics.

The Fundamentals of Modern Statistical Genetics

Author : Nan M. Laird,Christoph Lange
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 52,8 Mb
Release : 2010-12-13
Category : Medical
ISBN : 9781441973382

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The Fundamentals of Modern Statistical Genetics by Nan M. Laird,Christoph Lange Pdf

This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.

A Statistical Approach to Genetic Epidemiology

Author : Andreas Ziegler,Inke R. Kônig,Friedrich Pahlke
Publisher : John Wiley & Sons
Page : 522 pages
File Size : 43,7 Mb
Release : 2011-08-24
Category : Science
ISBN : 9783527633661

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A Statistical Approach to Genetic Epidemiology by Andreas Ziegler,Inke R. Kônig,Friedrich Pahlke Pdf

A Statistical Approach to Genetic Epidemiology After studying statistics and mathematics at the University of Munich and obtaining his doctoral degree from the University of Dortmund, Andreas Ziegler received the Johann-Peter-Süssmilch-Medal of the German Association for Medical Informatics, Biometry and Epidemiology for his post-doctoral work on “Model Free Linkage Analysis of Quantitative Traits” in 1999. In 2004, he was one of the recipients of the Fritz-Linder-Forum-Award from the German Association for Surgery.

Statistical Human Genetics

Author : Robert C. Elston
Publisher : Humana
Page : 0 pages
File Size : 42,6 Mb
Release : 2018-08-14
Category : Medical
ISBN : 1493984381

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Statistical Human Genetics by Robert C. Elston Pdf

The aim of this volume is to make computer programs for analyzing human genetic data more easily accessible to the beginner.Statistical Human Genetics: Methods and Protocols, Second Edition provides updated and new chapters detailing genetic terms, analysis software, and how to interpret the program outputs. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, step-by-step instructions, and tips on troubleshooting and avoiding known pitfalls. The purpose of Statistical Human Genetics: Methods and Protocols, Second Edition is to ensure successful and meaningful results in the fast-growing field of genetic epidemiology.

An Introduction to Genetic Epidemiology

Author : Palmer, Lyle J.,Burton, Paul R.,George Davey Smith
Publisher : Policy Press
Page : 240 pages
File Size : 52,8 Mb
Release : 2011-05-31
Category : Medical
ISBN : 9781861348975

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An Introduction to Genetic Epidemiology by Palmer, Lyle J.,Burton, Paul R.,George Davey Smith Pdf

This book brings together leading experts to provide an introduction to genetic epidemiology that begins with a primer in human molecular genetics through all the standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field.

Analysis of Genetic Association Studies

Author : Gang Zheng,Yaning Yang,Xiaofeng Zhu,Robert C. Elston
Publisher : Springer Science & Business Media
Page : 419 pages
File Size : 55,7 Mb
Release : 2012-01-10
Category : Mathematics
ISBN : 9781461422440

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Analysis of Genetic Association Studies by Gang Zheng,Yaning Yang,Xiaofeng Zhu,Robert C. Elston Pdf

Analysis of Genetic Association Studies is both a graduate level textbook in statistical genetics and genetic epidemiology, and a reference book for the analysis of genetic association studies. Students, researchers, and professionals will find the topics introduced in Analysis of Genetic Association Studies particularly relevant. The book is applicable to the study of statistics, biostatistics, genetics and genetic epidemiology. In addition to providing derivations, the book uses real examples and simulations to illustrate step-by-step applications. Introductory chapters on probability and genetic epidemiology terminology provide the reader with necessary background knowledge. The organization of this work allows for both casual reference and close study.

Biostatistics for Epidemiology and Public Health Using R

Author : Bertram K.C. Chan, PhD
Publisher : Springer Publishing Company
Page : 500 pages
File Size : 55,9 Mb
Release : 2015-11-05
Category : Medical
ISBN : 9780826110268

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Biostatistics for Epidemiology and Public Health Using R by Bertram K.C. Chan, PhD Pdf

Since it first appeared in 1996, the open-source programming language R has become increasingly popular as an environment for statistical analysis and graphical output. This is the first textbook to present classical biostatistical analysis for epidemiology and related public health sciences to students using the R language. Based on the assumption that readers have minimal familiarity with statistical concepts, the author uses a step-by-step approach to building skills. The text encompasses biostatistics from basic descriptive and quantitative statistics to survival analysis and missing data analysis in epidemiology. Illustrative examples, including real-life research problems drawn from such areas as nutrition, environmental health, and behavioral health, engage students and reinforce the understanding of R. These examples illustrate the replication of R for biostatistical calculations and graphical display of results. The text covers both essential and advanced techniques and applications in biostatistics that are relevant to epidemiology. Also included are an instructor's guide, student solutions manual, and downloadable data sets. Key Features: First overview biostatistics textbook for epidemiology and public health that uses the open-source R program Covers essential and advanced techniques and applications in biostatistics as relevant to epidemiology Features abundant examples to illustrate the application of R language for biostatistical calculations and graphical displays of results Includes instructor's guide, student solutions manual, and downloadable data sets.

Statistics in Human Genetics

Author : Pak Sham
Publisher : Wiley
Page : 0 pages
File Size : 49,7 Mb
Release : 1997-12-08
Category : Science
ISBN : 0470689285

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Statistics in Human Genetics by Pak Sham Pdf

Rigorous statistical analysis methods for human genetics application Statistics in Human Genetics explores the statistical analysis methods that are critical to good science. Beginning with a brief review of genes, gene structure, variation, and terminology, the book moves into analysis of segregation, genetic linkage, allelic associations, and continuity for a wide range of conditions. From the classic Hardy-Weinberg equation to advanced modeling, algorithms and more, this book provides authoritative guidance toward methods, analysis, and applications for anyone performing quantitative analysis of human genetics.

Biostatistics and Epidemiology

Author : Sylvia Wassertheil-Smoller
Publisher : Springer Science & Business Media
Page : 132 pages
File Size : 43,6 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781475738872

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Biostatistics and Epidemiology by Sylvia Wassertheil-Smoller Pdf

Biostatistics and Epidemiology/A Primer for Health Professionals offers practical guidelines and gives a concise framework for research and interpretation in the field. In addition to major sections covering statistics and epidemiology, the book includes a comprehensive exploration of scientific methodology, probability, and the clinical trial. The principles and methods described in this book are basic and apply to all medical subspecialties, psychology and education. The primer will be especially useful to public health officials and students looking for an understandable treatment of the subject.