Statistics In Human Genetics

Author : Robert C. Elston,Jaya M. Satagopan,Shuying Sun
Publisher : Humana Press
Page : 564 pages
File Size : 46,7 Mb
Release : 2012-02-04
Category : Science
ISBN : 1617795542

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Statistical Human Genetics by Robert C. Elston,Jaya M. Satagopan,Shuying Sun Pdf

Recent advances in genetics over the last quarter of a century, especially in molecular techniques, have dramatically reduced the cost of determining genetic markers and hence opened up a field of research that is increasingly helping to detect, prevent and/or cure many diseases that afflict humans. In Statistical Human Genetics: Methods and Protocols expert researchers in the field describe statistical methods and computer programs in the detail necessary to make them more easily accessible to the beginner analyzing data. Written in the highly successful Methods in Molecular BiologyTM series format, with examples of running the programs and interpreting the program outputs, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results from human genetic data collected in the laboratory. Thorough and as much as possible intuitive, Statistical Human Genetics: Methods and Protocols aids scientists in understanding the computer programs and analytical procedures they need to use.

Author : Pak Sham
Publisher : Wiley
Page : 0 pages
File Size : 51,9 Mb
Release : 1997-12-08
Category : Science
ISBN : 0470689285

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Statistics in Human Genetics by Pak Sham Pdf

Rigorous statistical analysis methods for human genetics application Statistics in Human Genetics explores the statistical analysis methods that are critical to good science. Beginning with a brief review of genes, gene structure, variation, and terminology, the book moves into analysis of segregation, genetic linkage, allelic associations, and continuity for a wide range of conditions. From the classic Hardy-Weinberg equation to advanced modeling, algorithms and more, this book provides authoritative guidance toward methods, analysis, and applications for anyone performing quantitative analysis of human genetics.

Author : Nan M. Laird,Christoph Lange
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 53,8 Mb
Release : 2010-12-13
Category : Medical
ISBN : 9781441973382

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The Fundamentals of Modern Statistical Genetics by Nan M. Laird,Christoph Lange Pdf

This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.

Author : Cavan Reilly
Publisher : CRC Press
Page : 284 pages
File Size : 46,9 Mb
Release : 2009-06-19
Category : Mathematics
ISBN : 9781420072648

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Statistics in Human Genetics and Molecular Biology by Cavan Reilly Pdf

Focusing on the roles of different segments of DNA, Statistics in Human Genetics and Molecular Biology provides a basic understanding of problems arising in the analysis of genetics and genomics. It presents statistical applications in genetic mapping, DNA/protein sequence alignment, and analyses of gene expression data from microarray experiments.

Author : Melinda C. Mills,Nicola Barban,Felix C. Tropf
Publisher : MIT Press
Page : 433 pages
File Size : 49,6 Mb
Release : 2020-02-18
Category : Science
ISBN : 9780262357449

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An Introduction to Statistical Genetic Data Analysis by Melinda C. Mills,Nicola Barban,Felix C. Tropf Pdf

A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.

Author : Duncan C. Thomas
Publisher : Oxford University Press
Page : 458 pages
File Size : 41,6 Mb
Release : 2004-01-29
Category : Medical
ISBN : 9780199748051

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Statistical Methods in Genetic Epidemiology by Duncan C. Thomas Pdf

This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

Author : Kenneth Lange
Publisher : Springer Science & Business Media
Page : 376 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9780387217505

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Mathematical and Statistical Methods for Genetic Analysis by Kenneth Lange Pdf

Written to equip students in the mathematical siences to understand and model the epidemiological and experimental data encountered in genetics research. This second edition expands the original edition by over 100 pages and includes new material. Sprinkled throughout the chapters are many new problems.

