Blood Platelets

Author : Alan D. Michelson
Publisher : Elsevier
Page : 1386 pages
File Size : 40,9 Mb
Release : 2011-08-29
Category : Medical
ISBN : 9780080465869

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Platelets by Alan D. Michelson Pdf

Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. First edition won Best Book in Medical Science Award from the Association of American Publishers Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

Author : Paolo Gresele,Neal S. Kleiman,José A. Lopez,Clive P. Page
Publisher : Springer
Page : 1445 pages
File Size : 53,9 Mb
Release : 2017-03-08
Category : Medical
ISBN : 9783319474625

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Platelets in Thrombotic and Non-Thrombotic Disorders by Paolo Gresele,Neal S. Kleiman,José A. Lopez,Clive P. Page Pdf

This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

Author : Jonathan M. Gibbins,Martyn P. Mahaut-Smith
Publisher : Springer Science & Business Media
Page : 389 pages
File Size : 41,7 Mb
Release : 2008-02-04
Category : Medical
ISBN : 9781592597826

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Platelets and Megakaryocytes by Jonathan M. Gibbins,Martyn P. Mahaut-Smith Pdf

12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.

Author : Laura Dean
Publisher : Unknown
Page : 128 pages
File Size : 54,9 Mb
Release : 2005
Category : Blood group antigens
ISBN : OCLC:225053075

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Blood Groups and Red Cell Antigens by Laura Dean Pdf

Author : Beth H. Shaz,Christopher D. Hillyer,Mikhail Roshal,Charles S. Abrams
Publisher : Newnes
Page : 1014 pages
File Size : 45,6 Mb
Release : 2013-05-13
Category : Science
ISBN : 9780123977885

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Transfusion Medicine and Hemostasis by Beth H. Shaz,Christopher D. Hillyer,Mikhail Roshal,Charles S. Abrams Pdf

The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). Updated content covers new coagulation tests, cellular therapies, and quality control issues Easy to use, with focused, well-defined chapters in a standardized format throughout Offers quick "cross-reference" lists at the end of each chapter Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities

Author : Shirley A. Johnson
Publisher : Elsevier
Page : 623 pages
File Size : 54,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323144322

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The Circulating Platelet by Shirley A. Johnson Pdf

The Circulating Platelet focuses on the biochemistry and physiology of platelets. Composed of contributions of authors, the compilation starts with the discussions on the origin, discovery, production, and life span of blood platelets. The discussions continue with the morphology of platelets. Concerns include peripheral, sol-gel, and organelle zones and the membrane systems. The book also looks at the energy metabolism of thrombocytes and highlights the presence of glycoproteins in blood platelets. These include polysaccharides, glucosaminoglycans, and glycoproteins. The text also discusses the properties, functions, and the physiological value of thrombosthenin. The compilation further discusses platelet aggregation and functions of platelets. Concerns include collection and processing of platelets; preparation of homogenates; and the agents that influence platelet aggregation. The role of platelets in blood clots and fibrinolysis is emphasized. The selection ends with discussions on the immunological reactions of platelets; the clinical diseases related to blood platelets; and blood transfusion and preservation. The text is vital for researchers interested in studying blood platelets.

Author : Steve W. Kerrigan,Niamh Moran
Publisher : BoD – Books on Demand
Page : 250 pages
File Size : 47,8 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9789535122081

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The Non-Thrombotic Role of Platelets in Health and Disease by Steve W. Kerrigan,Niamh Moran Pdf

Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

Author : Pier Mannuccio Mannucci,Sergio Gorini
Publisher : Springer
Page : 384 pages
File Size : 54,5 Mb
Release : 1972
Category : Medical
ISBN : UCAL:B4530689

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Platelet Function and Thrombosis by Pier Mannuccio Mannucci,Sergio Gorini Pdf

The special contribution of the present volume is that of gathering a large amount of up-to-date information on the formidable problem of the methods used for testing platelet function in thrombosis. The methods used for studying platelet behavior in hemorrhagic disorders due to abnormal platelet function are undoubtedly characterized by difficulties in interpretation and by poor reproducibility. However, all will agree that the problem of the significance and importance of platelet function tests in thrombosis and atherosclerosis is an absolute "morass," and recent and past papers on the measurement of platelet adhesiveness in myocardial infarction could well appear in a special issue of the new "Journal of Irreproducible Results". This volume includes both general papers on the role of platelets in thrombosis by G. V. R. Born, Duncan P. Thomas, and J. R.

Author : Meinrad Gawaz
Publisher : Georg Thieme Verlag
Page : 204 pages
File Size : 40,7 Mb
Release : 2001
Category : Medical
ISBN : 3131058110

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Blood Platelets by Meinrad Gawaz Pdf

This book provides a comprehensive survey of the importance of blood platelets for coronary heart diseases. It gives both research workers and clinicians an insight into the function of thrombocytes and the significance of platelets in the clinical framework of coronary heart diseases in order to create an understanding of the differntiated use of antithrombocytic principles. The first part is dedicated to the function of platelets hemostasis and their connections with coagulation cascades. Further sections are devoted to the current methods in the functional diagnostics of thrombocytes.

Author : Ronald Hoffman
Publisher : Unknown
Page : 2821 pages
File Size : 45,9 Mb
Release : 2005
Category : Blood
ISBN : 0443066280

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Hematology by Ronald Hoffman Pdf

Author : Gesina Longenecker
Publisher : Elsevier
Page : 508 pages
File Size : 51,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323147705

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The Platelets by Gesina Longenecker Pdf

The Platelets: Physiology and Pharmacology is a critical review of the basic platelet systems, methodologic critiques, and platelet involvement in major disease states. This book is composed of 20 chapters that specifically deal with the physiology and biochemistry of the platelet system, along with possibilities for, and consequences of, pharmacologic manipulation. The opening chapters examine the basic processes of platelet aggregation and adhesion. These topics are followed by discussions on the types and functions of platelet a-granule proteins; the aspects of adenine nucleotide levels, regulation, and storage; and receptors for catecholamines and consequences of their agonism. Other chapters are devoted to the metabolism of arachidonic acid, its manipulation, consequences, and metabolite receptors. The discussion then shifts to the second-messenger entities, specifically calmodulin, calcium, and cyclic adenosine monophosphate. A chapter presents the comparisons of man and commonly used laboratory animals concerning platelet behavior variability. Another chapter looks into the use and appropriateness of the use of platelets as models of neurons, with a special emphasis on serotonergic neurons. The remaining chapters contain critical reviews of platelet involvement in diabetes, hypertension and peripheral vascular disease, atherogenesis/atherosclerosis, and ischemic heart disease. These chapters also include specific techniques for platelet analysis, including lumiaggregometry, eicosanoid measurements, and serotonin uptake and release. This book is an invaluable source for pharmacologists, biochemists, researchers, and clinicians who are interested in platelet involvement in disease.

Author : Asim K. Duttaroy
Publisher : John Wiley & Sons
Page : 262 pages
File Size : 40,5 Mb
Release : 2018-06-05
Category : Technology & Engineering
ISBN : 9781119376019

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Nutraceuticals and Human Blood Platelet Function by Asim K. Duttaroy Pdf

A comprehensive review of the impact of dietary nutraceuticals on platelet function and its relationship to cardiovascular disease Nutraceuticals and Human Blood Platelet Function offers a summary of the most current evidence on the effects of anti-platelet factors isolated mainly from food and natural sources, their structure function relationship, bioavailability, mechanisms of actions, and also information on human trials data. The author—a noted expert in the field— explores platelet function and their roles in development of CVD, functional foods and bioactive compounds in CVD risk factors. The author highlights platelets, their mechanisms of actions, data from epidemiological studies, structure-function relationship clinical trial data, ex vivo and in vitro data. This important resource will focus primarily on human studies and emphasize functional and physiological implications of the nutritional impact on platelet function and CVD that could be an important approach to highlight the concept of preventive CVD nutrition. An authoritative text, Nutraceuticals and Human Blood Platelet Function: Offers a unique resource that connects nutrition with platelet function and its impact on cardiovascular disease Contains an evidenced-based approach, including data from human and animal clinical studies Reveals the impact of bioactive compounds and their effect on platelets Presents a text that is authored by an expert with vast experience in the field of nutrition and platelet function Written for professionals, academics, researchers, and students associated in the area of nutrition, Nutraceuticals and Human Blood Platelet Function offers a review of the most current research on the effects of platelet function and their roles in development of CVD, functional foods and bioactive compounds in CVD risk factors.