Author : Bertram K. C. Chan
Publisher : Springer
Page : 355 pages
File Size : 55,7 Mb
Release : 2018-10-24
Category : Medical
ISBN : 9783319937915

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Biostatistics for Human Genetic Epidemiology by Bertram K. C. Chan Pdf

The book illustrates how biostatistics may numerically summarize human genetic epidemiology using R, and may be used successfully to solve problems in quantitative Genetic Epidemiology Biostatistics for Human Genetic Epidemiology provides statistical methodologies and R recipes for human genetic epidemiologic problems. It begins by introducing all the necessary probabilistic and statistical foundations, before moving on to topics related human genetic epidemiology, with R codes illustrations for various examples. This clear and concise book covers human genetic epidemiology, using R in data analysis, including multivariate data analysis. It examines probabilistic and statistical theories for modeling human genetic epidemiology – leading the readers through an effective epidemiologic model, from simple to advanced levels. Classical mathematical, probabilistic, and statistical theory are thoroughly discussed and presented. This book also presents R as a calculator and using R in data analysis. Additionally, it covers Advanced Human Genetic Data Concepts, the Study of Human Genetic Variation, Manhattan Plots, as well as the Procedures for Multiple Comparison. Numerous Worked Examples are provided for illustrations of concepts and real-life applications. Biostatistics for Human Genetic Epidemiology is an ideal reference for professionals and students in Medicine (particularly in Preventive Medicine and Public Health Medical Practices), as well as in Genetics, Epidemiology, and Biostatistics.

Author : David J. Balding,Martin Bishop,Chris Cannings
Publisher : John Wiley & Sons
Page : 1616 pages
File Size : 48,8 Mb
Release : 2008-06-10
Category : Science
ISBN : 0470997621

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Handbook of Statistical Genetics by David J. Balding,Martin Bishop,Chris Cannings Pdf

The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.

Author : Pak Sham
Publisher : John Wiley & Sons
Page : 290 pages
File Size : 45,7 Mb
Release : 1998-01
Category : Genetics
ISBN : 0471194883

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Statistics in Human Genetics by Pak Sham Pdf

This is one of the first introductions to the sophisticated statistical methods that play a key role in research on human genetics. Topics include the estimation of allele frequencies, the testing for Hardy-Weinberg equilibrium, classical and complex segregation analysis, linkage analysis for Mendelian and complex diseases and quantitative traits, the detection of allelic associations, the estimation of heritability for multifactorial traits and path analysis.

Author : Melinda C. Mills,Nicola Barban,Felix C. Tropf
Publisher : MIT Press
Page : 433 pages
File Size : 42,9 Mb
Release : 2020-02-18
Category : Science
ISBN : 9780262538381

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An Introduction to Statistical Genetic Data Analysis by Melinda C. Mills,Nicola Barban,Felix C. Tropf Pdf

A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.

Author : Benjamin Neale,Manuel Ferreira,Sarah Medland,Danielle Posthuma
Publisher : Garland Science
Page : 608 pages
File Size : 53,8 Mb
Release : 2007-11-30
Category : Science
ISBN : 9781134129331

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Statistical Genetics by Benjamin Neale,Manuel Ferreira,Sarah Medland,Danielle Posthuma Pdf

Statistical Genetics is an advanced textbook focusing on conducting genome-wide linkage and association analysis in order to identify the genes responsible for complex behaviors and diseases. Starting with an introductory section on statistics and quantitative genetics, it covers both established and new methodologies, providing the genetic and statistical theory on which they are based. Each chapter is written by leading researchers, who give the reader the benefit of their experience with worked examples, study design, and sources of error. The text can be used in conjunction with an associated website (www.genemapping.org) that provides supplementary material and links to downloadable software.

Author : David J. Balding,Ida Moltke,John Marioni
Publisher : John Wiley & Sons
Page : 1223 pages
File Size : 49,9 Mb
Release : 2019-09-10
Category : Science
ISBN : 9781119429142

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Handbook of Statistical Genomics by David J. Balding,Ida Moltke,John Marioni Pdf

A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

Author : Oscar Kempthorne
Publisher : Unknown
Page : 576 pages
File Size : 48,5 Mb
Release : 1969
Category : Biomathematics
ISBN : WISC:89031182876

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An Introduction to Genetic Statistics by Oscar Kempthorne Pdf

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Human Genome Diversity
Publisher : National Academies Press
Page : 101 pages
File Size : 47,6 Mb
Release : 1998-01-19
Category : Science
ISBN : 9780309184748

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Evaluating Human Genetic Diversity by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Human Genome Diversity Pdf

This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.