Author : Barbara J. Bain
Publisher : John Wiley & Sons
Page : 489 pages
File Size : 41,5 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405171601

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Blood Cells by Barbara J. Bain Pdf

Blood Cells has been written with both the practisinghaematologist and the trainee in mind. It aims to provide a guidefor use in the diagnostic haematology laboratory, covering methodsof collection of blood specimens, blood film preparation andstaining, the principles of manual and automated blood counts andthe assessment of the morphological features of blood cells. Thepractising haematologist should find this book sufficientlycomprehensive to be a reference source while, at the same time, thetrainee haematologist and biomedical scientist should find it astraightforward and practical bench manual. Enables both the haematologist and laboratory scientist toidentify blood cell features, from the most common to the moreobscure Provides essential information on methods of collection, bloodfilm preparation and staining, together with the principles ofmanual and automated blood counts Completely revised and updated, incorporating much newlypublished information: now includes advice on further tests when aspecific diagnosis is suspected Four hundred high quality photographs to aid with blood cellidentification Highlights the purpose and clinical relevance of haematologylaboratory tests throughout

Author : Alan D. Michelson
Publisher : Academic Press
Page : 1399 pages
File Size : 53,7 Mb
Release : 2013-01-09
Category : Medical
ISBN : 9780123878373

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Platelets by Alan D. Michelson Pdf

Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. Highly Commended BMA Medical Book Award 2013: Internal Medicine Comprehensive and definitive source of knowledge about platelets for clinicians, pathologists and scientists Integrates the entire field of platelet biology, pathophysiology, and clinical medicine Full color reference comprising 64 chapters, 1400 pages, and 16,000 references Contributions from 126 world leaders in their fields New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets ex vivo

Author : José Fábio Santos Duarte Lana,Maria Helena Andrade Santana,William Dias Belangero,Angela Cristina Malheiros Luzo
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 49,7 Mb
Release : 2013-10-29
Category : Technology & Engineering
ISBN : 9783642401176

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Platelet-Rich Plasma by José Fábio Santos Duarte Lana,Maria Helena Andrade Santana,William Dias Belangero,Angela Cristina Malheiros Luzo Pdf

Platelet-Rich Plasma (PRP) has gained tremendous popularity in recent years as a treatment option for specialties including Orthopedics, Dentistry, Sports Medicine, Otorhinolaryngology, Neurosurgery, Ophthalmology, Urology, Vascular, Cardiothoracic and Maxillofacial Surgery, and Veterinarian Medicine. Nowadays, PRP and Stem Cell Science have added an exciting dimension to tissue repair. This book begins by giving the reader a broad overview of current progress as well as a discussion of the technical aspects of preparation and therapeutic use of autologous PRP. It is followed by a review of platelet structure, function and major growth factors in PRP (PDGF and TGFβ).The third chapter outlines the basic principles of biochemical cellular metabolism that increases the efficacy of PRP. Analogous to the preparation of soil for a garden, restoring cellular health should be the first consideration in Regenerative Medicine. Standardization of PRP preparation to clinical use still remains a challenging prospect. In this sense, a feasible strategy for studying PRP preparation is illustrated, which also allows to modulate and tailor the quality of PRP for further clinical applications. The science behind PRP and stem cells, on tissue regeneration, cell proliferation and mesenchyme stem-cells are emphasized and reviewed. Various specific uses of PRP are described with detailed illustrations of various personal experiences mainly in orthopedic injuries, ligament and tend on repair, degenerative diseases, sports medicine, chronic wound healing as well as rehabilitation aspects in tendinopathy. Expertly written by leading scientists in the field, this book provides for beginners and experienced readers scientific fundamentals, the state of art of PRP, specific uses and personal experiences with a practical approach and reference for current trends in use. Finally, this book paves the way for future developments.